JP2007501210A5 - - Google Patents
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- Publication number
- JP2007501210A5 JP2007501210A5 JP2006522400A JP2006522400A JP2007501210A5 JP 2007501210 A5 JP2007501210 A5 JP 2007501210A5 JP 2006522400 A JP2006522400 A JP 2006522400A JP 2006522400 A JP2006522400 A JP 2006522400A JP 2007501210 A5 JP2007501210 A5 JP 2007501210A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- amino
- alkanoyl
- alkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 349
- 125000003545 alkoxy group Chemical group 0.000 claims 96
- 125000001424 substituent group Chemical group 0.000 claims 72
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 68
- -1 R 31 Chemical compound 0.000 claims 58
- 125000003282 alkyl amino group Chemical group 0.000 claims 55
- 125000001589 carboacyl group Chemical group 0.000 claims 52
- 229910052757 nitrogen Inorganic materials 0.000 claims 50
- 229910052739 hydrogen Inorganic materials 0.000 claims 49
- 239000001257 hydrogen Substances 0.000 claims 49
- 125000000623 heterocyclic group Chemical group 0.000 claims 47
- 150000002431 hydrogen Chemical class 0.000 claims 41
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 34
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 31
- 125000005843 halogen group Chemical group 0.000 claims 29
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- 125000005842 heteroatom Chemical group 0.000 claims 27
- 229910052760 oxygen Inorganic materials 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000003342 alkenyl group Chemical group 0.000 claims 24
- 125000000304 alkynyl group Chemical group 0.000 claims 24
- 125000004043 oxo group Chemical group O=* 0.000 claims 23
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims 18
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 16
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 16
- 125000004103 aminoalkyl group Chemical group 0.000 claims 16
- 125000004122 cyclic group Chemical group 0.000 claims 16
- 229920006395 saturated elastomer Polymers 0.000 claims 16
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 15
- 125000002619 bicyclic group Chemical group 0.000 claims 14
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 10
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 7
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 6
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 6
- 125000004193 piperazinyl group Chemical group 0.000 claims 6
- 125000003386 piperidinyl group Chemical group 0.000 claims 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 6
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 5
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- QEMQZTUAJCGRIH-UHFFFAOYSA-N 1-[4-[2-[4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCN1CCN(CC(C)=O)CC1 QEMQZTUAJCGRIH-UHFFFAOYSA-N 0.000 claims 2
- KIDITLRMHHRNNQ-UHFFFAOYSA-N 1-[4-[2-[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxyethyl]piperazin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C=C(C)NC4=CC=3)N=CN=C2C=C1OCCN1CCN(CC(C)=O)CC1 KIDITLRMHHRNNQ-UHFFFAOYSA-N 0.000 claims 2
- HRVVCEOIDNXSIV-UHFFFAOYSA-N 5-[2-[4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxyquinazolin-7-yl]oxyethyl]-3a,4,6,6a-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole Chemical compound C1=C2NC(C)=CC2=C(F)C(OC2=C3C=C(C(=CC3=NC=N2)OCCN2CC3OCOC3C2)OC)=C1 HRVVCEOIDNXSIV-UHFFFAOYSA-N 0.000 claims 2
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000466 oxiranyl group Chemical group 0.000 claims 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 2
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- PLQFHSGCVXIPKH-UHFFFAOYSA-N 1-[4-[2-[4-[(2,3-dimethyl-1h-indol-5-yl)oxy]-6-methoxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C(C)=C(C)NC4=CC=3)N=CN=C2C=C1OCCN1CCN(CC(C)=O)CC1 PLQFHSGCVXIPKH-UHFFFAOYSA-N 0.000 claims 1
- UAQNJPXMOZCSEZ-UHFFFAOYSA-N 1-[4-[2-[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxyethyl]piperazin-1-yl]-2-pyrrolidin-1-ylethanone Chemical compound COC1=CC2=C(OC=3C=C4C=C(C)NC4=CC=3)N=CN=C2C=C1OCCN(CC1)CCN1C(=O)CN1CCCC1 UAQNJPXMOZCSEZ-UHFFFAOYSA-N 0.000 claims 1
- IELFRTCUXMQWBP-UHFFFAOYSA-N 1-[4-[2-[6-methoxy-4-[(3-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxyethyl]piperazin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C(C)=CNC4=CC=3)N=CN=C2C=C1OCCN1CCN(CC(C)=O)CC1 IELFRTCUXMQWBP-UHFFFAOYSA-N 0.000 claims 1
- UDNVOJWOIXRDLF-UHFFFAOYSA-N 1-[4-[4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-6-methoxyquinazolin-7-yl]oxypiperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OC1CCN(CC(C)=O)CC1 UDNVOJWOIXRDLF-UHFFFAOYSA-N 0.000 claims 1
- JIDBTFNSOGJOPT-UHFFFAOYSA-N 1-[4-[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxypiperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C=C(C)NC4=CC=3)N=CN=C2C=C1OC1CCN(CC(C)=O)CC1 JIDBTFNSOGJOPT-UHFFFAOYSA-N 0.000 claims 1
- HWFNODHJXDEFNM-UHFFFAOYSA-N 1-[4-[6-methoxy-4-[(2-methyl-1h-indol-6-yl)oxy]quinazolin-7-yl]oxypiperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4NC(C)=CC4=CC=3)N=CN=C2C=C1OC1CCN(CC(C)=O)CC1 HWFNODHJXDEFNM-UHFFFAOYSA-N 0.000 claims 1
- IKXIOUNJXDGJHC-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]-2-pyrrolidin-1-ylethanone Chemical compound COC1=CC2=C(OC=3C=C4C=C(C)NC4=CC=3)N=CN=C2C=C1OCC(CC1)CCN1C(=O)CN1CCCC1 IKXIOUNJXDGJHC-UHFFFAOYSA-N 0.000 claims 1
- SDCNZLCBPPVHFM-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C=C(C)NC4=CC=3)N=CN=C2C=C1OCC1CCN(CC(C)=O)CC1 SDCNZLCBPPVHFM-UHFFFAOYSA-N 0.000 claims 1
- GKAMEQKEZGOKEK-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(2-methyl-1h-indol-6-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]-2-pyrrolidin-1-ylethanone Chemical compound COC1=CC2=C(OC=3C=C4NC(C)=CC4=CC=3)N=CN=C2C=C1OCC(CC1)CCN1C(=O)CN1CCCC1 GKAMEQKEZGOKEK-UHFFFAOYSA-N 0.000 claims 1
- RZQRGWIRKGAYAD-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(2-methyl-1h-indol-6-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4NC(C)=CC4=CC=3)N=CN=C2C=C1OCC1CCN(CC(C)=O)CC1 RZQRGWIRKGAYAD-UHFFFAOYSA-N 0.000 claims 1
- ATGHIPRSDSWTAH-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(3-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]-2-pyrrolidin-1-ylethanone Chemical compound COC1=CC2=C(OC=3C=C4C(C)=CNC4=CC=3)N=CN=C2C=C1OCC(CC1)CCN1C(=O)CN1CCCC1 ATGHIPRSDSWTAH-UHFFFAOYSA-N 0.000 claims 1
- RHKWHQSLWYKYCM-UHFFFAOYSA-N 1-[4-[[6-methoxy-4-[(3-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxymethyl]piperidin-1-yl]propan-2-one Chemical compound COC1=CC2=C(OC=3C=C4C(C)=CNC4=CC=3)N=CN=C2C=C1OCC1CCN(CC(C)=O)CC1 RHKWHQSLWYKYCM-UHFFFAOYSA-N 0.000 claims 1
- CVILSJNFFNFRHL-UHFFFAOYSA-N 5-[2-[4-[(2,3-dimethyl-1h-indol-5-yl)oxy]-6-methoxyquinazolin-7-yl]oxyethyl]-3a,4,6,6a-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole Chemical compound C1=C2NC(C)=C(C)C2=CC(OC2=C3C=C(C(=CC3=NC=N2)OCCN2CC3OCOC3C2)OC)=C1 CVILSJNFFNFRHL-UHFFFAOYSA-N 0.000 claims 1
- SMUZSLBRTYLRAN-UHFFFAOYSA-N 5-[2-[6-methoxy-4-[(2-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxyethyl]-3a,4,6,6a-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole Chemical compound C1=C2NC(C)=CC2=CC(OC2=C3C=C(C(=CC3=NC=N2)OCCN2CC3OCOC3C2)OC)=C1 SMUZSLBRTYLRAN-UHFFFAOYSA-N 0.000 claims 1
- IOHSSFHJTGVTOZ-UHFFFAOYSA-N 5-[2-[6-methoxy-4-[(3-methyl-1h-indol-5-yl)oxy]quinazolin-7-yl]oxyethyl]-3a,4,6,6a-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole Chemical compound C1=C2NC=C(C)C2=CC(OC2=C3C=C(C(=CC3=NC=N2)OCCN2CC3OCOC3C2)OC)=C1 IOHSSFHJTGVTOZ-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001603 reducing effect Effects 0.000 claims 1
- 230000008728 vascular permeability Effects 0.000 claims 1
- 0 C1CC*CC1 Chemical compound C1CC*CC1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0318422.3 | 2003-08-06 | ||
| GBGB0318422.3A GB0318422D0 (en) | 2003-08-06 | 2003-08-06 | Chemical compounds |
| PCT/GB2004/003376 WO2005014582A1 (en) | 2003-08-06 | 2004-08-05 | Quinazoline derivatives as angiogenesis inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007501210A JP2007501210A (ja) | 2007-01-25 |
| JP2007501210A5 true JP2007501210A5 (enExample) | 2007-09-13 |
| JP4890249B2 JP4890249B2 (ja) | 2012-03-07 |
Family
ID=27839732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006522400A Expired - Fee Related JP4890249B2 (ja) | 2003-08-06 | 2004-08-05 | 血管新生阻害剤としてのキナゾリン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7989460B2 (enExample) |
| EP (1) | EP1658280A1 (enExample) |
| JP (1) | JP4890249B2 (enExample) |
| KR (1) | KR20060058705A (enExample) |
| CN (1) | CN1863794B (enExample) |
| AU (1) | AU2004263360A1 (enExample) |
| BR (1) | BRPI0413284A (enExample) |
| CA (1) | CA2534811A1 (enExample) |
| GB (1) | GB0318422D0 (enExample) |
| IL (1) | IL173484A0 (enExample) |
| MX (1) | MXPA06001395A (enExample) |
| NO (1) | NO20060650L (enExample) |
| WO (1) | WO2005014582A1 (enExample) |
| ZA (1) | ZA200601025B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL199802B1 (pl) | 1999-02-10 | 2008-10-31 | Astrazeneca Ab | Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania |
| JP4329003B2 (ja) * | 2001-03-23 | 2009-09-09 | バイエル コーポレイション | Ｒｈｏキナーゼ阻害剤 |
| NZ534171A (en) * | 2002-02-01 | 2007-06-29 | Astrazeneca Ab | Quinazoline compounds for the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| WO2006040520A1 (en) | 2004-10-12 | 2006-04-20 | Astrazeneca Ab | Quinazoline derivatives |
| UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| US7851623B2 (en) * | 2006-11-02 | 2010-12-14 | Astrazeneca Ab | Chemical process |
| RU2010120671A (ru) * | 2007-10-24 | 2011-11-27 | Мерк Шарп Энд Домэ Корп. (Us) | Гетероциклические фениламидные антагонисты кальциевых каналов т-типа |
| US8211911B2 (en) * | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| CN105189462B (zh) * | 2013-02-20 | 2017-11-10 | 卡拉制药公司 | 治疗性化合物和其用途 |
| USD746538S1 (en) * | 2014-02-03 | 2015-12-29 | Nautilus Hyosung Inc. | Automated teller machine |
| USD765340S1 (en) * | 2014-03-24 | 2016-08-30 | Nautilus Hyosung Inc. | Automated teller machine |
| USD746539S1 (en) * | 2014-03-24 | 2015-12-29 | Nautilus Hyosung Inc. | Automated teller machine |
| MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
| CN112996784B (zh) * | 2018-09-18 | 2023-05-30 | 北京越之康泰生物医药科技有限公司 | 吲哚衍生物及其在医药上的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| GB9514265D0 (en) * | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| PL199802B1 (pl) * | 1999-02-10 | 2008-10-31 | Astrazeneca Ab | Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania |
| GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| AU7652101A (en) * | 2000-08-09 | 2002-02-18 | Astrazeneca Ab | Cinnoline compounds |
| AU2001292137A1 (en) * | 2000-10-13 | 2002-04-22 | Astrazeneca Ab | Quinazoline derivatives |
| WO2002034744A1 (en) * | 2000-10-25 | 2002-05-02 | Astrazeneca Ab | Quinazoline derivatives |
| DE60215178T2 (de) * | 2001-07-16 | 2007-08-23 | Astrazeneca Ab | Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase |
| AU2002347336A1 (en) * | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Quinoline derivatives |
| NZ534171A (en) | 2002-02-01 | 2007-06-29 | Astrazeneca Ab | Quinazoline compounds for the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| EP1971338B8 (en) * | 2005-12-22 | 2011-09-21 | AstraZeneca AB | Combination of zd6474 and pemetrexed |
-
2003
- 2003-08-06 GB GBGB0318422.3A patent/GB0318422D0/en not_active Ceased
-
2004
- 2004-08-05 AU AU2004263360A patent/AU2004263360A1/en not_active Abandoned
- 2004-08-05 WO PCT/GB2004/003376 patent/WO2005014582A1/en not_active Ceased
- 2004-08-05 CA CA002534811A patent/CA2534811A1/en not_active Abandoned
- 2004-08-05 CN CN2004800290795A patent/CN1863794B/zh not_active Expired - Fee Related
- 2004-08-05 BR BRPI0413284-0A patent/BRPI0413284A/pt not_active IP Right Cessation
- 2004-08-05 EP EP04743664A patent/EP1658280A1/en not_active Withdrawn
- 2004-08-05 KR KR1020067002540A patent/KR20060058705A/ko not_active Withdrawn
- 2004-08-05 US US10/566,842 patent/US7989460B2/en not_active Expired - Fee Related
- 2004-08-05 MX MXPA06001395A patent/MXPA06001395A/es unknown
- 2004-08-05 JP JP2006522400A patent/JP4890249B2/ja not_active Expired - Fee Related
-
2006
- 2006-01-31 IL IL173484A patent/IL173484A0/en unknown
- 2006-02-03 ZA ZA200601025A patent/ZA200601025B/en unknown
- 2006-02-09 NO NO20060650A patent/NO20060650L/no not_active Application Discontinuation
-
2011
- 2011-06-20 US US13/164,310 patent/US20120046300A1/en not_active Abandoned
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