JP2004283828A - 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法 - Google Patents

粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法 Download PDF

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Publication number
JP2004283828A
JP2004283828A JP2004083639A JP2004083639A JP2004283828A JP 2004283828 A JP2004283828 A JP 2004283828A JP 2004083639 A JP2004083639 A JP 2004083639A JP 2004083639 A JP2004083639 A JP 2004083639A JP 2004283828 A JP2004283828 A JP 2004283828A
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microstructure
separation
liquid
separation zone
separation apparatus
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JP2004283828A5 (enExample
Inventor
Ralf-Peter Peters
ペーターズ，ラルフ−ペーター
Gert Blankenstein
ブランケンシュタイン，ゲルト
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Boehringer Ingelheim Microparts GmbH
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Steag Microparts GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Water Supply & Treatment (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Ecology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2004083639A 2003-03-21 2004-03-22 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法 Pending JP2004283828A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10313201A DE10313201A1 (de) 2003-03-21 2003-03-21 Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält

Publications (2)

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JP2004283828A true JP2004283828A (ja) 2004-10-14
JP2004283828A5 JP2004283828A5 (enExample) 2007-08-02

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JP2004083639A Pending JP2004283828A (ja) 2003-03-21 2004-03-22 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法

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US (2) US20040232074A1 (enExample)
EP (1) EP1459773B1 (enExample)
JP (1) JP2004283828A (enExample)
CN (1) CN1613542A (enExample)
AT (1) ATE556731T1 (enExample)
DE (1) DE10313201A1 (enExample)

Cited By (30)

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JP2005292092A (ja) * 2004-04-05 2005-10-20 Advance Co Ltd 能動流路及びこれを用いた血球分離構造物
JP2006226753A (ja) * 2005-02-16 2006-08-31 Seiko Instruments Inc 成分分離機構と成分分離方法
JP2006266924A (ja) * 2005-03-24 2006-10-05 Konica Minolta Medical & Graphic Inc 検査用マイクロチップおよびそれを用いた検査装置
JP2007538259A (ja) * 2004-05-19 2007-12-27 エクシジェント テクノロジーズ エルエルシー 粒子の処理方法
JP2008089381A (ja) * 2006-09-29 2008-04-17 Fujifilm Corp 血漿回収方法及び血漿回収器具
JP2008149287A (ja) * 2006-12-19 2008-07-03 Nsk Ltd 物質分級装置及び物質分級方法
WO2008130032A1 (ja) * 2007-04-19 2008-10-30 The Ritsumeikan Trust 液中粒子分級装置及び液中粒子分級方法、粒径測定装置及び粒径測定方法
WO2008142850A1 (ja) * 2007-05-15 2008-11-27 Panasonic Corporation 成分分離デバイス及びこれを用いた成分分離方法
WO2009044552A1 (ja) * 2007-10-04 2009-04-09 Panasonic Corporation 分析用デバイスとこれを使用する分析装置および分析方法
JP2009092391A (ja) * 2007-10-04 2009-04-30 Panasonic Corp 分析用デバイスとこれを使用する分析装置および分析方法
JP2009092390A (ja) * 2007-10-04 2009-04-30 Panasonic Corp 分析用デバイスとこれを使用する分析装置および分析方法
WO2009060617A1 (ja) * 2007-11-08 2009-05-14 Panasonic Corporation 分析用デバイスとこれを使用する分析方法
JP2009115670A (ja) * 2007-11-08 2009-05-28 Panasonic Corp 分析用デバイスとこれを使用する分析装置および分析方法
WO2009125997A1 (en) * 2008-04-11 2009-10-15 Incyto Co., Ltd. Microfluidic circuit element comprising microfluidic channel with nano interstices and fabrication method thereof
JP2010002229A (ja) * 2008-06-18 2010-01-07 Nippon Telegr & Teleph Corp <Ntt> フローセル
JP2010025775A (ja) * 2008-07-21 2010-02-04 Brother Ind Ltd 検査対象受体及び当該検査対象受体を備えた検査装置
JP2011504588A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 物理障壁を含む隔離デバイス
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
JP2011221020A (ja) * 2010-04-05 2011-11-04 Nanoentek Inc 外部動力無しで流体が移動する流体分析用チップ
WO2011142518A1 (ko) * 2010-05-10 2011-11-17 광주과학기술원 쯔바이파흐-풍 효과를 이용한 세포 발열량 측정 센서 및 이의 제조방법
JP2012020286A (ja) * 2011-10-05 2012-02-02 Nsk Ltd 物質分級装置及び物質分級方法
JP2012532327A (ja) * 2009-07-07 2012-12-13 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 血漿分離リザーバ
JP2013515599A (ja) * 2009-12-23 2013-05-09 サイトベラ， インコーポレイテッド 粒子を濾過するためのシステム及び方法
JP5251882B2 (ja) * 2007-10-26 2013-07-31 凸版印刷株式会社 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置
KR101475440B1 (ko) * 2012-10-29 2014-12-22 고려대학교 산학협력단 미세유체회로소자
JP2017094327A (ja) * 2008-04-23 2017-06-01 アングル ノース アメリカ、インク． 粒子を分離する方法及び装置
US10005082B2 (en) 2008-04-11 2018-06-26 Incyto Co., Ltd. Microfluidic circuit element comprising microfluidic channel with nano interstices and fabrication method thereof
JP2019506600A (ja) * 2015-12-24 2019-03-07 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 細胞懸濁液の決定のための方法及びシステム
WO2020144754A1 (ja) * 2019-01-09 2020-07-16 株式会社日立ハイテク サイズ分布計測装置、サイズ分布計測方法、サンプル容器
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Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005292092A (ja) * 2004-04-05 2005-10-20 Advance Co Ltd 能動流路及びこれを用いた血球分離構造物
JP2007538259A (ja) * 2004-05-19 2007-12-27 エクシジェント テクノロジーズ エルエルシー 粒子の処理方法
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