JP2003535057A5 - - Google Patents

Download PDF

Info

Publication number
JP2003535057A5
JP2003535057A5 JP2001585719A JP2001585719A JP2003535057A5 JP 2003535057 A5 JP2003535057 A5 JP 2003535057A5 JP 2001585719 A JP2001585719 A JP 2001585719A JP 2001585719 A JP2001585719 A JP 2001585719A JP 2003535057 A5 JP2003535057 A5 JP 2003535057A5
Authority
JP
Japan
Prior art keywords
omega
pharmaceutical composition
weight
water
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001585719A
Other languages
English (en)
Other versions
JP2003535057A (ja
Filing date
Publication date
Priority claimed from GBGB0012597.1A external-priority patent/GB0012597D0/en
Application filed filed Critical
Publication of JP2003535057A publication Critical patent/JP2003535057A/ja
Publication of JP2003535057A5 publication Critical patent/JP2003535057A5/ja
Pending legal-status Critical Current

Links

Description

【特許請求の範囲】
【請求項1】 80%:20%〜20%:80%のオメガ−3:オメガ−6の比率の1種または数種のオメガ−3油と1種または数種のオメガ−6油との混合物である、オメガ−3に富む水非混和性溶剤に溶解したフリーラジカル捕獲性鎮静剤が水で乳化されており、そして界面活性剤によって安定化されている水中油滴型エマルジョンを含み、直接にまたは液体希釈剤で希釈したのちに温血動物への非経口投与に適する、非経口投与用滅菌医薬組成物。
【請求項2】 フリーラジカル捕獲性鎮静剤がプロポホールである、請求項1に記載の非経口投与用滅菌医薬組成物。
【請求項3】 金属イオンキレート化剤がエデテートである、請求項1または2に記載の滅菌医薬組成物。
【請求項4】 約30重量%までのオメガ−3に富む水非混和性溶剤を含む、請求項1〜3の何れか1項に記載の滅菌医薬組成物。
【請求項5】 約10重量%〜約20重量%までのオメガ−3に富む水非混和性溶剤を含む、請求項1〜4の何れか1項に記載の滅菌医薬組成物。
【請求項6】 オメガ−3油がエイコサペンタエン酸(EPA)、ドコサヘキサエン酸(DHA)、またはEPAとDHAとの混合物である、請求項1〜5の何れか1項に記載の滅菌医薬組成物。
【請求項7】 オメガ−6油がダイズ油である、請求項1〜6の何れか1項に記載の滅菌医薬組成物。
【請求項8】 界面活性剤が天然に存在するホスファチドである、請求項項1〜7の何れか1項に記載の滅菌医薬組成物。
【請求項9】 ホスファチドが卵ホスファチドまたはダイズホスファチドである、請求項8に記載の滅菌医薬組成物。
【請求項10】 約1重量%〜約2重量%のプロポホールを含む、請求項2〜9の何れか1項に記載の滅菌医薬組成物。
【請求項11】 (a)1重量%のプロポホール、
(b)10重量%の、80%:20%〜20%:80%のオメガ−3:オメガ−6の比率の1種または数種のオメガ−3油と1種または数種のオメガ−6油との混合物である、オメガ−3に富む水非混和性溶剤、
(c)1.2重量%の卵ホスファチド、
(d)2.25重量%のグリセロール、
(e)水酸化ナトリウム、
(f)水
(g)エデテート
を含む、水中油滴型エマルジョンの形態にある滅菌医薬組成物。
【請求項12】 (a)2重量%のプロポホール、
(b)10重量%の、80%:20%〜20%:80%のオメガ−3:オメガ−6の比率の1種または数種のオメガ−3油と1種または数種のオメガ−6油との混合物である、オメガ−3に富む水非混和性溶剤、
(c)1.2重量%の卵ホスファチド、
(d)2.25重量%のグリセロール、
(e)水酸化ナトリウム、
(f)水
(g)エデテート
を含む、水中油滴型エマルジョンの形態にある滅菌医薬組成物。
【請求項13】 滅菌医薬組成物が0.005重量%のエデト酸二ナトリウムを含む、請求項11または12に記載の滅菌医薬組成物。
JP2001585719A 2000-05-25 2001-05-22 処方物 Pending JP2003535057A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0012597.1 2000-05-25
GBGB0012597.1A GB0012597D0 (en) 2000-05-25 2000-05-25 Formulation
PCT/GB2001/002259 WO2001089474A2 (en) 2000-05-25 2001-05-22 O/w emulsion

Publications (2)

Publication Number Publication Date
JP2003535057A JP2003535057A (ja) 2003-11-25
JP2003535057A5 true JP2003535057A5 (ja) 2008-05-08

Family

ID=9892262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001585719A Pending JP2003535057A (ja) 2000-05-25 2001-05-22 処方物

Country Status (18)

Country Link
US (3) US20030144356A1 (ja)
EP (1) EP1289503B1 (ja)
JP (1) JP2003535057A (ja)
KR (1) KR20030009501A (ja)
CN (1) CN1430503A (ja)
AT (1) ATE365538T1 (ja)
AU (2) AU5858801A (ja)
BR (1) BR0111136A (ja)
CA (1) CA2407764A1 (ja)
DE (1) DE60129134T2 (ja)
ES (1) ES2287128T3 (ja)
GB (1) GB0012597D0 (ja)
IL (1) IL152773A0 (ja)
MX (1) MXPA02011532A (ja)
NO (1) NO20025629L (ja)
NZ (1) NZ522365A (ja)
WO (1) WO2001089474A2 (ja)
ZA (1) ZA200208853B (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1166368C (zh) * 2003-02-26 2004-09-15 刘威 海狗油脂肪乳注射液、其制备方法及其在制备静脉注射剂中的应用
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
MX2007000208A (es) * 2004-07-01 2007-08-07 Schepens Eye Res Inst Composiciones y metodos para tratar trastornos y condiciones del ojo.
CN100358513C (zh) * 2005-04-07 2008-01-02 常州市第四制药厂有限公司 一种丙泊酚注射液的制备工艺
CN101304728A (zh) * 2005-08-05 2008-11-12 印度血清及疫苗有限公司 具有防腐功效的静脉内用丙泊酚乳剂组合物
WO2007059431A1 (en) * 2005-11-14 2007-05-24 The Trustees Of Columbia University In The City Of New York Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
WO2008036353A2 (en) * 2006-09-19 2008-03-27 The Trustees Of Columbia University In The City Of New York Omega-3 diglyceride emulsions
CN101411685B (zh) * 2007-10-19 2011-04-20 上海医药工业研究院 一种静脉麻醉药2,6-二异丙基苯酚微乳组合物及其制备方法
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US8241672B2 (en) * 2009-03-11 2012-08-14 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
US20110071090A1 (en) * 2009-03-11 2011-03-24 Stable Solutions Llc Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle
US9034389B2 (en) 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
RU2589837C2 (ru) 2009-06-05 2016-07-10 Аллерган, Инк. Искусственные слезы и терапевтические применения
WO2011047091A1 (en) * 2009-10-13 2011-04-21 Martek Biosciences Corporation Methods for treating traumatic brain injury
WO2011103512A1 (en) * 2010-02-18 2011-08-25 Martek Biosciences Corporation Dha free fatty acid emulsions
US20110206741A1 (en) * 2010-02-18 2011-08-25 Martek Biosciences Corporation DHA Triglyceride Emulsions
WO2011103510A1 (en) * 2010-02-18 2011-08-25 Martek Biosciences Corporation Dha ester emulsions
EP2560633B8 (en) * 2010-04-23 2020-08-12 The Government of the United States, as represented by The Secretary of the Army Intravenous omega-3 fatty acid compositions & method of use
US11236351B2 (en) 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
US20150224074A1 (en) * 2010-05-25 2015-08-13 Eric Kuhrts Stable formulations of fatty acids
CN103327963A (zh) * 2010-07-06 2013-09-25 诺华股份有限公司 阳离子水包油乳液
NZ610465A (en) 2010-10-12 2015-05-29 Medicines Co Clevidipine emulsion formulations containing antimicrobial agents
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
US20120251685A1 (en) * 2011-04-04 2012-10-04 Martek Biosciences Corporation Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same
US10052352B2 (en) 2011-06-15 2018-08-21 Stable Solutions Llc Therapeutic application of parenteral krill oil
DK2720701T3 (en) * 2011-06-15 2017-10-30 Stable Solutions Llc THERAPEUTIC PARENTERAL APPLICATION OF KRILL OIL
TW201307553A (zh) * 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術
CN102366404B (zh) * 2011-10-20 2015-10-07 四川百利药业有限责任公司 一种丙泊酚中/长链脂肪乳剂
WO2014033751A2 (en) * 2012-08-16 2014-03-06 Emcure Pharmaceuticals Limited Pharmaceutical composition of propofol
US10070643B2 (en) 2013-03-28 2018-09-11 The Trustees Of Columbia University In The City Of New York Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation
ES2607715B1 (es) * 2015-10-01 2018-01-17 Solutex Na, Lcc Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637404A (en) * 1992-01-31 1997-06-10 Aluminum Company Of America Reflective aluminum strip
US5478414A (en) * 1992-01-31 1995-12-26 Aluminum Company Of America Reflective aluminum strip, protected with fluoropolymer coating and a laminate of the strip with a thermoplastic polymer
EP0797432B1 (en) * 1994-02-04 2001-06-13 Scotia Lipidteknik Ab Oil-in-water emulsions
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
AU759641B2 (en) * 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
US6140374A (en) * 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US6582723B2 (en) * 2001-05-03 2003-06-24 Wayne F. Gorsek Cancer immune composition for prevention and treatment of individuals

Similar Documents

Publication Publication Date Title
JP2003535057A5 (ja)
US11523999B2 (en) Compositions comprising a fatty aged oil mixture and a free fatty acid, and methods and uses thereof
WO2001089474A3 (en) O/w emulsion
KR20220003639A (ko) 나노에멀젼 전달 시스템의 조성물
KR940018091A (ko) 불포화 지방산을 포함하는 처방
ATE380541T1 (de) Herstellung von vitaminemulsionen und konzentrate davon
JP2010524992A5 (ja)
JP5864735B2 (ja) 非経口オキアミ油の治療用途
JP2002541086A5 (ja)
US20220202768A1 (en) Dihydromyricetin nanoemulsion formulations and methods for forming them
Inapurapu et al. Development and characterization of ω-3 fatty acid nanoemulsions with improved physicochemical stability and bioaccessibility
JP2016512828A (ja) ラセカドトリル脂質組成物
CA2514511A1 (en) Edible emulsions
CA2695605C (en) Pyrazolone derivative emulsion formulations
CA2937167C (en) Composition comprising epa and dha triglycerides for parenteral administration
Costa et al. Control of Lipid Oxidation in Oil-in Water Emulsions: Effects of Antioxidant Partitioning and Surfactant Concentration
JP2003505424A5 (ja)
US8895074B2 (en) Therapeutic application of parenteral krill oil
JPH0469340A (ja) プロスタグランジンe↓1脂肪乳剤
JP2019085349A (ja) 難溶性物質を含有する経口摂取用組成物、難溶性物質の消化管吸収性の向上方法及び難溶性物質を含有する水中油型乳化物の胃内での乳化安定化方法
JPH04338333A (ja) プロスタグランジンe1脂肪乳剤
JPH01113315A (ja) ビタミンk↓2含有脂肪乳剤
JPH04108732A (ja) Paf拮抗剤含有脂肪乳剤
Verma et al. Formulation and Evaluation of Indomethacin Loaded Anhydrous Microemulsions
JP2004210688A (ja) 脂肪乳剤のプレフィルドシリンジ製剤およびその製造方法