JP2003533986A5 - - Google Patents
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- JP2003533986A5 JP2003533986A5 JP2001580347A JP2001580347A JP2003533986A5 JP 2003533986 A5 JP2003533986 A5 JP 2003533986A5 JP 2001580347 A JP2001580347 A JP 2001580347A JP 2001580347 A JP2001580347 A JP 2001580347A JP 2003533986 A5 JP2003533986 A5 JP 2003533986A5
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- Prior art keywords
- seq
- nucleotide sequence
- mrna
- protein
- compound
- Prior art date
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- 239000002773 nucleotide Substances 0.000 description 33
- 125000003729 nucleotide group Chemical group 0.000 description 33
- 150000001875 compounds Chemical class 0.000 description 32
- 108020004999 messenger RNA Proteins 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 19
- 108090000623 proteins and genes Proteins 0.000 description 19
- 230000000692 anti-sense effect Effects 0.000 description 14
- 108020005067 RNA Splice Sites Proteins 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 108091026890 Coding region Proteins 0.000 description 4
- 101000775732 Homo sapiens Androgen receptor Proteins 0.000 description 4
- 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 4
- 102000046818 human AR Human genes 0.000 description 4
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 3
- 241000725303 Human immunodeficiency virus Species 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 210000003527 eukaryotic cell Anatomy 0.000 description 3
- 102000053563 human MYC Human genes 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 241000702617 Human parvovirus B19 Species 0.000 description 2
- 101710163270 Nuclease Proteins 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 108700020121 Human Immunodeficiency Virus-1 rev Proteins 0.000 description 1
- 102000015872 Human beta Subunit Chorionic Gonadotropin Human genes 0.000 description 1
- 108010010590 Human beta Subunit Chorionic Gonadotropin Proteins 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- 101710150912 Myc protein Proteins 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20237600P | 2000-05-04 | 2000-05-04 | |
| US60/202,376 | 2000-05-04 | ||
| PCT/US2001/014410 WO2001083740A2 (en) | 2000-05-04 | 2001-05-04 | Splice-region antisense composition and method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011131668A Division JP2011172597A (ja) | 2000-05-04 | 2011-06-13 | スプライス領域アンチセンス組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003533986A JP2003533986A (ja) | 2003-11-18 |
| JP2003533986A5 true JP2003533986A5 (enExample) | 2011-07-28 |
Family
ID=22749613
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001580347A Pending JP2003533986A (ja) | 2000-05-04 | 2001-05-04 | スプライス領域アンチセンス組成物および方法 |
| JP2011131668A Pending JP2011172597A (ja) | 2000-05-04 | 2011-06-13 | スプライス領域アンチセンス組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011131668A Pending JP2011172597A (ja) | 2000-05-04 | 2011-06-13 | スプライス領域アンチセンス組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US6784291B2 (enExample) |
| EP (1) | EP1282699B1 (enExample) |
| JP (2) | JP2003533986A (enExample) |
| KR (1) | KR20020097241A (enExample) |
| AU (2) | AU2001257526B2 (enExample) |
| CA (1) | CA2408011A1 (enExample) |
| WO (1) | WO2001083740A2 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CA2447052A1 (en) * | 2001-05-17 | 2002-11-21 | Avi Biopharma, Inc. | Combined approach to treatment of cancer using a c-myc antisense oligomer |
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| AU2003219781A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc | RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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| EP1476459A4 (en) * | 2002-02-20 | 2005-05-25 | Sirna Therapeutics Inc | INHIBITION OF RNA INTERFERENCE-INDUCED CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
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2001
- 2001-05-04 JP JP2001580347A patent/JP2003533986A/ja active Pending
- 2001-05-04 WO PCT/US2001/014410 patent/WO2001083740A2/en not_active Ceased
- 2001-05-04 AU AU2001257526A patent/AU2001257526B2/en not_active Expired
- 2001-05-04 KR KR1020027014612A patent/KR20020097241A/ko not_active Ceased
- 2001-05-04 CA CA002408011A patent/CA2408011A1/en not_active Abandoned
- 2001-05-04 US US09/848,868 patent/US6784291B2/en not_active Expired - Lifetime
- 2001-05-04 AU AU5752601A patent/AU5752601A/xx active Pending
- 2001-05-04 EP EP01931051A patent/EP1282699B1/en not_active Expired - Lifetime
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2004
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2006
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2011
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2013
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2014
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2016
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