|
US3854480A
(en)
*
|
1969-04-01 |
1974-12-17 |
Alza Corp |
Drug-delivery system
|
|
US4320121A
(en)
*
|
1976-10-12 |
1982-03-16 |
Sears Barry D |
Method of emulsifying cholesterol, cholesterol esters and triglyceride compounds
|
|
US4235871A
(en)
*
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4394448A
(en)
*
|
1978-02-24 |
1983-07-19 |
Szoka Jr Francis C |
Method of inserting DNA into living cells
|
|
DE3068743D1
(en)
*
|
1980-01-16 |
1984-08-30 |
Weder Hans G |
Process and dialysis-installation for the preparation of bilayer-vesicles and their use
|
|
US4598051A
(en)
*
|
1980-03-12 |
1986-07-01 |
The Regents Of The University Of California |
Liposome conjugates and diagnostic methods therewith
|
|
US4469863A
(en)
*
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US4675189A
(en)
*
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
US5023243A
(en)
*
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
US4452775A
(en)
*
|
1982-12-03 |
1984-06-05 |
Syntex (U.S.A.) Inc. |
Cholesterol matrix delivery system for sustained release of macromolecules
|
|
US4501728A
(en)
*
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5208036A
(en)
*
|
1985-01-07 |
1993-05-04 |
Syntex (U.S.A.) Inc. |
N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5550289A
(en)
*
|
1985-01-07 |
1996-08-27 |
Syntex (U.S.A.) Inc. |
N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
*
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4737323A
(en)
*
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5075109A
(en)
*
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US4837028A
(en)
*
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5262168A
(en)
*
|
1987-05-22 |
1993-11-16 |
The Liposome Company, Inc. |
Prostaglandin-lipid formulations
|
|
US5703055A
(en)
*
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5133974A
(en)
*
|
1989-05-05 |
1992-07-28 |
Kv Pharmaceutical Company |
Extended release pharmaceutical formulations
|
|
US5013556A
(en)
*
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5225212A
(en)
*
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5279833A
(en)
*
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5407686A
(en)
*
|
1991-11-27 |
1995-04-18 |
Sidmak Laboratories, Inc. |
Sustained release composition for oral administration of active ingredient
|
|
DK0678017T3
(da)
*
|
1993-11-05 |
1998-10-19 |
Amgen Inc |
Liposomfremstilling og materialeindkapslingsfremgangsmåde
|
|
WO1995026204A1
(en)
*
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
AU713040B2
(en)
*
|
1994-07-15 |
1999-11-18 |
University Of Iowa Research Foundation, The |
Immunomodulatory oligonucleotides
|
|
US6207646B1
(en)
*
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
*
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6239116B1
(en)
*
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
ATE219660T1
(de)
*
|
1994-09-30 |
2002-07-15 |
Inex Pharmaceuticals Corp |
Mittel zum einbringen polyanionischer materialien in zellen
|
|
US5820873A
(en)
*
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
US5885613A
(en)
*
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5705385A
(en)
*
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US6673364B1
(en)
*
|
1995-06-07 |
2004-01-06 |
The University Of British Columbia |
Liposome having an exchangeable component
|
|
US7422902B1
(en)
*
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
JP4335310B2
(ja)
*
|
1995-06-07 |
2009-09-30 |
ザ ユニバーシティ オブ ブリティッシュ コロンビア |
疎水性脂質−核酸複合中間体を通して調製される脂質−核酸粒子、及び遺伝子移送のための使用
|
|
US5981501A
(en)
*
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US6627616B2
(en)
*
|
1995-12-13 |
2003-09-30 |
Mirus Corporation |
Intravascular delivery of non-viral nucleic acid
|
|
US5736152A
(en)
*
|
1995-10-27 |
1998-04-07 |
Atrix Laboratories, Inc. |
Non-polymeric sustained release delivery system
|
|
US6086913A
(en)
*
|
1995-11-01 |
2000-07-11 |
University Of British Columbia |
Liposomal delivery of AAV vectors
|
|
US6447800B2
(en)
*
|
1996-01-18 |
2002-09-10 |
The University Of British Columbia |
Method of loading preformed liposomes using ethanol
|
|
WO1997038010A2
(en)
*
|
1996-04-11 |
1997-10-16 |
The University Of British Columbia |
Fusogenic liposomes
|
|
US6093816A
(en)
*
|
1996-06-27 |
2000-07-25 |
Isis Pharmaceuticals, Inc. |
Cationic lipids
|
|
GB9618376D0
(en)
*
|
1996-09-04 |
1996-10-16 |
Ciba Geigy Ag |
Pharmaceutical compositions
|
|
WO1998016240A1
(en)
*
|
1996-10-15 |
1998-04-23 |
The Liposome Company, Inc. |
Peptide-lipid conjugates, liposomes and liposomal drug delivery
|
|
US6406705B1
(en)
*
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US5965542A
(en)
*
|
1997-03-18 |
1999-10-12 |
Inex Pharmaceuticals Corp. |
Use of temperature to control the size of cationic liposome/plasmid DNA complexes
|
|
US6143276A
(en)
*
|
1997-03-21 |
2000-11-07 |
Imarx Pharmaceutical Corp. |
Methods for delivering bioactive agents to regions of elevated temperatures
|
|
US6426334B1
(en)
*
|
1997-04-30 |
2002-07-30 |
Hybridon, Inc. |
Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
|
|
US6835395B1
(en)
*
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
|
US20030104044A1
(en)
*
|
1997-05-14 |
2003-06-05 |
Semple Sean C. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
CA2289702C
(en)
*
|
1997-05-14 |
2008-02-19 |
Inex Pharmaceuticals Corp. |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
|
EP1003531B1
(en)
*
|
1997-05-20 |
2007-08-22 |
Ottawa Health Research Institute |
Processes for preparing nucleic acid constructs
|
|
AU8532198A
(en)
*
|
1997-06-11 |
1998-12-30 |
Isis Pharma Gmbh |
Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same
|
|
WO1999005303A1
(en)
*
|
1997-07-24 |
1999-02-04 |
Inex Pharmaceuticals Corporation |
Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
|
|
AU8525098A
(en)
*
|
1997-07-24 |
1999-02-16 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for the delivery of nucleic acid catalysts
|
|
US6734171B1
(en)
*
|
1997-10-10 |
2004-05-11 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating nucleic acids in lipid bilayers
|
|
US6320017B1
(en)
*
|
1997-12-23 |
2001-11-20 |
Inex Pharmaceuticals Corp. |
Polyamide oligomers
|
|
US6410328B1
(en)
*
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
|
US6841537B1
(en)
*
|
1998-04-22 |
2005-01-11 |
Protiva Biotherapeutics Inc. |
Combination therapy using nucleic acids and conventional drugs
|
|
DK1077722T3
(da)
*
|
1998-05-22 |
2006-11-27 |
Ottawa Health Research Inst |
Fremgangsmåder og produkter til induktion af mukosaimmunitet
|
|
US6693086B1
(en)
*
|
1998-06-25 |
2004-02-17 |
National Jewish Medical And Research Center |
Systemic immune activation method using nucleic acid-lipid complexes
|
|
FR2790955B1
(fr)
*
|
1999-03-19 |
2003-01-17 |
Assist Publ Hopitaux De Paris |
Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
|
|
US6379698B1
(en)
*
|
1999-04-06 |
2002-04-30 |
Isis Pharmaceuticals, Inc. |
Fusogenic lipids and vesicles
|
|
HUP0201425A3
(en)
*
|
1999-04-23 |
2006-07-28 |
Hadasit Med Res Service |
Conjugate having a cleavable linkage for use in a liposome
|
|
US7094423B1
(en)
*
|
1999-07-15 |
2006-08-22 |
Inex Pharmaceuticals Corp. |
Methods for preparation of lipid-encapsulated therapeutic agents
|
|
AU780535B2
(en)
*
|
1999-08-27 |
2005-03-24 |
Inex Pharmaceuticals Corp. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
US20050249794A1
(en)
*
|
1999-08-27 |
2005-11-10 |
Semple Sean C |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
WO2001022972A2
(en)
*
|
1999-09-25 |
2001-04-05 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acids
|
|
US6949520B1
(en)
*
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
EP1296714B1
(en)
*
|
2000-06-22 |
2009-08-26 |
University Of Iowa Research Foundation |
Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.
|
|
DE10038668C2
(de)
*
|
2000-08-08 |
2002-05-23 |
Siemens Ag |
Verfahren zur Datenkommunikation mit Teilnehmerstationen und Funk-Kommunikationsnetz zur Durchführung des Verfahrens
|
|
US20030050268A1
(en)
*
|
2001-03-29 |
2003-03-13 |
Krieg Arthur M. |
Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
|
|
US20030119774A1
(en)
*
|
2001-09-25 |
2003-06-26 |
Marianna Foldvari |
Compositions and methods for stimulating an immune response
|
|
WO2003039595A2
(en)
*
|
2001-11-07 |
2003-05-15 |
Inex Pharmaceuticals Corporation |
Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
|
|
US7223887B2
(en)
*
|
2001-12-18 |
2007-05-29 |
The University Of British Columbia |
Multivalent cationic lipids and methods of using same in the production of lipid particles
|
|
EP1505942B1
(en)
*
|
2002-05-10 |
2008-08-13 |
Tekmira Pharmaceuticals Corporation |
Pathogen vaccines and methods for using the same
|
|
US20040009943A1
(en)
*
|
2002-05-10 |
2004-01-15 |
Inex Pharmaceuticals Corporation |
Pathogen vaccines and methods for using the same
|
|
US20040013649A1
(en)
*
|
2002-05-10 |
2004-01-22 |
Inex Pharmaceuticals Corporation |
Cancer vaccines and methods of using the same
|
|
US20040009944A1
(en)
*
|
2002-05-10 |
2004-01-15 |
Inex Pharmaceuticals Corporation |
Methylated immunostimulatory oligonucleotides and methods of using the same
|
|
AR040996A1
(es)
*
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
JP4989225B2
(ja)
*
|
2003-09-25 |
2012-08-01 |
コーリー ファーマシューティカル グループ，インコーポレイテッド |
核酸親油性接合体
|
|
TWI267791B
(en)
*
|
2005-05-13 |
2006-12-01 |
Lite On Semiconductor Corp |
Handheld device for acquiring fingerprint information
|