JP2003531184A - （ｒ）−１−（アリールオキシ）プロパン−２−オールの製造方法 - Google Patents

（ｒ）−１−（アリールオキシ）プロパン−２−オールの製造方法

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Publication number
JP2003531184A
JP2003531184A JP2001578384A JP2001578384A JP2003531184A JP 2003531184 A JP2003531184 A JP 2003531184A JP 2001578384 A JP2001578384 A JP 2001578384A JP 2001578384 A JP2001578384 A JP 2001578384A JP 2003531184 A JP2003531184 A JP 2003531184A
Authority
JP
Japan
Prior art keywords
aryloxy
propan
trialkylsiloxypropane
mixture
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001578384A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003531184A5 (enExample
Inventor
ジェイ・フランシス・ラロウ
Original Assignee
ローディア／カイレックス・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ローディア／カイレックス・インコーポレイテッド filed Critical ローディア／カイレックス・インコーポレイテッド
Publication of JP2003531184A publication Critical patent/JP2003531184A/ja
Publication of JP2003531184A5 publication Critical patent/JP2003531184A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/02—Preparation of ethers from oxiranes
    • C07C41/03—Preparation of ethers from oxiranes by reaction of oxirane rings with hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1884—Preparation; Treatments not provided for in C07F7/20 by dismutation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2001578384A 2000-04-21 2001-04-20 （ｒ）−１−（アリールオキシ）プロパン−２−オールの製造方法 Pending JP2003531184A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19894200P 2000-04-21 2000-04-21
US60/198,942 2000-04-21
PCT/US2001/012792 WO2001081286A1 (en) 2000-04-21 2001-04-20 Process for preparation of r-1-(aryloxy)propan-2-ol

Publications (2)

Publication Number Publication Date
JP2003531184A true JP2003531184A (ja) 2003-10-21
JP2003531184A5 JP2003531184A5 (enExample) 2008-06-19

Family

ID=22735535

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001578384A Pending JP2003531184A (ja) 2000-04-21 2001-04-20 （ｒ）−１−（アリールオキシ）プロパン−２−オールの製造方法

Country Status (7)

Country Link
US (1) US6448449B2 (enExample)
EP (1) EP1280753A1 (enExample)
JP (1) JP2003531184A (enExample)
KR (1) KR20020097223A (enExample)
CN (1) CN1438981A (enExample)
CA (1) CA2406215A1 (enExample)
WO (1) WO2001081286A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
AU2001268459A1 (en) * 2000-06-14 2001-12-24 Sleep Solutions, Inc. Secure test and test result delivery system
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
PT1575951E (pt) 2002-12-06 2014-09-15 Debiopharm Int Sa Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
US8450307B2 (en) * 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
KR101503745B1 (ko) * 2010-02-25 2015-03-19 에스케이이노베이션 주식회사 나이트레이트 음이온의 이산화탄소/에폭사이드 공중합 촉매 시스템
EP2861608B8 (en) 2012-06-19 2019-06-19 Debiopharm International SA Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
DK3419628T3 (da) 2016-02-26 2021-01-11 Debiopharm Int Sa Medikament til behandling af diabetiske fodinfektioner
ES2944535T3 (es) 2019-02-14 2023-06-22 Debiopharm Int Sa Formulación de afabicina, método para preparar la misma
CN112079958A (zh) * 2019-06-12 2020-12-15 中国石化扬子石油化工有限公司 一种碳五共聚石油树脂的制备方法
UA129222C2 (uk) 2019-06-14 2025-02-12 Дебіофарм Інтернешнл С.А. Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135487A (ja) * 1985-10-21 1987-06-18 マクニ−ラブ・インコ−ポレ−テツド ４，１´，６´―トリクロル―４，１´，６´―トリデオキシガラクトスクロースペンタアセテートの製造方法
JPS62155289A (ja) * 1985-10-21 1987-07-10 マクニ−ラブ・インコ−ポレ−テツド ２，３，６，３´，４´―ペンタ―ｏ―アセチルスクロースの製造法
JPH01233288A (ja) * 1988-03-11 1989-09-19 Asahi Denka Kogyo Kk シリルオキシ基を有するアリールエーテル化合物の製造法
JPH02178287A (ja) * 1988-11-07 1990-07-11 Gist Brocades Nv 光学活性ベンゾオキサジン及びベンゾチアジン及びそれらの立体選択的製造方法
JPH08245685A (ja) * 1995-02-03 1996-09-24 Eli Lilly & Co ２−デオキシ−２，２−ジフルオロ−β−Ｄ−リボ−ペントピラノースからの１−（２’−デオキシ−２’，２’−ジフルオロ−Ｄ−リボ−ペントフラノシル）−シトシンの製造法
JPH11279100A (ja) * 1998-03-25 1999-10-12 Asahi Glass Co Ltd 光学活性な１−置換−２−プロパノールの製造方法
JP2000063314A (ja) * 1998-08-14 2000-02-29 Asahi Glass Co Ltd 光学活性な１−置換−２−プロパノールの製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637739A (en) 1990-03-21 1997-06-10 Research Corporation Technologies, Inc. Chiral catalysts and catalytic epoxidation catalyzed thereby
US5665890A (en) * 1995-03-14 1997-09-09 President And Fellows Of Harvard College Stereoselective ring opening reactions
ATE249467T1 (de) 1997-07-10 2003-09-15 Du Pont Herstellung von optisch aktiven halohydrintrialkylsilylethern
JPH11269131A (ja) 1998-03-20 1999-10-05 Asahi Glass Co Ltd １−アシルオキシ−２−プロパノールの製造方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62135487A (ja) * 1985-10-21 1987-06-18 マクニ−ラブ・インコ−ポレ−テツド ４，１´，６´―トリクロル―４，１´，６´―トリデオキシガラクトスクロースペンタアセテートの製造方法
JPS62155289A (ja) * 1985-10-21 1987-07-10 マクニ−ラブ・インコ−ポレ−テツド ２，３，６，３´，４´―ペンタ―ｏ―アセチルスクロースの製造法
JPH01233288A (ja) * 1988-03-11 1989-09-19 Asahi Denka Kogyo Kk シリルオキシ基を有するアリールエーテル化合物の製造法
JPH02178287A (ja) * 1988-11-07 1990-07-11 Gist Brocades Nv 光学活性ベンゾオキサジン及びベンゾチアジン及びそれらの立体選択的製造方法
JPH08245685A (ja) * 1995-02-03 1996-09-24 Eli Lilly & Co ２−デオキシ−２，２−ジフルオロ−β−Ｄ−リボ−ペントピラノースからの１−（２’−デオキシ−２’，２’−ジフルオロ−Ｄ−リボ−ペントフラノシル）−シトシンの製造法
JPH11279100A (ja) * 1998-03-25 1999-10-12 Asahi Glass Co Ltd 光学活性な１−置換−２−プロパノールの製造方法
JP2000063314A (ja) * 1998-08-14 2000-02-29 Asahi Glass Co Ltd 光学活性な１−置換−２−プロパノールの製造方法

Also Published As

Publication number Publication date
CN1438981A (zh) 2003-08-27
CA2406215A1 (en) 2001-11-01
WO2001081286A1 (en) 2001-11-01
EP1280753A1 (en) 2003-02-05
US20020007090A1 (en) 2002-01-17
US6448449B2 (en) 2002-09-10
KR20020097223A (ko) 2002-12-31

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