|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
ES2788383T3
(es)
|
2000-04-25 |
2020-10-21 |
Icos Corp |
Inhibidores de delta fosfatidilo-inositol 3-quinasa humana
|
|
GB0119865D0
(en)
*
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
GB0119863D0
(en)
|
2001-08-14 |
2001-10-10 |
Cancer Res Campaign Tech |
DNA-PK inhibitors
|
|
GB2405093B
(en)
*
|
2001-08-14 |
2005-07-06 |
Cancer Rec Tech Ltd |
DNA-PK inhibitors
|
|
CN1551766A
(zh)
*
|
2001-09-05 |
2004-12-01 |
������������ʽ���� |
淋巴细胞活化抑制剂和自身免疫性疾病治疗剂
|
|
US7049313B2
(en)
|
2002-02-25 |
2006-05-23 |
Kudos Pharmaceuticals Ltd. |
ATM inhibitors
|
|
TWI314928B
(en)
|
2002-02-28 |
2009-09-21 |
Novartis A |
5-phenylthiazole derivatives and use as pi3 kinase inhibitors
|
|
EP2311818B1
(en)
*
|
2002-02-28 |
2013-01-16 |
Novartis AG |
Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
|
|
JP4646626B2
(ja)
*
|
2002-08-16 |
2011-03-09 |
アストラゼネカ アクチボラグ |
ホスホイノシチド3−キナーゼβの阻害
|
|
CN101260104A
(zh)
*
|
2002-08-16 |
2008-09-10 |
阿斯利康(瑞典)有限公司 |
抑制磷酸肌醇3-激酶β
|
|
KR101050700B1
(ko)
*
|
2002-08-26 |
2011-07-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
칼슘 수용체 조절 화합물 및 이의 용도
|
|
CA2508601A1
(en)
|
2002-12-06 |
2004-06-24 |
Warner-Lambert Company Llc |
Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k
|
|
GB0305152D0
(en)
|
2003-03-06 |
2003-04-09 |
Novartis Ag |
Organic compounds
|
|
WO2004092154A1
(en)
*
|
2003-04-03 |
2004-10-28 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
KR20070087266A
(ko)
*
|
2003-04-03 |
2007-08-28 |
세마포르 파머슈티컬즈, 아이엔씨. |
피아이-3 키나아제 억제제 프로드러그
|
|
EP1636212B1
(en)
*
|
2003-06-05 |
2007-06-27 |
Warner-Lambert Company LLC |
Cycloalkylsulfanyl substituted benzo¬b|thiophenes as therapeutic agents
|
|
US20040259926A1
(en)
*
|
2003-06-05 |
2004-12-23 |
Bruendl Michelle M. |
3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents
|
|
MXPA05012894A
(es)
*
|
2003-06-05 |
2006-02-22 |
Warner Lambert Co |
Benzofuranos 3-sustituidos como agentes terapeuticos.
|
|
EP1654257B1
(en)
|
2003-08-13 |
2010-03-17 |
Kudos Pharmaceuticals Limited |
Aminopyrones and their use as atm inhibitors
|
|
JP2007504209A
(ja)
*
|
2003-09-04 |
2007-03-01 |
ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー |
PI3K阻害活性を有する治療薬としてのハロゲン置換ベンゾ(b)チオフェン類
|
|
ES2285517T3
(es)
*
|
2003-10-31 |
2007-11-16 |
Warner-Lambert Company Llc |
Pirimidinas como inhibidores de fosfoinositida-3-cinasas(pi3k).
|
|
US7855214B2
(en)
*
|
2004-01-26 |
2010-12-21 |
Vertex Pharmaceuticals Incorporated |
Fused cyclic systems useful as inhibitors of TEC family protein kinases
|
|
SI2612862T1
(sl)
|
2004-05-13 |
2017-04-26 |
Icos Corporation |
Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta
|
|
CN1300163C
(zh)
*
|
2004-06-23 |
2007-02-14 |
南京大学 |
3-羟基色原酮糖苷及其制法和用途
|
|
TW200616986A
(en)
|
2004-09-20 |
2006-06-01 |
Kudos Pharm Ltd |
DNA-pk inhibitors
|
|
JP2008529995A
(ja)
|
2005-02-09 |
2008-08-07 |
クドス ファーマシューティカルズ リミテッド |
Atm阻害剤
|
|
AR054438A1
(es)
|
2005-04-15 |
2007-06-27 |
Kudos Pharm Ltd |
Inhibidores de adn -pk
|
|
US7691858B2
(en)
|
2006-04-25 |
2010-04-06 |
Targegen, Inc. |
Kinase inhibitors and methods of use thereof
|
|
CA2656825C
(en)
*
|
2006-06-22 |
2013-12-10 |
Prana Biotechnology Limited |
Method of treatment and agents useful for same
|
|
US8106071B2
(en)
*
|
2007-02-21 |
2012-01-31 |
Biobud Co., Ltd. |
Compositions for treating hyperproliferative vascular disorders and cancers
|
|
WO2008126920A1
(ja)
|
2007-04-11 |
2008-10-23 |
Ajinomoto Co., Inc. |
糖尿病治療薬
|
|
WO2008150827A1
(en)
*
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
US20100130597A1
(en)
*
|
2007-07-06 |
2010-05-27 |
The United State Of America, As Represented By The Secretary Of The Dept Of Health And Human Service |
Dna-pkcs modulates energy regulation and brain function
|
|
KR20100118977A
(ko)
*
|
2008-01-25 |
2010-11-08 |
아스트라제네카 아베 |
거울상이성질체적으로 순수한 (-) 2-[1-(7-메틸-2-(모르폴린-4-일)-4-옥소-4H-피리도[1,2-α]피리미딘-9-일)에틸아미노]벤조산, 의학 치료에서의 이의 용도 및 이를 포함하는 약학 조성물-026
|
|
EP2262366A4
(en)
*
|
2008-04-18 |
2012-02-22 |
Shenogen Pharma Group Ltd |
COMPOUNDS AND METHODS FOR TREATING STROGEN RECEPTOR-RELATED DISEASES
|
|
US9326986B2
(en)
|
2008-09-29 |
2016-05-03 |
Glaxosmithkline Llc |
Quinazolinone, quinolone and related analogs as sirtuin modulators
|
|
US8110578B2
(en)
*
|
2008-10-27 |
2012-02-07 |
Signal Pharmaceuticals, Llc |
Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
|
|
US9492449B2
(en)
|
2008-11-13 |
2016-11-15 |
Gilead Calistoga Llc |
Therapies for hematologic malignancies
|
|
CN102271683B
(zh)
|
2008-11-13 |
2014-07-09 |
吉里德卡利斯托加公司 |
恶性血液病的治疗
|
|
JP5680639B2
(ja)
|
2009-07-02 |
2015-03-04 |
サノフイ |
新規6−モルホリン−4−イル−ピリミジン−4−(3h)−オン誘導体、およびakt(pkb)リン酸化阻害剤としてのこの医薬調製物
|
|
AR077364A1
(es)
|
2009-07-02 |
2011-08-24 |
Sanofi Aventis |
Derivados de 6-oxo-1,6- dihidro -pirimidin-2-il-) amida, su preparacion y su utilizacion farmaceutica como inhibidores de fosforilacion de akt (pkb)
|
|
BRPI1015943A8
(pt)
|
2009-07-02 |
2018-01-09 |
Sanofi Sa |
derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
|
|
ES2627428T3
(es)
|
2009-07-02 |
2017-07-28 |
Sanofi |
Nuevos derivados de 2,3-dihidro-1H-imidazo{1,2-a}pirimidin-5-ona, su preparación y su utilización farmacéutica
|
|
EA201270184A1
(ru)
|
2009-07-21 |
2012-08-30 |
ГИЛИЭД КАЛИСТОГА ЭлЭлСи |
Лечение расстройств печени ингибиторами pi3k
|
|
US8399460B2
(en)
|
2009-10-27 |
2013-03-19 |
Astrazeneca Ab |
Chromenone derivatives
|
|
IT1403156B1
(it)
|
2010-12-01 |
2013-10-04 |
Università Degli Studi Di Torino |
Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi.
|
|
FR2969613B1
(fr)
*
|
2010-12-23 |
2013-02-08 |
Sanofi Aventis |
Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique
|
|
FR2969612B1
(fr)
*
|
2010-12-23 |
2013-02-08 |
Sanofi Aventis |
Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique
|
|
DK2655375T3
(en)
|
2010-12-23 |
2015-03-09 |
Sanofi Sa |
PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF
|
|
PL2658844T3
(pl)
|
2010-12-28 |
2017-04-28 |
Sanofi |
Nowe pochodne pirymidyn, ich wytwarzanie i ich zastosowanie farmaceutyczne jako inhibitorów fosforylacji AKT(pkb)
|
|
EP2808322B1
(en)
*
|
2012-01-26 |
2017-08-23 |
Daiichi Sankyo Company, Limited |
Chromone derivative having osteogenesis promoting effect
|
|
EP2812004B1
(en)
*
|
2012-02-10 |
2018-06-27 |
PTC Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
CA2865957C
(en)
|
2012-03-01 |
2020-02-11 |
F. Hoffmann-La Roche Ag |
Compounds for treating spinal muscular atrophy
|
|
SI2834241T1
(sl)
|
2012-03-05 |
2021-06-30 |
Gilead Calistoga Llc |
Polimorfne oblike (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilkinazolin-4(3H)-ONA
|
|
CA2868026C
(en)
|
2012-03-23 |
2021-02-16 |
Ptc Therapeutics, Inc. |
Compounds for treating spinal muscular atrophy
|
|
ITMI20120514A1
(it)
*
|
2012-03-29 |
2013-09-30 |
Cnr Consiglio Naz Delle Ric Erche |
Agente terapeutico per il trattamento dei vasi sanguigni
|
|
FR2992314B1
(fr)
|
2012-06-22 |
2015-10-16 |
Sanofi Sa |
Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
|
|
US10195202B2
(en)
|
2013-12-19 |
2019-02-05 |
Ptc Therapeutics, Inc. |
Methods for modulating the amount of RNA transcripts
|
|
US9708327B2
(en)
|
2013-12-20 |
2017-07-18 |
Gilead Calistoga Llc |
Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
|
|
WO2015095601A1
(en)
|
2013-12-20 |
2015-06-25 |
Gilead Calistoga Llc |
Process methods for phosphatidylinositol 3-kinase inhibitors
|
|
EP3154960A1
(en)
|
2014-06-13 |
2017-04-19 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
CN107635999B
(zh)
*
|
2015-05-20 |
2020-09-25 |
豪夫迈·罗氏有限公司 |
用于治疗脊髓性肌萎缩的化合物
|
|
US10668171B2
(en)
|
2015-05-30 |
2020-06-02 |
Ptc Therapeutics, Inc. |
Methods for modulating RNA splicing
|
|
EA201800367A1
(ru)
|
2015-12-10 |
2019-02-28 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Способы лечения болезни хантингтона
|
|
US11129824B2
(en)
|
2015-12-17 |
2021-09-28 |
Biokine Therapeutics Ltd. |
Small molecules for inhibiting chemokine activity and/or cancer cells growth
|
|
WO2017103931A1
(en)
|
2015-12-17 |
2017-06-22 |
Biokine Therapeutics Ltd. |
Small molecules against cancer
|
|
WO2018031987A1
(en)
|
2016-08-12 |
2018-02-15 |
Nanjing Gator Meditech Company, Ltd. |
Protein kinase regulators
|
|
JP2019535789A
(ja)
|
2016-11-28 |
2019-12-12 |
ピーティーシー セラピューティクス,インコーポレーテッド |
Rnaスプライシングを調節する方法
|
|
EP3573619A4
(en)
|
2017-01-27 |
2020-10-28 |
SignalRX Pharmaceuticals, Inc. |
THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN AND CHECKPOINT INHIBITORS
|
|
EP3634953B1
(en)
|
2017-06-05 |
2024-01-03 |
PTC Therapeutics, Inc. |
Compounds for treating huntington's disease
|
|
JP2020523365A
(ja)
|
2017-06-14 |
2020-08-06 |
ピーティーシー セラピューティクス,インコーポレーテッド |
Rnaスプライシングを改変する方法
|
|
CN111182898B
(zh)
|
2017-06-28 |
2024-04-16 |
Ptc医疗公司 |
用于治疗亨廷顿氏病的方法
|
|
MX2019015580A
(es)
|
2017-06-28 |
2020-07-28 |
Ptc Therapeutics Inc |
Metodos para tratar la enfermedad de huntington.
|
|
EA202092001A1
(ru)
|
2018-03-27 |
2021-01-29 |
ПиТиСи ТЕРАПЬЮТИКС, ИНК. |
Соединения для лечения болезни гентингтона
|
|
WO2020005877A1
(en)
|
2018-06-27 |
2020-01-02 |
Ptc Therapeutics, Inc. |
Heteroaryl compounds for treating huntington's disease
|
|
EP3814360B8
(en)
|
2018-06-27 |
2024-11-06 |
PTC Therapeutics, Inc. |
Heteroaryl compounds for treating huntington's disease
|
|
HRP20240935T1
(hr)
|
2018-06-27 |
2024-11-22 |
Ptc Therapeutics, Inc. |
Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti
|
|
CN109748914B
(zh)
*
|
2018-12-29 |
2021-05-25 |
上海珂臻医药科技有限公司 |
吡啶并嘧啶类化合物及其应用
|
|
JP7649257B2
(ja)
|
2019-05-13 |
2025-03-19 |
ピーティーシー セラピューティクス, インコーポレイテッド |
ハンチントン病を処置するための化合物
|
|
AU2020276793A1
(en)
|
2019-05-15 |
2022-01-20 |
Alonbio Ltd. |
Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
|
|
AR121719A1
(es)
|
2020-04-03 |
2022-06-29 |
Petra Pharma Corp |
Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
|
|
CN111533721B
(zh)
*
|
2020-05-15 |
2022-04-26 |
浙江大学 |
苯并吡喃酮或喹啉酮类化合物及其应用
|
|
EP4161926A4
(en)
*
|
2020-06-03 |
2024-06-19 |
Yumanity Therapeutics, Inc. |
PYRIDOPYRIMIDINES AND THEIR METHODS OF USE
|
|
US20240166617A1
(en)
*
|
2021-02-01 |
2024-05-23 |
Geode Therapeutics Inc. |
Phosphoinositide 3 kinase beta inhibitors and compositions and methods thereof
|
|
IL307950A
(en)
|
2021-05-03 |
2023-12-01 |
Petra Pharma Corp |
Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases
|
|
MX2023013987A
(es)
|
2021-05-27 |
2024-02-12 |
Petra Pharma Corp |
Inhibidores alostéricos de cromenona de la fosfoinosítido 3-quinasa (pi3k) para el tratamiento contra el cáncer.
|
|
TW202329930A
(zh)
|
2021-09-30 |
2023-08-01 |
美商佩特拉製藥公司 |
用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
|
|
US20250084048A1
(en)
*
|
2021-10-07 |
2025-03-13 |
Relay Therapeutics, Inc. |
Pi3k-alpha inhibitors and methods of use thereof
|
|
WO2025136936A1
(en)
*
|
2023-12-19 |
2025-06-26 |
Merck Sharp & Dohme Llc |
Agonists of trem2 activity
|