JP2023106403A5 - - Google Patents
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- JP2023106403A5 JP2023106403A5 JP2023072147A JP2023072147A JP2023106403A5 JP 2023106403 A5 JP2023106403 A5 JP 2023106403A5 JP 2023072147 A JP2023072147 A JP 2023072147A JP 2023072147 A JP2023072147 A JP 2023072147A JP 2023106403 A5 JP2023106403 A5 JP 2023106403A5
- Authority
- JP
- Japan
- Prior art keywords
- pharma
- acceptable salt
- ceutically acceptable
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 206010069351 acute lung injury Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862776837P | 2018-12-07 | 2018-12-07 | |
| US62/776,837 | 2018-12-07 | ||
| JP2021532311A JP7594787B2 (ja) | 2018-12-07 | 2019-12-06 | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532311A Division JP7594787B2 (ja) | 2018-12-07 | 2019-12-06 | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023106403A JP2023106403A (ja) | 2023-08-01 |
| JP2023106403A5 true JP2023106403A5 (https=) | 2025-04-10 |
Family
ID=70974384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532311A Active JP7594787B2 (ja) | 2018-12-07 | 2019-12-06 | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
| JP2023072147A Pending JP2023106403A (ja) | 2018-12-07 | 2023-04-26 | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532311A Active JP7594787B2 (ja) | 2018-12-07 | 2019-12-06 | 非ＡＴＰ／触媒部位ｐ３８マイトジェン活性化プロテインキナーゼ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11078171B2 (https=) |
| EP (2) | EP4606792A1 (https=) |
| JP (2) | JP7594787B2 (https=) |
| CN (1) | CN113395963B (https=) |
| AU (3) | AU2019392904B9 (https=) |
| CA (1) | CA3122371A1 (https=) |
| ES (1) | ES3025468T3 (https=) |
| IL (1) | IL283755B2 (https=) |
| MX (2) | MX2021006731A (https=) |
| WO (1) | WO2020118194A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017223284A1 (en) | 2016-06-23 | 2017-12-28 | University Of Maryland, Baltimore | NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF |
| AU2019392904B9 (en) | 2018-12-07 | 2022-12-22 | University Of Maryland, Baltimore | Non-ATP/catalytic site p38 mitogen activated protein kinase inhibitors |
| JP7554829B2 (ja) | 2019-12-19 | 2024-09-20 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換直鎖スピロ誘導体 |
| EP4153303A1 (en) | 2020-05-18 | 2023-03-29 | GEN1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| EP4237415A1 (en) * | 2020-10-29 | 2023-09-06 | GEN1E Lifesciences Inc. | Crystalline 5-(dimethylamino)-n-(4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate |
| JP2024506858A (ja) | 2021-02-02 | 2024-02-15 | リミナル・バイオサイエンシーズ・リミテッド | Ｇｐｒ８４アンタゴニストおよびその使用 |
| WO2022204046A1 (en) * | 2021-03-23 | 2022-09-29 | Gen1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
| AR125196A1 (es) | 2021-03-26 | 2023-06-21 | Novartis Ag | Derivados de ciclobutilo 1,3-sustituidos y sus usos |
| EP4448492B1 (en) | 2021-12-17 | 2026-03-04 | Reglagene, Inc. | Compositions and methods of making and using small molecules in the treatment of cancer |
| JP2026500305A (ja) | 2022-12-16 | 2026-01-06 | アストラゼネカ・アクチエボラーグ | ２，６，９三置換プリン |
| US12215102B2 (en) | 2023-02-28 | 2025-02-04 | Reglagene, Inc. | Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions |
| CN116621794B (zh) * | 2023-05-22 | 2025-03-11 | 上海大学 | 一种5-苄基-2-氨基-1,3-噻唑类衍生物及其合成方法与应用 |
| US12116353B1 (en) * | 2024-04-25 | 2024-10-15 | Genie Lifesciences Inc. | Crystalline chloro-n-(4-(morpholinomethyl)phenyl)benzamide and crystalline hydrochloride salt |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR96352E (fr) | 1967-12-29 | 1972-06-16 | Science Union & Cie | Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation. |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| DE19801646A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
| JPH11269146A (ja) | 1998-03-24 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| BR0010655A (pt) | 1999-03-24 | 2002-02-13 | Anormed Inc | Compostos heterocìclicos para ligação ao receptor de quimiocina |
| PT1537116E (pt) * | 2002-09-04 | 2010-09-03 | Schering Corp | Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| WO2004072077A1 (de) | 2003-02-13 | 2004-08-26 | Aventis Pharma Deutshland Gmbh | STICKSTOFF SUBSTITUIERTE HEXAHYDRO-PYRAZINO[1,2-a]PYRIMIDIN-4,7-DIONDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL |
| US7297817B2 (en) | 2004-04-13 | 2007-11-20 | Cephalon France | Thio-substituted arylmethanesulfinyl derivatives |
| JP2007532615A (ja) * | 2004-04-13 | 2007-11-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2006010082A1 (en) * | 2004-07-08 | 2006-01-26 | Arqule, Inc. | 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase |
| WO2006105237A2 (en) | 2005-03-29 | 2006-10-05 | The University Of Maryland, Baltimore | Inhibitors for extracellular signal-regulated kinase docking domains and uses therefor |
| WO2008094319A2 (en) * | 2007-02-01 | 2008-08-07 | The Board Of Regents Of The University Of Texas Sytem | Methods and compositions of trail-death receptor agonists/activators |
| TW200904421A (en) | 2007-05-03 | 2009-02-01 | Astellas Pharma Inc | New compounds |
| US8778953B2 (en) * | 2008-02-29 | 2014-07-15 | Chroma Therapeutics Ltd. | Inhibitors of P38 map kinase |
| US20120172375A1 (en) | 2008-11-07 | 2012-07-05 | Bruce Trapp | Compounds and methods of promoting oligodendrocyte precursor differentiation |
| WO2010082912A1 (en) | 2009-01-15 | 2010-07-22 | Avalon Pharmaceuticals | Derivatives of multi-ring aromatic compounds and uses as anti-tumor agents |
| WO2010094977A1 (en) | 2009-02-23 | 2010-08-26 | Arrow Therapeutics Limited | Novel biphenyl compounds useful for the treatment of hepatitis c |
| SG194697A1 (en) * | 2011-05-03 | 2013-12-30 | Agios Pharmaceuticals Inc | Pyruvate kinase activators for use in therapy |
| WO2014111130A1 (en) | 2013-01-15 | 2014-07-24 | Müller Karl Alex | Rapid solid-state reaction of oxides with ultraviolet radiation |
| KR102283876B1 (ko) | 2013-04-02 | 2021-07-29 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제로서 유용한 우레아 유도체 |
| US9025712B2 (en) | 2013-07-30 | 2015-05-05 | Pixart Imaging Inc. | Sensor, clock frequency adjusting system and method thereof |
| EA201691169A1 (ru) * | 2013-12-05 | 2016-09-30 | Асерта Фарма Б.В. | Терапевтическая комбинация ингибитора pi3k и ингибитора btk |
| ES2677595T3 (es) | 2014-02-14 | 2018-08-03 | Respivert Limited | Compuestos heterocíclicos aromáticos como compuestos antiinflamatorios |
| NZ724368A (en) * | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| GB201417168D0 (en) | 2014-09-29 | 2014-11-12 | Univ Hertfordshire Higher Education Corp | Compounds |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| WO2016073633A1 (en) | 2014-11-05 | 2016-05-12 | University Of Kansas | SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP) |
| US10858316B2 (en) * | 2015-07-10 | 2020-12-08 | University Of Maryland, Baltimore | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof |
| WO2017223284A1 (en) | 2016-06-23 | 2017-12-28 | University Of Maryland, Baltimore | NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF |
| WO2018085348A1 (en) * | 2016-11-03 | 2018-05-11 | Actavalon, Inc. | Substituted quinolines and methods for treating cancer |
| TW201829381A (zh) | 2016-12-22 | 2018-08-16 | 美商拜奧馬林製藥公司 | 組蛋白脫乙醯基酶抑制劑 |
| EP3720436A4 (en) | 2017-12-06 | 2021-06-02 | Lin Bioscience, Pty Ltd. | TUBULIN INHIBITORS |
| AU2019392904B9 (en) * | 2018-12-07 | 2022-12-22 | University Of Maryland, Baltimore | Non-ATP/catalytic site p38 mitogen activated protein kinase inhibitors |
| WO2021183970A1 (en) | 2020-03-13 | 2021-09-16 | University Of Maryland, Baltimore | Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors |
| EP4153303A1 (en) | 2020-05-18 | 2023-03-29 | GEN1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| WO2022204046A1 (en) | 2021-03-23 | 2022-09-29 | Gen1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
-
2019
- 2019-12-06 AU AU2019392904A patent/AU2019392904B9/en active Active
- 2019-12-06 EP EP25161840.1A patent/EP4606792A1/en active Pending
- 2019-12-06 ES ES19893204T patent/ES3025468T3/es active Active
- 2019-12-06 CN CN201980091398.5A patent/CN113395963B/zh active Active
- 2019-12-06 JP JP2021532311A patent/JP7594787B2/ja active Active
- 2019-12-06 MX MX2021006731A patent/MX2021006731A/es unknown
- 2019-12-06 IL IL283755A patent/IL283755B2/en unknown
- 2019-12-06 CA CA3122371A patent/CA3122371A1/en active Pending
- 2019-12-06 EP EP19893204.8A patent/EP3890733B1/en active Active
- 2019-12-06 WO PCT/US2019/064960 patent/WO2020118194A1/en not_active Ceased
-
2020
- 2020-05-11 US US16/872,114 patent/US11078171B2/en active Active
-
2021
- 2021-06-07 MX MX2024004162A patent/MX2024004162A/es unknown
- 2021-06-16 US US17/349,468 patent/US11718595B2/en active Active
-
2022
- 2022-11-04 AU AU2022263608A patent/AU2022263608B2/en active Active
-
2023
- 2023-04-26 JP JP2023072147A patent/JP2023106403A/ja active Pending
- 2023-06-07 US US18/206,925 patent/US12202810B2/en active Active
-
2024
- 2024-05-22 AU AU2024203398A patent/AU2024203398A1/en active Pending
- 2024-12-05 US US18/970,196 patent/US20250100985A1/en active Pending
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