JP2004500406A5 - - Google Patents
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- Publication number
- JP2004500406A5 JP2004500406A5 JP2001570600A JP2001570600A JP2004500406A5 JP 2004500406 A5 JP2004500406 A5 JP 2004500406A5 JP 2001570600 A JP2001570600 A JP 2001570600A JP 2001570600 A JP2001570600 A JP 2001570600A JP 2004500406 A5 JP2004500406 A5 JP 2004500406A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- group
- analogue
- composition
- proliferation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 229920000768 polyamine Polymers 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 229940040145 liniment Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19183900P | 2000-03-24 | 2000-03-24 | |
| PCT/US2001/040360 WO2001072685A2 (en) | 2000-03-24 | 2001-03-23 | Polyamine analogues as cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004500406A JP2004500406A (ja) | 2004-01-08 |
| JP2004500406A5 true JP2004500406A5 (https=) | 2005-02-17 |
Family
ID=22707114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001570600A Pending JP2004500406A (ja) | 2000-03-24 | 2001-03-23 | 細胞毒性剤としてのポリアミン類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6872852B2 (https=) |
| EP (1) | EP1296931B1 (https=) |
| JP (1) | JP2004500406A (https=) |
| KR (1) | KR20020081433A (https=) |
| CN (1) | CN1426391A (https=) |
| AT (1) | ATE327973T1 (https=) |
| AU (2) | AU5173501A (https=) |
| CA (1) | CA2403814A1 (https=) |
| DE (1) | DE60120162T2 (https=) |
| ES (1) | ES2271000T3 (https=) |
| HU (1) | HUP0400494A3 (https=) |
| IL (1) | IL151692A0 (https=) |
| PL (1) | PL365473A1 (https=) |
| RU (1) | RU2002128917A (https=) |
| WO (1) | WO2001072685A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030013772A1 (en) * | 2000-02-23 | 2003-01-16 | Murphy Michael A. | Composition, synthesis and therapeutic applications of polyamines |
| CN100582084C (zh) * | 2001-01-08 | 2010-01-20 | 麦迪凯斯特治疗学股份有限公司 | 疏水性多胺类似物及其使用方法 |
| USRE43327E1 (en) | 2001-01-08 | 2012-04-24 | Aminex Therapeutics, Inc. | Hydrophobic polyamine analogs and methods for their use |
| IL147812A0 (en) * | 2001-03-16 | 2002-08-14 | N S T Neurosurvival Technologi | Method for targeting chemical compounds to cells and pharmaceutical compositions used therein |
| ES2318041T3 (es) | 2001-07-23 | 2009-05-01 | Laboratoires Serono Sa | Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales. |
| WO2003013245A1 (en) | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| US7199267B1 (en) * | 2005-10-21 | 2007-04-03 | Mediquest Therapeutics, Inc. | Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases |
| EP2149568A1 (en) * | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
| PT2858975T (pt) | 2012-06-08 | 2019-07-16 | Univ Pittsburgh Commonwealth Sys Higher Education | Inibidores de fbxo3 |
| WO2015089087A1 (en) * | 2013-12-09 | 2015-06-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compositions and methods for treating respiratory injury or disease |
| CN104892449B (zh) * | 2014-03-06 | 2017-06-13 | 天津红日药业股份有限公司 | 一种精胺类似物及其药用盐的制备方法和用途 |
| US10487076B2 (en) * | 2014-12-10 | 2019-11-26 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compositions and methods for treating diseases and conditions |
| MX2018010768A (es) | 2016-03-25 | 2018-11-29 | Aminex Therapeutics Inc | Poliaminas biodisponibles. |
| EP3833352A4 (en) | 2018-08-10 | 2022-04-06 | University of Central Florida Research Foundation, Inc. | Non-polyamine based polyamine transport inhibitors and their use in the treatment of human cancers |
| US11865095B2 (en) | 2020-09-30 | 2024-01-09 | Aminex Therapeutics, Inc. | Combination drug substance of polyamine transport inhibitor and DFMO |
| US11752118B2 (en) * | 2020-12-02 | 2023-09-12 | Gongwin Biopharm Co., Ltd | Method for treating melanoma |
| WO2024130693A1 (zh) * | 2022-12-23 | 2024-06-27 | 中国医学科学院基础医学研究所 | 精胺衍生物及其在疾病中的治疗用途 |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3634316A (en) * | 1968-08-23 | 1972-01-11 | Showa Denko Kk | Sulfur-vulcanizable natural and synthetic rubbery polymers containing xylylene diamines as antiozonants |
| US4851447A (en) | 1983-12-06 | 1989-07-25 | Merrell Dow Pharmaceuticals Inc. | N-2,3-butadienyl-1,4-butanediamine derivatives |
| NZ212053A (en) * | 1984-05-17 | 1988-02-29 | Merrell Dow Pharma | Polyamine containing pharmaceutical compositions for treating neoplasms |
| ZA903804B (en) | 1989-05-23 | 1991-03-27 | Merrell Dow Pharma | A method of potentiating cell-mediated immunity utilizing polyamine derivatives |
| RU2147574C1 (ru) | 1991-08-23 | 2000-04-20 | Эн-Пи-Эс Фармасьютикалз, Инк. | Арилалкиламины, композиции, способы лечения и диагностики, способы идентификации соединения |
| AU679972B2 (en) * | 1993-02-23 | 1997-07-17 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as radioprotective agents |
| US5677350A (en) | 1995-06-07 | 1997-10-14 | Wisconsin Alumni Research Foundation | Inhibition of cancer cell growth, proliferation, and metastasis using N,N'-dα,ω-diaminoalkanes |
| US5962533A (en) | 1996-02-06 | 1999-10-05 | University Of Florida Research Foundation, Inc. | Hydroxy polyamines |
| JP4044728B2 (ja) * | 1997-07-15 | 2008-02-06 | メディクエスト セラピューティックス インク | 治療および診断薬剤としての新規なポリアミンアナログ |
| US5886185A (en) * | 1997-11-20 | 1999-03-23 | Development Center For Biotechnoloy | Polyamine-linked acridine dimers |
-
2001
- 2001-03-23 HU HU0400494A patent/HUP0400494A3/hu unknown
- 2001-03-23 ES ES01925146T patent/ES2271000T3/es not_active Expired - Lifetime
- 2001-03-23 WO PCT/US2001/040360 patent/WO2001072685A2/en not_active Ceased
- 2001-03-23 RU RU2002128917/04A patent/RU2002128917A/ru unknown
- 2001-03-23 AU AU5173501A patent/AU5173501A/xx active Pending
- 2001-03-23 JP JP2001570600A patent/JP2004500406A/ja active Pending
- 2001-03-23 AU AU2001251735A patent/AU2001251735B2/en not_active Ceased
- 2001-03-23 US US10/239,521 patent/US6872852B2/en not_active Expired - Fee Related
- 2001-03-23 PL PL01365473A patent/PL365473A1/xx not_active Application Discontinuation
- 2001-03-23 CN CN01807059A patent/CN1426391A/zh active Pending
- 2001-03-23 AT AT01925146T patent/ATE327973T1/de not_active IP Right Cessation
- 2001-03-23 IL IL15169201A patent/IL151692A0/xx unknown
- 2001-03-23 EP EP01925146A patent/EP1296931B1/en not_active Expired - Lifetime
- 2001-03-23 DE DE60120162T patent/DE60120162T2/de not_active Expired - Fee Related
- 2001-03-23 KR KR1020027011949A patent/KR20020081433A/ko not_active Withdrawn
- 2001-03-23 CA CA002403814A patent/CA2403814A1/en not_active Abandoned
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