JP2003528864A5 - - Google Patents
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- Publication number
- JP2003528864A5 JP2003528864A5 JP2001570634A JP2001570634A JP2003528864A5 JP 2003528864 A5 JP2003528864 A5 JP 2003528864A5 JP 2001570634 A JP2001570634 A JP 2001570634A JP 2001570634 A JP2001570634 A JP 2001570634A JP 2003528864 A5 JP2003528864 A5 JP 2003528864A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- imidazol
- ylmethyl
- tetrahydro
- benzodiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 description 41
- 150000003839 salts Chemical class 0.000 description 30
- -1 diinene Substances 0.000 description 28
- 239000002254 cytotoxic agent Substances 0.000 description 27
- 229940127089 cytotoxic agent Drugs 0.000 description 26
- 231100000599 cytotoxic agent Toxicity 0.000 description 26
- 229930012538 Paclitaxel Natural products 0.000 description 23
- 229960001592 paclitaxel Drugs 0.000 description 23
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 22
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- 239000008194 pharmaceutical composition Substances 0.000 description 21
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 19
- 125000000217 alkyl group Chemical group 0.000 description 12
- 239000000824 cytostatic agent Substances 0.000 description 12
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| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| CN103374000B (zh) * | 2012-04-13 | 2015-11-11 | 中国科学院广州生物医药与健康研究院 | 嘧啶并二氮杂卓类化合物及其药用组合物和应用 |
| IL294463A (en) | 2013-07-12 | 2022-09-01 | Iveric Bio Inc | Methods for treating or preventing eye conditions |
| CN107043456B (zh) * | 2017-04-19 | 2019-05-17 | 川北医学院 | 对氧环己酮与l-苯丙氨酸氮芥共聚物及其应用 |
| ES3014942T3 (en) | 2017-06-21 | 2025-04-28 | Univ North Carolina Chapel Hill | Methods and compositions for chimeric antigen receptor targeting cancer cells |
| WO2019240935A1 (en) | 2018-06-13 | 2019-12-19 | The University Of North Carolina At Chapel Hill | Methods and compositions for chimeric antigen receptor targeting cancer cells |
| US11068254B1 (en) | 2020-06-10 | 2021-07-20 | Cigna Intellectual Property, Inc. | Systems and methods for generating and managing domain-based technology architecture |
| CA3222225A1 (en) * | 2021-06-03 | 2022-12-08 | University Of Cincinnati | Bzd-1 as a chemosensitizer of cancer |
| CN120695174A (zh) * | 2021-07-01 | 2025-09-26 | 江苏先声生物制药有限公司 | 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用 |
| US11879010B2 (en) | 2021-09-30 | 2024-01-23 | The Charlotte Mecklenburg Hospital Authority | Methods and compositions for pretargeted immunotherapy |
| CN114712377B (zh) * | 2022-04-26 | 2023-08-15 | 江苏师范大学 | 断血流皂苷a在制造药物中的用途 |
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| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| DE19706584C2 (de) * | 1997-02-21 | 2002-09-26 | Aeg Energietechnik Gmbh | Hochtemperaturbrennstoffzellen mit Erwärmung des Reaktionsgases |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| AU8382698A (en) * | 1997-07-08 | 1999-02-08 | Union Carbide Chemicals & Plastics Technology Corporation | Method for reducing sheeting during olefin polymerization |
| IL136462A0 (en) | 1997-12-22 | 2001-06-14 | Schering Corp | Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases |
| EE200100382A (et) * | 1999-01-21 | 2002-12-16 | Bristol-Myers Squibb Company | Ras-farnesüültransferaasi inhibiitori ja sulfobutüüleeter-7-ß-tsüklodekstriini või 2-hüdroksüpropüül-ß-tsüklodekstriini kompleks ja selle valmistamise meetod |
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2001
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