ZA200207766B - Synergistic methods and compositions for treating cancer. - Google Patents
Synergistic methods and compositions for treating cancer. Download PDFInfo
- Publication number
- ZA200207766B ZA200207766B ZA200207766A ZA200207766A ZA200207766B ZA 200207766 B ZA200207766 B ZA 200207766B ZA 200207766 A ZA200207766 A ZA 200207766A ZA 200207766 A ZA200207766 A ZA 200207766A ZA 200207766 B ZA200207766 B ZA 200207766B
- Authority
- ZA
- South Africa
- Prior art keywords
- compound
- tetrahydro
- benzodiazepine
- imidazol
- optionally substituted
- Prior art date
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- 238000000034 method Methods 0.000 title claims 23
- 239000000203 mixture Substances 0.000 title claims 23
- 206010028980 Neoplasm Diseases 0.000 title claims 6
- 201000011510 cancer Diseases 0.000 title claims 4
- 230000002195 synergetic effect Effects 0.000 title claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 32
- 239000002254 cytotoxic agent Substances 0.000 claims 32
- 231100000599 cytotoxic agent Toxicity 0.000 claims 32
- 150000003839 salts Chemical class 0.000 claims 28
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Classifications
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
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| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
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| KR20020084254A (ko) | 2002-11-04 |
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| CN1419452A (zh) | 2003-05-21 |
| ATE430570T1 (de) | 2009-05-15 |
| CZ20023220A3 (cs) | 2003-11-12 |
| CN100384424C (zh) | 2008-04-30 |
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| PE20011291A1 (es) | 2002-01-13 |
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| AU2001247683B2 (en) | 2006-01-12 |
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