JP2003523364A5 - - Google Patents
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- Publication number
- JP2003523364A5 JP2003523364A5 JP2001561027A JP2001561027A JP2003523364A5 JP 2003523364 A5 JP2003523364 A5 JP 2003523364A5 JP 2001561027 A JP2001561027 A JP 2001561027A JP 2001561027 A JP2001561027 A JP 2001561027A JP 2003523364 A5 JP2003523364 A5 JP 2003523364A5
- Authority
- JP
- Japan
- Prior art keywords
- mol
- hydrogenation
- isomer
- hplc
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10003586 | 2000-01-28 | ||
| DE10003586.8 | 2000-01-28 | ||
| PCT/EP2001/000523 WO2001055175A2 (en) | 2000-01-28 | 2001-01-18 | Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003523364A JP2003523364A (ja) | 2003-08-05 |
| JP2003523364A5 true JP2003523364A5 (cg-RX-API-DMAC7.html) | 2008-02-28 |
| JP4778181B2 JP4778181B2 (ja) | 2011-09-21 |
Family
ID=7628946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001561027A Expired - Fee Related JP4778181B2 (ja) | 2000-01-28 | 2001-01-18 | アセチル−アミジニオフェニルアラニル−シクロヘキシルグリシル−ピリジニオアラニンアミドの製造方法 |
Country Status (29)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH695999A5 (de) | 2002-02-28 | 2006-11-15 | Wilex Ag | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
| WO2007065691A2 (en) * | 2005-12-07 | 2007-06-14 | Technische Universität München | Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins |
| CN101774942B (zh) * | 2010-01-27 | 2012-08-22 | 宁波武盛化学有限公司 | 制备n-乙酰基-dl-环己基甘氨酸的方法 |
| CN102984945B (zh) * | 2010-04-20 | 2014-08-20 | 凯瑞斯德生化(苏州)有限公司 | 一种环烯基在β位取代的丙氨酸的不对称合成方法 |
| JP5913352B2 (ja) * | 2010-11-29 | 2016-04-27 | 高砂香料工業株式会社 | 不斉水素化触媒、およびそれを用いた光学活性カルボニル化合物の製造方法 |
| CN115068469B (zh) * | 2022-07-08 | 2024-02-27 | 深圳市小分子新药创新中心有限公司 | Tigit抑制剂及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2916711A1 (de) | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| US4623717A (en) | 1980-03-05 | 1986-11-18 | Miles Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| US4440679A (en) | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| DE69426897T2 (de) * | 1993-10-15 | 2001-07-05 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Antithrombotisch wirkende azacycloalkyl-alkanoyl-peptide und-pseudopeptide |
| US5849510A (en) | 1994-04-26 | 1998-12-15 | Selectide Corporation | Factor Xa inhibitors |
| RU2152954C1 (ru) * | 1994-04-26 | 2000-07-20 | Селектид Корпорейшн | Ингибиторы фактора ха |
| RU2170764C2 (ru) * | 1995-12-20 | 2001-07-20 | Авентис Фармасьютикалз Инк. | НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ N-АЦЕТИЛ-(L)-4-ЦИАНОФЕНИЛАЛАНИНА АС-(L)-PHE(4-CN)-OH И N-АЦЕТИЛ-(L)-N-АМИДИНОФЕНИЛАЛАНИН-ЦИКЛОГЕКСИЛ-ГЛИЦИН-β-(3-N-МЕТИЛПИРИДИН ИЯ)-АЛАНИНА АС-(L)-PАPH-СHG-РAL МE(3)-NH2 |
| DE19856443A1 (de) | 1998-12-08 | 2000-06-21 | Centeon Pharma Gmbh | Stabilisiertes Antithrombin III-Präparat |
-
2001
- 2001-01-18 AR ARP010100225A patent/AR027246A1/es unknown
- 2001-01-18 CA CA2398497A patent/CA2398497C/en not_active Expired - Fee Related
- 2001-01-18 PT PT01911497T patent/PT1254159E/pt unknown
- 2001-01-18 PL PL01356801A patent/PL356801A1/xx unknown
- 2001-01-18 AU AU40516/01A patent/AU779722B2/en not_active Ceased
- 2001-01-18 MX MXPA02006762A patent/MXPA02006762A/es active IP Right Grant
- 2001-01-18 ES ES01911497T patent/ES2262632T3/es not_active Expired - Lifetime
- 2001-01-18 IL IL15089701A patent/IL150897A0/xx active IP Right Grant
- 2001-01-18 JP JP2001561027A patent/JP4778181B2/ja not_active Expired - Fee Related
- 2001-01-18 HR HRP20020631 patent/HRP20020631A2/hr not_active Application Discontinuation
- 2001-01-18 EE EEP200200410A patent/EE200200410A/xx unknown
- 2001-01-18 CZ CZ20022583A patent/CZ20022583A3/cs unknown
- 2001-01-18 BR BR0107804-6A patent/BR0107804A/pt not_active Application Discontinuation
- 2001-01-18 CN CNB018041523A patent/CN1176104C/zh not_active Expired - Fee Related
- 2001-01-18 HU HU0301986A patent/HUP0301986A2/hu unknown
- 2001-01-18 AT AT01911497T patent/ATE325810T1/de active
- 2001-01-18 SK SK1084-2002A patent/SK10842002A3/sk unknown
- 2001-01-18 DK DK01911497T patent/DK1254159T3/da active
- 2001-01-18 WO PCT/EP2001/000523 patent/WO2001055175A2/en not_active Ceased
- 2001-01-18 RU RU2002123046/04A patent/RU2250212C2/ru not_active IP Right Cessation
- 2001-01-18 EP EP01911497A patent/EP1254159B9/en not_active Expired - Lifetime
- 2001-01-18 KR KR1020027009583A patent/KR100758141B1/ko not_active Expired - Fee Related
- 2001-01-18 DE DE60119491T patent/DE60119491T2/de not_active Expired - Lifetime
- 2001-01-18 NZ NZ520427A patent/NZ520427A/en unknown
- 2001-01-18 YU YU51202A patent/YU51202A/sh unknown
- 2001-01-26 US US09/769,487 patent/US20010031858A1/en not_active Abandoned
- 2001-03-07 TW TW090101207A patent/TWI236481B/zh not_active IP Right Cessation
-
2002
- 2002-07-24 IL IL150897A patent/IL150897A/en not_active IP Right Cessation
- 2002-07-26 ZA ZA200205990A patent/ZA200205990B/en unknown
- 2002-07-26 NO NO20023577A patent/NO20023577L/no unknown
-
2004
- 2004-06-17 US US10/869,076 patent/US7084250B2/en not_active Expired - Lifetime
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