JP2003513071A5 - - Google Patents
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- Publication number
- JP2003513071A5 JP2003513071A5 JP2001534771A JP2001534771A JP2003513071A5 JP 2003513071 A5 JP2003513071 A5 JP 2003513071A5 JP 2001534771 A JP2001534771 A JP 2001534771A JP 2001534771 A JP2001534771 A JP 2001534771A JP 2003513071 A5 JP2003513071 A5 JP 2003513071A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- disorder
- pharmaceutical composition
- composition according
- nicotine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 230000006735 deficit Effects 0.000 description 8
- 229960002715 nicotine Drugs 0.000 description 8
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 6
- 208000024827 Alzheimer disease Diseases 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 230000002265 prevention Effects 0.000 description 5
- 208000000044 Amnesia Diseases 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 4
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 4
- 208000020925 Bipolar disease Diseases 0.000 description 4
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 description 4
- 206010009900 Colitis ulcerative Diseases 0.000 description 4
- 208000023105 Huntington disease Diseases 0.000 description 4
- 208000001456 Jet Lag Syndrome Diseases 0.000 description 4
- 208000009829 Lewy Body Disease Diseases 0.000 description 4
- 201000002832 Lewy body dementia Diseases 0.000 description 4
- 206010026749 Mania Diseases 0.000 description 4
- 208000026139 Memory disease Diseases 0.000 description 4
- 206010057852 Nicotine dependence Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- 208000025569 Tobacco Use disease Diseases 0.000 description 4
- 208000000323 Tourette Syndrome Diseases 0.000 description 4
- 208000016620 Tourette disease Diseases 0.000 description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 description 4
- 230000036506 anxiety Effects 0.000 description 4
- 230000003935 attention Effects 0.000 description 4
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 4
- 208000028683 bipolar I disease Diseases 0.000 description 4
- 230000001713 cholinergic effect Effects 0.000 description 4
- 230000007278 cognition impairment Effects 0.000 description 4
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 description 4
- 230000006984 memory degeneration Effects 0.000 description 4
- 208000023060 memory loss Diseases 0.000 description 4
- 208000015122 neurodegenerative disease Diseases 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 201000000980 schizophrenia Diseases 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000036626 Mental retardation Diseases 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 239000000018 receptor agonist Substances 0.000 description 2
- 229940044601 receptor agonist Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000005586 smoking cessation Effects 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 230000007470 synaptic degeneration Effects 0.000 description 2
- NNUQNQHIDUAHFO-UHFFFAOYSA-N 1-(furan-2-ylmethyl)-3-(1h-indol-5-yl)thiourea Chemical compound C=1C=C2NC=CC2=CC=1NC(=S)NCC1=CC=CO1 NNUQNQHIDUAHFO-UHFFFAOYSA-N 0.000 description 1
- QCRHULZENHWRMA-UHFFFAOYSA-N 2-(1h-indol-5-yl)-n-phenylacetamide Chemical compound C=1C=C2NC=CC2=CC=1CC(=O)NC1=CC=CC=C1 QCRHULZENHWRMA-UHFFFAOYSA-N 0.000 description 1
- ADPRFNVFBYHCJQ-UHFFFAOYSA-N 2-(5-phenylmethoxy-1h-indol-3-yl)acetonitrile Chemical compound C1=C2C(CC#N)=CNC2=CC=C1OCC1=CC=CC=C1 ADPRFNVFBYHCJQ-UHFFFAOYSA-N 0.000 description 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- CRJAGJQFPQEDGO-UHFFFAOYSA-N 5-(2-phenoxyethoxy)-1h-indole Chemical compound C=1C=C2NC=CC2=CC=1OCCOC1=CC=CC=C1 CRJAGJQFPQEDGO-UHFFFAOYSA-N 0.000 description 1
- LSOSOBIBHAOODO-UHFFFAOYSA-N 5-(naphthalen-2-ylmethoxy)-1h-indole Chemical compound C1=CC=CC2=CC(COC=3C=C4C=CNC4=CC=3)=CC=C21 LSOSOBIBHAOODO-UHFFFAOYSA-N 0.000 description 1
- -1 5-cinnamyloxindole Chemical compound 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903997A SE9903997D0 (sv) | 1999-11-03 | 1999-11-03 | New compounds |
| SE9903997-6 | 1999-11-03 | ||
| PCT/SE2000/002148 WO2001032619A1 (en) | 1999-11-03 | 2000-11-01 | Positive modulators of nicotinic receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003513071A JP2003513071A (ja) | 2003-04-08 |
| JP2003513071A5 true JP2003513071A5 (enExample) | 2007-11-22 |
Family
ID=20417607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001534771A Abandoned JP2003513071A (ja) | 1999-11-03 | 2000-11-01 | ニコチン受容体作用薬の正のモジュレーター |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6750242B1 (enExample) |
| EP (1) | EP1230216A1 (enExample) |
| JP (1) | JP2003513071A (enExample) |
| KR (1) | KR20020063176A (enExample) |
| CN (1) | CN1239482C (enExample) |
| AU (1) | AU783507B2 (enExample) |
| BR (1) | BR0015195A (enExample) |
| CA (1) | CA2387745A1 (enExample) |
| CO (1) | CO5251458A1 (enExample) |
| IL (1) | IL149098A0 (enExample) |
| MX (1) | MXPA02004232A (enExample) |
| NO (1) | NO323076B1 (enExample) |
| NZ (2) | NZ518450A (enExample) |
| SE (1) | SE9903997D0 (enExample) |
| WO (1) | WO2001032619A1 (enExample) |
| ZA (1) | ZA200203171B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903998D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| DE10234424A1 (de) * | 2002-07-29 | 2004-02-12 | Bayer Ag | Benzothiophen-, Benzofuran- und Indolharnstoffe |
| JP2006501246A (ja) | 2002-08-30 | 2006-01-12 | メモリー・ファーマシューティカルズ・コーポレイション | 神経変性疾患の治療において有用なアナバセイン誘導体 |
| AU2003276919B2 (en) | 2002-09-25 | 2013-05-16 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| US20050234095A1 (en) | 2004-03-25 | 2005-10-20 | Wenge Xie | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| CN101247853B (zh) * | 2005-04-13 | 2014-11-12 | 轴突公司 | 具有nos抑制活性的取代的吲哚化合物 |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| US7989447B2 (en) | 2006-04-13 | 2011-08-02 | Neuraxon, Inc. | 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity |
| AU2008321353A1 (en) * | 2007-11-16 | 2009-05-22 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating visceral pain |
| MX2010005343A (es) * | 2007-11-16 | 2010-08-09 | Neuraxon Inc | Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina. |
| JP2011503120A (ja) * | 2007-11-16 | 2011-01-27 | ニューラクソン，インコーポレーテッド | 内臓痛を治療するためのインドール化合物および方法 |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| AU2009212259A1 (en) * | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
| UY31769A1 (es) | 2008-04-17 | 2009-09-30 | Derivados del indol con actividad modulatoria del receptor nicotínico de acetilcolina | |
| JP5642154B2 (ja) * | 2009-04-16 | 2014-12-17 | プロキシマジェン エルティーディーＰｒｏｘｉｍａｇｅｎ Ｌｔｄ． | α７ｎＡＣｈＲのインドール誘導体モジュレータ |
| JP5749797B2 (ja) * | 2010-05-17 | 2015-07-15 | フォルム ファーマシューティカルズ、インコーポレイテッド | （ｒ）−７−クロロ−ｎ−（キヌクリジン−３−イル）ベンゾ［ｂ］チオフェン−２−カルボキサミド塩酸塩一水和物の結晶形 |
| TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
| AR086791A1 (es) | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | Moduladores alostericos positivos del receptor de acetilcolina nicotinico |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| WO2020045982A1 (ko) * | 2018-08-29 | 2020-03-05 | 숙명여자대학교산학협력단 | 치환된 인돌 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 PPARα, PPARγ 및 PPARδ 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2787551A (en) * | 1954-02-24 | 1957-04-02 | Eastman Kodak Co | Compositions stabilized with hydroxyindole |
| BE758766A (fr) * | 1969-11-17 | 1971-05-10 | Ici Ltd | Nouveaux derives de la morpholine et de la |
| US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| KR930702334A (ko) * | 1990-09-13 | 1993-09-08 | 데이비드 로버트 | 5 하이드록시트립타민 수용체 길항제로서의 인돌우레아 |
| RU2126399C1 (ru) * | 1991-11-25 | 1999-02-20 | Пфайзер Инк. | Производные индола, замещенные индолы и способ ингибирования 5ht1 рецептора серотонина |
| WO1993018026A1 (en) * | 1992-03-04 | 1993-09-16 | Beecham Group Plc | Indole ureas as 5-ht1c receptor antogonists |
| US5504101A (en) * | 1994-05-06 | 1996-04-02 | Allelix Biopharmaceuticals, Inc. | 5-HT-1D receptor ligands |
| FR2722686B1 (fr) * | 1994-07-22 | 1996-08-30 | Oreal | Set, procede, dispositif et composition de teinture des fibres keratiniques |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
-
1999
- 1999-11-03 SE SE9903997A patent/SE9903997D0/xx unknown
-
2000
- 2000-11-01 CA CA002387745A patent/CA2387745A1/en not_active Abandoned
- 2000-11-01 EP EP00976500A patent/EP1230216A1/en not_active Withdrawn
- 2000-11-01 IL IL14909800A patent/IL149098A0/xx unknown
- 2000-11-01 KR KR1020027005706A patent/KR20020063176A/ko not_active Ceased
- 2000-11-01 NZ NZ518450A patent/NZ518450A/en unknown
- 2000-11-01 MX MXPA02004232A patent/MXPA02004232A/es unknown
- 2000-11-01 CN CNB008154414A patent/CN1239482C/zh not_active Expired - Fee Related
- 2000-11-01 BR BR0015195-5A patent/BR0015195A/pt not_active IP Right Cessation
- 2000-11-01 JP JP2001534771A patent/JP2003513071A/ja not_active Abandoned
- 2000-11-01 US US10/111,027 patent/US6750242B1/en not_active Expired - Fee Related
- 2000-11-01 AU AU14264/01A patent/AU783507B2/en not_active Ceased
- 2000-11-01 WO PCT/SE2000/002148 patent/WO2001032619A1/en not_active Ceased
- 2000-11-01 NZ NZ530161A patent/NZ530161A/en unknown
- 2000-11-01 CO CO00083175A patent/CO5251458A1/es not_active Application Discontinuation
-
2002
- 2002-04-22 ZA ZA200203171A patent/ZA200203171B/xx unknown
- 2002-04-26 NO NO20022009A patent/NO323076B1/no unknown
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