JP2003505343A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003505343A5 JP2003505343A5 JP2001501237A JP2001501237A JP2003505343A5 JP 2003505343 A5 JP2003505343 A5 JP 2003505343A5 JP 2001501237 A JP2001501237 A JP 2001501237A JP 2001501237 A JP2001501237 A JP 2001501237A JP 2003505343 A5 JP2003505343 A5 JP 2003505343A5
- Authority
- JP
- Japan
- Prior art keywords
- botulinum
- complex
- counterpart
- medicament
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19925739A DE19925739A1 (de) | 1999-06-07 | 1999-06-07 | Therapeutikum mit einem Botulinum-Neurotoxin |
| DE19925739.6 | 1999-06-07 | ||
| PCT/DE2000/001777 WO2000074703A2 (de) | 1999-06-07 | 2000-05-26 | Therapeutikum mit einem botulinum-neurotoxin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007130686A Division JP2007238627A (ja) | 1999-06-07 | 2007-05-16 | ボツリヌス神経毒を含む治療薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505343A JP2003505343A (ja) | 2003-02-12 |
| JP2003505343A5 true JP2003505343A5 (https=) | 2007-06-28 |
Family
ID=7910318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001501237A Pending JP2003505343A (ja) | 1999-06-07 | 2000-05-26 | ボツリヌス神経毒を含む治療薬 |
| JP2007130686A Withdrawn JP2007238627A (ja) | 1999-06-07 | 2007-05-16 | ボツリヌス神経毒を含む治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007130686A Withdrawn JP2007238627A (ja) | 1999-06-07 | 2007-05-16 | ボツリヌス神経毒を含む治療薬 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7964199B1 (https=) |
| EP (1) | EP1185291B2 (https=) |
| JP (2) | JP2003505343A (https=) |
| KR (1) | KR100466407B1 (https=) |
| CN (2) | CN100389820C (https=) |
| AR (1) | AR024306A1 (https=) |
| AT (1) | ATE258803T1 (https=) |
| AU (1) | AU774590B2 (https=) |
| CA (1) | CA2376193C (https=) |
| CO (1) | CO5170431A1 (https=) |
| CZ (1) | CZ20014351A3 (https=) |
| DE (3) | DE19925739A1 (https=) |
| DK (1) | DK1185291T3 (https=) |
| EA (1) | EA004202B1 (https=) |
| ES (1) | ES2215056T5 (https=) |
| GE (1) | GEP20043200B (https=) |
| HU (1) | HUP0201530A3 (https=) |
| IL (2) | IL146974A0 (https=) |
| MX (1) | MXPA01012540A (https=) |
| NO (1) | NO20015964L (https=) |
| PL (1) | PL198958B1 (https=) |
| PT (1) | PT1185291E (https=) |
| TW (1) | TWI251492B (https=) |
| UA (1) | UA72253C2 (https=) |
| WO (1) | WO2000074703A2 (https=) |
| ZA (1) | ZA200110074B (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US20080038274A1 (en) | 1999-09-23 | 2008-02-14 | Foster Keith A | Inhibition of secretion from non-neuronal cells |
| US7838007B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating mammary gland disorders |
| US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
| US6821520B2 (en) | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
| JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
| US7140371B2 (en) | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
| US6688311B2 (en) | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
| US20050163809A1 (en) * | 2002-03-29 | 2005-07-28 | Ryuji Kaji | Remedy for hypermyotonia |
| US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
| EP2272340B1 (en) * | 2002-08-19 | 2018-03-14 | Ira Sanders | Botulinum toxin |
| US20120114697A1 (en) | 2002-08-19 | 2012-05-10 | Ira Sanders | Treatment of holocrine gland dysfunction with clostridia neurotoxins |
| US7824693B2 (en) | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
| US8071550B2 (en) | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
| BRPI0408131A (pt) * | 2003-03-06 | 2006-03-01 | Botulinum Toxin Res Ass Inc | tratamento com toxina botulina de dor facial e cefaléia crÈnicas relacionadas com sinusite |
| US6838434B2 (en) * | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
| WO2004112821A1 (ja) * | 2003-06-20 | 2004-12-29 | Santen Pharmaceutical Co., Ltd. | 筋緊張亢進性疾患の治療剤 |
| US6974579B2 (en) * | 2004-01-08 | 2005-12-13 | Allergan, Inc. | Methods for treating vascular disorders |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| JP2007527431A (ja) | 2004-03-03 | 2007-09-27 | ルバンス セラピュティックス | 局所的診断及び治療用の輸送のための組成物及び方法 |
| BRPI0508410B8 (pt) | 2004-03-03 | 2021-05-25 | Revance Therapeutics Inc | composições e métodos para a aplicação tópica e liberação transdérmica de toxinas botulínicas |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| EP2266599B1 (en) | 2004-07-26 | 2014-04-16 | Merz Pharma GmbH & Co. KGaA | Therapeutic composition with a botulinum neurotoxin |
| US7179474B2 (en) | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
| US7429386B2 (en) | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
| AU2005288758A1 (en) * | 2004-09-27 | 2006-04-06 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins for use in tissue healing |
| ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| ES2509872T3 (es) * | 2005-03-03 | 2014-10-20 | Allergan, Inc. | Procedimientos para obtener una toxina clostrídica |
| US7419675B2 (en) | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
| KR101176248B1 (ko) * | 2005-06-17 | 2012-08-22 | 메르츠 파마 게엠베하 운트 코. 카가아 | 발효에 의해 생물학적 활성 화합물을 제조하기 위한 장치및 방법 |
| CN103126971A (zh) | 2005-11-17 | 2013-06-05 | 雷文斯治疗公司 | 减少非毒素蛋白质的肉毒杆菌毒素组合物和其局部施用及透皮递送方法 |
| EP1834962A1 (de) * | 2006-03-15 | 2007-09-19 | Biotecon Therapeutics GmbH | PEGyliertes mutiertes Clostridium botulinum Toxin |
| US10792344B2 (en) | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
| AR061669A1 (es) | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| EP2048156A1 (en) * | 2007-10-12 | 2009-04-15 | Merz Pharma GmbH & Co.KGaA | Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin |
| RU2009149604A (ru) * | 2007-06-01 | 2011-07-20 | Мерц Фарма Гмбх Унд Ко. Кгаа (De) | Способ предоставления устойчивого к температуре миорелаксанта на основе нейротоксичного компонента ботулинического токсина в твердой форме |
| DE102007038015A1 (de) | 2007-08-10 | 2009-02-19 | Hefter, Harald, Prof. Dr. med. Dr. rer. nat. | Verwendung eines Neurotoxins |
| US9161970B2 (en) * | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
| EP2072057A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury |
| EP2072039A1 (en) * | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
| US8540987B2 (en) * | 2008-01-29 | 2013-09-24 | Institute For Antibodies Co., Ltd. | Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody |
| US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
| PT2271670E (pt) * | 2008-03-14 | 2014-11-28 | Allergan Inc | Ensaio imunobaseado da atividade do serotipo a da toxina botulínica |
| US20110033431A1 (en) * | 2008-03-31 | 2011-02-10 | The Chemo-Sero-Therapeutic Research Institute | Type a2 botulinum toxin preparation |
| KR20110060903A (ko) | 2008-08-29 | 2011-06-08 | 메르츠 파마 게엠베하 운트 코. 카가아 | 지속성이 변경된 클로스트리듐 신경독 |
| EP2161033B1 (en) | 2008-09-09 | 2013-05-01 | Susanne Dr. Grafe | Botulinum toxin to introduce temporal infertiliy in a vertebrate (e.g. human) |
| CN101386648B (zh) * | 2008-09-25 | 2012-05-30 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途 |
| WO2010096134A1 (en) | 2008-12-04 | 2010-08-26 | Botulinum Toxin Research Associates, Inc. | Extended length botulinum toxin formulation for human or mammalian use |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| JP2011074025A (ja) * | 2009-09-30 | 2011-04-14 | Chemo-Sero-Therapeutic Research Inst | ボツリヌス毒素の精製方法 |
| SI2490986T1 (sl) * | 2009-10-21 | 2018-12-31 | Revance Therapeutics, Inc. | Metode in sistemi za prečiščenje nekompleksiranega nevrotoksina botulina |
| KR101134146B1 (ko) | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| WO2012048854A2 (en) | 2010-10-12 | 2012-04-19 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
| BR112013033363A2 (pt) * | 2011-06-27 | 2017-01-31 | Duck Kim Sang | composição farmacêutica para tratamento de cicatrizes na pele, e método para tratar cicatrizes na pele usando a mesma |
| US9393291B2 (en) | 2012-04-12 | 2016-07-19 | Botulinum Toxin Research Associates, Inc. | Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds |
| HK1225744A1 (zh) | 2013-07-30 | 2017-09-15 | Merz Pharma Gmbh & Co. Kgaa | 制备高纯度的肉毒杆菌毒素神经毒性组分的方法及其应用 |
| US9901627B2 (en) | 2014-07-18 | 2018-02-27 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| EP3285800B1 (en) * | 2015-04-24 | 2019-09-18 | Consiglio Nazionale Delle Ricerche | A new therapeutic use of the botulinum neurotoxin serotype a |
| KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| KR102480965B1 (ko) | 2016-09-13 | 2022-12-26 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
| KR102463881B1 (ko) * | 2016-10-04 | 2022-11-07 | (주)메디톡스 | 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법 |
| EP3600221A4 (en) * | 2017-03-22 | 2021-01-13 | Bonti, Inc. | BOTULINARY NEUROTOXINS FOR USE IN THERAPY |
| AU2018237799B2 (en) | 2017-03-24 | 2024-11-14 | Merz Pharma Gmbh & Co. Kgaa | Improved use of botulinum neurotoxin in the treatment of sialorrhea |
| US11191819B2 (en) | 2018-08-28 | 2021-12-07 | Ira Sanders | Skin therapeutics |
| EP3860640A1 (en) | 2018-10-02 | 2021-08-11 | Merz Pharma GmbH & Co. KGaA | Novel uses of botulinum neurotoxin for treating lipoedema |
| KR20210130711A (ko) | 2019-02-21 | 2021-11-01 | 메르츠 파마 게엠베하 운트 코. 카가아 | 진전의 치료를 위한 보툴리눔 신경독의 신규 용도 |
| BR112022023413A2 (pt) | 2020-06-05 | 2022-12-20 | Merz Pharma Gmbh & Co Kgaa | Tratamento de rugas faciais com toxina botulínica de alta dose e baixo volume |
| KR102724651B1 (ko) * | 2021-07-08 | 2024-11-01 | 주식회사 파마리서치바이오 | 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법 |
| TW202400122A (zh) | 2022-02-28 | 2024-01-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素用於降低皮膚毛孔尺寸及／或皮脂產生之用途、以及降低皮膚毛孔尺寸及／或皮脂產生的方法 |
| AR131172A1 (es) | 2022-11-28 | 2025-02-19 | Merz Pharma Gmbh & Co Kgaa | Inyección de toxina botulínica en el platisma para el rejuvenecimiento del rostro inferior y del cuello |
| IL320937A (en) | 2022-11-28 | 2025-07-01 | Merz Pharma Gmbh & Co Kgaa | High-concentration botulinum toxin treatment for neck rejuvenation |
| WO2024194181A1 (en) | 2023-03-20 | 2024-09-26 | Merz Therapeutics GmbH | Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient |
| WO2024240868A1 (en) | 2023-05-23 | 2024-11-28 | Merz Therapeutics GmbH | Botulinum toxin for treating peripheral neuropathic pain |
| CN121511091A (zh) | 2023-07-12 | 2026-02-10 | 莫茨药物股份两合公司 | 通过肉毒杆菌毒素的色素沉着过度病况治疗 |
| WO2025228877A1 (en) | 2024-04-29 | 2025-11-06 | Merz Therapeutics GmbH | Botulinum toxin for the preventive treatment of migraine |
| WO2026021713A1 (en) | 2024-07-23 | 2026-01-29 | Merz Therapeutics GmbH | Uses of magnetic nerve stimulation associated with botulinum neurotoxin administration |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE286405T1 (de) | 1993-05-14 | 2005-01-15 | Stephen S Arnon | Verfahren zur verhütung der nebenwirkungen und unempfindlichkeit gegenüber therapeutischen verwendungen von toxinen |
| AU683275B2 (en) * | 1993-06-10 | 1997-11-06 | Allergan, Inc. | Multiple botulinum toxins for treating neuromuscular disorders and conditions |
| DE69428813T2 (de) | 1993-12-28 | 2002-04-04 | Allergan Sales Inc | Verwendung von Botulinustoxin zur Behandlung von Spannungs-Kopfschmerz |
| US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| EP0758900B1 (en) | 1994-05-09 | 2002-04-10 | BINDER, William J. | Botulinum toxin FOR REDUCTION OF migraine HEADACHE PAIN |
| AU2907695A (en) | 1994-08-08 | 1996-03-07 | Wisconsin Alumni Research Foundation | Purification and pharmaceutical compositions containing type g botulinum neurotoxin |
| US5756468A (en) * | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
| US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| EP0773788B1 (en) * | 1995-06-06 | 2003-05-07 | L. Bruce Pearce | Improved compositions and methods for chemodenervation using neurotoxins |
| US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
| KR100544060B1 (ko) * | 1997-07-15 | 2006-01-23 | 더 리젠트스 오브 더 유니버시티 오브 콜로라도 | 비뇨기과학 및 관련 부전증을 치료하기 위한 신경독요법의 용도 |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| DE19856897A1 (de) * | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
| DE19925739A1 (de) | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US6358917B1 (en) * | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
| US6787517B1 (en) * | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| BRPI1014253A2 (pt) * | 2009-07-02 | 2016-04-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento |
-
1999
- 1999-06-07 DE DE19925739A patent/DE19925739A1/de not_active Withdrawn
-
2000
- 2000-05-26 HU HU0201530A patent/HUP0201530A3/hu unknown
- 2000-05-26 MX MXPA01012540A patent/MXPA01012540A/es active IP Right Grant
- 2000-05-26 EP EP00943666A patent/EP1185291B2/de not_active Expired - Lifetime
- 2000-05-26 CA CA002376193A patent/CA2376193C/en not_active Expired - Fee Related
- 2000-05-26 AT AT00943666T patent/ATE258803T1/de active
- 2000-05-26 DE DE10081516T patent/DE10081516D2/de not_active Ceased
- 2000-05-26 DE DE50005208T patent/DE50005208D1/de not_active Expired - Lifetime
- 2000-05-26 US US10/018,373 patent/US7964199B1/en not_active Expired - Lifetime
- 2000-05-26 AU AU58047/00A patent/AU774590B2/en not_active Ceased
- 2000-05-26 CZ CZ20014351A patent/CZ20014351A3/cs unknown
- 2000-05-26 IL IL14697400A patent/IL146974A0/xx active IP Right Grant
- 2000-05-26 CN CNB008086419A patent/CN100389820C/zh not_active Expired - Fee Related
- 2000-05-26 ES ES00943666T patent/ES2215056T5/es not_active Expired - Lifetime
- 2000-05-26 UA UA2002010181A patent/UA72253C2/uk unknown
- 2000-05-26 PL PL352468A patent/PL198958B1/pl not_active IP Right Cessation
- 2000-05-26 GE GEAP20006278A patent/GEP20043200B/en unknown
- 2000-05-26 EA EA200200017A patent/EA004202B1/ru not_active IP Right Cessation
- 2000-05-26 JP JP2001501237A patent/JP2003505343A/ja active Pending
- 2000-05-26 KR KR10-2001-7015668A patent/KR100466407B1/ko not_active Expired - Fee Related
- 2000-05-26 CN CNA2007101102394A patent/CN101062009A/zh active Pending
- 2000-05-26 WO PCT/DE2000/001777 patent/WO2000074703A2/de not_active Ceased
- 2000-05-26 DK DK00943666T patent/DK1185291T3/da active
- 2000-05-26 PT PT00943666T patent/PT1185291E/pt unknown
- 2000-06-07 CO CO00042309A patent/CO5170431A1/es not_active Application Discontinuation
- 2000-06-07 AR ARP000102818A patent/AR024306A1/es unknown
- 2000-08-24 TW TW089111212A patent/TWI251492B/zh not_active IP Right Cessation
-
2001
- 2001-12-06 IL IL146974A patent/IL146974A/en not_active IP Right Cessation
- 2001-12-06 NO NO20015964A patent/NO20015964L/no unknown
- 2001-12-06 ZA ZA200110074A patent/ZA200110074B/xx unknown
-
2007
- 2007-05-16 JP JP2007130686A patent/JP2007238627A/ja not_active Withdrawn
-
2011
- 2011-05-11 US US13/068,439 patent/US20110217287A1/en not_active Abandoned
- 2011-11-23 US US13/303,973 patent/US8398998B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003505343A5 (https=) | ||
| CY2020003I2 (el) | Anti-il-12 αντισωματα, συνθεσεις, μεθοδοι και χρησεις για την θεραπευτικη αγωγη της παθολογιας του crohn | |
| AT500379B8 (de) | Tau-proteine | |
| CY1110128T1 (el) | Καταλυτικα μονοκλωνικα αντισωματα με δραστικοτητα πρωτεασης για την εκλεκτικη λυση του πρωτεϊνικου συστατικου των πλακων και συνονθυλευματων που σχετιζονται με παθολογικες καταστασεις | |
| ATE376559T1 (de) | Methoden der verhinderung und behandlung der alzheimer'schen krankheit | |
| WO2002094228A8 (en) | Prevention and treatment of allergies by helminthic regulation of ige | |
| CY1107609T1 (el) | Απεικoνιση, διaγνωση και θεραπεiα ασθeνειας | |
| WO2001098317A3 (en) | Alpha-glycosylceramides for treating bacterial and fungal infections | |
| JP2001515920A5 (https=) | ||
| ATE425248T1 (de) | Arzneimittel zur behandlung von c. pneumoniae infektionen | |
| ATE319439T1 (de) | Mittel zur behandlung von erkrankungen des tracheo-bronchialtraktes, insbesondere der copd | |
| WO2003005880A3 (en) | Replikin peptides and uses thereof | |
| DE69928384D1 (de) | Behandlung und nachweis von staphylokokkeninfektionen | |
| DE69530844D1 (de) | Verfahren und substanzen gegen protozoen | |
| EP1610678A4 (en) | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF FOR INHIBITING THE ACTIVITY OF METAL PROTEINS | |
| JP2003533188A5 (https=) | ||
| WO2007021886A3 (en) | Truncated memapsin 2 for use for treating alzheimer's disease | |
| ATE369429T1 (de) | Strukturproteine des virus, welches die pankreas- krankheit bei fischen verursacht, und ihre verwendungen | |
| WO2002055560A3 (en) | Monoclonal antibodies specific for the e2 glycoprotein of hepatitis c virus and their use in the diagnosis, treatment, and prevention of hepatitis c | |
| EP2436774A3 (en) | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins | |
| ATE165826T1 (de) | 4-aminoderivate von 5-substituierten mycophenolsäuren | |
| DE60124093D1 (de) | S-methyl-dihydro-ziprasidon zur Behandlung von Augenerkrankungen. | |
| BR0317780A (pt) | Formulação na forma de supositório para a administração retal, método para o tratamento de hemorróidas, e uso de peptìdeos e proteìnas com ação trombolìtica para o tratamento de hemorróidas | |
| WO2002029023A8 (en) | Nicastrin protein | |
| RU2000104127A (ru) | Штамм bacillus subtilis x-15, используемый для профилактики и лечения эндометритов у коров |