JP2003505343A5 - - Google Patents

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Publication number
JP2003505343A5
JP2003505343A5 JP2001501237A JP2001501237A JP2003505343A5 JP 2003505343 A5 JP2003505343 A5 JP 2003505343A5 JP 2001501237 A JP2001501237 A JP 2001501237A JP 2001501237 A JP2001501237 A JP 2001501237A JP 2003505343 A5 JP2003505343 A5 JP 2003505343A5
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JP
Japan
Prior art keywords
botulinum
complex
counterpart
medicament
animal
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Pending
Application number
JP2001501237A
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English (en)
Japanese (ja)
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JP2003505343A (ja
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Priority claimed from DE19925739A external-priority patent/DE19925739A1/de
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Publication of JP2003505343A publication Critical patent/JP2003505343A/ja
Publication of JP2003505343A5 publication Critical patent/JP2003505343A5/ja
Pending legal-status Critical Current

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JP2001501237A 1999-06-07 2000-05-26 ボツリヌス神経毒を含む治療薬 Pending JP2003505343A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19925739.6 1999-06-07
DE19925739A DE19925739A1 (de) 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin
PCT/DE2000/001777 WO2000074703A2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007130686A Division JP2007238627A (ja) 1999-06-07 2007-05-16 ボツリヌス神経毒を含む治療薬

Publications (2)

Publication Number Publication Date
JP2003505343A JP2003505343A (ja) 2003-02-12
JP2003505343A5 true JP2003505343A5 (https=) 2007-06-28

Family

ID=7910318

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001501237A Pending JP2003505343A (ja) 1999-06-07 2000-05-26 ボツリヌス神経毒を含む治療薬
JP2007130686A Withdrawn JP2007238627A (ja) 1999-06-07 2007-05-16 ボツリヌス神経毒を含む治療薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2007130686A Withdrawn JP2007238627A (ja) 1999-06-07 2007-05-16 ボツリヌス神経毒を含む治療薬

Country Status (26)

Country Link
US (3) US7964199B1 (https=)
EP (1) EP1185291B2 (https=)
JP (2) JP2003505343A (https=)
KR (1) KR100466407B1 (https=)
CN (2) CN101062009A (https=)
AR (1) AR024306A1 (https=)
AT (1) ATE258803T1 (https=)
AU (1) AU774590B2 (https=)
CA (1) CA2376193C (https=)
CO (1) CO5170431A1 (https=)
CZ (1) CZ20014351A3 (https=)
DE (3) DE19925739A1 (https=)
DK (1) DK1185291T3 (https=)
EA (1) EA004202B1 (https=)
ES (1) ES2215056T5 (https=)
GE (1) GEP20043200B (https=)
HU (1) HUP0201530A3 (https=)
IL (2) IL146974A0 (https=)
MX (1) MXPA01012540A (https=)
NO (1) NO20015964L (https=)
PL (1) PL198958B1 (https=)
PT (1) PT1185291E (https=)
TW (1) TWI251492B (https=)
UA (1) UA72253C2 (https=)
WO (1) WO2000074703A2 (https=)
ZA (1) ZA200110074B (https=)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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DE19925739A1 (de) 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
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US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
JP2003009897A (ja) 2001-07-03 2003-01-14 Keiji Oguma ボツリヌス毒素の分離・精製法
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WO2003082315A1 (fr) * 2002-03-29 2003-10-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Remede contre l'hypermyotonie
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20120114697A1 (en) 2002-08-19 2012-05-10 Ira Sanders Treatment of holocrine gland dysfunction with clostridia neurotoxins
US7288259B2 (en) * 2002-08-19 2007-10-30 Ira Sanders Treatment of holocrine gland dysfunction with clostridia neurotoxins
US7824693B2 (en) 2002-08-19 2010-11-02 Ira Sanders Treatment of fine wrinkles with clostridia neurotoxins
US8071550B2 (en) 2003-03-03 2011-12-06 Allergan, Inc. Methods for treating uterine disorders
ES2381091T3 (es) * 2003-03-06 2012-05-23 Botulinum Toxin Research Associates, Inc. Tratamiento del dolor facial crónico y cefalea relacionados con la sinusitis con toxina botulínica
US6838434B2 (en) * 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
WO2004112821A1 (ja) * 2003-06-20 2004-12-29 Santen Pharmaceutical Co., Ltd. 筋緊張亢進性疾患の治療剤
US6974579B2 (en) * 2004-01-08 2005-12-13 Allergan, Inc. Methods for treating vascular disorders
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
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CN1946431B (zh) 2004-03-03 2011-12-07 雷文斯治疗公司 用于肉毒毒素的局部施用和透皮递送的组合物和方法
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BRPI0513850A (pt) * 2004-07-26 2008-05-20 Merz Pharma Gmbh & Co Kgaa composição terapêutica com uma neurotoxina botulìnica
US7179474B2 (en) 2004-09-03 2007-02-20 Allergan, Inc. Methods for treating a buttock deformity
US7429386B2 (en) 2004-09-03 2008-09-30 Allergan, Inc. Stretch mark treatment
AU2005288758A1 (en) * 2004-09-27 2006-04-06 Merz Pharma Gmbh & Co. Kgaa Clostridial neurotoxins for use in tissue healing
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US7419675B2 (en) 2005-05-26 2008-09-02 Allergan, Inc. Method for treating peritoneal adhesions
HRP20090382T1 (hr) * 2005-06-17 2009-09-30 Merz Pharma Gmbh & Co.Kgaa Uređaj i postupak za proizvodnju biološko aktivnih spojeva fermentacijom
NZ568216A (en) 2005-11-17 2012-09-28 Revance Therapeutics Inc Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
EP1834962A1 (de) * 2006-03-15 2007-09-19 Biotecon Therapeutics GmbH PEGyliertes mutiertes Clostridium botulinum Toxin
AR061669A1 (es) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
US10792344B2 (en) 2006-06-29 2020-10-06 Merz Pharma Gmbh & Co. Kgaa High frequency application of botulinum toxin therapy
EP2048156A1 (en) * 2007-10-12 2009-04-15 Merz Pharma GmbH & Co.KGaA Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
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EP2072039A1 (en) 2007-12-21 2009-06-24 Merz Pharma GmbH & Co.KGaA Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects
EP2072057A1 (en) 2007-12-21 2009-06-24 Merz Pharma GmbH & Co.KGaA Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury
EP2246426A4 (en) * 2008-01-29 2011-08-10 Inst Antibodies Co Ltd COMPOSITION FOR THE NEUTRALIZATION OF BOTULINUS TOXIN TYPE-A AND HUMAN ANTIBODIES AGAINST BOTULINUS TOXIN TYPE-A
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WO2009123174A1 (ja) * 2008-03-31 2009-10-08 財団法人化学及血清療法研究所 A2型ボツリヌス神経毒素製剤
EP2337790B1 (en) 2008-08-29 2016-07-13 Merz Pharma GmbH & Co. KGaA Clostridial neurotoxins with altered persistency
ES2426667T3 (es) 2008-09-09 2013-10-24 Susanne Grafe Toxina botulínica para introducir infertilidad temporal en un vertebrado (por ejemplo, un ser humano)
CN101386648B (zh) * 2008-09-25 2012-05-30 中国人民解放军军事医学科学院微生物流行病研究所 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途
WO2010096134A1 (en) 2008-12-04 2010-08-26 Botulinum Toxin Research Associates, Inc. Extended length botulinum toxin formulation for human or mammalian use
EP2248518B1 (en) 2009-04-17 2013-01-16 Merz Pharma GmbH & Co. KGaA Formulation for stabilizing proteins, peptides or mixtures thereof.
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
JP2011074025A (ja) * 2009-09-30 2011-04-14 Chemo-Sero-Therapeutic Research Inst ボツリヌス毒素の精製方法
PH12012500549A1 (en) 2009-10-21 2017-08-23 Revance Therapeutics Inc Methods and systems for purifying non-complexed botulinum neurotoxin
KR101134146B1 (ko) 2010-05-31 2012-04-19 메덱스젠 주식회사 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법
JP5990176B2 (ja) 2010-10-12 2016-09-07 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン タンパク質の安定化に好適な哺乳動物性賦形剤非含有製剤
EP2724725B1 (en) * 2011-06-27 2016-09-07 Sang Duck Kim Pharmaceutical composition for use in treating scars on the skin
US9393291B2 (en) 2012-04-12 2016-07-19 Botulinum Toxin Research Associates, Inc. Use of botulinum toxin for the treatment of cerebrovascular disease, renovascular and retinovascular circulatory beds
KR102272580B1 (ko) * 2013-07-30 2021-07-05 메르츠 파마 게엠베하 운트 코. 카가아 보툴리눔 독소의 고순도 신경독성 성분의 제조 방법 및 이의 용도
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US9901627B2 (en) 2014-07-18 2018-02-27 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US20180140685A1 (en) * 2015-04-24 2018-05-24 Consiglio Nazionale Delle Ricerche A new therapeutic use of the botulinum neurotoxin serotype a
KR101775682B1 (ko) * 2015-11-30 2017-09-06 주식회사 대웅 보툴리눔 독소의 제조방법
BR112019004935A2 (pt) 2016-09-13 2019-06-04 Allergan, Inc. composições de toxina clostridial não proteíca estabilizada
KR102463881B1 (ko) 2016-10-04 2022-11-07 (주)메디톡스 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법
JP7604222B2 (ja) 2017-03-22 2024-12-23 ボンチ インコーポレイテッド 治療用のボツリヌス神経毒素
BR112019016585A2 (pt) 2017-03-24 2020-03-31 Merz Pharma Gmbh & Co. Kgaa Uso melhorado da neurotoxina botulínica no tratamento da sialorreia
EP3843777A4 (en) 2018-08-28 2022-05-04 Ira Sanders THERAPEUTICS FOR THE SKIN
EP3860640A1 (en) 2018-10-02 2021-08-11 Merz Pharma GmbH & Co. KGaA Novel uses of botulinum neurotoxin for treating lipoedema
MX2021009922A (es) 2019-02-21 2021-09-14 Merz Pharma Gmbh & Co Kgaa Usos novedosos de neurotoxina botulinica para el tratamiento del temblor.
IL298399A (en) 2020-06-05 2023-01-01 Merz Pharma Gmbh & Co Kgaa Treatment of facial wrinkles with the botulinum toxin in high dose and low volume
KR102724651B1 (ko) * 2021-07-08 2024-11-01 주식회사 파마리서치바이오 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법
TW202400122A (zh) 2022-02-28 2024-01-01 德商梅茲製藥有限兩合公司 肉毒桿菌毒素用於降低皮膚毛孔尺寸及/或皮脂產生之用途、以及降低皮膚毛孔尺寸及/或皮脂產生的方法
EP4626556A1 (en) 2022-11-28 2025-10-08 Merz Pharma GmbH & Co. KGaA High concentration botulinum toxin treatment for neck rejuvenation
AU2023400491A1 (en) 2022-11-28 2025-04-10 Merz Pharma Gmbh & Co. Kgaa Botulinum toxin injection in platysma for lower face and neck rejuvenation
WO2024194181A1 (en) 2023-03-20 2024-09-26 Merz Therapeutics GmbH Nh3 scavenger for use in the treatment of mobility disability in a post-stroke patient
WO2024240868A1 (en) 2023-05-23 2024-11-28 Merz Therapeutics GmbH Botulinum toxin for treating peripheral neuropathic pain
KR20260035809A (ko) 2023-07-12 2026-03-13 메르츠 파마 게엠베하 운트 코. 카가아 보툴리눔 독소에 의한 과색소침착 상태의 치료
WO2025228877A1 (en) 2024-04-29 2025-11-06 Merz Therapeutics GmbH Botulinum toxin for the preventive treatment of migraine
WO2026021713A1 (en) 2024-07-23 2026-01-29 Merz Therapeutics GmbH Uses of magnetic nerve stimulation associated with botulinum neurotoxin administration

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DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
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