DE19925739A1 - Therapeutikum mit einem Botulinum-Neurotoxin - Google Patents

Therapeutikum mit einem Botulinum-Neurotoxin

Info

Publication number
DE19925739A1
DE19925739A1 DE19925739A DE19925739A DE19925739A1 DE 19925739 A1 DE19925739 A1 DE 19925739A1 DE 19925739 A DE19925739 A DE 19925739A DE 19925739 A DE19925739 A DE 19925739A DE 19925739 A1 DE19925739 A1 DE 19925739A1
Authority
DE
Germany
Prior art keywords
therapeutic agent
botulinum
agent according
neurotoxin
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19925739A
Other languages
German (de)
English (en)
Inventor
Hans Bigalke
Juergen Frevert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Biotecon GmbH Gesellschaft fuer Biotechnologische Entwicklung und Consultimg mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7910318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19925739(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotecon GmbH Gesellschaft fuer Biotechnologische Entwicklung und Consultimg mbH filed Critical Biotecon GmbH Gesellschaft fuer Biotechnologische Entwicklung und Consultimg mbH
Priority to DE19925739A priority Critical patent/DE19925739A1/de
Priority to AU58047/00A priority patent/AU774590B2/en
Priority to PT00943666T priority patent/PT1185291E/pt
Priority to EA200200017A priority patent/EA004202B1/ru
Priority to HK02108892.0A priority patent/HK1047403B/xx
Priority to CZ20014351A priority patent/CZ20014351A3/cs
Priority to DK00943666T priority patent/DK1185291T3/da
Priority to DE10081516T priority patent/DE10081516D2/de
Priority to DE20023785U priority patent/DE20023785U1/de
Priority to ES00943666T priority patent/ES2215056T5/es
Priority to JP2001501237A priority patent/JP2003505343A/ja
Priority to IL14697400A priority patent/IL146974A0/xx
Priority to DE50005208T priority patent/DE50005208D1/de
Priority to UA2002010181A priority patent/UA72253C2/uk
Priority to CNB008086419A priority patent/CN100389820C/zh
Priority to GEAP20006278A priority patent/GEP20043200B/en
Priority to US10/018,373 priority patent/US7964199B1/en
Priority to AT00943666T priority patent/ATE258803T1/de
Priority to PL352468A priority patent/PL198958B1/pl
Priority to KR10-2001-7015668A priority patent/KR100466407B1/ko
Priority to CNA2007101102394A priority patent/CN101062009A/zh
Priority to CA002376193A priority patent/CA2376193C/en
Priority to EP00943666A priority patent/EP1185291B2/de
Priority to SI200030341T priority patent/SI1185291T1/xx
Priority to PCT/DE2000/001777 priority patent/WO2000074703A2/de
Priority to MXPA01012540A priority patent/MXPA01012540A/es
Priority to HU0201530A priority patent/HUP0201530A3/hu
Priority to CO00042309A priority patent/CO5170431A1/es
Priority to ARP000102818A priority patent/AR024306A1/es
Priority to TW089111212A priority patent/TWI251492B/zh
Publication of DE19925739A1 publication Critical patent/DE19925739A1/de
Priority to ZA200110074A priority patent/ZA200110074B/xx
Priority to IL146974A priority patent/IL146974A/en
Priority to NO20015964A priority patent/NO20015964L/no
Priority to JP2007130686A priority patent/JP2007238627A/ja
Priority to US13/068,439 priority patent/US20110217287A1/en
Priority to US13/303,973 priority patent/US8398998B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19925739A 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin Withdrawn DE19925739A1 (de)

Priority Applications (36)

Application Number Priority Date Filing Date Title
DE19925739A DE19925739A1 (de) 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin
HU0201530A HUP0201530A3 (en) 1999-06-07 2000-05-26 Use of therapeutic agent comprising a botulinum neurotoxin
PL352468A PL198958B1 (pl) 1999-06-07 2000-05-26 Zastosowanie neurotoksyny botulinowej z Clostridium botulinum
KR10-2001-7015668A KR100466407B1 (ko) 1999-06-07 2000-05-26 보툴리누스 신경독소를 함유하는 약학적 조성물
EA200200017A EA004202B1 (ru) 1999-06-07 2000-05-26 Терапевтическое средство с ботулиническим нейротоксином
HK02108892.0A HK1047403B (en) 1999-06-07 2000-05-26 Therapeutic agent comprising a botulinum neurotoxin
CZ20014351A CZ20014351A3 (cs) 1999-06-07 2000-05-26 Léčivo s botulinovým neurotoxinem
CA002376193A CA2376193C (en) 1999-06-07 2000-05-26 Therapeutic agent comprising a botulinum neurotoxin
DE10081516T DE10081516D2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem Botulinum-Neurotoxin
DE20023785U DE20023785U1 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem Botulinum-Neurotoxin
ES00943666T ES2215056T5 (es) 1999-06-07 2000-05-26 Agente terapéutico que comprende una neurotoxina botulínica .
JP2001501237A JP2003505343A (ja) 1999-06-07 2000-05-26 ボツリヌス神経毒を含む治療薬
IL14697400A IL146974A0 (en) 1999-06-07 2000-05-26 Therapeutic composition comprising a botulinum neurotoxin
DE50005208T DE50005208D1 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin
UA2002010181A UA72253C2 (uk) 1999-06-07 2000-05-26 Застосування ботулінічного нейротоксину, вільного від комплексоутворюючих білків, для одержання фармацевтичного засобу
CNB008086419A CN100389820C (zh) 1999-06-07 2000-05-26 含肉毒神经毒素的治疗剂
GEAP20006278A GEP20043200B (en) 1999-06-07 2000-05-26 Therapeutic Agent Comprising a Botulinum Neurotoxin
US10/018,373 US7964199B1 (en) 1999-06-07 2000-05-26 Therapeutic composition comprising a botulinum neurotoxin
AT00943666T ATE258803T1 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin
AU58047/00A AU774590B2 (en) 1999-06-07 2000-05-26 Therapeutic agent comprising a botulinum neurotoxin
CNA2007101102394A CN101062009A (zh) 1999-06-07 2000-05-26 含肉毒神经毒素的治疗剂
PT00943666T PT1185291E (pt) 1999-06-07 2000-05-26 Agente terapeutico contendo uma neurotoxina botulinica
DK00943666T DK1185291T3 (da) 1999-06-07 2000-05-26 Terapeutisk middel til et botulinum-neurotoksin
EP00943666A EP1185291B2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin
SI200030341T SI1185291T1 (en) 1999-06-07 2000-05-26 Therapeutic agent comprising a botulinum neurotoxin
PCT/DE2000/001777 WO2000074703A2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin
MXPA01012540A MXPA01012540A (es) 1999-06-07 2000-05-26 Agente terapeutico que contiene una neurotoxina de botulismo.
ARP000102818A AR024306A1 (es) 1999-06-07 2000-06-07 Preparacion farmaceutica que contiene una neurotoxina botulinica.
CO00042309A CO5170431A1 (es) 1999-06-07 2000-06-07 Preparacion farmaceutica que contiene una de las neurotoxinas botulinicas de clostridium botulinum de los tipos a,b,c,d,e,f, o g, o una mezcla de dos o mas de estas neuroxinas
TW089111212A TWI251492B (en) 1999-06-07 2000-08-24 Pharmaceutical composition containing botulinum neurotoxin and novel use thereof
ZA200110074A ZA200110074B (en) 1999-06-07 2001-12-06 Therapeutic agent comprising a botulinum neurotoxin.
IL146974A IL146974A (en) 1999-06-07 2001-12-06 Use of a botulinum neurotoxin for the manufacture of a medicament
NO20015964A NO20015964L (no) 1999-06-07 2001-12-06 Terapeutisk middel omfattende et botulinum-neurotoksin
JP2007130686A JP2007238627A (ja) 1999-06-07 2007-05-16 ボツリヌス神経毒を含む治療薬
US13/068,439 US20110217287A1 (en) 1999-06-07 2011-05-11 Therapeutic composition comprising a botulinum neurotoxin
US13/303,973 US8398998B2 (en) 1999-06-07 2011-11-23 Therapeutic composition comprising a botulinum neurotoxin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19925739A DE19925739A1 (de) 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin

Publications (1)

Publication Number Publication Date
DE19925739A1 true DE19925739A1 (de) 2000-12-21

Family

ID=7910318

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19925739A Withdrawn DE19925739A1 (de) 1999-06-07 1999-06-07 Therapeutikum mit einem Botulinum-Neurotoxin
DE10081516T Ceased DE10081516D2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem Botulinum-Neurotoxin
DE50005208T Expired - Lifetime DE50005208D1 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE10081516T Ceased DE10081516D2 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem Botulinum-Neurotoxin
DE50005208T Expired - Lifetime DE50005208D1 (de) 1999-06-07 2000-05-26 Therapeutikum mit einem botulinum-neurotoxin

Country Status (26)

Country Link
US (3) US7964199B1 (https=)
EP (1) EP1185291B2 (https=)
JP (2) JP2003505343A (https=)
KR (1) KR100466407B1 (https=)
CN (2) CN101062009A (https=)
AR (1) AR024306A1 (https=)
AT (1) ATE258803T1 (https=)
AU (1) AU774590B2 (https=)
CA (1) CA2376193C (https=)
CO (1) CO5170431A1 (https=)
CZ (1) CZ20014351A3 (https=)
DE (3) DE19925739A1 (https=)
DK (1) DK1185291T3 (https=)
EA (1) EA004202B1 (https=)
ES (1) ES2215056T5 (https=)
GE (1) GEP20043200B (https=)
HU (1) HUP0201530A3 (https=)
IL (2) IL146974A0 (https=)
MX (1) MXPA01012540A (https=)
NO (1) NO20015964L (https=)
PL (1) PL198958B1 (https=)
PT (1) PT1185291E (https=)
TW (1) TWI251492B (https=)
UA (1) UA72253C2 (https=)
WO (1) WO2000074703A2 (https=)
ZA (1) ZA200110074B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101386648B (zh) * 2008-09-25 2012-05-30 中国人民解放军军事医学科学院微生物流行病研究所 抗b型肉毒神经毒素中和性单克隆抗体、其制备方法及用途
EP2283849A4 (en) * 2008-03-31 2013-04-10 Chemo Sero Therapeut Res Inst PREPARATION OF BOTULINUM NEUROTOXIN TYPE A2

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925739A1 (de) 1999-06-07 2000-12-21 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh Therapeutikum mit einem Botulinum-Neurotoxin
US20080038274A1 (en) 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
US7838008B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating diverse cancers
US7838007B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating mammary gland disorders
US6821520B2 (en) 2000-02-15 2004-11-23 Allergan, Inc. Clostridial toxin therapy for Hashimoto's thyroiditis
JP2003009897A (ja) 2001-07-03 2003-01-14 Keiji Oguma ボツリヌス毒素の分離・精製法
US7140371B2 (en) 2002-03-14 2006-11-28 Allergan, Inc. Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins
US6688311B2 (en) 2002-03-14 2004-02-10 Allergan, Inc. Method for determining effect of a clostridial toxin upon a muscle
WO2003082315A1 (fr) * 2002-03-29 2003-10-09 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Remede contre l'hypermyotonie
US7691394B2 (en) * 2002-05-28 2010-04-06 Botulinum Toxin Research Associates, Inc. High-potency botulinum toxin formulations
US20120114697A1 (en) 2002-08-19 2012-05-10 Ira Sanders Treatment of holocrine gland dysfunction with clostridia neurotoxins
US7288259B2 (en) * 2002-08-19 2007-10-30 Ira Sanders Treatment of holocrine gland dysfunction with clostridia neurotoxins
US7824693B2 (en) 2002-08-19 2010-11-02 Ira Sanders Treatment of fine wrinkles with clostridia neurotoxins
US8071550B2 (en) 2003-03-03 2011-12-06 Allergan, Inc. Methods for treating uterine disorders
ES2381091T3 (es) * 2003-03-06 2012-05-23 Botulinum Toxin Research Associates, Inc. Tratamiento del dolor facial crónico y cefalea relacionados con la sinusitis con toxina botulínica
US6838434B2 (en) * 2003-05-02 2005-01-04 Allergan, Inc. Methods for treating sinus headache
WO2004112821A1 (ja) * 2003-06-20 2004-12-29 Santen Pharmaceutical Co., Ltd. 筋緊張亢進性疾患の治療剤
US6974579B2 (en) * 2004-01-08 2005-12-13 Allergan, Inc. Methods for treating vascular disorders
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
CA2558676C (en) 2004-03-03 2019-04-16 Essentia Biosystems, Inc. Compositions and methods for topical diagnostic and therapeutic transport
CN1946431B (zh) 2004-03-03 2011-12-07 雷文斯治疗公司 用于肉毒毒素的局部施用和透皮递送的组合物和方法
GB2416122A (en) * 2004-07-12 2006-01-18 Ipsen Ltd Botulinum neurotoxin composition
BRPI0513850A (pt) * 2004-07-26 2008-05-20 Merz Pharma Gmbh & Co Kgaa composição terapêutica com uma neurotoxina botulìnica
US7179474B2 (en) 2004-09-03 2007-02-20 Allergan, Inc. Methods for treating a buttock deformity
US7429386B2 (en) 2004-09-03 2008-09-30 Allergan, Inc. Stretch mark treatment
AU2005288758A1 (en) * 2004-09-27 2006-04-06 Merz Pharma Gmbh & Co. Kgaa Clostridial neurotoxins for use in tissue healing
SG160357A1 (en) 2005-03-03 2010-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
WO2006096163A1 (en) * 2005-03-03 2006-09-14 Allergan, Inc. Animal product free system and process for purifying a botulinum toxin
US7419675B2 (en) 2005-05-26 2008-09-02 Allergan, Inc. Method for treating peritoneal adhesions
HRP20090382T1 (hr) * 2005-06-17 2009-09-30 Merz Pharma Gmbh & Co.Kgaa Uređaj i postupak za proizvodnju biološko aktivnih spojeva fermentacijom
NZ568216A (en) 2005-11-17 2012-09-28 Revance Therapeutics Inc Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
EP1834962A1 (de) * 2006-03-15 2007-09-19 Biotecon Therapeutics GmbH PEGyliertes mutiertes Clostridium botulinum Toxin
AR061669A1 (es) * 2006-06-29 2008-09-10 Merz Pharma Gmbh & Co Kgaa Aplicacion de alta frecuencia de terapia con toxina botulinica
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