JP2002541218A5 - - Google Patents
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- Publication number
- JP2002541218A5 JP2002541218A5 JP2000610523A JP2000610523A JP2002541218A5 JP 2002541218 A5 JP2002541218 A5 JP 2002541218A5 JP 2000610523 A JP2000610523 A JP 2000610523A JP 2000610523 A JP2000610523 A JP 2000610523A JP 2002541218 A5 JP2002541218 A5 JP 2002541218A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- polysaccharide
- reduced
- iron oxide
- oxide complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 32
- 239000005017 polysaccharide Substances 0.000 description 30
- 150000004676 glycans Chemical class 0.000 description 22
- 238000000034 method Methods 0.000 description 22
- 229920001282 polysaccharide Polymers 0.000 description 22
- 229920002307 Dextran Polymers 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- -1 carboxymethylIron oxide Chemical compound 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical compound [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000003173 antianemic agent Substances 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12857999P | 1999-04-09 | 1999-04-09 | |
| US60/128,579 | 1999-04-09 | ||
| PCT/US2000/006047 WO2000061191A2 (en) | 1999-04-09 | 2000-03-08 | Heat stable coated colloidal iron oxides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010275172A Division JP2011046752A (ja) | 1999-04-09 | 2010-12-09 | 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002541218A JP2002541218A (ja) | 2002-12-03 |
| JP2002541218A5 true JP2002541218A5 (enExample) | 2007-04-12 |
| JP5064612B2 JP5064612B2 (ja) | 2012-10-31 |
Family
ID=22436002
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000610523A Expired - Fee Related JP5064612B2 (ja) | 1999-04-09 | 2000-03-08 | 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄 |
| JP2010275172A Withdrawn JP2011046752A (ja) | 1999-04-09 | 2010-12-09 | 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010275172A Withdrawn JP2011046752A (ja) | 1999-04-09 | 2010-12-09 | 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6599498B1 (enExample) |
| EP (1) | EP1169062B1 (enExample) |
| JP (2) | JP5064612B2 (enExample) |
| AT (1) | ATE446108T1 (enExample) |
| CY (1) | CY1109527T1 (enExample) |
| DE (1) | DE60043188D1 (enExample) |
| DK (1) | DK1169062T3 (enExample) |
| ES (1) | ES2334555T3 (enExample) |
| LU (1) | LU92114I2 (enExample) |
| PT (1) | PT1169062E (enExample) |
| WO (1) | WO2000061191A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| US7169618B2 (en) * | 2000-06-28 | 2007-01-30 | Skold Technology | Magnetic particles and methods of producing coated magnetic particles |
| DE10046514A1 (de) * | 2000-09-15 | 2002-04-25 | Diagnostikforschung Inst | Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel |
| US6690962B2 (en) | 2000-09-15 | 2004-02-10 | Institut fur Diagnostikforshung GmbH | Process for graphic visualization and diagnosis of thrombi by means of nuclear spin tomography with use of particulate contrast media |
| RU2003121403A (ru) * | 2000-12-07 | 2004-12-27 | АД "ЗДРАВЛЬЕ" Фармасеутско-кемийска индустри , Сентар за истразиванье и развой (YU) | Полиядерный комплекс fe(iii) с олигомерами пуллулана, способ его получения и фармацевтические препараты на его основе |
| WO2003002159A1 (en) * | 2001-06-29 | 2003-01-09 | Biovitrum Ab | Process for bulk autoclaving |
| AU2003207438A1 (en) | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US20060018835A1 (en) * | 2004-04-02 | 2006-01-26 | General Electric Company | Nanoparticles with inorganic core and methods of using them |
| US20060014938A1 (en) * | 2004-07-14 | 2006-01-19 | Groman Ernest V | Stable aqueous colloidal lanthanide oxides |
| US20060140867A1 (en) * | 2004-12-28 | 2006-06-29 | Helfer Jeffrey L | Coated stent assembly and coating materials |
| CA2606924C (en) | 2005-05-09 | 2013-04-16 | The General Hospital Corporation | Water relaxation-based sensors |
| JP5295769B2 (ja) | 2005-08-31 | 2013-09-18 | ティツー・バイオシステムズ・インコーポレーテッド | 分析物を検出するためのｎｍｒ装置 |
| US20070077313A1 (en) * | 2005-10-04 | 2007-04-05 | U.S. Pharmaceutical Corporation | Toleration iron supplement compositions |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| PT1973549T (pt) | 2006-01-06 | 2016-10-25 | Luitpold Pharm Inc | Métodos e composições para administração de ferro |
| AU2013206429B2 (en) * | 2006-01-06 | 2016-04-28 | Vifor (International) Ag | Methods and compositions for administration of iron |
| AU2016205002C1 (en) * | 2006-01-06 | 2020-09-24 | Vifor (International) Ag | Methods and compositions for administration of iron |
| NO329127B1 (no) * | 2006-09-12 | 2010-08-30 | Epitarget As | Sporbart partikulaert materiale for legemiddelavlevering omfattende et matriseeller membranmateriale, et legemiddel, og et T1- og et T2*- magnetisk resonanskontrastmiddel |
| WO2008057578A1 (en) * | 2006-11-08 | 2008-05-15 | T2 Biosystems, Inc. | Nmr systems for in vivo detection of analytes |
| US9375495B2 (en) * | 2007-04-12 | 2016-06-28 | Industry-Academic Cooperation Foundation, Yonsei University | Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles |
| US20120003160A1 (en) * | 2007-06-29 | 2012-01-05 | Amag Pharmaceuticals, Inc. | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session |
| JP2010540929A (ja) | 2007-09-28 | 2010-12-24 | ティツー・バイオシステムズ・インコーポレーテッド | プラスチック製サンプル容器を用いるｎｍｒ装置による診断 |
| JP2011503541A (ja) * | 2007-11-06 | 2011-01-27 | ティツー・バイオシステムズ・インコーポレーテッド | 磁気共鳴緩和測定用の小型の磁石およびｒｆコイル |
| JP2011503232A (ja) | 2007-11-20 | 2011-01-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 免疫応答の調節 |
| CA2721256A1 (en) * | 2008-04-16 | 2009-10-22 | Stemcell Technologies Inc. | Magnetic particles |
| CA2741550C (en) | 2008-10-29 | 2018-12-04 | T2 Biosystems, Inc. | Nmr detection of coagulation time |
| WO2010091183A2 (en) * | 2009-02-04 | 2010-08-12 | The Regents Of The University Of Colorado, A Body Corporate | Non-invasive detection of complement-mediated inflammation using cr2-targeted nanoparticles |
| US9358302B2 (en) | 2009-03-23 | 2016-06-07 | The Brigham And Women's Hospital, Inc. | Glycoconjugate vaccines |
| JP5426010B2 (ja) | 2009-03-25 | 2014-02-26 | ファーマコスモス ホールディング エー／エス | 安定な鉄オリゴ糖化合物 |
| WO2011005496A2 (en) | 2009-06-22 | 2011-01-13 | Massachusetts Eye & Ear Infirmary | Islet1 (isl1) and hearing loss |
| US8945628B2 (en) | 2010-05-26 | 2015-02-03 | The General Hospital Corporation | Magnetic nanoparticles |
| WO2011153331A2 (en) | 2010-06-02 | 2011-12-08 | The General Hospital Corporation | Optical sensor conjugates for detecting reactive oxygen and/or reactive nitrogen species in vivo |
| CN102451185A (zh) | 2010-10-19 | 2012-05-16 | 长春纳米生技公司 | 金属离子纳米簇组合物 |
| US9714940B2 (en) | 2010-10-22 | 2017-07-25 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| CN102086232B (zh) * | 2010-12-15 | 2012-05-23 | 吕辉 | 一种多糖铁的制备方法 |
| AU2012281017B2 (en) | 2011-07-13 | 2017-07-20 | T2 Biosystems, Inc. | NMR methods for monitoring blood clot formation |
| DK2741765T3 (en) | 2011-08-10 | 2016-06-13 | Adocia | Injectable solution of at least one type of basal insulin |
| US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
| US9958416B2 (en) | 2011-11-23 | 2018-05-01 | The General Hospital Corporation | Analyte detection using magnetic hall effect |
| BR112014016889A8 (pt) | 2012-01-09 | 2017-07-04 | Adocia | composição sob a forma de uma solução aquosa injetável, sujo ph está compreendido entre 6,0 e 8,0 e, formulação de dose unitária com ph compreendido entre 7 e 7,8 |
| EP2647389A1 (en) | 2012-04-04 | 2013-10-09 | Charité - Universitätsmedizin Berlin | Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| WO2013187954A1 (en) | 2012-06-12 | 2013-12-19 | The General Hospital Corporation | Magnetic labeling of bacteria |
| CN104540594B (zh) | 2012-06-25 | 2019-07-02 | 通用医疗公司 | 使用高梯度磁场对粒子进行分类 |
| US9675640B2 (en) * | 2012-08-07 | 2017-06-13 | Southwest Research Institute | Magnetic calcium phosphate nanoparticles, applications and methods of preparation thereof |
| US20150314003A2 (en) | 2012-08-09 | 2015-11-05 | Adocia | Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer |
| AU2013355183A1 (en) | 2012-12-07 | 2015-06-11 | T2 Biosystems, Inc. | Methods for monitoring tight clot formation |
| BR112015022123B1 (pt) | 2013-03-15 | 2022-08-09 | Intrinsic Lifesciences, Llc | Anticorpos, fragmentos de ligação ao antígeno dos mesmos que se ligam especificamente à hepcidina ou um peptídeo de hepcidina, uso, meio contentor e kit |
| US9370202B2 (en) * | 2013-03-15 | 2016-06-21 | LG Bionano, LLC | Encapsulated metal ion nanoclusters |
| WO2015058206A1 (en) | 2013-10-18 | 2015-04-23 | The General Hosptial Corporation | Microfluidic sorting using high gradient magnetic fields |
| US9566216B2 (en) | 2013-11-18 | 2017-02-14 | Southwest Research Institute | Bone cements containing magnetic calcium phosphate nanoparticles |
| KR20150078375A (ko) | 2013-12-30 | 2015-07-08 | 한화케미칼 주식회사 | 철산화물 나노입자를 포함하는 철결핍증의 예방 또는 치료용 약학 조성물 |
| US10898581B2 (en) | 2014-01-16 | 2021-01-26 | The Brigham And Women's Hospital, Inc. | Targeted delivery of immunoregulatory drugs |
| TWI689310B (zh) | 2014-07-11 | 2020-04-01 | 巨生生醫股份有限公司 | 治療鐵缺乏症之方法 |
| AU2015321462B2 (en) | 2014-09-22 | 2020-04-30 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| CN107110763B (zh) | 2014-11-03 | 2020-12-15 | 通用医疗公司 | 分选微流体装置中的颗粒 |
| CN105597105B (zh) * | 2014-11-19 | 2020-03-10 | 连云港润众制药有限公司 | 一种菲立莫妥的制备方法 |
| EP3274053A4 (en) | 2015-03-23 | 2018-12-05 | The Brigham and Women's Hospital, Inc. | Tolerogenic nanoparticles for treating diabetes mellitus |
| US10258647B2 (en) | 2015-09-01 | 2019-04-16 | Particle Dynamics International, Llc | Iron-polysaccharide complexes and methods for the preparation thereof |
| CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| CN105708792A (zh) * | 2016-01-28 | 2016-06-29 | 山西普德药业股份有限公司 | 一种还原型羧烷基葡聚糖铁注射液及其制备方法 |
| CN105708805A (zh) * | 2016-01-28 | 2016-06-29 | 山西普德药业股份有限公司 | 一种还原型羧烷基葡聚糖铁及其制备方法 |
| CN105616372A (zh) * | 2016-01-28 | 2016-06-01 | 山西普德药业股份有限公司 | 一种还原型羧烷基葡聚糖铁片剂 |
| TR201703251A2 (tr) | 2017-03-03 | 2017-07-21 | Berna Buelbuel | Kansizliğin transdermal yoldan tedavi̇si̇nde kullanilacak demi̇r oksi̇t nanokri̇stalleri̇ i̇çeren solüsyon |
| CN108403716B (zh) * | 2018-06-25 | 2021-11-05 | 博瑞生物医药（苏州）股份有限公司 | 一种超顺磁氧化铁的制备方法 |
| WO2020167912A1 (en) | 2019-02-13 | 2020-08-20 | The Brigham And Women's Hospital, Inc. | Anti-peripheral lymph node addressin antibodies and uses thereof |
| WO2025043086A1 (en) | 2023-08-22 | 2025-02-27 | Navinta, Llc | An improved process for the preparation of solid ferumoxytol |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2885393A (en) | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| US2862920A (en) | 1956-06-07 | 1958-12-02 | Ohio Commw Eng Co | Ferrous carboxymethyl dextran |
| US3000872A (en) | 1956-06-15 | 1961-09-19 | Ohio Commw Eng Co | Preparation of carboxymethyl dextran-iron complexes |
| US2856398A (en) | 1956-06-15 | 1958-10-14 | Ohio Commw Eng Co | Carboxymethyl dextran-iron complexes |
| US2856366A (en) | 1956-07-30 | 1958-10-14 | Ohio Commw Eng Co | Stable alkaline metal solutions containing carboxymethyl dextran |
| US3151107A (en) | 1960-12-22 | 1964-09-29 | Central Pharmacal Company | Water-soluble iron complexes of carboxymethyl dextran |
| GB1019513A (en) * | 1961-08-07 | 1966-02-09 | Chemicals Inc | Iron dextran complexes |
| US3234209A (en) * | 1963-09-13 | 1966-02-08 | Chemicals Inc | Process for making iron hydrogenated dextran |
| JPS5913521B2 (ja) | 1975-06-19 | 1984-03-30 | メイトウサンギヨウ カブシキガイシヤ | 磁性酸化鉄・デキストラン複合体の製造法 |
| US4180567A (en) | 1977-09-02 | 1979-12-25 | Pharmachem Corporation | Iron preparations and methods of making and administering the same |
| US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US5076950A (en) | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| JP2806924B2 (ja) | 1985-12-20 | 1998-09-30 | ベーリングヴェルケ・アクチェンゲゼルシャフト | 粒子分離方法 |
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| US5262176A (en) | 1986-07-03 | 1993-11-16 | Advanced Magnetics, Inc. | Synthesis of polysaccharide covered superparamagnetic oxide colloids |
| US5102652A (en) | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| US4827945A (en) | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| US5055288A (en) | 1987-06-26 | 1991-10-08 | Advanced Magnetics, Inc. | Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides |
| US5160726A (en) | 1990-02-15 | 1992-11-03 | Advanced Magnetics Inc. | Filter sterilization for production of colloidal, superparamagnetic MR contrast agents |
| GB8808305D0 (en) * | 1988-04-08 | 1988-05-11 | Nycomed As | Compositions |
| JP2726520B2 (ja) | 1989-10-20 | 1998-03-11 | 名糖産業株式会社 | 有機磁性複合体 |
| EP0506880A1 (en) | 1989-12-22 | 1992-10-07 | Molecular Bioquest, Inc. | Organo-metallic coated particles for use in separations |
| GB9416767D0 (en) * | 1994-08-18 | 1994-10-12 | Nycomed Innovation Ab | Compositions |
| EP0783325B2 (en) | 1994-09-27 | 2004-03-31 | Amersham Health AS | Contrast agent |
| DE69725746T2 (de) * | 1996-08-30 | 2004-05-13 | Meito Sangyo K.K., Nagoya | Zusammensetzung enthaltend ein polysaccharidderivat und magnetisches eisenoxid |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| DK173138B1 (da) | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
-
2000
- 2000-03-08 DE DE60043188T patent/DE60043188D1/de not_active Expired - Lifetime
- 2000-03-08 AT AT00914867T patent/ATE446108T1/de active
- 2000-03-08 JP JP2000610523A patent/JP5064612B2/ja not_active Expired - Fee Related
- 2000-03-08 US US09/521,264 patent/US6599498B1/en not_active Expired - Lifetime
- 2000-03-08 ES ES00914867T patent/ES2334555T3/es not_active Expired - Lifetime
- 2000-03-08 DK DK00914867.7T patent/DK1169062T3/da active
- 2000-03-08 EP EP00914867A patent/EP1169062B1/en not_active Revoked
- 2000-03-08 PT PT00914867T patent/PT1169062E/pt unknown
- 2000-03-08 WO PCT/US2000/006047 patent/WO2000061191A2/en not_active Ceased
-
2003
- 2003-03-11 US US10/386,394 patent/US7553479B2/en not_active Expired - Fee Related
-
2009
- 2009-12-01 CY CY20091101262T patent/CY1109527T1/el unknown
-
2010
- 2010-12-09 JP JP2010275172A patent/JP2011046752A/ja not_active Withdrawn
-
2012
- 2012-12-14 LU LU92114C patent/LU92114I2/fr unknown
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