JP2002539135A5 - - Google Patents
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- Publication number
- JP2002539135A5 JP2002539135A5 JP2000604054A JP2000604054A JP2002539135A5 JP 2002539135 A5 JP2002539135 A5 JP 2002539135A5 JP 2000604054 A JP2000604054 A JP 2000604054A JP 2000604054 A JP2000604054 A JP 2000604054A JP 2002539135 A5 JP2002539135 A5 JP 2002539135A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- hydrogen
- cyano
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 51
- 125000000217 alkyl group Chemical group 0.000 description 46
- 229910052736 halogen Inorganic materials 0.000 description 45
- 150000002367 halogens Chemical class 0.000 description 45
- 239000001257 hydrogen Substances 0.000 description 41
- 125000004093 cyano group Chemical group *C#N 0.000 description 39
- 125000003545 alkoxy group Chemical group 0.000 description 33
- 150000002431 hydrogen Chemical group 0.000 description 33
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 27
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 21
- 125000004043 oxo group Chemical group O=* 0.000 description 21
- 229910052799 carbon Inorganic materials 0.000 description 20
- 125000004432 carbon atom Chemical group C* 0.000 description 16
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 15
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 13
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 13
- 125000000304 alkynyl group Chemical group 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000002252 acyl group Chemical group 0.000 description 7
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 7
- 125000000392 cycloalkenyl group Chemical group 0.000 description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 3
- 0 **[C@](C(*)C1O*)(C(*)(*)*)[C@@](*)(C(*)C2*)[C@@]1(*)C(C(*)C1*)C2[C@@](*)(CC2)C1C(*)[C@@]2(*)I Chemical compound **[C@](C(*)C1O*)(C(*)(*)*)[C@@](*)(C(*)C2*)[C@@]1(*)C(C(*)C1*)C2[C@@](*)(CC2)C1C(*)[C@@]2(*)I 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000002070 alkenylidene group Chemical group 0.000 description 3
- 125000001118 alkylidene group Chemical group 0.000 description 3
- 150000001924 cycloalkanes Chemical class 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- -1 steroid compound Chemical class 0.000 description 3
- 239000002583 male contraceptive agent Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 150000003431 steroids Chemical group 0.000 description 2
- 206010002261 Androgen deficiency Diseases 0.000 description 1
- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99200665.0 | 1999-03-08 | ||
| EP99200665 | 1999-03-08 | ||
| PCT/EP2000/001755 WO2000053619A1 (en) | 1999-03-08 | 2000-03-02 | 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539135A JP2002539135A (ja) | 2002-11-19 |
| JP2002539135A5 true JP2002539135A5 (enExample) | 2007-05-10 |
| JP4749550B2 JP4749550B2 (ja) | 2011-08-17 |
Family
ID=8239953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604054A Expired - Lifetime JP4749550B2 (ja) | 1999-03-08 | 2000-03-02 | アンドロゲンとしての１４β，１７α−ヒドロキシメチルアンドロスタン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6881728B1 (enExample) |
| EP (1) | EP1163259B1 (enExample) |
| JP (1) | JP4749550B2 (enExample) |
| AR (1) | AR022852A1 (enExample) |
| AT (1) | ATE228143T1 (enExample) |
| AU (1) | AU3162200A (enExample) |
| CA (1) | CA2359218A1 (enExample) |
| CO (1) | CO5150195A1 (enExample) |
| DE (1) | DE60000826T2 (enExample) |
| PE (1) | PE20001489A1 (enExample) |
| WO (1) | WO2000053619A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL202999B1 (pl) * | 1999-12-02 | 2009-08-31 | Organon Nv | Androgeny zawierające pierścień cyklopropanowy w pozycjach 14, 15 i zastosowanie takich androgenów |
| DE60134266D1 (de) | 2000-12-11 | 2008-07-10 | Organon Nv | Methylensteroide als neue androgene |
| DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
| TWI221154B (en) * | 2001-09-12 | 2004-09-21 | Akzo Nobel Nv | 17alpha-hydroxy-14beta-steroids with hormonal effect |
| PE20050677A1 (es) | 2003-12-22 | 2005-10-04 | Akzo Nobel Nv | Esteroides con perfil androgenico y progestagenico mixto |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002746A (en) * | 1959-09-25 | 1977-01-11 | Herchel Smith | Synthesis of gon-4-enes |
| US3086027A (en) | 1960-01-22 | 1963-04-16 | Lilly Co Eli | 19-nor-4, 9(10)-steroids and process |
| IE60780B1 (en) * | 1987-01-23 | 1994-08-10 | Akzo Nv | New 11-aryl steroid derivatives |
| US5264427A (en) * | 1992-01-29 | 1993-11-23 | Research Corporation Technologies, Inc. | 20-substituted pregnene derivatives and their use as androgen synthesis inhibitors |
| US6180682B1 (en) * | 1999-01-26 | 2001-01-30 | Virgil A. Place | Buccal drug delivery system for use in male contraception |
-
2000
- 2000-03-02 WO PCT/EP2000/001755 patent/WO2000053619A1/en not_active Ceased
- 2000-03-02 DE DE60000826T patent/DE60000826T2/de not_active Expired - Lifetime
- 2000-03-02 JP JP2000604054A patent/JP4749550B2/ja not_active Expired - Lifetime
- 2000-03-02 AT AT00909281T patent/ATE228143T1/de not_active IP Right Cessation
- 2000-03-02 EP EP00909281A patent/EP1163259B1/en not_active Expired - Lifetime
- 2000-03-02 CA CA002359218A patent/CA2359218A1/en not_active Abandoned
- 2000-03-02 AU AU31622/00A patent/AU3162200A/en not_active Abandoned
- 2000-03-02 US US09/890,845 patent/US6881728B1/en not_active Expired - Lifetime
- 2000-03-07 AR ARP000101000A patent/AR022852A1/es unknown
- 2000-03-07 PE PE2000000200A patent/PE20001489A1/es not_active Application Discontinuation
- 2000-03-08 CO CO00016933A patent/CO5150195A1/es unknown
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