JP2001524525A5 - - Google Patents
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- Publication number
- JP2001524525A5 JP2001524525A5 JP2000522921A JP2000522921A JP2001524525A5 JP 2001524525 A5 JP2001524525 A5 JP 2001524525A5 JP 2000522921 A JP2000522921 A JP 2000522921A JP 2000522921 A JP2000522921 A JP 2000522921A JP 2001524525 A5 JP2001524525 A5 JP 2001524525A5
- Authority
- JP
- Japan
- Prior art keywords
- sulfamate
- compound
- compound according
- group
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 sulfamate compound Chemical class 0.000 description 20
- 125000003544 oxime group Chemical group 0.000 description 7
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 102100038021 Steryl-sulfatase Human genes 0.000 description 4
- 108010087999 Steryl-Sulfatase Proteins 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 150000003431 steroids Chemical group 0.000 description 2
- 0 COS(N(*)*)(=O)=O Chemical compound COS(N(*)*)(=O)=O 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010067572 Oestrogenic effect Diseases 0.000 description 1
- 102000005262 Sulfatase Human genes 0.000 description 1
- 150000001923 cyclic compounds Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 108010005041 estrone sulfatase Proteins 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- BBNRSHIAFWOPAK-UHFFFAOYSA-L steroid d Chemical group [Na+].[Na+].O1C2CC3C4CCC5CC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)CC5(C)C4CCC3(C)C2C2(C)OC1(CCC)OC2CC1(C(C)C)CC1C BBNRSHIAFWOPAK-UHFFFAOYSA-L 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9725749A GB2331987B (en) | 1997-12-04 | 1997-12-04 | Polycyclic sulphamate inhibitors of oestrone sulphatase |
| GB9725749.7 | 1997-12-04 | ||
| PCT/GB1998/003620 WO1999027936A1 (en) | 1997-12-04 | 1998-12-03 | Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001524525A JP2001524525A (ja) | 2001-12-04 |
| JP2001524525A5 true JP2001524525A5 (enExample) | 2006-01-05 |
Family
ID=10823155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000522921A Pending JP2001524525A (ja) | 1997-12-04 | 1998-12-03 | エストロンスルファターゼのインヒビターとしてのステロイド３−ｏ−スルファメート誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6670353B2 (enExample) |
| EP (1) | EP1051178B1 (enExample) |
| JP (1) | JP2001524525A (enExample) |
| AT (1) | ATE451107T1 (enExample) |
| AU (1) | AU1345899A (enExample) |
| DE (1) | DE69841374D1 (enExample) |
| ES (1) | ES2337427T3 (enExample) |
| GB (1) | GB2331987B (enExample) |
| WO (1) | WO1999027936A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
| GB2331987B (en) | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
| AU783910B2 (en) | 1999-04-30 | 2005-12-22 | Sterix Limited | Use of estrone derivatives as antitumour agents |
| US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
| GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
| JP4931312B2 (ja) * | 1999-12-13 | 2012-05-16 | ステリックス リミテッド | ステロイドスルファターゼのインヒビターとしてのハロゲン化スルファメート−、ホスホネート−、チオホスホネート−、スルホネート−、およびスルホンアミド−化合物 |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| JPWO2001081364A1 (ja) | 2000-04-24 | 2004-01-08 | 協和醗酵工業株式会社 | エストラ−１，３，５（１０）−トリエン誘導体 |
| GB0025788D0 (en) * | 2000-10-20 | 2000-12-06 | Sterix Ltd | Use |
| AU2004224053B2 (en) * | 2003-03-24 | 2011-06-09 | Sterix Limited | Oestrogen derivatives as inhibitors of steroid sulphatase |
| GB0306718D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| GB0306717D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
| GB0511190D0 (en) * | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
| GB0624105D0 (en) * | 2006-12-01 | 2007-01-10 | Sterix Ltd | Use |
| EP2149371A1 (en) * | 2008-07-28 | 2010-02-03 | PregLem S.A. | Use of steroid sulfatase inhibitors for the treatment of preterm labor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1398026A (en) * | 1972-11-10 | 1975-06-18 | Jenapharm Veb | Steroid esters |
| DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| US5273993A (en) * | 1989-06-12 | 1993-12-28 | A. H. Robins Company, Incorporated | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals |
| GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US6083978A (en) * | 1996-03-05 | 2000-07-04 | Sterix Limited | Compounds with a sulfamate group |
| US6011024A (en) * | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| GB9118465D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US5556847A (en) * | 1994-10-27 | 1996-09-17 | Duquesne University Of The Holy Ghost | Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors |
| US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
| US5567831A (en) * | 1995-08-16 | 1996-10-22 | Duguesne University Of The Holy Ghost | Non-steroidal sulfatase inhibitor compounds and their method of use |
| US5763492A (en) | 1996-10-01 | 1998-06-09 | Duguesne University Of The Holy Ghost | Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors |
| GB2331987B (en) | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
| US6248780B1 (en) | 1998-10-01 | 2001-06-19 | Duquesne University Of The Holy Ghost | Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same |
-
1997
- 1997-12-04 GB GB9725749A patent/GB2331987B/en not_active Expired - Fee Related
-
1998
- 1998-12-03 JP JP2000522921A patent/JP2001524525A/ja active Pending
- 1998-12-03 AU AU13458/99A patent/AU1345899A/en not_active Abandoned
- 1998-12-03 DE DE69841374T patent/DE69841374D1/de not_active Expired - Lifetime
- 1998-12-03 AT AT98957034T patent/ATE451107T1/de not_active IP Right Cessation
- 1998-12-03 ES ES98957034T patent/ES2337427T3/es not_active Expired - Lifetime
- 1998-12-03 EP EP98957034A patent/EP1051178B1/en not_active Expired - Lifetime
- 1998-12-03 WO PCT/GB1998/003620 patent/WO1999027936A1/en not_active Ceased
-
2000
- 2000-05-17 US US09/572,237 patent/US6670353B2/en not_active Expired - Fee Related
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