DE69841374D1 - 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase - Google Patents
3-o-sulfamatsteroidderivate als hemmer von estronsulfataseInfo
- Publication number
- DE69841374D1 DE69841374D1 DE69841374T DE69841374T DE69841374D1 DE 69841374 D1 DE69841374 D1 DE 69841374D1 DE 69841374 T DE69841374 T DE 69841374T DE 69841374 T DE69841374 T DE 69841374T DE 69841374 D1 DE69841374 D1 DE 69841374D1
- Authority
- DE
- Germany
- Prior art keywords
- estronsulfatase
- inhibitors
- steroid derivatives
- sulfamate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9725749A GB2331987B (en) | 1997-12-04 | 1997-12-04 | Polycyclic sulphamate inhibitors of oestrone sulphatase |
PCT/GB1998/003620 WO1999027936A1 (en) | 1997-12-04 | 1998-12-03 | Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69841374D1 true DE69841374D1 (de) | 2010-01-21 |
Family
ID=10823155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69841374T Expired - Lifetime DE69841374D1 (de) | 1997-12-04 | 1998-12-03 | 3-o-sulfamatsteroidderivate als hemmer von estronsulfatase |
Country Status (9)
Country | Link |
---|---|
US (1) | US6670353B2 (de) |
EP (1) | EP1051178B1 (de) |
JP (1) | JP2001524525A (de) |
AT (1) | ATE451107T1 (de) |
AU (1) | AU1345899A (de) |
DE (1) | DE69841374D1 (de) |
ES (1) | ES2337427T3 (de) |
GB (1) | GB2331987B (de) |
WO (1) | WO1999027936A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
GB2331987B (en) | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
WO2000066095A2 (en) * | 1999-04-30 | 2000-11-09 | Sterix Limited | Use of estrone derivatives as antitumour agents |
GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
DK1237902T3 (da) * | 1999-12-13 | 2006-03-06 | Sterix Ltd | Halogenerede sulphamat-, fosfonat-, thiofosfonat-, sulfonat- og sulfonamidforbindelser som hæmmere af steroid sulfatase |
US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
WO2001081364A1 (fr) | 2000-04-24 | 2001-11-01 | Kyowa Hakko Kogyo Co., Ltd. | Derives d'estra-1,3,5(10)-triene |
GB0025788D0 (en) * | 2000-10-20 | 2000-12-06 | Sterix Ltd | Use |
GB0306718D0 (en) | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
EP1608671B1 (de) * | 2003-03-24 | 2010-01-06 | Sterix Limited | Oestrogenderivate als steroid sulphatase inhibitoren |
GB0306717D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
GB0511190D0 (en) * | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
GB0624105D0 (en) * | 2006-12-01 | 2007-01-10 | Sterix Ltd | Use |
EP2149371A1 (de) * | 2008-07-28 | 2010-02-03 | PregLem S.A. | Verwendung von Steroid-Sulfatase-Hemmern zur Behandlung von Frühgeburtsleiden |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1398026A (en) * | 1972-11-10 | 1975-06-18 | Jenapharm Veb | Steroid esters |
DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
US5273993A (en) * | 1989-06-12 | 1993-12-28 | A. H. Robins Company, Incorporated | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals |
US6011024A (en) * | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
GB9118465D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US5556847A (en) * | 1994-10-27 | 1996-09-17 | Duquesne University Of The Holy Ghost | Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors |
US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
US5567831A (en) * | 1995-08-16 | 1996-10-22 | Duguesne University Of The Holy Ghost | Non-steroidal sulfatase inhibitor compounds and their method of use |
ES2233998T3 (es) * | 1996-03-05 | 2005-06-16 | Sterix Limited | Compuestos que comprenden un grupo sulfamato. |
US5763492A (en) | 1996-10-01 | 1998-06-09 | Duguesne University Of The Holy Ghost | Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors |
GB2331987B (en) | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
US6248780B1 (en) | 1998-10-01 | 2001-06-19 | Duquesne University Of The Holy Ghost | Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same |
-
1997
- 1997-12-04 GB GB9725749A patent/GB2331987B/en not_active Expired - Fee Related
-
1998
- 1998-12-03 ES ES98957034T patent/ES2337427T3/es not_active Expired - Lifetime
- 1998-12-03 AU AU13458/99A patent/AU1345899A/en not_active Abandoned
- 1998-12-03 JP JP2000522921A patent/JP2001524525A/ja active Pending
- 1998-12-03 DE DE69841374T patent/DE69841374D1/de not_active Expired - Lifetime
- 1998-12-03 AT AT98957034T patent/ATE451107T1/de not_active IP Right Cessation
- 1998-12-03 WO PCT/GB1998/003620 patent/WO1999027936A1/en active Application Filing
- 1998-12-03 EP EP98957034A patent/EP1051178B1/de not_active Expired - Lifetime
-
2000
- 2000-05-17 US US09/572,237 patent/US6670353B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2001524525A (ja) | 2001-12-04 |
EP1051178A1 (de) | 2000-11-15 |
US20020198396A1 (en) | 2002-12-26 |
ES2337427T3 (es) | 2010-04-23 |
ATE451107T1 (de) | 2009-12-15 |
US6670353B2 (en) | 2003-12-30 |
GB2331987B (en) | 2002-11-27 |
WO1999027936A1 (en) | 1999-06-10 |
GB2331987A (en) | 1999-06-09 |
GB9725749D0 (en) | 1998-02-04 |
EP1051178B1 (de) | 2009-12-09 |
AU1345899A (en) | 1999-06-16 |
GB2331987A9 (en) | 1900-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |