TR200001288T2 - Östrojen yoksunluğu sendromunun tedavisinde faydalı 2-arilbenzo (b) tiyofenler. - Google Patents
Östrojen yoksunluğu sendromunun tedavisinde faydalı 2-arilbenzo (b) tiyofenler.Info
- Publication number
- TR200001288T2 TR200001288T2 TR2000/01288T TR200001288T TR200001288T2 TR 200001288 T2 TR200001288 T2 TR 200001288T2 TR 2000/01288 T TR2000/01288 T TR 2000/01288T TR 200001288 T TR200001288 T TR 200001288T TR 200001288 T2 TR200001288 T2 TR 200001288T2
- Authority
- TR
- Turkey
- Prior art keywords
- arylbenzo
- thiophene
- useful
- treatment
- withdrawal syndrome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Bu bulus, formül I'e sahip bilesikleri kulanarak osteoporoz ve hiperlipidemi dahil olmak üzere östrojen yoksunlugu sendromu ile iliskili çesitli tibbi durumlarin önlenmesinde faydali yöntemler saglar.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6585497P | 1997-11-14 | 1997-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001288T2 true TR200001288T2 (tr) | 2000-09-21 |
Family
ID=22065580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01288T TR200001288T2 (tr) | 1997-11-14 | 1998-11-09 | Östrojen yoksunluğu sendromunun tedavisinde faydalı 2-arilbenzo (b) tiyofenler. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6096781A (tr) |
EP (1) | EP0920862A1 (tr) |
JP (1) | JP2001523676A (tr) |
KR (1) | KR20010031903A (tr) |
CN (1) | CN1109683C (tr) |
AU (1) | AU748395B2 (tr) |
BR (1) | BR9813996A (tr) |
CA (1) | CA2309859A1 (tr) |
EA (1) | EA003471B1 (tr) |
HR (1) | HRP20000288A2 (tr) |
HU (1) | HUP0004731A3 (tr) |
ID (1) | ID26865A (tr) |
IL (1) | IL135511A0 (tr) |
NO (1) | NO20002371L (tr) |
NZ (1) | NZ503988A (tr) |
PL (1) | PL340431A1 (tr) |
TR (1) | TR200001288T2 (tr) |
TW (1) | TW467909B (tr) |
WO (1) | WO1999025707A1 (tr) |
ZA (1) | ZA9810214B (tr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE39049E1 (en) | 1992-07-28 | 2006-03-28 | Eli Lilly And Company | Methods for inhibiting bone loss |
TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
USRE38968E1 (en) | 1992-07-28 | 2006-02-07 | Eli Lilly And Company | Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride |
US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
US6096781A (en) * | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
US6258826B1 (en) | 1998-10-13 | 2001-07-10 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
DE19913349A1 (de) * | 1999-03-24 | 2000-09-28 | Clariant Gmbh | Benzothiophene und ihre Verwendung in flüssigkristallinen Mischungen |
BRPI0307791B1 (pt) * | 2002-02-20 | 2020-08-11 | J.R. Simplot Company | Métodos para modificar característica de planta selecionada |
AU2002953533A0 (en) | 2002-12-24 | 2003-01-16 | Arthron Limited | Fc receptor modulating compounds and compositions |
US20060106010A1 (en) * | 2003-05-27 | 2006-05-18 | Black Larry J | Methods for inhibiting bone loss |
ITTO20040125A1 (it) * | 2004-03-01 | 2004-06-01 | Rotta Research Lab | Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica |
EP1730132A2 (en) * | 2004-12-23 | 2006-12-13 | Teva Pharmaceutical Industries Ltd | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
KR101123178B1 (ko) * | 2009-04-09 | 2012-06-13 | (주)에스메디 | 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
EP3192795B1 (en) | 2012-10-24 | 2020-12-02 | The Board of Trustees of the University of Illionis | Compositions and methods for treating estrogen-related medical disorders |
ES2774935T3 (es) | 2012-10-24 | 2020-07-23 | Univ Illinois | Composiciones y métodos para tratar trastornos médicos relacionados con estrógeno |
CN107325067B (zh) * | 2017-05-03 | 2020-05-12 | 广州中医药大学 | 磷酸二酯酶4抑制剂桑辛素m衍生物及其用途 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4588484A (en) * | 1985-02-28 | 1986-05-13 | Eli Lilly And Company | Electrochemical reduction of 3-chlorobenzo[b]thiophenes |
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
TW383306B (en) * | 1992-12-22 | 2000-03-01 | Lilly Co Eli | New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol |
US5391557A (en) * | 1993-10-15 | 1995-02-21 | Eli Lilly And Company | Methods for the treatment of peri-menopausal syndrome |
US5462950A (en) * | 1993-12-21 | 1995-10-31 | Eli Lilly And Company | Methods of treating menstrual symptoms and compositions therefore |
US5389670A (en) * | 1993-12-21 | 1995-02-14 | Eli Lilly Company | Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder |
US5552415A (en) * | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
US5534526A (en) * | 1993-12-21 | 1996-07-09 | Eli Lilly And Company | Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome |
US5591753A (en) * | 1994-01-28 | 1997-01-07 | Eli Lilly And Company | Combination treatment for osteoporosis |
US5811120A (en) * | 1994-03-02 | 1998-09-22 | Eli Lilly And Company | Solid orally administerable raloxifene hydrochloride pharmaceutical formulation |
US5478847A (en) * | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
US5972383A (en) * | 1994-03-02 | 1999-10-26 | Eli Lilly And Company | Solid orally administerable raloxifene hydrochloride pharmaceutical formulation |
SG90193A1 (en) * | 1995-02-28 | 2002-07-23 | Lilly Co Eli | Benzothiophene compounds, intermediates, compositions, and methods |
US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
US5514703A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophene compounds useful for inhibiting lipoxygenase |
US5532382A (en) * | 1995-03-13 | 1996-07-02 | Eli Lilly And Company | Benzothiophenes substituted at the 3-carbonyl |
US5514704A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophenes to inhibit leukotrienes |
US5550134A (en) * | 1995-05-10 | 1996-08-27 | Eli Lilly And Company | Methods for inhibiting bone loss |
US6444688B1 (en) * | 1995-06-07 | 2002-09-03 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side chains |
EP0842169B1 (en) * | 1995-06-26 | 2001-01-03 | Eli Lilly And Company | Benzothiophene compounds |
US5731342A (en) * | 1996-02-22 | 1998-03-24 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
ID24978A (id) * | 1997-11-14 | 2000-08-31 | Lilly Co Eli | 2-ARYL-3-AROYLBENZO (b) THIOPHENES BERGUNA UNTUK PENGOBATAN SINDROM DEPRIVASI ESTROGEN |
US6096781A (en) * | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
-
1998
- 1998-11-04 US US09/185,927 patent/US6096781A/en not_active Expired - Fee Related
- 1998-11-07 TW TW087118568A patent/TW467909B/zh not_active IP Right Cessation
- 1998-11-09 JP JP2000521090A patent/JP2001523676A/ja not_active Withdrawn
- 1998-11-09 WO PCT/US1998/023719 patent/WO1999025707A1/en not_active Application Discontinuation
- 1998-11-09 PL PL98340431A patent/PL340431A1/xx not_active Application Discontinuation
- 1998-11-09 EA EA200000519A patent/EA003471B1/ru not_active IP Right Cessation
- 1998-11-09 AU AU13861/99A patent/AU748395B2/en not_active Ceased
- 1998-11-09 CA CA002309859A patent/CA2309859A1/en not_active Abandoned
- 1998-11-09 TR TR2000/01288T patent/TR200001288T2/tr unknown
- 1998-11-09 KR KR1020007005002A patent/KR20010031903A/ko not_active Application Discontinuation
- 1998-11-09 HU HU0004731A patent/HUP0004731A3/hu unknown
- 1998-11-09 IL IL13551198A patent/IL135511A0/xx unknown
- 1998-11-09 NZ NZ503988A patent/NZ503988A/en unknown
- 1998-11-09 BR BR9813996-7A patent/BR9813996A/pt not_active IP Right Cessation
- 1998-11-09 ZA ZA9810214A patent/ZA9810214B/xx unknown
- 1998-11-09 ID IDW20000835A patent/ID26865A/id unknown
- 1998-11-09 CN CN98810962A patent/CN1109683C/zh not_active Expired - Fee Related
- 1998-11-11 EP EP98309227A patent/EP0920862A1/en not_active Withdrawn
-
2000
- 2000-05-05 NO NO20002371A patent/NO20002371L/no not_active Application Discontinuation
- 2000-05-10 HR HR20000288A patent/HRP20000288A2/hr not_active Application Discontinuation
- 2000-05-12 US US09/569,409 patent/US6395769B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0920862A1 (en) | 1999-06-09 |
HUP0004731A2 (hu) | 2001-08-28 |
WO1999025707A1 (en) | 1999-05-27 |
KR20010031903A (ko) | 2001-04-16 |
BR9813996A (pt) | 2000-09-26 |
EA003471B1 (ru) | 2003-06-26 |
EA200000519A1 (ru) | 2000-10-30 |
AU1386199A (en) | 1999-06-07 |
PL340431A1 (en) | 2001-02-12 |
US6096781A (en) | 2000-08-01 |
TW467909B (en) | 2001-12-11 |
NO20002371L (no) | 2000-07-05 |
NZ503988A (en) | 2001-09-28 |
HRP20000288A2 (en) | 2000-08-31 |
CN1278811A (zh) | 2001-01-03 |
IL135511A0 (en) | 2001-05-20 |
NO20002371D0 (no) | 2000-05-05 |
AU748395B2 (en) | 2002-06-06 |
CN1109683C (zh) | 2003-05-28 |
ZA9810214B (en) | 2000-05-09 |
CA2309859A1 (en) | 1999-05-27 |
JP2001523676A (ja) | 2001-11-27 |
US6395769B1 (en) | 2002-05-28 |
HUP0004731A3 (en) | 2003-01-28 |
ID26865A (id) | 2001-02-15 |
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