JP2010507685A5 - - Google Patents
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- JP2010507685A5 JP2010507685A5 JP2009534845A JP2009534845A JP2010507685A5 JP 2010507685 A5 JP2010507685 A5 JP 2010507685A5 JP 2009534845 A JP2009534845 A JP 2009534845A JP 2009534845 A JP2009534845 A JP 2009534845A JP 2010507685 A5 JP2010507685 A5 JP 2010507685A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 7
- -1 methyloxy, formyloxy, acetoxy Chemical group 0.000 claims 6
- 239000000044 progesterone antagonist Substances 0.000 claims 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000262 estrogen Substances 0.000 claims 4
- 229940011871 estrogen Drugs 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Chemical group 0.000 claims 4
- 230000005906 menstruation Effects 0.000 claims 4
- 201000009273 Endometriosis Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- JVBGZFRPTRKSBB-MJBQOYBXSA-N Telapristone acetate Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(C(=O)COC)OC(C)=O)=CC=C(N(C)C)C=C1 JVBGZFRPTRKSBB-MJBQOYBXSA-N 0.000 claims 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- CXHHBNMLPJOKQD-UHFFFAOYSA-M methyl carbonate Chemical compound COC([O-])=O CXHHBNMLPJOKQD-UHFFFAOYSA-M 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000000583 progesterone congener Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 102100033417 Glucocorticoid receptor Human genes 0.000 claims 1
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 claims 1
- 102100025803 Progesterone receptor Human genes 0.000 claims 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 1
- HKDLNTKNLJPAIY-WKWWZUSTSA-N Ulipristal Chemical group C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(O)C(C)=O)[C@]2(C)C1 HKDLNTKNLJPAIY-WKWWZUSTSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- 239000002474 gonadorelin antagonist Substances 0.000 claims 1
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 claims 1
- 229960002899 hydroxyprogesterone Drugs 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 229960004616 medroxyprogesterone Drugs 0.000 claims 1
- FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 230000035807 sensation Effects 0.000 claims 1
- 0 CC(CC1c2ccc(*)cc2)(C(CC2)C(CC3)C1=C1C3=CC(*)CC1)[C@]2(C(C*)=O)O* Chemical compound CC(CC1c2ccc(*)cc2)(C(CC2)C(CC3)C1=C1C3=CC(*)CC1)[C@]2(C(C*)=O)O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86263206P | 2006-10-24 | 2006-10-24 | |
| US88534807P | 2007-01-17 | 2007-01-17 | |
| PCT/US2007/082432 WO2008067086A2 (en) | 2006-10-24 | 2007-10-24 | Compositions and methods for suppressing endometrial proliferation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259154A Division JP6175364B2 (ja) | 2006-10-24 | 2013-12-16 | 子宮内膜増殖を抑制するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507685A JP2010507685A (ja) | 2010-03-11 |
| JP2010507685A5 true JP2010507685A5 (enExample) | 2010-11-25 |
Family
ID=39468586
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534845A Pending JP2010507685A (ja) | 2006-10-24 | 2007-10-24 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2013259154A Expired - Fee Related JP6175364B2 (ja) | 2006-10-24 | 2013-12-16 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2016147279A Pending JP2016183199A (ja) | 2006-10-24 | 2016-07-27 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2017163450A Pending JP2017203049A (ja) | 2006-10-24 | 2017-08-28 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2019071622A Pending JP2019131587A (ja) | 2006-10-24 | 2019-04-03 | 子宮内膜増殖を抑制するための組成物および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259154A Expired - Fee Related JP6175364B2 (ja) | 2006-10-24 | 2013-12-16 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2016147279A Pending JP2016183199A (ja) | 2006-10-24 | 2016-07-27 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2017163450A Pending JP2017203049A (ja) | 2006-10-24 | 2017-08-28 | 子宮内膜増殖を抑制するための組成物および方法 |
| JP2019071622A Pending JP2019131587A (ja) | 2006-10-24 | 2019-04-03 | 子宮内膜増殖を抑制するための組成物および方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9283234B2 (enExample) |
| EP (3) | EP2078032B1 (enExample) |
| JP (5) | JP2010507685A (enExample) |
| KR (1) | KR20090067198A (enExample) |
| AU (1) | AU2007327707B2 (enExample) |
| BR (1) | BRPI0717747A2 (enExample) |
| CA (1) | CA2673128C (enExample) |
| CR (1) | CR10826A (enExample) |
| CY (2) | CY1119521T1 (enExample) |
| DK (2) | DK2078032T3 (enExample) |
| EA (1) | EA017227B1 (enExample) |
| EC (1) | ECSP099349A (enExample) |
| ES (2) | ES2814343T3 (enExample) |
| HK (1) | HK1216849A1 (enExample) |
| HU (2) | HUE036870T2 (enExample) |
| IL (2) | IL197893A (enExample) |
| LT (2) | LT3263112T (enExample) |
| MX (2) | MX2009003953A (enExample) |
| MY (1) | MY150763A (enExample) |
| NO (1) | NO342085B1 (enExample) |
| NZ (1) | NZ576274A (enExample) |
| PL (2) | PL2078032T3 (enExample) |
| PT (2) | PT2078032T (enExample) |
| SI (2) | SI2078032T1 (enExample) |
| WO (1) | WO2008067086A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5193196B2 (ja) | 2006-06-02 | 2013-05-08 | ペア ツリー ウーマンズ ヘルス ケア | 萎縮性膣炎の治療の方法 |
| EP2078032B1 (en) * | 2006-10-24 | 2017-08-02 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
| TWI477276B (zh) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
| TW201002736A (en) * | 2008-04-28 | 2010-01-16 | Repros Therapeutics Inc | Compositions and methods for treating progesterone-dependent conditions |
| RU2373977C1 (ru) * | 2008-08-05 | 2009-11-27 | Государственное образовательное учреждение дополнительного профессионального образования "Новокузнецкий государственный институт усовершенствования врачей Федерального агентства по здравоохранению и социальному развитию" | Способ лечения болевого синдрома при викарном увеличении яичника после односторонней аднексэктомии |
| US8512745B2 (en) | 2008-12-08 | 2013-08-20 | Laboratoire Hra Pharma | Ulipristal acetate tablets |
| UA113283C2 (xx) * | 2010-12-23 | 2017-01-10 | 19-норстероїди і їх застосування для лікування прогестеронзалежних станів | |
| EP2471537A1 (en) * | 2010-12-30 | 2012-07-04 | PregLem S.A. | Treatment of pain associated with dislocation of basal endometrium |
| SG10201704858PA (en) | 2012-05-31 | 2017-07-28 | Repros Therapeutics Inc | Formulations and methods for vaginal delivery of antiprogestins |
| EP2914268B1 (en) | 2012-11-02 | 2018-07-04 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| FR2997628B1 (fr) * | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant un modulateur selectif des recepteurs a la progesterone |
| JP2016516764A (ja) | 2013-04-10 | 2016-06-09 | プレグレム ソシエテ アノニム | 子宮筋腫治療に用いるプロゲステロン受容体調節剤 |
| US20190008804A1 (en) * | 2016-01-12 | 2019-01-10 | Repros Therapeutics Inc. | Trans-Clomiphene and Progesterone Receptor Antagonist Combination Therapy for Treating Hormone-Dependent Conditions |
Family Cites Families (59)
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| US4038389A (en) * | 1975-05-07 | 1977-07-26 | The Upjohn Company | Medroxyprogesterone acetate compositions |
| US4409208A (en) | 1980-04-15 | 1983-10-11 | The Salk Institute For Biological Studies | GnRH antagonists |
| ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| US4619914A (en) | 1983-03-10 | 1986-10-28 | The Salk Institute For Biological Studies | GNRH antagonists IIIB |
| US4780461A (en) | 1983-06-15 | 1988-10-25 | Schering Aktiengesellschaft | 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same |
| US4547370A (en) | 1983-11-29 | 1985-10-15 | The Salk Institute For Biological Studies | GnRH Antagonists |
| DE3347126A1 (de) | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
| US4569927A (en) | 1984-02-23 | 1986-02-11 | The Salk Institute For Biological Studies | GnRH Antagonists IV |
| US4565804A (en) | 1984-09-07 | 1986-01-21 | The Salk Institute For Biological Studies | GnRH Antagonists VI |
| DE3506785A1 (de) | 1985-02-22 | 1986-08-28 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
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| DE3866410D1 (de) | 1987-04-24 | 1992-01-09 | Akzo Nv | 11-arylestranderivate und 11-arylpregnanderivate. |
| ATE85342T1 (de) | 1987-12-12 | 1993-02-15 | Akzo Nv | 11-arylsteroid-derivate. |
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| DE3921059A1 (de) | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
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| AU775831B2 (en) | 1999-12-29 | 2004-08-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Process for preparing 17alpha-acetoxy-11beta-(4-N,N-(dimethylamino)phenyl)-21- methoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes for preparing such intermediates |
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| KR101229701B1 (ko) * | 2004-07-09 | 2013-02-05 | 라보라토이레 에이치알에이 파르마 | 프로게스테론 수용체 조절제를 함유하는 서방형 조성물 |
| EP2078032B1 (en) * | 2006-10-24 | 2017-08-02 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
-
2007
- 2007-10-24 EP EP07871232.0A patent/EP2078032B1/en active Active
- 2007-10-24 MX MX2009003953A patent/MX2009003953A/es active IP Right Grant
- 2007-10-24 KR KR1020097009508A patent/KR20090067198A/ko not_active Ceased
- 2007-10-24 CA CA2673128A patent/CA2673128C/en not_active Expired - Fee Related
- 2007-10-24 DK DK07871232.0T patent/DK2078032T3/da active
- 2007-10-24 MY MYPI20091368 patent/MY150763A/en unknown
- 2007-10-24 PL PL07871232T patent/PL2078032T3/pl unknown
- 2007-10-24 EP EP20167723.4A patent/EP3693376A1/en not_active Withdrawn
- 2007-10-24 EP EP17184128.1A patent/EP3263112B1/en not_active Not-in-force
- 2007-10-24 LT LTEP17184128.1T patent/LT3263112T/lt unknown
- 2007-10-24 NZ NZ576274A patent/NZ576274A/en not_active IP Right Cessation
- 2007-10-24 DK DK17184128.1T patent/DK3263112T3/da active
- 2007-10-24 PT PT78712320T patent/PT2078032T/pt unknown
- 2007-10-24 HU HUE07871232A patent/HUE036870T2/hu unknown
- 2007-10-24 WO PCT/US2007/082432 patent/WO2008067086A2/en not_active Ceased
- 2007-10-24 PT PT171841281T patent/PT3263112T/pt unknown
- 2007-10-24 LT LTEP07871232.0T patent/LT2078032T/lt unknown
- 2007-10-24 SI SI200731976T patent/SI2078032T1/sl unknown
- 2007-10-24 JP JP2009534845A patent/JP2010507685A/ja active Pending
- 2007-10-24 US US12/446,567 patent/US9283234B2/en not_active Expired - Fee Related
- 2007-10-24 ES ES17184128T patent/ES2814343T3/es active Active
- 2007-10-24 AU AU2007327707A patent/AU2007327707B2/en not_active Ceased
- 2007-10-24 EA EA200970409A patent/EA017227B1/ru unknown
- 2007-10-24 MX MX2013010762A patent/MX343130B/es unknown
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