JP2006507311A5 - - Google Patents
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- Publication number
- JP2006507311A5 JP2006507311A5 JP2004550523A JP2004550523A JP2006507311A5 JP 2006507311 A5 JP2006507311 A5 JP 2006507311A5 JP 2004550523 A JP2004550523 A JP 2004550523A JP 2004550523 A JP2004550523 A JP 2004550523A JP 2006507311 A5 JP2006507311 A5 JP 2006507311A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- glucocorticoid receptor
- receptor antagonist
- administration
- reflux disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 25
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 claims 14
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 claims 13
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 10
- 230000037396 body weight Effects 0.000 claims 4
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical group C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 claims 3
- 229960003248 mifepristone Drugs 0.000 claims 3
- 230000003637 steroidlike Effects 0.000 claims 3
- 239000000443 aerosol Substances 0.000 claims 2
- -1 dimethylaminophenyl moiety Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- YWROELXZPBSUCO-IYXRBSQSSA-N (2r)-1,2,3,4,4a,4b,5,6-octahydrophenanthrene-2,7-diol Chemical compound C12CCC(O)=CC2=CC=C2C1CC[C@@H](O)C2 YWROELXZPBSUCO-IYXRBSQSSA-N 0.000 claims 1
- ZCAUIZYRNPHJJO-CAMMJAKZSA-N (8s,10s,13s,14s)-10,13-dimethyl-1,2,6,7,8,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one Chemical compound C([C@H]12)CC3=CC(=O)CC[C@]3(C)C1=CC[C@@]1(C)[C@H]2CCC1 ZCAUIZYRNPHJJO-CAMMJAKZSA-N 0.000 claims 1
- 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 claims 1
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42419902P | 2002-11-05 | 2002-11-05 | |
| PCT/US2003/035341 WO2004041215A2 (en) | 2002-11-05 | 2003-11-05 | Methods for treating gastroesophageal reflux disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006507311A JP2006507311A (ja) | 2006-03-02 |
| JP2006507311A5 true JP2006507311A5 (enExample) | 2006-12-14 |
Family
ID=32312768
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550521A Pending JP2006508951A (ja) | 2002-11-05 | 2003-11-05 | 片頭痛を処置するための方法 |
| JP2004550523A Pending JP2006507311A (ja) | 2002-11-05 | 2003-11-05 | 胃食道逆流性疾患を処置するための方法 |
| JP2010249214A Pending JP2011021044A (ja) | 2002-11-05 | 2010-11-05 | 片頭痛を処置するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550521A Pending JP2006508951A (ja) | 2002-11-05 | 2003-11-05 | 片頭痛を処置するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249214A Pending JP2011021044A (ja) | 2002-11-05 | 2010-11-05 | 片頭痛を処置するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7361646B2 (enExample) |
| EP (2) | EP1581234A4 (enExample) |
| JP (3) | JP2006508951A (enExample) |
| AU (2) | AU2003291314B2 (enExample) |
| CA (2) | CA2504751C (enExample) |
| WO (2) | WO2004041214A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| CA2649894A1 (en) * | 2006-05-02 | 2007-11-15 | Corcept Therapeutics, Inc. | The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2 |
| CA2676670C (en) | 2007-02-02 | 2012-03-13 | Pfizer Products Inc. | Tricyclic compounds, compositions, and methods |
| ES2626131T3 (es) * | 2007-10-17 | 2017-07-24 | Laboratoire Hra Pharma | Antagonistas del receptor de glucocorticoides tales como mifepristona para tratar el síndrome de Cushing |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20090143343A1 (en) * | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| KR101245604B1 (ko) | 2007-11-13 | 2013-03-21 | 메리테이지 파마, 인크. | 코르티코스테로이드 조성물 |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| WO2010144865A2 (en) * | 2009-06-12 | 2010-12-16 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| US20150209374A1 (en) | 2014-01-29 | 2015-07-30 | Faro Owiesy | Composition and Method for Curing Migraine Headaches |
| US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
| MX383318B (es) | 2015-08-13 | 2025-03-13 | Corcept Therapeutics Inc | Metodo para diagnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina. |
| CA3011728A1 (en) | 2016-01-19 | 2017-07-27 | Corcept Therapeutics, Inc. | Differential diagnosis of ectopic cushing's syndrome |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2576025B1 (fr) * | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
| FR2598421B1 (fr) | 1986-05-06 | 1988-08-19 | Roussel Uclaf | Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
| US5250529A (en) * | 1990-02-08 | 1993-10-05 | Kos Pharmaceuticals, Inc. | Method alleviating migraine headache with mast cell degranulation blocking agents |
| US5468741A (en) * | 1993-05-28 | 1995-11-21 | The Regents Of The University Of California | Use of low levels of mifepristone to treat leiomyomata |
| US5521166A (en) * | 1994-12-19 | 1996-05-28 | Ortho Pharmaceitical Corporation | Antiprogestin cyclophasic hormonal regimen |
| IL118974A (en) | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| US5914129A (en) * | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| US5697112A (en) * | 1996-11-08 | 1997-12-16 | Glaxo Wellcome Inc. | Therapy pillow useful for treating gastroesophageal reflux disease (gerd) and other applications |
| US6166013A (en) * | 1998-07-30 | 2000-12-26 | Abbott Laboratories | Glucocortiocoid-selective agents |
| HUP0201243A3 (en) | 1999-04-30 | 2002-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators, pharmaceutical compositions containing them and their use |
| IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| US6579898B2 (en) | 2001-03-01 | 2003-06-17 | Pfizer Inc. | Compositions having improved bioavailability |
| AU2002361861A1 (en) * | 2001-12-21 | 2003-07-30 | Rhode Island Hospital | SELECTIVE 11Beta-HSD INHIBITORS AND METHODS FOR USE THEREOF |
-
2003
- 2003-11-05 CA CA2504751A patent/CA2504751C/en not_active Expired - Fee Related
- 2003-11-05 JP JP2004550521A patent/JP2006508951A/ja active Pending
- 2003-11-05 AU AU2003291314A patent/AU2003291314B2/en not_active Ceased
- 2003-11-05 JP JP2004550523A patent/JP2006507311A/ja active Pending
- 2003-11-05 WO PCT/US2003/035328 patent/WO2004041214A2/en not_active Ceased
- 2003-11-05 CA CA2504697A patent/CA2504697C/en not_active Expired - Fee Related
- 2003-11-05 EP EP03768706A patent/EP1581234A4/en not_active Withdrawn
- 2003-11-05 AU AU2003291322A patent/AU2003291322B2/en not_active Ceased
- 2003-11-05 EP EP03768714A patent/EP1567167A4/en not_active Ceased
- 2003-11-05 WO PCT/US2003/035341 patent/WO2004041215A2/en not_active Ceased
- 2003-11-05 US US10/702,950 patent/US7361646B2/en not_active Expired - Lifetime
- 2003-11-05 US US10/703,069 patent/US8450379B2/en active Active
-
2010
- 2010-11-05 JP JP2010249214A patent/JP2011021044A/ja active Pending
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