JP2002531498A5 - - Google Patents
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- Publication number
- JP2002531498A5 JP2002531498A5 JP2000586327A JP2000586327A JP2002531498A5 JP 2002531498 A5 JP2002531498 A5 JP 2002531498A5 JP 2000586327 A JP2000586327 A JP 2000586327A JP 2000586327 A JP2000586327 A JP 2000586327A JP 2002531498 A5 JP2002531498 A5 JP 2002531498A5
- Authority
- JP
- Japan
- Prior art keywords
- oxime
- methylisatin
- dichloroisatin
- pharmaceutically acceptable
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
- OIKFZVUNSNWSAD-UHFFFAOYSA-N 3-(hydroxyamino)-6,7-dimethylindol-2-one Chemical compound CC1=C(C)C=CC2=C(NO)C(=O)N=C21 OIKFZVUNSNWSAD-UHFFFAOYSA-N 0.000 description 1
- CVOUSAVHMDXCKG-UHFFFAOYSA-N 6,7-dichloro-3-(hydroxyamino)indol-2-one Chemical compound C1=CC(Cl)=C(Cl)C2=NC(=O)C(NO)=C21 CVOUSAVHMDXCKG-UHFFFAOYSA-N 0.000 description 1
- IGTXKVJLOUTKNB-UHFFFAOYSA-N 6,7-dichloro-3-hydroxyimino-1-methylindol-2-one Chemical compound C1=C(Cl)C(Cl)=C2N(C)C(=O)C(=NO)C2=C1 IGTXKVJLOUTKNB-UHFFFAOYSA-N 0.000 description 1
- HJFLMFUUYLJUPD-UHFFFAOYSA-N 6,7-difluoro-3-(hydroxyamino)indol-2-one Chemical compound C1=CC(F)=C(F)C2=C1C(=NO)C(=O)N2 HJFLMFUUYLJUPD-UHFFFAOYSA-N 0.000 description 1
- PNSCLWDBNGJLCG-UHFFFAOYSA-N 6-chloro-3-(hydroxyamino)-7-methylindol-2-one Chemical compound CC1=C(Cl)C=CC2=C(NO)C(=O)N=C12 PNSCLWDBNGJLCG-UHFFFAOYSA-N 0.000 description 1
- SHFGGAMLXGAYLG-UHFFFAOYSA-N 6-fluoro-3-(hydroxyamino)-7-methylindol-2-one Chemical compound C1=C(F)C(C)=C2NC(=O)C(=NO)C2=C1 SHFGGAMLXGAYLG-UHFFFAOYSA-N 0.000 description 1
- 206010048994 Bladder spasm Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199801608 | 1998-12-04 | ||
| DKPA199801608 | 1998-12-04 | ||
| PCT/DK1999/000679 WO2000033834A1 (en) | 1998-12-04 | 1999-12-03 | Use of isatin derivatives as ion channel activating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531498A JP2002531498A (ja) | 2002-09-24 |
| JP2002531498A5 true JP2002531498A5 (enExample) | 2007-01-25 |
Family
ID=8106503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586327A Pending JP2002531498A (ja) | 1998-12-04 | 1999-12-03 | イオンチャネル活性剤としてのイサチン誘導体の使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020016354A1 (enExample) |
| EP (1) | EP1135123B1 (enExample) |
| JP (1) | JP2002531498A (enExample) |
| AT (1) | ATE285769T1 (enExample) |
| AU (1) | AU1648600A (enExample) |
| DE (1) | DE69922997T2 (enExample) |
| WO (1) | WO2000033834A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1736468A3 (en) * | 2000-01-24 | 2007-01-03 | NeuroSearch A/S | Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation |
| WO2002000222A1 (en) * | 2000-06-26 | 2002-01-03 | Novo Nordisk A/S | Use of potassium channel agonists for the treatment of cancer |
| EP1345618B1 (de) * | 2000-12-28 | 2005-03-23 | Switch Biotech Aktiengesellschaft | Chlorzoxazon zur behandlung von psoriasis |
| JP2004520396A (ja) * | 2001-02-15 | 2004-07-08 | ニューロサーチ、アクティーゼルスカブ | 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療 |
| US20020183395A1 (en) | 2001-04-04 | 2002-12-05 | Wyeth | Methods for treating hyperactive gastric motility |
| US7148007B2 (en) * | 2001-07-24 | 2006-12-12 | Kabushiki Kaisha Toshiba | Method for evaluating immunotoxicity of test substance |
| DE10250870A1 (de) * | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
| FR2849773B1 (fr) * | 2003-01-15 | 2006-07-14 | Oreal | Composition capillaire contenant un 2-alkylidene aminooxy-acetamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute |
| WO2004069213A2 (en) * | 2003-01-15 | 2004-08-19 | L'oreal | Cosmetic composition comprising a 2-alkylideneaminooxyacetamide |
| US9408405B2 (en) | 2003-10-03 | 2016-08-09 | Veijlen N.V. | Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals |
| DE602004021010D1 (de) | 2003-10-03 | 2009-06-18 | Veijlen N V | Tierfutterzusammensetzung |
| WO2008034011A2 (en) | 2006-09-13 | 2008-03-20 | Mcw Research Foundation, Inc. | Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases |
| US8232310B2 (en) * | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US20120190723A1 (en) * | 2010-12-14 | 2012-07-26 | Fatah Kashanchi | Viral modulators and processes thereof |
| CA2821480A1 (en) | 2010-12-20 | 2012-06-28 | Astrazeneca Ab | 2-carboxamide-4-piperazinyl-benzofuran derivative |
| NZ700612A (en) | 2012-04-12 | 2016-09-30 | Univ Georgetown | Methods and compositions for treating ewings sarcoma family of tumors |
| US9511050B2 (en) | 2013-10-24 | 2016-12-06 | Georgetown University | Methods and compositions for treating cancer |
| WO2015160842A1 (en) * | 2014-04-14 | 2015-10-22 | Flex Pharma, Inc. | Methods and formulatiions of capsaicinoids and capsinoids |
| MX2016013486A (es) * | 2014-04-14 | 2017-05-10 | Flex Pharma Inc | Activadores de canales ionicos y metodos de uso. |
| CN104130175A (zh) * | 2014-06-13 | 2014-11-05 | 天津科技大学 | 不同位置取代吲哚酮类衍生物及其应用 |
| CN111777596A (zh) | 2014-10-09 | 2020-10-16 | 英克特诺治疗公司 | 吲哚酮化合物及其用途 |
| WO2017172368A1 (en) | 2016-03-31 | 2017-10-05 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CN109789127B (zh) | 2016-07-29 | 2022-03-25 | 英克特诺治疗公司 | 吲哚啉酮化合物的用途 |
| ES3055314T3 (en) | 2017-01-06 | 2026-02-11 | Iovance Biotherapeutics Inc | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| US11253493B2 (en) | 2017-01-23 | 2022-02-22 | Cliff-Cartwright Corporation | Compositions and methods affecting exercise performance |
| CN108017570A (zh) * | 2017-12-21 | 2018-05-11 | 常州大学 | 一种靛红的生产方法 |
| CN108403690A (zh) * | 2018-05-15 | 2018-08-17 | 泰山医学院 | 一种抑制黑色素瘤细胞增殖的药物及其应用 |
| CN108721297A (zh) * | 2018-05-15 | 2018-11-02 | 泰山医学院 | 一种减轻免疫抑制的抗肿瘤药物及其应用 |
| CN113564623A (zh) * | 2021-06-17 | 2021-10-29 | 福建师范大学 | 电化学氧化n-取代吲哚衍生物制备靛红化合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR65270B (en) * | 1978-10-10 | 1980-07-31 | Fujisawa Pharmaceutical Co | Isatin derivatives and processes for the preparation thereof |
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| US4780477A (en) * | 1985-06-08 | 1988-10-25 | Kissei Pharmaceutical Co., Ltd. | Isatin compositions having anti-ulcer activities |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
| US5192792A (en) * | 1990-12-07 | 1993-03-09 | Warner-Lambert Company | Isatine derivatives, and their method of use |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5514690A (en) * | 1992-11-17 | 1996-05-07 | E. R. Squibb & Sons, Inc. | Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
| JP3419539B2 (ja) * | 1993-02-17 | 2003-06-23 | 中外製薬株式会社 | インドリン−２−オン誘導体 |
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| EP1002535A1 (en) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | New use of glutamate antagonists for the treatment of cancer |
-
1999
- 1999-12-03 AT AT99959238T patent/ATE285769T1/de not_active IP Right Cessation
- 1999-12-03 AU AU16486/00A patent/AU1648600A/en not_active Abandoned
- 1999-12-03 JP JP2000586327A patent/JP2002531498A/ja active Pending
- 1999-12-03 WO PCT/DK1999/000679 patent/WO2000033834A1/en not_active Ceased
- 1999-12-03 DE DE69922997T patent/DE69922997T2/de not_active Expired - Lifetime
- 1999-12-03 EP EP99959238A patent/EP1135123B1/en not_active Expired - Lifetime
-
2001
- 2001-05-15 US US09/854,355 patent/US20020016354A1/en not_active Abandoned
-
2002
- 2002-10-16 US US10/270,536 patent/US6969729B2/en not_active Expired - Fee Related