DE69922997T2 - Verwendung von isatinderivaten als ionenkanalaktivierende mittel - Google Patents
Verwendung von isatinderivaten als ionenkanalaktivierende mittel Download PDFInfo
- Publication number
- DE69922997T2 DE69922997T2 DE69922997T DE69922997T DE69922997T2 DE 69922997 T2 DE69922997 T2 DE 69922997T2 DE 69922997 T DE69922997 T DE 69922997T DE 69922997 T DE69922997 T DE 69922997T DE 69922997 T2 DE69922997 T2 DE 69922997T2
- Authority
- DE
- Germany
- Prior art keywords
- oxime
- dichloroisatin
- disease
- channels
- methylisatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK160898 | 1998-12-04 | ||
| DKPA199801608 | 1998-12-04 | ||
| PCT/DK1999/000679 WO2000033834A1 (en) | 1998-12-04 | 1999-12-03 | Use of isatin derivatives as ion channel activating agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69922997D1 DE69922997D1 (de) | 2005-02-03 |
| DE69922997T2 true DE69922997T2 (de) | 2005-12-15 |
Family
ID=8106503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69922997T Expired - Lifetime DE69922997T2 (de) | 1998-12-04 | 1999-12-03 | Verwendung von isatinderivaten als ionenkanalaktivierende mittel |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20020016354A1 (enExample) |
| EP (1) | EP1135123B1 (enExample) |
| JP (1) | JP2002531498A (enExample) |
| AT (1) | ATE285769T1 (enExample) |
| AU (1) | AU1648600A (enExample) |
| DE (1) | DE69922997T2 (enExample) |
| WO (1) | WO2000033834A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2394292A1 (en) | 2000-01-24 | 2001-08-02 | Neurosearch A/S | Isatine derivatives with neurotrophic activity |
| WO2002000222A1 (en) * | 2000-06-26 | 2002-01-03 | Novo Nordisk A/S | Use of potassium channel agonists for the treatment of cancer |
| ATE291435T1 (de) * | 2000-12-28 | 2005-04-15 | Switch Biotech Ag | Chlorzoxazon zur behandlung von psoriasis |
| WO2002064128A1 (en) * | 2001-02-15 | 2002-08-22 | Neurosearch A/S | Treatment of diseases characterized by excessive or insufficient cell death |
| AR033095A1 (es) | 2001-04-04 | 2003-12-03 | Wyeth Corp | Metodos para el tratamiento de motilidad gastrica hiperactiva |
| US7148007B2 (en) * | 2001-07-24 | 2006-12-12 | Kabushiki Kaisha Toshiba | Method for evaluating immunotoxicity of test substance |
| DE10250870A1 (de) * | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
| FR2849773B1 (fr) * | 2003-01-15 | 2006-07-14 | Oreal | Composition capillaire contenant un 2-alkylidene aminooxy-acetamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute |
| WO2004069213A2 (en) * | 2003-01-15 | 2004-08-19 | L'oreal | Cosmetic composition comprising a 2-alkylideneaminooxyacetamide |
| SI1667678T1 (sl) | 2003-10-03 | 2009-12-31 | Veijlen N V | Sestavek za ĺ˝ivalsko hrano |
| WO2005039546A2 (en) | 2003-10-03 | 2005-05-06 | Veijlen N.V. | Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases |
| EP2061450B1 (en) | 2006-09-13 | 2017-04-19 | The Medical College of Wisconsin, Inc. | Methods of modulating cell proliferation and cyst formation in polycystic kidney and liver diseases |
| US8232310B2 (en) * | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| JP5305704B2 (ja) * | 2008-03-24 | 2013-10-02 | 富士フイルム株式会社 | 新規化合物、光重合性組成物、カラーフィルタ用光重合性組成物、カラーフィルタ、及びその製造方法、固体撮像素子、並びに、平版印刷版原版 |
| US20120190009A1 (en) * | 2010-12-14 | 2012-07-26 | Fatah Kashanchi | Viral Modulators and Processes Thereof |
| KR20130132932A (ko) | 2010-12-20 | 2013-12-05 | 아스트라제네카 아베 | 2-카르복스아미드-4-피페라지닐-벤조푸란 유도체 |
| MX377618B (es) | 2012-04-12 | 2025-03-07 | Univ Georgetown | Métodos y composiciones para el tratamiento de la familia de tumores del sarcoma de ewing. |
| MX2016004678A (es) * | 2013-10-24 | 2017-03-10 | Univ Georgetown | Composiciones para el tratamiento del cancer. |
| KR20160143792A (ko) * | 2014-04-14 | 2016-12-14 | 플렉스 파마, 인크. | 이온 통로 활성제 및 사용 방법 |
| WO2015160842A1 (en) * | 2014-04-14 | 2015-10-22 | Flex Pharma, Inc. | Methods and formulatiions of capsaicinoids and capsinoids |
| CN104130175A (zh) * | 2014-06-13 | 2014-11-05 | 天津科技大学 | 不同位置取代吲哚酮类衍生物及其应用 |
| EP3204376B1 (en) | 2014-10-09 | 2023-04-19 | Oncternal Therapeutics, Inc. | Indolinone compounds and uses thereof |
| EP3436434B1 (en) | 2016-03-31 | 2020-07-08 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| EP3490553B1 (en) | 2016-07-29 | 2024-08-28 | Oncternal Therapeutics, Inc. | Combination comprising an indolinone compound and its use in the treatment of lymphoma |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| WO2018136943A1 (en) | 2017-01-23 | 2018-07-26 | Flex Pharma, Inc. | Compositions and methods affecting exercise performance |
| CN108017570A (zh) * | 2017-12-21 | 2018-05-11 | 常州大学 | 一种靛红的生产方法 |
| CN108721297A (zh) * | 2018-05-15 | 2018-11-02 | 泰山医学院 | 一种减轻免疫抑制的抗肿瘤药物及其应用 |
| CN108403690A (zh) * | 2018-05-15 | 2018-08-17 | 泰山医学院 | 一种抑制黑色素瘤细胞增殖的药物及其应用 |
| CN113564623A (zh) * | 2021-06-17 | 2021-10-29 | 福建师范大学 | 电化学氧化n-取代吲哚衍生物制备靛红化合物的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR65270B (en) * | 1978-10-10 | 1980-07-31 | Fujisawa Pharmaceutical Co | Isatin derivatives and processes for the preparation thereof |
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| US4780477A (en) * | 1985-06-08 | 1988-10-25 | Kissei Pharmaceutical Co., Ltd. | Isatin compositions having anti-ulcer activities |
| GB8816944D0 (en) * | 1988-07-15 | 1988-08-17 | Sobio Lab | Compounds |
| IE69677B1 (en) * | 1989-12-11 | 1996-10-02 | Neurosearch As | Isatine derivatives their preparation and use |
| US5192792A (en) | 1990-12-07 | 1993-03-09 | Warner-Lambert Company | Isatine derivatives, and their method of use |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5514690A (en) * | 1992-11-17 | 1996-05-07 | E. R. Squibb & Sons, Inc. | Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
| TW281669B (enExample) * | 1993-02-17 | 1996-07-21 | Chugai Pharmaceutical Co Ltd | |
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| EP1002535A1 (en) * | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | New use of glutamate antagonists for the treatment of cancer |
-
1999
- 1999-12-03 EP EP99959238A patent/EP1135123B1/en not_active Expired - Lifetime
- 1999-12-03 WO PCT/DK1999/000679 patent/WO2000033834A1/en not_active Ceased
- 1999-12-03 AT AT99959238T patent/ATE285769T1/de not_active IP Right Cessation
- 1999-12-03 DE DE69922997T patent/DE69922997T2/de not_active Expired - Lifetime
- 1999-12-03 JP JP2000586327A patent/JP2002531498A/ja active Pending
- 1999-12-03 AU AU16486/00A patent/AU1648600A/en not_active Abandoned
-
2001
- 2001-05-15 US US09/854,355 patent/US20020016354A1/en not_active Abandoned
-
2002
- 2002-10-16 US US10/270,536 patent/US6969729B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020016354A1 (en) | 2002-02-07 |
| JP2002531498A (ja) | 2002-09-24 |
| DE69922997D1 (de) | 2005-02-03 |
| US6969729B2 (en) | 2005-11-29 |
| WO2000033834A1 (en) | 2000-06-15 |
| ATE285769T1 (de) | 2005-01-15 |
| EP1135123B1 (en) | 2004-12-29 |
| US20030114513A1 (en) | 2003-06-19 |
| AU1648600A (en) | 2000-06-26 |
| EP1135123A1 (en) | 2001-09-26 |
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| 8364 | No opposition during term of opposition |