|
US7833528B2
(en)
|
1998-06-22 |
2010-11-16 |
Immunomedics, Inc. |
Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
|
|
US7387772B1
(en)
|
1999-06-22 |
2008-06-17 |
Immunimedics, Inc. |
Chimeric, human and humanized anti-CSAP monoclonal antibodies
|
|
US7405320B2
(en)
|
1998-06-22 |
2008-07-29 |
Immunomedics, Inc. |
Therapeutic and diagnostic conjugates for use with multispecific antibodies
|
|
US20040166115A1
(en)
*
|
2002-11-15 |
2004-08-26 |
Immunomedics, Inc. |
Use of multi-specific, non-covalent complexes for targeted delivery of therapeutics
|
|
JP4113670B2
(ja)
|
1998-06-22 |
2008-07-09 |
イムノメディクス， インコーポレイテッド |
プレターゲッティング診断およびプレターゲッティング治療のための二重特異性抗体の使用
|
|
US6962702B2
(en)
*
|
1998-06-22 |
2005-11-08 |
Immunomedics Inc. |
Production and use of novel peptide-based agents for use with bi-specific antibodies
|
|
US7138103B2
(en)
|
1998-06-22 |
2006-11-21 |
Immunomedics, Inc. |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
|
|
US7052872B1
(en)
|
1999-06-22 |
2006-05-30 |
Immunomedics, Inc. |
Bi-specific antibodies for pre-targeting diagnosis and therapy
|
|
US6361774B1
(en)
|
1999-09-17 |
2002-03-26 |
Immunomedics, Inc. |
Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug
|
|
ATE499115T1
(de)
*
|
1998-09-18 |
2011-03-15 |
Immunomedics Inc |
Antikörper verwiesene enzymprodrugtherapie mit glukuronidase
|
|
US6897044B1
(en)
*
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
ATE414151T1
(de)
|
2000-03-03 |
2008-11-15 |
Cambridge Antibody Tech |
Antikörper gegen eotaxin und deren verwendung
|
|
WO2002008293A2
(en)
*
|
2000-07-25 |
2002-01-31 |
Immunomedics Inc. |
Multivalent target binding protein
|
|
WO2003011342A2
(en)
*
|
2001-07-31 |
2003-02-13 |
Immunomedics, Inc. |
Targeted polymeric delivery systems
|
|
CN1604910A
(zh)
*
|
2001-10-15 |
2005-04-06 |
免疫医疗公司 |
亲和性增强物质
|
|
US20030162709A1
(en)
*
|
2001-12-26 |
2003-08-28 |
Edmund Rossi |
Methods of generating multispecific, multivalent agents from VH and VL domains
|
|
US20040018557A1
(en)
*
|
2002-03-01 |
2004-01-29 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
|
ES2871905T3
(es)
*
|
2002-03-01 |
2021-11-02 |
Immunomedics Inc |
Inmunoconjugado que comprende anticuerpos de RS7 humanizados
|
|
EP1507562B1
(en)
*
|
2002-05-29 |
2010-03-24 |
Immunomedics, Inc. |
Compositions for radioimmunotherapy of brain
|
|
US20040022726A1
(en)
*
|
2002-06-03 |
2004-02-05 |
Goldenberg David M. |
Methods and compositions for intravesical therapy of bladder cancer
|
|
US7601351B1
(en)
|
2002-06-26 |
2009-10-13 |
Human Genome Sciences, Inc. |
Antibodies against protective antigen
|
|
WO2004005531A2
(en)
*
|
2002-07-05 |
2004-01-15 |
Roger Williams Medical Center |
Targeting and tracking of cells to specific organs and tissues in vivo
|
|
EP1572131B1
(en)
*
|
2002-10-08 |
2016-07-06 |
Immunomedics, Inc. |
Antibody therapy
|
|
US7820787B2
(en)
*
|
2003-01-23 |
2010-10-26 |
The Regents Of The University Of California |
Multi-functional antibodies
|
|
US7528235B2
(en)
*
|
2003-01-23 |
2009-05-05 |
The Regents Of The Univarsity Of California |
Multi-functional antibodies
|
|
EP1587550B1
(en)
*
|
2003-01-31 |
2011-07-27 |
Immunomedics, Inc. |
Methods and compositions for administering therapeutic and diagnostic agents
|
|
KR20060041205A
(ko)
|
2003-07-01 |
2006-05-11 |
이뮤노메딕스, 인코오포레이티드 |
양특이성 항체들의 다가 담체들
|
|
JP2007524412A
(ja)
*
|
2004-01-22 |
2007-08-30 |
イムノメディクス， インコーポレイテッド |
葉酸コンジュゲートおよびコンプレックス
|
|
KR20070034512A
(ko)
|
2004-06-18 |
2007-03-28 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
EP3332808B1
(en)
|
2005-03-03 |
2020-09-09 |
Immunomedics Inc. |
Humanized l243 antibodies
|
|
PL1874821T3
(pl)
|
2005-04-26 |
2013-09-30 |
Trion Pharma Gmbh |
Kombinacja przeciwciał i glikokortykoidów do leczenia raka
|
|
WO2007025166A2
(en)
*
|
2005-08-25 |
2007-03-01 |
Repair Technologies, Inc. |
Devices, compositions and methods for the protection and repair of cells and tissues
|
|
GB2431352B
(en)
*
|
2005-09-12 |
2011-03-16 |
Essential Nutrition Ltd |
Device
|
|
US8741260B2
(en)
|
2005-10-07 |
2014-06-03 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of GDNF to the CNS
|
|
JP5231231B2
(ja)
*
|
2005-10-19 |
2013-07-10 |
アイビーシー・ファーマシューティカルズ・インコーポレーテッド |
複雑性が増大した生理活性アセンブリーを生成するための方法および組成物ならびに使用
|
|
CN105837690A
(zh)
*
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
US20100086522A1
(en)
*
|
2006-07-18 |
2010-04-08 |
Ottawa Health Research Institute |
Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses
|
|
WO2008022349A2
(en)
|
2006-08-18 |
2008-02-21 |
Armagen Technologies, Inc. |
Agents for blood-brain barrier delivery
|
|
CA2694762A1
(en)
|
2007-07-27 |
2009-02-05 |
Armagen Technologies, Inc. |
Methods and compositions for increasing alpha-l-iduronidase activity in the cns
|
|
JP2009051784A
(ja)
*
|
2007-08-28 |
2009-03-12 |
Inst Nuclear Energy Research Rocaec |
癌を抑制する放射性物質及びその調整方法
|
|
ES2667729T3
(es)
*
|
2007-09-26 |
2018-05-14 |
Ucb Biopharma Sprl |
Fusiones de anticuerpos con doble especificidad
|
|
US8450106B2
(en)
*
|
2007-10-17 |
2013-05-28 |
The Ohio State University Research Foundation |
Oncolytic virus
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
WO2010035012A1
(en)
*
|
2008-09-26 |
2010-04-01 |
Ucb Pharma S.A. |
Biological products
|
|
BRPI1014089A2
(pt)
|
2009-04-02 |
2016-04-19 |
Roche Glycart Ag |
anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
|
|
DK2417156T3
(en)
|
2009-04-07 |
2015-03-02 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
MX2011010158A
(es)
*
|
2009-04-07 |
2011-10-17 |
Roche Glycart Ag |
Anticuerpos biespecificos anti-erbb-2/anti-c-met.
|
|
RU2570633C2
(ru)
*
|
2009-05-27 |
2015-12-10 |
Ф.Хоффманн-Ля Рош Аг |
Три- или тетраспецифические антитела
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
US8703132B2
(en)
*
|
2009-06-18 |
2014-04-22 |
Hoffmann-La Roche, Inc. |
Bispecific, tetravalent antigen binding proteins
|
|
WO2011003780A1
(en)
|
2009-07-06 |
2011-01-13 |
F. Hoffmann-La Roche Ag |
Bi-specific digoxigenin binding antibodies
|
|
WO2011011592A1
(en)
|
2009-07-22 |
2011-01-27 |
Actinium Pharmaceuticals Inc. |
Methods for generating radioimmunoconjugates
|
|
US9493578B2
(en)
*
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
CA2781519A1
(en)
|
2009-09-16 |
2011-03-24 |
Genentech, Inc. |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
CN102482701B
(zh)
|
2009-09-16 |
2015-05-13 |
免疫医疗公司 |
I类抗-cea抗体及其使用
|
|
HUE044865T2
(hu)
|
2009-10-09 |
2019-11-28 |
Armagen Inc |
Eljárások és készítmények a központi idegrendszerben iduronát-2-szulfatáz-aktivitás növelésére
|
|
CA2782194C
(en)
|
2009-12-02 |
2018-01-16 |
Immunomedics, Inc. |
Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer
|
|
JP6184695B2
(ja)
|
2009-12-04 |
2017-08-23 |
ジェネンテック， インコーポレイテッド |
多重特異性抗体、抗体アナログ、組成物、及び方法
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
CA2806252C
(en)
|
2010-07-29 |
2019-05-14 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
CA2807278A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann - La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
CN103328514B
(zh)
*
|
2010-11-09 |
2015-12-02 |
阿尔蒂单抗治疗公司 |
用于抗原结合的蛋白复合物及其使用方法
|
|
EP2640750A1
(en)
*
|
2010-11-16 |
2013-09-25 |
Boehringer Ingelheim International GmbH |
Agents and methods for treating diseases that correlate with bcma expression
|
|
WO2012071557A1
(en)
|
2010-11-24 |
2012-05-31 |
Litron Laboratories, Ltd |
Rapid in vivo gene mutation assay based on the pig-a gene
|
|
WO2012085111A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
CN103403025B
(zh)
|
2011-02-28 |
2016-10-12 |
弗·哈夫曼-拉罗切有限公司 |
单价抗原结合蛋白
|
|
JP5764677B2
(ja)
|
2011-02-28 |
2015-08-19 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
抗原結合タンパク質
|
|
JP6024025B2
(ja)
|
2011-05-02 |
2016-11-09 |
イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． |
少容量投与用のアロタイプ選択抗体の限外濾過濃縮
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對ｂｃｍａ之e3以及ｃｄ３的結合分子
|
|
ES2983576T3
(es)
|
2011-12-02 |
2024-10-23 |
Armagen Inc |
Métodos y composiciones para aumentar la actividad arilsulfatasa en el SNC
|
|
WO2013119966A2
(en)
|
2012-02-10 |
2013-08-15 |
Genentech, Inc. |
Single-chain antibodies and other heteromultimers
|
|
KR20150030744A
(ko)
|
2012-06-27 |
2015-03-20 |
에프. 호프만-라 로슈 아게 |
표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
|
|
RU2639287C2
(ru)
|
2012-06-27 |
2017-12-20 |
Ф. Хоффманн-Ля Рош Аг |
Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
|
|
US10487155B2
(en)
|
2013-01-14 |
2019-11-26 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10131710B2
(en)
|
2013-01-14 |
2018-11-20 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
HRP20191865T1
(hr)
|
2013-01-14 |
2020-01-10 |
Xencor, Inc. |
Novi heterodimerni proteini
|
|
US10968276B2
(en)
|
2013-03-12 |
2021-04-06 |
Xencor, Inc. |
Optimized anti-CD3 variable regions
|
|
US11053316B2
(en)
|
2013-01-14 |
2021-07-06 |
Xencor, Inc. |
Optimized antibody variable regions
|
|
US9605084B2
(en)
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
WO2014113510A1
(en)
|
2013-01-15 |
2014-07-24 |
Xencor, Inc. |
Rapid clearance of antigen complexes using novel antibodies
|
|
US10106624B2
(en)
|
2013-03-15 |
2018-10-23 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CA3093606A1
(en)
|
2013-03-15 |
2014-09-18 |
Xencor, Inc. |
Heterodimeric proteins for induction of t cells
|
|
US10519242B2
(en)
|
2013-03-15 |
2019-12-31 |
Xencor, Inc. |
Targeting regulatory T cells with heterodimeric proteins
|
|
RU2016115866A
(ru)
|
2013-10-11 |
2017-11-16 |
Ф. Хоффманн-Ля Рош Аг |
Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи
|
|
US9139649B2
(en)
|
2014-02-25 |
2015-09-22 |
Immunomedics, Inc. |
Humanized anti-CD22 antibody
|
|
EP3954713A3
(en)
|
2014-03-28 |
2022-03-30 |
Xencor, Inc. |
Bispecific antibodies that bind to cd38 and cd3
|
|
AU2015328370B2
(en)
|
2014-10-07 |
2021-08-05 |
Immunomedics, Inc. |
Neoadjuvant use of antibody-drug conjugates
|
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
|
CN116333153A
(zh)
|
2014-11-26 |
2023-06-27 |
森科股份有限公司 |
结合cd3和肿瘤抗原的异二聚体抗体
|
|
EP3223907A2
(en)
|
2014-11-26 |
2017-10-04 |
Xencor, Inc. |
Heterodimeric antibodies that bind cd3 and cd38
|
|
PL3227332T3
(pl)
|
2014-12-03 |
2020-06-15 |
F. Hoffmann-La Roche Ag |
Wielospecyficzne przeciwciała
|
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
|
US10538589B2
(en)
|
2015-01-14 |
2020-01-21 |
Armagen Inc. |
Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
|
|
US10227411B2
(en)
|
2015-03-05 |
2019-03-12 |
Xencor, Inc. |
Modulation of T cells with bispecific antibodies and FC fusions
|
|
CA2981543A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
SG11201709573YA
(en)
|
2015-05-20 |
2017-12-28 |
Univ Kagoshima |
Specific modification of antibody with igg-binding peptide
|
|
PL3316885T3
(pl)
|
2015-07-01 |
2021-12-06 |
Immunomedics, Inc. |
Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
|
|
WO2017053469A2
(en)
|
2015-09-21 |
2017-03-30 |
Aptevo Research And Development Llc |
Cd3 binding polypeptides
|
|
KR20180085800A
(ko)
|
2015-12-07 |
2018-07-27 |
젠코어 인코포레이티드 |
Cd3 및 psma에 결합하는 이종이합체성 항체
|
|
CN109071606A
(zh)
*
|
2016-06-13 |
2018-12-21 |
国立大学法人鹿儿岛大学 |
利用IgG结合肽的位点特异性放射性同位素标记抗体
|
|
IL263542B2
(en)
|
2016-06-14 |
2024-10-01 |
Xencor Inc |
Bispecific antibodies inhibit immunological checkpoint
|
|
KR20190020341A
(ko)
|
2016-06-28 |
2019-02-28 |
젠코어 인코포레이티드 |
소마토스타틴 수용체 2에 결합하는 이종이량체 항체
|
|
US10793632B2
(en)
|
2016-08-30 |
2020-10-06 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
CN110214148A
(zh)
|
2016-10-14 |
2019-09-06 |
Xencor股份有限公司 |
含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白
|
|
AU2018291497A1
(en)
|
2017-06-30 |
2020-01-16 |
Xencor, Inc. |
Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains
|
|
US10981992B2
(en)
|
2017-11-08 |
2021-04-20 |
Xencor, Inc. |
Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
|
|
AU2018366199A1
(en)
|
2017-11-08 |
2020-05-28 |
Xencor, Inc. |
Bispecific and monospecific antibodies using novel anti-PD-1 sequences
|
|
MX2020006322A
(es)
|
2017-12-19 |
2020-09-18 |
Xencor Inc |
Proteinas de fusion il-2 fc modificadas.
|
|
CN112469477A
(zh)
|
2018-04-04 |
2021-03-09 |
Xencor股份有限公司 |
与成纤维细胞活化蛋白结合的异源二聚体抗体
|
|
EP3781598A1
(en)
|
2018-04-18 |
2021-02-24 |
Xencor, Inc. |
Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
|
|
AU2019256539A1
(en)
|
2018-04-18 |
2020-11-26 |
Xencor, Inc. |
PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof
|
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