JP2002516384A5 - - Google Patents
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- Publication number
- JP2002516384A5 JP2002516384A5 JP2000551008A JP2000551008A JP2002516384A5 JP 2002516384 A5 JP2002516384 A5 JP 2002516384A5 JP 2000551008 A JP2000551008 A JP 2000551008A JP 2000551008 A JP2000551008 A JP 2000551008A JP 2002516384 A5 JP2002516384 A5 JP 2002516384A5
- Authority
- JP
- Japan
- Prior art keywords
- biological system
- hydroxyvalerate
- polymer
- hydroxybutyrate
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 description 22
- 238000000034 method Methods 0.000 description 12
- ALRHLSYJTWAHJZ-UHFFFAOYSA-M 3-hydroxypropionate Chemical compound OCCC([O-])=O ALRHLSYJTWAHJZ-UHFFFAOYSA-M 0.000 description 10
- FMHKPLXYWVCLME-UHFFFAOYSA-N 4-hydroxy-valeric acid Chemical compound CC(O)CCC(O)=O FMHKPLXYWVCLME-UHFFFAOYSA-N 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 8
- PHOJOSOUIAQEDH-UHFFFAOYSA-N 5-hydroxypentanoic acid Chemical compound OCCCCC(O)=O PHOJOSOUIAQEDH-UHFFFAOYSA-N 0.000 description 6
- 108090000992 Transferases Proteins 0.000 description 6
- 102000004357 Transferases Human genes 0.000 description 6
- 108010069175 acyl-CoA transferase Proteins 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- AFENDNXGAFYKQO-VKHMYHEASA-N (S)-2-hydroxybutyric acid Chemical compound CC[C@H](O)C(O)=O AFENDNXGAFYKQO-VKHMYHEASA-N 0.000 description 5
- 108010010718 poly(3-hydroxyalkanoic acid) synthase Proteins 0.000 description 5
- WHBMMWSBFZVSSR-UHFFFAOYSA-M 3-hydroxybutyrate Chemical compound CC(O)CC([O-])=O WHBMMWSBFZVSSR-UHFFFAOYSA-M 0.000 description 4
- REKYPYSUBKSCAT-UHFFFAOYSA-N 3-hydroxypentanoic acid Chemical compound CCC(O)CC(O)=O REKYPYSUBKSCAT-UHFFFAOYSA-N 0.000 description 4
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- WHBMMWSBFZVSSR-UHFFFAOYSA-N R3HBA Natural products CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 229920000070 poly-3-hydroxybutyrate Polymers 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- HPMGFDVTYHWBAG-UHFFFAOYSA-N 3-hydroxyhexanoic acid Chemical compound CCCC(O)CC(O)=O HPMGFDVTYHWBAG-UHFFFAOYSA-N 0.000 description 2
- IWHLYPDWHHPVAA-UHFFFAOYSA-N 6-hydroxyhexanoic acid Chemical compound OCCCCCC(O)=O IWHLYPDWHHPVAA-UHFFFAOYSA-N 0.000 description 2
- 102100037458 Dephospho-CoA kinase Human genes 0.000 description 2
- 108010049285 dephospho-CoA kinase Proteins 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- BERBFZCUSMQABM-IEXPHMLFSA-N 3-hydroxypropanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCO)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BERBFZCUSMQABM-IEXPHMLFSA-N 0.000 description 1
- -1 4-hydroxyvaleryl Chemical group 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8639698P | 1998-05-22 | 1998-05-22 | |
| US60/086,396 | 1998-05-22 | ||
| PCT/US1999/011417 WO1999061624A2 (en) | 1998-05-22 | 1999-05-21 | Polyhydroxyalkanoate biopolymer compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010060249A Division JP2010213700A (ja) | 1998-05-22 | 2010-03-17 | ポリヒドロキシアルカノエートバイオポリマー組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516384A JP2002516384A (ja) | 2002-06-04 |
| JP2002516384A5 true JP2002516384A5 (https=) | 2008-05-22 |
Family
ID=22198310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000551008A Pending JP2002516384A (ja) | 1998-05-22 | 1999-05-21 | ポリヒドロキシアルカノエートバイオポリマー組成物 |
| JP2010060249A Pending JP2010213700A (ja) | 1998-05-22 | 2010-03-17 | ポリヒドロキシアルカノエートバイオポリマー組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010060249A Pending JP2010213700A (ja) | 1998-05-22 | 2010-03-17 | ポリヒドロキシアルカノエートバイオポリマー組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6323010B1 (https=) |
| EP (2) | EP2267133B1 (https=) |
| JP (2) | JP2002516384A (https=) |
| AT (1) | ATE483023T1 (https=) |
| AU (1) | AU4199599A (https=) |
| CA (2) | CA2328471C (https=) |
| DE (1) | DE69942799D1 (https=) |
| MX (1) | MXPA00011401A (https=) |
| WO (1) | WO1999061624A2 (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5031144B2 (ja) | 1999-03-25 | 2012-09-19 | メタボリックス,インコーポレイテッド | ポリヒドロキシアルカノエートポリマーの医療デバイスおよび医療適用 |
| JP3684150B2 (ja) | 1999-12-27 | 2005-08-17 | キヤノン株式会社 | ポリヒドロキシアルカノエート |
| US6225438B1 (en) * | 2000-01-31 | 2001-05-01 | The Procter & Gamble Company | Medium chain length PHA copolymer and process for producing same |
| AU2001275996B2 (en) | 2000-07-21 | 2005-08-04 | Cj Cheiljedang Corporation | Production of polyhydroxyalkanoates from polyols |
| BR0115877A (pt) * | 2000-11-20 | 2003-10-07 | Cargill Inc | ácido 3-hidroxipropiÈnico e outros compostos orgánicos |
| US7230144B2 (en) | 2001-12-18 | 2007-06-12 | Metabolix Inc. | Methods of making intermediates from polyhydroxyalkanoates |
| KR100482776B1 (ko) | 2003-04-23 | 2005-04-14 | 한국과학기술원 | MaoC 단백질을 이용한 폴리히드록시알칸산의 제조방법 |
| ES2527857T3 (es) | 2003-05-08 | 2015-01-30 | Tepha, Inc. | Tejidos y fibras médicas de polihidroxialcanoato |
| US7353020B2 (en) * | 2003-11-17 | 2008-04-01 | Hitachi Communication Technologies, Ltd. | Radio access point testing apparatus and method of testing radio access point |
| US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
| PT1778305E (pt) | 2004-08-03 | 2010-07-27 | Tepha Inc | Suturas de poli-hidroxialcanoato que no se enrolam |
| KR100979694B1 (ko) | 2005-05-24 | 2010-09-02 | 한국과학기술원 | 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법 |
| US8637126B2 (en) * | 2006-02-06 | 2014-01-28 | International Paper Co. | Biodegradable paper-based laminate with oxygen and moisture barrier properties and method for making biodegradable paper-based laminate |
| US7618448B2 (en) * | 2006-02-07 | 2009-11-17 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| US9592325B2 (en) * | 2006-02-07 | 2017-03-14 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| US8979921B2 (en) * | 2006-02-07 | 2015-03-17 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| ES2624589T3 (es) * | 2006-02-07 | 2017-07-17 | Tepha, Inc. | Métodos y dispositivos para la reparación del manguito de los rotadores |
| US9089627B2 (en) | 2006-07-11 | 2015-07-28 | Abbott Cardiovascular Systems Inc. | Stent fabricated from polymer composite toughened by a dispersed phase |
| JP2010504396A (ja) * | 2006-09-19 | 2010-02-12 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 強化ポリ(ヒドロキシアルカン酸)組成物 |
| JP5565938B2 (ja) | 2006-11-21 | 2014-08-06 | エルジー・ケム・リミテッド | 4−ヒドロキシブチレート単位とラクテート単位を含有する共重合体及びその製造方法 |
| US7943683B2 (en) | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
| AU2008213973A1 (en) * | 2007-02-02 | 2008-08-14 | Tornier, Inc. | System and method for repairing tendons and ligaments |
| EP2167638A4 (en) * | 2007-06-27 | 2010-08-11 | Univ Arizona | REAGENTS AND METHODS FOR THE CYANOBACTERIAL PRODUCTION OF BIOPOLICS AND BIOMATERIALS |
| US8287909B2 (en) * | 2007-12-19 | 2012-10-16 | Tepha, Inc. | Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof |
| WO2009145840A2 (en) * | 2008-04-04 | 2009-12-03 | Massachusetts Institute Of Technology | Cellular production of hydroxyvalerates from levulinate |
| EP3260532A1 (en) | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| US20110028622A1 (en) | 2009-07-28 | 2011-02-03 | E. I. Du Pont De Nemours And Company | Poly(hydroxyalkanoic acid) blown film |
| WO2011034945A1 (en) | 2009-09-15 | 2011-03-24 | Metabolix, Inc. | Generation of high polyhydroxybutrate producing oilseeds |
| WO2011038178A1 (en) | 2009-09-24 | 2011-03-31 | E. I. Du Pont De Nemours And Company | Poly(hydroxyalkanoic acid) plasticized with poly(trimethylene ether) glycol |
| MX2012009134A (es) | 2010-02-11 | 2012-11-30 | Metabolix Inc | Proceso para producir componente monomerico de biomasa de polihidroxialcanoato geneticamente modificado. |
| PT2558133T (pt) | 2010-03-26 | 2020-04-23 | Tepha Inc | Revestimentos para o fabrico e aplicação de dispositivos médicos de polihidroxialcanqato |
| US10227718B2 (en) | 2010-06-15 | 2019-03-12 | Tepha, Inc. | Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers |
| US9511169B2 (en) | 2010-06-15 | 2016-12-06 | Tepha, Inc. | Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties |
| ES2644478T3 (es) | 2010-11-09 | 2017-11-29 | Tepha, Inc. | Implantes cocleares liberadores de fármacos |
| EP2646563A1 (en) | 2010-11-29 | 2013-10-09 | Micromidas, Inc. | Pha-producing bacteria |
| KR101328567B1 (ko) * | 2011-03-11 | 2013-11-13 | 한국화학연구원 | 2하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트를 생산하는 능력을 가지는 재조합 미생물 및 이를 이용한 2하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법 |
| KR101575585B1 (ko) | 2011-03-11 | 2015-12-21 | 한국과학기술원 | 글루코오스로부터〔락테이트co글리콜레이트〕공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 〔락테이트co글리콜레이트〕공중합체의 제조방법 |
| WO2013049161A1 (en) | 2011-09-27 | 2013-04-04 | Tepha, Inc. | Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers |
| AU2012328677A1 (en) | 2011-10-26 | 2014-04-17 | Performance Materials Na, Inc. | Multilayer film structure comprising renewably sourced materials |
| KR101630003B1 (ko) * | 2011-11-28 | 2016-06-13 | 주식회사 엘지화학 | 2-하이드록시알카노에이트 중합체의 제조방법 |
| EP2852417B1 (en) | 2012-05-21 | 2019-06-12 | Tepha, Inc. | Resorbable bioceramic compositions of poly-4-hydroxybutyrate and copolymers |
| MY185155A (en) | 2012-05-31 | 2021-04-30 | Micromidas Inc | Polyhydroxyalkanoate derivatives, preparation and uses thereof |
| US9850192B2 (en) | 2012-06-08 | 2017-12-26 | Cj Cheiljedang Corporation | Renewable acrylic acid production and products made therefrom |
| ES2751398T3 (es) | 2013-01-15 | 2020-03-31 | Tepha Inc | Implantes para regeneración de tejido blando y tejido duro |
| US20150376152A1 (en) | 2013-02-13 | 2015-12-31 | Metabolix, Inc. | Process for Ultra Pure Chemical Production from Biobased Raw Starting Materials |
| US10201640B2 (en) | 2013-03-13 | 2019-02-12 | Tepha, Inc. | Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof |
| US9687585B2 (en) | 2013-08-20 | 2017-06-27 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
| ES2878122T3 (es) | 2013-08-20 | 2021-11-18 | Tepha Inc | Espumas de celda cerrada que incluyen poli-4-hidroxibutirato y copolímeros del mismo |
| US9302029B2 (en) | 2013-10-31 | 2016-04-05 | Tepha, Inc. | Pultrusion of poly-4-hydroxybutyrate and copolymers thereof |
| US9480780B2 (en) | 2013-11-05 | 2016-11-01 | Tepha, Inc. | Compositions and devices of poly-4-hydroxybutyrate |
| ES2834498T3 (es) | 2013-12-26 | 2021-06-17 | Tepha Inc | Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo |
| EP3119930B1 (en) | 2014-03-18 | 2018-06-13 | Tepha, Inc. | Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning |
| EP3137015B1 (en) | 2014-04-30 | 2022-01-26 | Tepha, Inc. | Three-dimensional resorbable implants for tissue reinforcement and hernia repair |
| ES2674807T3 (es) | 2014-05-16 | 2018-07-04 | Tepha, Inc. | Dispositivos médicos que contienen materiales no tejidos hilados en seco de poli-4-hidroxibutirato y copolímeros con propiedades anisótropas |
| EP3180040B1 (en) | 2014-08-15 | 2020-05-13 | Tepha, Inc. | Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof |
| EP3183012B1 (en) | 2014-08-20 | 2017-12-20 | Tepha, Inc. | Thermoformed poly-4-hydroxybutyrate medical implants |
| WO2016048950A1 (en) | 2014-09-22 | 2016-03-31 | Tepha, Inc. | Oriented p4hb implants containing antimicrobial agents |
| WO2016094669A1 (en) | 2014-12-11 | 2016-06-16 | Tepha, Inc. | Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof |
| US10626521B2 (en) | 2014-12-11 | 2020-04-21 | Tepha, Inc. | Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof |
| US10801050B2 (en) | 2015-10-23 | 2020-10-13 | Metabolic Explorer | Microorganism modified for the assimilation of levulinic acid |
| KR101774431B1 (ko) | 2016-01-28 | 2017-09-05 | 한국과학기술원 | 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법 |
| US20230183418A1 (en) * | 2016-03-28 | 2023-06-15 | Lg Chem,Ltd | Liquid biopolymer, use thereof, and preparation method |
| WO2018159965A1 (ko) | 2017-02-28 | 2018-09-07 | 한국과학기술원 | 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법 |
| KR102036828B1 (ko) | 2017-02-28 | 2019-10-25 | 한국과학기술원 | 2-하이드록시이소카프로에이트-CoA 전이효소를 이용한 폴리하이드록시알카노에이트의 제조방법 |
| US11040170B2 (en) | 2017-05-25 | 2021-06-22 | Tepha, Inc. | Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof |
| WO2019050936A1 (en) | 2017-09-06 | 2019-03-14 | Tepha, Inc. | CALANDERATED SURGICAL TRELLIS COMPRISING POLYHYDROXYALKANOATES |
| EP3720514B1 (en) | 2017-12-04 | 2022-04-13 | Tepha, Inc. | Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants |
| EP4442767A3 (en) | 2018-06-11 | 2025-01-22 | Tepha, Inc. | Methods for 3d printing of poly-4-hydroxybutyrate |
| ES2956815T3 (es) | 2018-10-29 | 2023-12-28 | Tepha Inc | Procedimientos de fabricación de suturas de malla a partir de poli-4-hidroxibutirato y sus copolímeros |
| CN109913510B (zh) * | 2019-03-29 | 2021-04-13 | 长春理工大学 | 一种聚羟基脂肪酸酯的体外合成方法 |
| JP7764034B2 (ja) * | 2020-02-28 | 2025-11-05 | 国立大学法人北海道大学 | ブロック共重合体、及びその製造方法 |
| JP2024510182A (ja) | 2021-03-11 | 2024-03-06 | テファ, インコーポレイテッド | 乳房再建インプラント |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3275610A (en) * | 1964-03-24 | 1966-09-27 | Mobil Oil Corp | Microbial synthesis of polymers |
| US4477654A (en) | 1981-07-07 | 1984-10-16 | Imperial Chemical Industries Plc | 3-Hydroxybutyrate polymers |
| US5250430A (en) | 1987-06-29 | 1993-10-05 | Massachusetts Institute Of Technology | Polyhydroxyalkanoate polymerase |
| US5229279A (en) | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| US5245023A (en) | 1987-06-29 | 1993-09-14 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| ATE172497T1 (de) | 1989-07-10 | 1998-11-15 | Massachusetts Inst Technology | Verfahren zur herstellung von polyester- biopolymeren |
| JPH03224492A (ja) * | 1990-01-29 | 1991-10-03 | Showa Denko Kk | 共重合体およびその製造法 |
| JPH0465425A (ja) * | 1990-07-06 | 1992-03-02 | Showa Denko Kk | 共重合体及びその製造法 |
| JPH04104717A (ja) * | 1990-08-23 | 1992-04-07 | Mitsubishi Agricult Mach Co Ltd | チューブ肥料 |
| GB9108756D0 (en) | 1991-04-24 | 1991-06-12 | Ici Plc | Production of polyalkanoate in plants |
| US5610041A (en) | 1991-07-19 | 1997-03-11 | Board Of Trustees Operating Michigan State University | Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants |
| JP2777757B2 (ja) * | 1991-09-17 | 1998-07-23 | 鐘淵化学工業株式会社 | 共重合体およびその製造方法 |
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| DE69733490T2 (de) | 1997-03-03 | 2006-03-16 | Metabolix, Inc., Cambridge | Verfahren zur polyestern-biosynthese |
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-
1999
- 1999-05-21 AT AT99925777T patent/ATE483023T1/de not_active IP Right Cessation
- 1999-05-21 EP EP10009227.9A patent/EP2267133B1/en not_active Expired - Lifetime
- 1999-05-21 AU AU41995/99A patent/AU4199599A/en not_active Abandoned
- 1999-05-21 DE DE69942799T patent/DE69942799D1/de not_active Expired - Lifetime
- 1999-05-21 US US09/316,565 patent/US6323010B1/en not_active Expired - Fee Related
- 1999-05-21 MX MXPA00011401A patent/MXPA00011401A/es not_active Application Discontinuation
- 1999-05-21 CA CA2328471A patent/CA2328471C/en not_active Expired - Fee Related
- 1999-05-21 WO PCT/US1999/011417 patent/WO1999061624A2/en not_active Ceased
- 1999-05-21 CA CA2726139A patent/CA2726139A1/en not_active Abandoned
- 1999-05-21 JP JP2000551008A patent/JP2002516384A/ja active Pending
- 1999-05-21 EP EP99925777A patent/EP1078068B1/en not_active Expired - Lifetime
-
2003
- 2003-06-20 US US10/600,480 patent/US7202064B2/en not_active Expired - Fee Related
-
2007
- 2007-03-08 US US11/683,887 patent/US8093022B2/en not_active Expired - Fee Related
-
2010
- 2010-03-17 JP JP2010060249A patent/JP2010213700A/ja active Pending
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