JP2002515973A5 - - Google Patents
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- JP2002515973A5 JP2002515973A5 JP1997527625A JP52762597A JP2002515973A5 JP 2002515973 A5 JP2002515973 A5 JP 2002515973A5 JP 1997527625 A JP1997527625 A JP 1997527625A JP 52762597 A JP52762597 A JP 52762597A JP 2002515973 A5 JP2002515973 A5 JP 2002515973A5
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- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1085696P | 1996-01-30 | 1996-01-30 | |
| US08/699,678 US5741650A (en) | 1996-01-30 | 1996-08-14 | Methods for detecting colon cancer from stool samples |
| US60/010,856 | 1996-08-14 | ||
| US08/699,678 | 1996-08-14 | ||
| PCT/US1996/020727 WO1997028450A1 (en) | 1996-01-30 | 1996-12-20 | Methods for detecting colon cancer from stool samples |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002515973A JP2002515973A (ja) | 2002-05-28 |
| JP2002515973A5 true JP2002515973A5 (enExample) | 2004-11-04 |
| JP4195508B2 JP4195508B2 (ja) | 2008-12-10 |
Family
ID=26681667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52762597A Expired - Lifetime JP4195508B2 (ja) | 1996-01-30 | 1996-12-20 | 糞便サンプルから結腸ガンを検出する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5741650A (enExample) |
| EP (1) | EP0817968B1 (enExample) |
| JP (1) | JP4195508B2 (enExample) |
| AT (1) | ATE246806T1 (enExample) |
| AU (1) | AU704696B2 (enExample) |
| CA (1) | CA2215263C (enExample) |
| DE (1) | DE69629363T2 (enExample) |
| DK (1) | DK0817968T3 (enExample) |
| ES (1) | ES2202497T3 (enExample) |
| WO (1) | WO1997028450A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952178A (en) * | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
| US6818404B2 (en) | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
| US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| CA2372667A1 (en) * | 1999-01-10 | 2000-11-23 | Steven Laken | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
| ATE330032T1 (de) | 1999-02-25 | 2006-07-15 | Exact Sciences Corp | Verfahren zur erhaltung der dns-integrität |
| CA2366778C (en) * | 1999-04-09 | 2008-07-22 | Exact Sciences Corporation | Methods for detecting nucleic acids indicative of cancer |
| US6335193B1 (en) | 1999-04-15 | 2002-01-01 | Padmanabhan P Nair | Isolated colonocytes |
| CA2373598C (en) * | 1999-05-20 | 2006-08-01 | National Research Council Of Canada | Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy |
| US6821784B1 (en) * | 1999-05-20 | 2004-11-23 | The University Of Manitoba | Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6994971B1 (en) | 1999-10-08 | 2006-02-07 | University Of Utah Research Foundation | Particle analysis assay for biomolecular quantification |
| AU7875600A (en) * | 1999-10-08 | 2001-04-23 | University Of Utah Research Foundation | Particle analysis assay for biomolecular quantification |
| EP1238113B1 (en) * | 1999-12-07 | 2010-02-24 | EXACT Sciences Corporation | Detection of lung neoplasms in stool |
| US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| US20030219765A1 (en) * | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| DE10032608A1 (de) * | 2000-07-07 | 2002-01-24 | Magnus Von Knebel Doeberitz Ch | Für mikrosatelliteninstabile (MSI+)-Tumore relevante Gene und ihre Genprodukte |
| US20020086431A1 (en) * | 2000-08-21 | 2002-07-04 | Markham Walter Bruce | Sample preparation and slide plating apparatus and method |
| FR2815509B1 (fr) * | 2000-10-18 | 2004-07-23 | Swap Com | Systeme d'informations personnalisees sur telephone mobile en utilisant la multidiffusion "cell broadcast", et un logiciel de controle d'acces a bord du telephone, telecommande par l'operateur du service |
| US6911308B2 (en) | 2001-01-05 | 2005-06-28 | Exact Sciences Corporation | Methods for detecting, grading or monitoring an H. pylori infection |
| US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
| US20030148260A1 (en) * | 2001-08-07 | 2003-08-07 | Bernard Levin | Method of diagnosing colorectal adenomas and cancer using proton maggnetic resonance spectroscopy |
| CA2457527A1 (en) * | 2001-08-31 | 2003-03-13 | Gen-Probe Incorporated | Affinity-shifted probes for quantifying analyte polynucleotides |
| WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
| US20040086895A1 (en) * | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Method of electrochemical detection of somatic cell mutations |
| CA2506066A1 (en) * | 2002-11-15 | 2004-06-03 | Genomic Health, Inc. | Gene expression profiling of egfr positive cancer |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| WO2004071572A2 (en) * | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| CA2516553C (en) * | 2003-02-20 | 2013-04-16 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
| CA2527321A1 (en) * | 2003-05-30 | 2004-12-23 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
| US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
| WO2005039382A2 (en) * | 2003-06-24 | 2005-05-06 | Genomic Health | Prediction of likelihood of cancer recurrence |
| EP1644858B1 (en) | 2003-07-10 | 2017-12-06 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| US20050014165A1 (en) * | 2003-07-18 | 2005-01-20 | California Pacific Medical Center | Biomarker panel for colorectal cancer |
| JP4033820B2 (ja) * | 2003-07-29 | 2008-01-16 | 株式会社日立製作所 | 細胞回収方法 |
| WO2005017501A1 (en) * | 2003-08-14 | 2005-02-24 | National Research Council Of Cananda | Method of diagnosing colorectal adenomas and cancer using infrared spectroscopy |
| AU2004284434A1 (en) * | 2003-10-16 | 2005-05-06 | Genomic Health, Inc. | qRT-PCR assay system for gene expression profiling |
| EP1685395A2 (en) * | 2003-11-05 | 2006-08-02 | EXACT Sciences Corporation | Repetitive reversed-field affinity electrophoresis and uses therefor |
| JP4718490B2 (ja) * | 2003-12-23 | 2011-07-06 | ジェノミック ヘルス, インコーポレイテッド | フラグメント化rnaの全般的増幅 |
| CA2848463A1 (en) | 2004-04-09 | 2005-10-27 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| US20080241827A1 (en) * | 2004-05-10 | 2008-10-02 | Exact Sciences Corporation | Methods For Detecting A Mutant Nucleic Acid |
| US20080124714A1 (en) * | 2004-05-14 | 2008-05-29 | Exact Sciences Corporation | Method for Stabilizing Biological Samples for Nucleic Acid Analysis |
| WO2006026654A2 (en) * | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| JP4939425B2 (ja) * | 2004-11-05 | 2012-05-23 | ジェノミック ヘルス, インコーポレイテッド | 乳癌の治療反応の予後および予測の分子指標 |
| CA3061785A1 (en) | 2004-11-05 | 2006-05-18 | Genomic Health, Inc. | Predicting response to chemotherapy using gene expression markers |
| WO2006065598A2 (en) * | 2004-12-13 | 2006-06-22 | Geneohm Sciences, Inc. | Fluidic cartridges for electrochemical detection of dna |
| US9777314B2 (en) * | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| US20070248546A1 (en) * | 2005-11-09 | 2007-10-25 | Exact Sciences Corporation | Clinical algorithm for excluding patients identified in virtual imaging |
| ES2355388T3 (es) * | 2006-01-31 | 2011-03-25 | Medical Research Fund Of Tel Aviv Sourasky Medical Center | Métodos para la detección precoz de cáncer. |
| EP2167683A4 (en) | 2007-05-31 | 2010-10-20 | California Pacific Med Center | METHOD FOR PREDICTING OR DIAGNOSING GASTROINTESTINAL DISORDER OR DISEASE |
| WO2009015299A1 (en) | 2007-07-26 | 2009-01-29 | California Pacific Medical Center | Method to predict or diagnose a gastrointestinal disorder or disease |
| EP2218792A4 (en) * | 2007-11-20 | 2010-12-08 | Olympus Corp | PROCESS FOR PREPARATION OF A KOTPROBE, SOLUTION FOR PREPARATION OF A KOTPROBE AND KOTSAMMELKIT |
| WO2009102788A2 (en) | 2008-02-15 | 2009-08-20 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US20120164238A1 (en) | 2009-02-03 | 2012-06-28 | Mdxhealth Sa | Methods of detecting colorectal cancer |
| JP5575239B2 (ja) | 2009-07-21 | 2014-08-20 | ジェン−プローブ・インコーポレーテッド | 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物 |
| WO2011119934A2 (en) | 2010-03-26 | 2011-09-29 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal neoplasm |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| WO2012106525A2 (en) | 2011-02-02 | 2012-08-09 | Exact Sciences Corporation | Digital sequence analysis of dna methylation |
| GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
| US9127318B2 (en) | 2011-10-18 | 2015-09-08 | Exact Sciences Corporation | Multiplexed KRAS mutation detection assay |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US10253358B2 (en) | 2013-11-04 | 2019-04-09 | Exact Sciences Development Company, Llc | Multiple-control calibrators for DNA quantitation |
| EP3084004A4 (en) | 2013-12-19 | 2017-08-16 | Exact Sciences Corporation | Synthetic nucleic acid control molecules |
| ES2812753T3 (es) | 2014-03-31 | 2021-03-18 | Mayo Found Medical Education & Res | Detección de neoplasma colorectal |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| AU2016315924B2 (en) | 2015-08-31 | 2022-08-25 | Exact Sciences Corporation | Detecting gastric neoplasm |
| US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| AU2017250663B2 (en) | 2016-04-14 | 2023-06-15 | Mayo Foundation For Medical Education And Research | Detecting pancreatic high-grade dysplasia |
| EP3488003B1 (en) | 2016-07-19 | 2023-10-25 | Exact Sciences Corporation | Nucleic acid control molecules from non-human organisms |
| ES2902174T3 (es) | 2016-07-19 | 2022-03-25 | Exact Sciences Dev Co Llc | ADN de control metilado |
| CA3054836A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Detecting prostate cancer |
| CN111655869B (zh) | 2017-11-30 | 2024-06-28 | 梅约医学教育与研究基金会 | 检测乳腺癌 |
| US10507010B1 (en) * | 2018-09-18 | 2019-12-17 | Hong Min Kim | Stool monitoring and health guidance apparatus |
| WO2021215986A1 (en) | 2020-04-21 | 2021-10-28 | Sjoeblom Tobias | Cancer biomarkers |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101279A (en) * | 1977-04-06 | 1978-07-18 | Muhammed Javed Aslam | Device for the collection and processing of stool specimens |
| US4333734A (en) * | 1980-01-18 | 1982-06-08 | Sloan-Kettering Institute For Cancer Research | Diagnostic device for fecal occult blood and method of use |
| US4535058A (en) * | 1982-10-01 | 1985-08-13 | Massachusetts Institute Of Technology | Characterization of oncogenes and assays based thereon |
| US4309782A (en) * | 1980-09-11 | 1982-01-12 | Esteban Paulin | Device for collecting fecal specimens |
| US4445235A (en) * | 1982-09-13 | 1984-05-01 | Pearl Slover | Stool specimen collector |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4871838A (en) * | 1985-07-23 | 1989-10-03 | The Board Of Rijks Universiteit Leiden | Probes and methods for detecting activated ras oncogenes |
| US4705050A (en) * | 1985-10-02 | 1987-11-10 | Markham Charles W | Moisture-activated floatation device |
| US5348855A (en) * | 1986-03-05 | 1994-09-20 | Miles Inc. | Assay for nucleic acid sequences in an unpurified sample |
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US4981783A (en) * | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
| CA1341576C (en) * | 1986-08-11 | 2008-07-08 | Thaddeus P. Dryja | Diagnosis of retinoblastoma |
| US4735905A (en) * | 1986-08-15 | 1988-04-05 | V-Tech, Inc. | Specimen-gathering apparatus and method |
| AU625169B2 (en) * | 1987-03-23 | 1992-07-02 | Imperial Chemical Industries Plc | Molecular markers |
| US4857300A (en) * | 1987-07-27 | 1989-08-15 | Cytocorp, Inc. | Cytological and histological fixative formulation and methods for using same |
| US5688657A (en) * | 1988-03-31 | 1997-11-18 | International Bio-Immune Systems, Inc. | Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor |
| IL89964A0 (en) * | 1988-04-15 | 1989-12-15 | Montefiore Med Center | Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same |
| FR2630000A1 (fr) * | 1988-04-18 | 1989-10-20 | Sultan Bernard | Flacon destine a recueillir un echantillon biologique urinaire pour examen cytobacteriologique |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5087617A (en) * | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US5248671A (en) * | 1989-02-15 | 1993-09-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US5380645A (en) * | 1989-03-16 | 1995-01-10 | The Johns Hopkins University | Generalized method for assessment of colorectal carcinoma |
| US5527676A (en) * | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| US5362623A (en) * | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| DE69032864T3 (de) * | 1989-03-29 | 2013-01-31 | The Johns Hopkins University | Nachweis des Ausfalls des Wildtyps des p53-Gens |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| ES2059895T3 (es) * | 1989-06-23 | 1994-11-16 | Canon Kk | Metodo para la deteccion de acido nucleico. |
| US5137806A (en) * | 1989-12-11 | 1992-08-11 | Board Of Regents, The University Of Texas System | Methods and compositions for the detection of sequences in selected DNA molecules |
| ATE164629T1 (de) * | 1990-01-04 | 1998-04-15 | Univ Johns Hopkins | In menschlichen kolorektalkarzinomen fehlendes gen |
| US5126239A (en) * | 1990-03-14 | 1992-06-30 | E. I. Du Pont De Nemours And Company | Process for detecting polymorphisms on the basis of nucleotide differences |
| JP3179481B2 (ja) * | 1990-06-27 | 2001-06-25 | プリンストン ユニバーシティ | 突然変異体p53検出用プローブ |
| JPH06510363A (ja) * | 1990-10-29 | 1994-11-17 | ディカルブ プラント ジェネティクス | 磁気性粒子を使用する生物学的材料の単離 |
| JPH04203966A (ja) * | 1990-11-29 | 1992-07-24 | Yuuken:Kk | 簡易採便器兼用便潜血検査具及びこの検査具を用いる検査方法 |
| US5352775A (en) * | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| ES2158847T3 (es) * | 1991-01-16 | 2001-09-16 | Univ Johns Hopkins | Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre. |
| JPH07500411A (ja) * | 1991-02-05 | 1995-01-12 | ファロク セィディ | 癌胎児性抗原を検出するための簡易検査法 |
| EP0570497B1 (en) * | 1991-02-05 | 1996-05-08 | Lifecodes Corporation | Molecular genetic identification using probes that recognize polymorphic loci |
| US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
| US5468610A (en) * | 1991-05-29 | 1995-11-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Three highly informative microsatellite repeat polymorphic DNA markers |
| US5378602A (en) * | 1991-05-29 | 1995-01-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six |
| US5149506A (en) * | 1991-08-09 | 1992-09-22 | Sage Products, Inc. | Stool collection and transport device |
| AU3919293A (en) * | 1992-03-27 | 1993-11-08 | University Of Maryland At Baltimore | Detection of gene mutations with mismatch repair enzymes |
| US5489508A (en) * | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| JP3399948B2 (ja) * | 1992-06-26 | 2003-04-28 | ザ トラスティーズ オブ プリンストン ユニバーシティ | P90抗体またはプローブを用いた前癌細胞または癌細胞の検出方法 |
| FI96064C (fi) * | 1992-07-15 | 1996-04-25 | Outokumpu Instr Oy | Menetelmä jäähdytyksen aikaansaamiseksi ja jäähdytykseen soveltuva jäähdytyslaite |
| US5409586A (en) * | 1992-08-26 | 1995-04-25 | Hitachi, Ltd. | Method for analyzing nucleic acid or protein and apparatus therefor |
| IL103600A0 (en) * | 1992-10-30 | 1993-03-15 | Yeda Res & Dev | Method and kit for cancer diagnosis |
| US5331973A (en) * | 1993-03-15 | 1994-07-26 | Fiedler Paul N | Method for obtaining stool samples for gastrointestinal cancer testing |
| US5492808A (en) * | 1993-05-05 | 1996-02-20 | The Johns Hopkins University | Means for detecting familial colon cancer (FCC) |
| US5466576A (en) * | 1993-07-02 | 1995-11-14 | Fred Hutchinson Cancer Research Center | Modulation of PIF-1-type helicases |
| FR2709761B1 (fr) * | 1993-09-10 | 1995-11-24 | Pasteur Institut | Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases . |
| WO1995009928A1 (en) * | 1993-10-06 | 1995-04-13 | The Regents Of The University Of California | Methods for detecting cancer-associated chromosome deletions using in situ hybridization |
| GB9322795D0 (en) * | 1993-11-05 | 1993-12-22 | Wellcome Found | Novel compounds |
| US5561041A (en) * | 1993-11-12 | 1996-10-01 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection by analysis of sputum |
| WO1995015400A1 (en) * | 1993-12-03 | 1995-06-08 | The Johns Hopkins University | Genotyping by simultaneous analysis of multiple microsatellite loci |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| AU1675895A (en) * | 1994-01-03 | 1995-08-01 | Children's Hospital Of Philadelphia, The | Polymorphism at codon 36 of the p53 gene |
| US6025127A (en) * | 1994-01-14 | 2000-02-15 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection in histologic tissue |
| CN1128049A (zh) * | 1994-03-18 | 1996-07-31 | 犹他大学研究基金会 | 多肿瘤抑制因子基因种系突变及检测该基因癌肿倾向性的方法 |
| SE9500023L (sv) * | 1994-05-17 | 1995-11-18 | Beki Ab | Sätt att detektera cancer |
| US5496470A (en) * | 1994-05-27 | 1996-03-05 | Barnes International, Inc. | Magnetic separator |
| US5667987A (en) * | 1994-07-12 | 1997-09-16 | Bristol-Myers Squibb Company | P53 response genes |
| CA2198702C (en) * | 1994-08-31 | 2010-11-02 | David Sidransky | Detection of hypermutable nucleic acid sequence in tissue |
| US5702886A (en) * | 1994-10-05 | 1997-12-30 | The Johns Hopkins University | Chromosome I8Q loss and prognosis in colorectal cancer |
| EP0787203A1 (en) * | 1994-10-21 | 1997-08-06 | Zeneca Limited | Method for characterising variability in telomere dna by pcr |
| US5629178A (en) * | 1994-10-28 | 1997-05-13 | Genetics & Ivf Institute | Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA) |
| US5512441A (en) * | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
| US5463782A (en) * | 1994-11-21 | 1995-11-07 | Eric V. Carlson | Foldable stool sample collection device |
-
1996
- 1996-08-14 US US08/699,678 patent/US5741650A/en not_active Expired - Lifetime
- 1996-12-20 DE DE69629363T patent/DE69629363T2/de not_active Expired - Lifetime
- 1996-12-20 WO PCT/US1996/020727 patent/WO1997028450A1/en not_active Ceased
- 1996-12-20 JP JP52762597A patent/JP4195508B2/ja not_active Expired - Lifetime
- 1996-12-20 AT AT96946136T patent/ATE246806T1/de active
- 1996-12-20 DK DK96946136T patent/DK0817968T3/da active
- 1996-12-20 ES ES96946136T patent/ES2202497T3/es not_active Expired - Lifetime
- 1996-12-20 AU AU22406/97A patent/AU704696B2/en not_active Expired
- 1996-12-20 EP EP96946136A patent/EP0817968B1/en not_active Expired - Lifetime
- 1996-12-20 CA CA002215263A patent/CA2215263C/en not_active Expired - Lifetime