CA2215263C - Methods for detecting colon cancer from stool samples - Google Patents

Methods for detecting colon cancer from stool samples Download PDF

Info

Publication number
CA2215263C
CA2215263C CA002215263A CA2215263A CA2215263C CA 2215263 C CA2215263 C CA 2215263C CA 002215263 A CA002215263 A CA 002215263A CA 2215263 A CA2215263 A CA 2215263A CA 2215263 C CA2215263 C CA 2215263C
Authority
CA
Canada
Prior art keywords
sample
stool
cells
assay
lesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002215263A
Other languages
English (en)
French (fr)
Other versions
CA2215263A1 (en
Inventor
Stanley N. Lapidus
Anthony P. Shuber
Kevin M. Ulmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Publication of CA2215263A1 publication Critical patent/CA2215263A1/en
Application granted granted Critical
Publication of CA2215263C publication Critical patent/CA2215263C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57419Specifically defined cancers of colon
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002215263A 1996-01-30 1996-12-20 Methods for detecting colon cancer from stool samples Expired - Lifetime CA2215263C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1085696P 1996-01-30 1996-01-30
US08/699,678 US5741650A (en) 1996-01-30 1996-08-14 Methods for detecting colon cancer from stool samples
US60/010,856 1996-08-14
US08/699,678 1996-08-14
PCT/US1996/020727 WO1997028450A1 (en) 1996-01-30 1996-12-20 Methods for detecting colon cancer from stool samples

Publications (2)

Publication Number Publication Date
CA2215263A1 CA2215263A1 (en) 1997-08-07
CA2215263C true CA2215263C (en) 2003-02-18

Family

ID=26681667

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215263A Expired - Lifetime CA2215263C (en) 1996-01-30 1996-12-20 Methods for detecting colon cancer from stool samples

Country Status (10)

Country Link
US (1) US5741650A (enExample)
EP (1) EP0817968B1 (enExample)
JP (1) JP4195508B2 (enExample)
AT (1) ATE246806T1 (enExample)
AU (1) AU704696B2 (enExample)
CA (1) CA2215263C (enExample)
DE (1) DE69629363T2 (enExample)
DK (1) DK0817968T3 (enExample)
ES (1) ES2202497T3 (enExample)
WO (1) WO1997028450A1 (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
CA2372667A1 (en) * 1999-01-10 2000-11-23 Steven Laken Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
ATE330032T1 (de) 1999-02-25 2006-07-15 Exact Sciences Corp Verfahren zur erhaltung der dns-integrität
CA2366778C (en) * 1999-04-09 2008-07-22 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
CA2373598C (en) * 1999-05-20 2006-08-01 National Research Council Of Canada Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy
US6821784B1 (en) * 1999-05-20 2004-11-23 The University Of Manitoba Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6994971B1 (en) 1999-10-08 2006-02-07 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
AU7875600A (en) * 1999-10-08 2001-04-23 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
EP1238113B1 (en) * 1999-12-07 2010-02-24 EXACT Sciences Corporation Detection of lung neoplasms in stool
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US20030219765A1 (en) * 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
DE10032608A1 (de) * 2000-07-07 2002-01-24 Magnus Von Knebel Doeberitz Ch Für mikrosatelliteninstabile (MSI+)-Tumore relevante Gene und ihre Genprodukte
US20020086431A1 (en) * 2000-08-21 2002-07-04 Markham Walter Bruce Sample preparation and slide plating apparatus and method
FR2815509B1 (fr) * 2000-10-18 2004-07-23 Swap Com Systeme d'informations personnalisees sur telephone mobile en utilisant la multidiffusion "cell broadcast", et un logiciel de controle d'acces a bord du telephone, telecommande par l'operateur du service
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US20030148260A1 (en) * 2001-08-07 2003-08-07 Bernard Levin Method of diagnosing colorectal adenomas and cancer using proton maggnetic resonance spectroscopy
CA2457527A1 (en) * 2001-08-31 2003-03-13 Gen-Probe Incorporated Affinity-shifted probes for quantifying analyte polynucleotides
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
US20040086895A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Method of electrochemical detection of somatic cell mutations
CA2506066A1 (en) * 2002-11-15 2004-06-03 Genomic Health, Inc. Gene expression profiling of egfr positive cancer
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
WO2004071572A2 (en) * 2003-02-06 2004-08-26 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
CA2516553C (en) * 2003-02-20 2013-04-16 Genomic Health, Inc. Use of intronic rna to measure gene expression
CA2527321A1 (en) * 2003-05-30 2004-12-23 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
WO2005039382A2 (en) * 2003-06-24 2005-05-06 Genomic Health Prediction of likelihood of cancer recurrence
EP1644858B1 (en) 2003-07-10 2017-12-06 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
JP4033820B2 (ja) * 2003-07-29 2008-01-16 株式会社日立製作所 細胞回収方法
WO2005017501A1 (en) * 2003-08-14 2005-02-24 National Research Council Of Cananda Method of diagnosing colorectal adenomas and cancer using infrared spectroscopy
AU2004284434A1 (en) * 2003-10-16 2005-05-06 Genomic Health, Inc. qRT-PCR assay system for gene expression profiling
EP1685395A2 (en) * 2003-11-05 2006-08-02 EXACT Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
JP4718490B2 (ja) * 2003-12-23 2011-07-06 ジェノミック ヘルス, インコーポレイテッド フラグメント化rnaの全般的増幅
CA2848463A1 (en) 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
US20080241827A1 (en) * 2004-05-10 2008-10-02 Exact Sciences Corporation Methods For Detecting A Mutant Nucleic Acid
US20080124714A1 (en) * 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
WO2006026654A2 (en) * 2004-08-27 2006-03-09 Exact Sciences Corporation Method for detecting a recombinant event
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
JP4939425B2 (ja) * 2004-11-05 2012-05-23 ジェノミック ヘルス, インコーポレイテッド 乳癌の治療反応の予後および予測の分子指標
CA3061785A1 (en) 2004-11-05 2006-05-18 Genomic Health, Inc. Predicting response to chemotherapy using gene expression markers
WO2006065598A2 (en) * 2004-12-13 2006-06-22 Geneohm Sciences, Inc. Fluidic cartridges for electrochemical detection of dna
US9777314B2 (en) * 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
US20070248546A1 (en) * 2005-11-09 2007-10-25 Exact Sciences Corporation Clinical algorithm for excluding patients identified in virtual imaging
ES2355388T3 (es) * 2006-01-31 2011-03-25 Medical Research Fund Of Tel Aviv Sourasky Medical Center Métodos para la detección precoz de cáncer.
EP2167683A4 (en) 2007-05-31 2010-10-20 California Pacific Med Center METHOD FOR PREDICTING OR DIAGNOSING GASTROINTESTINAL DISORDER OR DISEASE
WO2009015299A1 (en) 2007-07-26 2009-01-29 California Pacific Medical Center Method to predict or diagnose a gastrointestinal disorder or disease
EP2218792A4 (en) * 2007-11-20 2010-12-08 Olympus Corp PROCESS FOR PREPARATION OF A KOTPROBE, SOLUTION FOR PREPARATION OF A KOTPROBE AND KOTSAMMELKIT
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
US20120164238A1 (en) 2009-02-03 2012-06-28 Mdxhealth Sa Methods of detecting colorectal cancer
JP5575239B2 (ja) 2009-07-21 2014-08-20 ジェン−プローブ・インコーポレーテッド 拡張されたダイナミックレンジにわたる核酸配列の定量的検出のための方法および組成物
WO2011119934A2 (en) 2010-03-26 2011-09-29 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
WO2012106525A2 (en) 2011-02-02 2012-08-09 Exact Sciences Corporation Digital sequence analysis of dna methylation
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
US9127318B2 (en) 2011-10-18 2015-09-08 Exact Sciences Corporation Multiplexed KRAS mutation detection assay
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
EP3084004A4 (en) 2013-12-19 2017-08-16 Exact Sciences Corporation Synthetic nucleic acid control molecules
ES2812753T3 (es) 2014-03-31 2021-03-18 Mayo Found Medical Education & Res Detección de neoplasma colorectal
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
AU2016315924B2 (en) 2015-08-31 2022-08-25 Exact Sciences Corporation Detecting gastric neoplasm
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
AU2017250663B2 (en) 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
EP3488003B1 (en) 2016-07-19 2023-10-25 Exact Sciences Corporation Nucleic acid control molecules from non-human organisms
ES2902174T3 (es) 2016-07-19 2022-03-25 Exact Sciences Dev Co Llc ADN de control metilado
CA3054836A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
CN111655869B (zh) 2017-11-30 2024-06-28 梅约医学教育与研究基金会 检测乳腺癌
US10507010B1 (en) * 2018-09-18 2019-12-17 Hong Min Kim Stool monitoring and health guidance apparatus
WO2021215986A1 (en) 2020-04-21 2021-10-28 Sjoeblom Tobias Cancer biomarkers

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101279A (en) * 1977-04-06 1978-07-18 Muhammed Javed Aslam Device for the collection and processing of stool specimens
US4333734A (en) * 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4535058A (en) * 1982-10-01 1985-08-13 Massachusetts Institute Of Technology Characterization of oncogenes and assays based thereon
US4309782A (en) * 1980-09-11 1982-01-12 Esteban Paulin Device for collecting fecal specimens
US4445235A (en) * 1982-09-13 1984-05-01 Pearl Slover Stool specimen collector
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4871838A (en) * 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US4705050A (en) * 1985-10-02 1987-11-10 Markham Charles W Moisture-activated floatation device
US5348855A (en) * 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
CA1341576C (en) * 1986-08-11 2008-07-08 Thaddeus P. Dryja Diagnosis of retinoblastoma
US4735905A (en) * 1986-08-15 1988-04-05 V-Tech, Inc. Specimen-gathering apparatus and method
AU625169B2 (en) * 1987-03-23 1992-07-02 Imperial Chemical Industries Plc Molecular markers
US4857300A (en) * 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same
US5688657A (en) * 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
IL89964A0 (en) * 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
FR2630000A1 (fr) * 1988-04-18 1989-10-20 Sultan Bernard Flacon destine a recueillir un echantillon biologique urinaire pour examen cytobacteriologique
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5087617A (en) * 1989-02-15 1992-02-11 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5248671A (en) * 1989-02-15 1993-09-28 Board Of Regents, The University Of Texas System Methods and compositions for treatment of cancer using oligonucleotides
US5380645A (en) * 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5362623A (en) * 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
DE69032864T3 (de) * 1989-03-29 2013-01-31 The Johns Hopkins University Nachweis des Ausfalls des Wildtyps des p53-Gens
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
ES2059895T3 (es) * 1989-06-23 1994-11-16 Canon Kk Metodo para la deteccion de acido nucleico.
US5137806A (en) * 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
ATE164629T1 (de) * 1990-01-04 1998-04-15 Univ Johns Hopkins In menschlichen kolorektalkarzinomen fehlendes gen
US5126239A (en) * 1990-03-14 1992-06-30 E. I. Du Pont De Nemours And Company Process for detecting polymorphisms on the basis of nucleotide differences
JP3179481B2 (ja) * 1990-06-27 2001-06-25 プリンストン ユニバーシティ 突然変異体p53検出用プローブ
JPH06510363A (ja) * 1990-10-29 1994-11-17 ディカルブ プラント ジェネティクス 磁気性粒子を使用する生物学的材料の単離
JPH04203966A (ja) * 1990-11-29 1992-07-24 Yuuken:Kk 簡易採便器兼用便潜血検査具及びこの検査具を用いる検査方法
US5352775A (en) * 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
ES2158847T3 (es) * 1991-01-16 2001-09-16 Univ Johns Hopkins Mutaciones heredadas y somaticas del gen apc en el cancer colorectal del hombre.
JPH07500411A (ja) * 1991-02-05 1995-01-12 ファロク セィディ 癌胎児性抗原を検出するための簡易検査法
EP0570497B1 (en) * 1991-02-05 1996-05-08 Lifecodes Corporation Molecular genetic identification using probes that recognize polymorphic loci
US5330892A (en) * 1991-03-13 1994-07-19 The Johns Hopkins University MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans
US5468610A (en) * 1991-05-29 1995-11-21 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Three highly informative microsatellite repeat polymorphic DNA markers
US5378602A (en) * 1991-05-29 1995-01-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six
US5149506A (en) * 1991-08-09 1992-09-22 Sage Products, Inc. Stool collection and transport device
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
JP3399948B2 (ja) * 1992-06-26 2003-04-28 ザ トラスティーズ オブ プリンストン ユニバーシティ P90抗体またはプローブを用いた前癌細胞または癌細胞の検出方法
FI96064C (fi) * 1992-07-15 1996-04-25 Outokumpu Instr Oy Menetelmä jäähdytyksen aikaansaamiseksi ja jäähdytykseen soveltuva jäähdytyslaite
US5409586A (en) * 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
IL103600A0 (en) * 1992-10-30 1993-03-15 Yeda Res & Dev Method and kit for cancer diagnosis
US5331973A (en) * 1993-03-15 1994-07-26 Fiedler Paul N Method for obtaining stool samples for gastrointestinal cancer testing
US5492808A (en) * 1993-05-05 1996-02-20 The Johns Hopkins University Means for detecting familial colon cancer (FCC)
US5466576A (en) * 1993-07-02 1995-11-14 Fred Hutchinson Cancer Research Center Modulation of PIF-1-type helicases
FR2709761B1 (fr) * 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
WO1995009928A1 (en) * 1993-10-06 1995-04-13 The Regents Of The University Of California Methods for detecting cancer-associated chromosome deletions using in situ hybridization
GB9322795D0 (en) * 1993-11-05 1993-12-22 Wellcome Found Novel compounds
US5561041A (en) * 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
WO1995015400A1 (en) * 1993-12-03 1995-06-08 The Johns Hopkins University Genotyping by simultaneous analysis of multiple microsatellite loci
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
AU1675895A (en) * 1994-01-03 1995-08-01 Children's Hospital Of Philadelphia, The Polymorphism at codon 36 of the p53 gene
US6025127A (en) * 1994-01-14 2000-02-15 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection in histologic tissue
CN1128049A (zh) * 1994-03-18 1996-07-31 犹他大学研究基金会 多肿瘤抑制因子基因种系突变及检测该基因癌肿倾向性的方法
SE9500023L (sv) * 1994-05-17 1995-11-18 Beki Ab Sätt att detektera cancer
US5496470A (en) * 1994-05-27 1996-03-05 Barnes International, Inc. Magnetic separator
US5667987A (en) * 1994-07-12 1997-09-16 Bristol-Myers Squibb Company P53 response genes
CA2198702C (en) * 1994-08-31 2010-11-02 David Sidransky Detection of hypermutable nucleic acid sequence in tissue
US5702886A (en) * 1994-10-05 1997-12-30 The Johns Hopkins University Chromosome I8Q loss and prognosis in colorectal cancer
EP0787203A1 (en) * 1994-10-21 1997-08-06 Zeneca Limited Method for characterising variability in telomere dna by pcr
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
US5512441A (en) * 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5463782A (en) * 1994-11-21 1995-11-07 Eric V. Carlson Foldable stool sample collection device

Also Published As

Publication number Publication date
EP0817968A1 (en) 1998-01-14
CA2215263A1 (en) 1997-08-07
US5741650A (en) 1998-04-21
JP4195508B2 (ja) 2008-12-10
ATE246806T1 (de) 2003-08-15
WO1997028450A1 (en) 1997-08-07
JP2002515973A (ja) 2002-05-28
DE69629363D1 (de) 2003-09-11
AU704696B2 (en) 1999-04-29
ES2202497T3 (es) 2004-04-01
EP0817968B1 (en) 2003-08-06
DE69629363T2 (de) 2004-06-09
AU2240697A (en) 1997-08-22
DK0817968T3 (da) 2003-12-01

Similar Documents

Publication Publication Date Title
CA2215263C (en) Methods for detecting colon cancer from stool samples
US5952178A (en) Methods for disease diagnosis from stool samples
US5670325A (en) Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5928870A (en) Methods for the detection of loss of heterozygosity
US6020137A (en) Methods for the detection of loss of heterozygosity
CA2352455C (en) Methods for stool sample preparation
EP0815263B1 (en) Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US6203993B1 (en) Methods for the detection of nucleic acids
US20020164631A1 (en) Methods for stool sample preparation
US20020004206A1 (en) Methods of screening for disease
US20020004201A1 (en) Methods for the detection of loss of heterozygosity
AU720489B2 (en) Methods for detecting colon cancer from stool samples
CA2331254A1 (en) Methods for the detection of nucleic acids
EP1291657A2 (en) Methods for detecting colon cancer from stool samples
JP3325270B6 (ja) ゲノム上不均一な細胞サンプルにおける形質転換細胞のクローン集団検出のための方法
Sugimura et al. Methods for genetic testing I: Assessing mutations in cancers

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20161220