JP2002515900A5 - - Google Patents
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- Publication number
- JP2002515900A5 JP2002515900A5 JP1998537985A JP53798598A JP2002515900A5 JP 2002515900 A5 JP2002515900 A5 JP 2002515900A5 JP 1998537985 A JP1998537985 A JP 1998537985A JP 53798598 A JP53798598 A JP 53798598A JP 2002515900 A5 JP2002515900 A5 JP 2002515900A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3518297P | 1997-03-04 | 1997-03-04 | |
| US60/035,182 | 1997-03-04 | ||
| PCT/US1998/004277 WO1998039326A1 (en) | 1997-03-04 | 1998-03-04 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002515900A JP2002515900A (ja) | 2002-05-28 |
| JP2002515900A5 true JP2002515900A5 (https=) | 2005-10-06 |
Family
ID=21881145
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53879998A Abandoned JP2001518081A (ja) | 1997-03-04 | 1998-03-04 | スルホニル２価アリールまたはヘテロアリールヒドロキサム酸化合物 |
| JP53879698A Abandoned JP2002513407A (ja) | 1997-03-04 | 1998-03-04 | Ｎ−ヒドロキシ４−スルホニルブタンアミド化合物 |
| JP53878098A Abandoned JP2002515901A (ja) | 1997-03-04 | 1998-03-04 | 芳香族スルホニルα−シクロアミノヒドロキサム酸化合物 |
| JP53798598A Abandoned JP2002515900A (ja) | 1997-03-04 | 1998-03-04 | 芳香族スルホニルアルファ−ヒドロキシヒドロキサム酸化合物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53879998A Abandoned JP2001518081A (ja) | 1997-03-04 | 1998-03-04 | スルホニル２価アリールまたはヘテロアリールヒドロキサム酸化合物 |
| JP53879698A Abandoned JP2002513407A (ja) | 1997-03-04 | 1998-03-04 | Ｎ−ヒドロキシ４−スルホニルブタンアミド化合物 |
| JP53878098A Abandoned JP2002515901A (ja) | 1997-03-04 | 1998-03-04 | 芳香族スルホニルα−シクロアミノヒドロキサム酸化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US6380258B2 (https=) |
| EP (4) | EP0983258A4 (https=) |
| JP (4) | JP2001518081A (https=) |
| KR (3) | KR20000075954A (https=) |
| CN (3) | CN1105114C (https=) |
| AT (1) | ATE254599T1 (https=) |
| AU (2) | AU750130B2 (https=) |
| BR (2) | BR9808166A (https=) |
| CA (4) | CA2283272A1 (https=) |
| DE (1) | DE69819878T2 (https=) |
| DK (1) | DK0973392T3 (https=) |
| EA (1) | EA199900792A1 (https=) |
| ES (2) | ES2209122T3 (https=) |
| IL (3) | IL131495A0 (https=) |
| NO (1) | NO315647B1 (https=) |
| NZ (1) | NZ337326A (https=) |
| PL (1) | PL335732A1 (https=) |
| PT (1) | PT973392E (https=) |
| WO (1) | WO1998038859A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
| US6696449B2 (en) | 1997-03-04 | 2004-02-24 | Pharmacia Corporation | Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors |
| US6380258B2 (en) | 1997-03-04 | 2002-04-30 | G. D. Searle, L.L.C. | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds |
| US7115632B1 (en) * | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| US6794511B2 (en) | 1997-03-04 | 2004-09-21 | G. D. Searle | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
| IL135586A0 (en) * | 1997-11-21 | 2001-05-20 | Upjohn Co | α-HYDROXY, -AMINO, AND HALO DERIVATIVES OF β-SULFONYL HYDROXAMIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| WO2000037433A1 (en) * | 1998-12-18 | 2000-06-29 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| WO2000056704A1 (en) * | 1999-03-22 | 2000-09-28 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
| HK1045501A1 (zh) * | 1999-05-12 | 2002-11-29 | G.D. Searle & Co. | 作为基质金属蛋白酶抑制剂的异羟肟酸衍生物 |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| KR20020070285A (ko) * | 1999-11-23 | 2002-09-05 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
| EP1335898B1 (en) | 2000-09-29 | 2005-11-23 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
| CA2423744C (en) * | 2000-09-29 | 2012-04-03 | Prolifix Limited | Hydroxamic acid compounds comprising a sulfonamide linkage as hdac inhibitors |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| CA2479906C (en) * | 2002-04-03 | 2011-02-08 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors |
| MXPA04010555A (es) | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
| GB0226855D0 (en) * | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| EP2181704B1 (en) | 2002-12-30 | 2015-05-06 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| US8088737B2 (en) | 2003-04-04 | 2012-01-03 | Incyte Corporation | Compositions, methods and kits relating to Her-2 cleavage |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| MXPA06010974A (es) * | 2004-03-22 | 2007-04-23 | Southern Res Inst | Inhibidores nopeptidos de metaloproteinasas de matriz. |
| WO2005117882A2 (en) * | 2004-04-20 | 2005-12-15 | Incyte Corporation | Hydroxamic acid derivatives as metalloprotease inhibitors |
| WO2006004598A2 (en) * | 2004-06-01 | 2006-01-12 | The Scripps Research Institute | Proteomic analysis |
| US20050277897A1 (en) * | 2004-06-14 | 2005-12-15 | Ghannoum Ziad R | Handpiece tip |
| TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| CN101273013B (zh) * | 2005-09-27 | 2013-06-12 | 盐野义制药株式会社 | 具有pgd2受体拮抗活性的磺酰胺衍生物 |
| RU2487124C2 (ru) * | 2008-10-27 | 2013-07-10 | Мицубиси Танабе Фарма Корпорейшн | Новое амидное производное и его использование в качестве лекарственного средства |
| CA2777108A1 (en) | 2009-10-09 | 2011-04-14 | Zafgen Corporation | Sulphone compounds and methods of making and using same |
| CN103249735B (zh) | 2010-07-22 | 2016-04-06 | 扎夫根股份有限公司 | 三环化合物及其制备和使用方法 |
| MX344238B (es) | 2011-01-26 | 2016-12-07 | Zafgen Inc | Compuestos de tetrazol y métodos para preparar y usar los mismos. |
| CN103764641B (zh) | 2011-05-06 | 2016-10-26 | 扎夫根股份有限公司 | 部分饱和的三环化合物及其制备和使用方法 |
| BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
| EP2705036B1 (en) | 2011-05-06 | 2015-08-12 | Zafgen Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| CN104892457B (zh) * | 2011-07-25 | 2017-07-28 | 中国医学科学院医药生物技术研究所 | 一种异羟肟酸类衍生物、其药物组合物、制备方法及用途 |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| JP2015509102A (ja) | 2012-01-18 | 2015-03-26 | ザフゲン，インコーポレイテッド | 三環式スルホン化合物並びにその作製および使用方法 |
| MX2014008706A (es) | 2012-01-18 | 2015-03-05 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos. |
| MX2015005733A (es) | 2012-11-05 | 2016-02-10 | Zafgen Inc | Compuestos triciclicos para usarse en el tratamiento y/o control de obesidad. |
| AU2013337282A1 (en) | 2012-11-05 | 2015-05-21 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| NZ707773A (en) | 2012-11-05 | 2019-05-31 | Zafgen Inc | Methods of treating liver diseases |
| ES2620323T3 (es) * | 2012-11-09 | 2017-06-28 | Unilever N.V. | Composición y método para tratar sustratos |
| JP6803235B2 (ja) * | 2014-05-14 | 2020-12-23 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | タンパク質脱アセチル化酵素阻害剤およびタンパク質脱アセチル化酵素−タンパク質キナーゼ二重阻害剤としての複素環式ヒドロキサム酸ならびにその使用方法 |
| JP2019513703A (ja) * | 2016-03-17 | 2019-05-30 | ゼニオプロ ゲーエムベーハー | ＮｏｔｃｈシグナリングのエンハンサーならびにＮｏｔｃｈのアップレギュレーションにより治療可能ながんおよび悪性腫瘍の治療におけるその使用 |
| WO2020006384A1 (en) | 2018-06-29 | 2020-01-02 | Loyola University Of Chicago | Carborane hydroxamic acid matrix metalloproteinase inhibitors and agents for boron neutron capture therapy |
| CN111217722B (zh) * | 2020-03-06 | 2024-01-02 | 华东理工大学 | 偶氮芳基脲类衍生物及其制备方法和应用 |
| CN116102391B (zh) * | 2023-01-06 | 2025-01-28 | 湖大粤港澳大湾区创新研究院(广州增城) | 二硫转移试剂及其合成与应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148801A (en) | 1978-07-03 | 1979-04-10 | American Home Products Corporation | 3-[(Chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives |
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| US5103014A (en) * | 1987-09-30 | 1992-04-07 | American Home Products Corporation | Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives |
| GB2212153B (en) | 1987-11-16 | 1992-01-15 | Squibb & Sons Inc | Phenyl hydroxamic acids |
| GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5527945A (en) * | 1989-02-10 | 1996-06-18 | Basf Aktiengesellschaft | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom |
| ES2110433T3 (es) * | 1990-12-17 | 1998-02-16 | Sankyo Co | Derivados de pirazoles de actividad herbicida, su preparacion y su utilizacion. |
| US5525629A (en) * | 1992-04-07 | 1996-06-11 | British Bio-Technology Limited | Inhibition of cytokine production |
| US5376664A (en) | 1992-07-27 | 1994-12-27 | The Du Pont Merck Pharmaceutical Company | Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| GB9323165D0 (en) | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
| AU2394795A (en) | 1994-04-28 | 1995-11-29 | Du Pont Merck Pharmaceutical Company, The | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| GB9416897D0 (en) | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
| BR9509237A (pt) | 1994-10-05 | 1997-10-21 | Chiroscience Ltd | Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| CA2238306A1 (en) | 1995-12-08 | 1997-06-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| DE69624081T2 (de) | 1995-12-20 | 2003-06-12 | Agouron Pharmaceuticals, Inc. | Matrix-metalloprotease Inhibitoren |
| JP4358908B2 (ja) * | 1996-01-02 | 2009-11-04 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換（アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル）ヒドロキサム酸化合物 |
| KR20000022532A (ko) | 1996-06-27 | 2000-04-25 | 오노 야꾸힝 고교 가부시키가이샤 | 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물 |
| DE69729007T2 (de) * | 1996-08-07 | 2005-04-07 | Darwin Discovery Ltd., Slough | Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung |
| WO1998013340A1 (en) * | 1996-09-27 | 1998-04-02 | Pharmacia & Upjohn Company | β-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS |
| DE69801530T2 (de) * | 1997-01-13 | 2002-05-08 | Fuji Photo Film Co., Ltd. | Wärmeentwickelbares, photoempfindliches Farbmaterial |
| JP2000507975A (ja) * | 1997-02-07 | 2000-06-27 | ファイザー・インク | Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
| PT973512E (pt) * | 1997-02-27 | 2004-07-30 | Wyeth Corp | N-hidroxi-2-(alquil, aril ou heteroaril sulfanil, sulfinilou sulfonil)-alquil, aril ou heteroarilamidas substituidas na posicao 3 como inibidores de metaloproteinases da matriz |
| US6380258B2 (en) | 1997-03-04 | 2002-04-30 | G. D. Searle, L.L.C. | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds |
| US20010014688A1 (en) * | 1997-11-14 | 2001-08-16 | Thomas E. Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
-
1998
- 1998-03-04 US US09/230,209 patent/US6380258B2/en not_active Expired - Fee Related
- 1998-03-04 WO PCT/US1998/004300 patent/WO1998038859A1/en not_active Ceased
- 1998-03-04 BR BR9808166-7A patent/BR9808166A/pt not_active Application Discontinuation
- 1998-03-04 CA CA002283272A patent/CA2283272A1/en not_active Abandoned
- 1998-03-04 KR KR1019997008036A patent/KR20000075954A/ko not_active Ceased
- 1998-03-04 CN CN98804575A patent/CN1105114C/zh not_active Expired - Fee Related
- 1998-03-04 DK DK98911481T patent/DK0973392T3/da active
- 1998-03-04 CA CA002283145A patent/CA2283145A1/en not_active Abandoned
- 1998-03-04 EP EP98908964A patent/EP0983258A4/en not_active Withdrawn
- 1998-03-04 KR KR1019997008037A patent/KR20000075955A/ko not_active Ceased
- 1998-03-04 JP JP53879998A patent/JP2001518081A/ja not_active Abandoned
- 1998-03-04 EP EP98908949A patent/EP0983257A4/en not_active Withdrawn
- 1998-03-04 AT AT98911481T patent/ATE254599T1/de not_active IP Right Cessation
- 1998-03-04 IL IL13149598A patent/IL131495A0/xx unknown
- 1998-03-04 AU AU65424/98A patent/AU750130B2/en not_active Ceased
- 1998-03-04 KR KR1019997008028A patent/KR20000075946A/ko not_active Ceased
- 1998-03-04 IL IL13149498A patent/IL131494A/xx not_active IP Right Cessation
- 1998-03-04 CA CA002283275A patent/CA2283275A1/en not_active Abandoned
- 1998-03-04 ES ES98910177T patent/ES2209122T3/es not_active Expired - Lifetime
- 1998-03-04 EA EA199900792A patent/EA199900792A1/ru unknown
- 1998-03-04 PL PL98335732A patent/PL335732A1/xx unknown
- 1998-03-04 EP EP98911481A patent/EP0973392B1/en not_active Expired - Lifetime
- 1998-03-04 JP JP53879698A patent/JP2002513407A/ja not_active Abandoned
- 1998-03-04 PT PT98911481T patent/PT973392E/pt unknown
- 1998-03-04 ES ES98911481T patent/ES2206903T3/es not_active Expired - Lifetime
- 1998-03-04 JP JP53878098A patent/JP2002515901A/ja not_active Abandoned
- 1998-03-04 DE DE69819878T patent/DE69819878T2/de not_active Expired - Fee Related
- 1998-03-04 CA CA002282318A patent/CA2282318A1/en not_active Abandoned
- 1998-03-04 AU AU66865/98A patent/AU750303B2/en not_active Ceased
- 1998-03-04 EP EP98910177A patent/EP0984959B1/en not_active Expired - Lifetime
- 1998-03-04 BR BR9808214-0A patent/BR9808214A/pt not_active IP Right Cessation
- 1998-03-04 IL IL13149398A patent/IL131493A/en not_active IP Right Cessation
- 1998-03-04 NZ NZ337326A patent/NZ337326A/en unknown
- 1998-03-04 JP JP53798598A patent/JP2002515900A/ja not_active Abandoned
- 1998-03-04 CN CN98804628A patent/CN1254337A/zh active Pending
- 1998-03-04 CN CN98804577A patent/CN1253474A/zh active Pending
-
1999
- 1999-09-02 NO NO19994252A patent/NO315647B1/no unknown
-
2001
- 2001-11-29 US US09/997,552 patent/US6656954B2/en not_active Expired - Fee Related
-
2003
- 2003-10-27 US US10/695,278 patent/US20040097487A1/en not_active Abandoned