JP2002514602A5 - - Google Patents
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- Publication number
- JP2002514602A5 JP2002514602A5 JP2000547982A JP2000547982A JP2002514602A5 JP 2002514602 A5 JP2002514602 A5 JP 2002514602A5 JP 2000547982 A JP2000547982 A JP 2000547982A JP 2000547982 A JP2000547982 A JP 2000547982A JP 2002514602 A5 JP2002514602 A5 JP 2002514602A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tetracycline
- active ingredient
- dedimethylamino
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 24
- 239000004098 Tetracycline Substances 0.000 description 8
- 229960002180 tetracycline Drugs 0.000 description 8
- 235000019364 tetracycline Nutrition 0.000 description 8
- 229930101283 tetracycline Natural products 0.000 description 8
- 150000003522 tetracyclines Chemical class 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 3
- 102000003777 Interleukin-1 beta Human genes 0.000 description 3
- 108090000193 Interleukin-1 beta Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
- 239000004100 Oxytetracycline Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960000625 oxytetracycline Drugs 0.000 description 2
- XCCHQGIGHCRZOS-KBKZQPOHSA-N (4as,5as,6s,12ar)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical group C1=CC=C2[C@@](C)(O)[C@@H](C[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)C3)(O)C3=O)C3=C(O)C2=C1O XCCHQGIGHCRZOS-KBKZQPOHSA-N 0.000 description 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 102000004125 Interleukin-1alpha Human genes 0.000 description 1
- 108010082786 Interleukin-1alpha Proteins 0.000 description 1
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003855 balanced salt solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004175 meibomian gland Anatomy 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical group C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 201000002002 recurrent corneal erosion Diseases 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 229940042129 topical gel Drugs 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8487398P | 1998-05-08 | 1998-05-08 | |
| US60/084,873 | 1998-05-08 | ||
| PCT/US1999/009965 WO1999058131A1 (en) | 1998-05-08 | 1999-05-07 | Use of tetracyclines for treating meibomian gland disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002514602A JP2002514602A (ja) | 2002-05-21 |
| JP2002514602A5 true JP2002514602A5 (https=) | 2006-06-29 |
| JP4860038B2 JP4860038B2 (ja) | 2012-01-25 |
Family
ID=22187748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000547982A Expired - Fee Related JP4860038B2 (ja) | 1998-05-08 | 1999-05-07 | マイボーム腺疾病の処置におけるテトラサイクリン類の使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6455583B1 (https=) |
| EP (2) | EP1676579B1 (https=) |
| JP (1) | JP4860038B2 (https=) |
| AT (2) | ATE319456T1 (https=) |
| AU (1) | AU763164B2 (https=) |
| CA (1) | CA2331257C (https=) |
| DE (2) | DE69940227D1 (https=) |
| DK (2) | DK1676579T3 (https=) |
| ES (2) | ES2260912T3 (https=) |
| PT (2) | PT1075265E (https=) |
| TW (2) | TWI255714B (https=) |
| WO (1) | WO1999058131A1 (https=) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69940227D1 (de) * | 1998-05-08 | 2009-02-12 | Univ Miami | Verwendung von sub-antimikrobiellen tetracyclinen zur Behandlung von okularer Rosacea |
| US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| EP1171163A1 (en) * | 1999-04-27 | 2002-01-16 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
| US7211267B2 (en) | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
| EP2311440A1 (en) * | 2001-04-05 | 2011-04-20 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| EP2327409A1 (en) * | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| US20030073068A1 (en) * | 2001-10-15 | 2003-04-17 | Campbell Robert Edward | Methods for application of tear-based biomarkers to ophthalmic product evaluation and clinical study management |
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| US8192749B2 (en) | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
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| US20060036220A1 (en) * | 2003-01-22 | 2006-02-16 | Kohji Kawahara | Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye |
| WO2004091483A2 (en) | 2003-04-07 | 2004-10-28 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| AU2004261143B2 (en) * | 2003-07-25 | 2009-11-05 | Allergan Pharmaceuticals International Limited | A doxycycline metal complex in a solid dosage form |
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| US7981145B2 (en) * | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
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| US10105441B2 (en) | 2007-08-16 | 2018-10-23 | The Schepens Eye Research Institute, Inc. | Method for inhibiting or reducing dry eye disease by IL-1Ra |
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| FR3064482B1 (fr) * | 2017-04-03 | 2020-11-13 | Horus Pharma | Composition topique de doxycycline |
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| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| EP4551552A1 (en) * | 2022-07-08 | 2025-05-14 | ICM (Institut du Cerveau et de la Moelle Épinière) | Tetracycline derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788479A (fr) * | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
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| DE69940227D1 (de) * | 1998-05-08 | 2009-02-12 | Univ Miami | Verwendung von sub-antimikrobiellen tetracyclinen zur Behandlung von okularer Rosacea |
| US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
-
1999
- 1999-05-07 DE DE69940227T patent/DE69940227D1/de not_active Expired - Lifetime
- 1999-05-07 DK DK06004523T patent/DK1676579T3/da active
- 1999-05-07 AT AT99921754T patent/ATE319456T1/de active
- 1999-05-07 AT AT06004523T patent/ATE418989T1/de active
- 1999-05-07 JP JP2000547982A patent/JP4860038B2/ja not_active Expired - Fee Related
- 1999-05-07 ES ES99921754T patent/ES2260912T3/es not_active Expired - Lifetime
- 1999-05-07 ES ES06004523T patent/ES2320579T3/es not_active Expired - Lifetime
- 1999-05-07 DK DK99921754T patent/DK1075265T3/da active
- 1999-05-07 EP EP06004523A patent/EP1676579B1/en not_active Expired - Lifetime
- 1999-05-07 CA CA2331257A patent/CA2331257C/en not_active Expired - Fee Related
- 1999-05-07 DE DE69930252T patent/DE69930252T2/de not_active Expired - Lifetime
- 1999-05-07 PT PT99921754T patent/PT1075265E/pt unknown
- 1999-05-07 WO PCT/US1999/009965 patent/WO1999058131A1/en not_active Ceased
- 1999-05-07 PT PT06004523T patent/PT1676579E/pt unknown
- 1999-05-07 AU AU38879/99A patent/AU763164B2/en not_active Ceased
- 1999-05-07 US US09/307,182 patent/US6455583B1/en not_active Expired - Fee Related
- 1999-05-07 EP EP99921754A patent/EP1075265B1/en not_active Expired - Lifetime
- 1999-05-25 TW TW094111310A patent/TWI255714B/zh not_active IP Right Cessation
- 1999-05-25 TW TW088107469A patent/TWI255713B/zh not_active IP Right Cessation
-
2002
- 2002-08-22 US US10/225,341 patent/US20030114426A1/en not_active Abandoned
-
2005
- 2005-12-07 US US11/297,780 patent/US20060154901A1/en not_active Abandoned
-
2007
- 2007-10-11 US US11/974,435 patent/US20080214510A1/en not_active Abandoned
-
2010
- 2010-07-21 US US12/841,058 patent/US20110039805A1/en not_active Abandoned
-
2011
- 2011-12-01 US US13/309,145 patent/US20120088739A1/en not_active Abandoned
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