TWI255714B - Method for treating meibomian gland disease - Google Patents

Method for treating meibomian gland disease

Info

Publication number
TWI255714B
TWI255714B TW094111310A TW94111310A TWI255714B TW I255714 B TWI255714 B TW I255714B TW 094111310 A TW094111310 A TW 094111310A TW 94111310 A TW94111310 A TW 94111310A TW I255714 B TWI255714 B TW I255714B
Authority
TW
Taiwan
Prior art keywords
meibomian gland
gland disease
tetracycline
treating
treating meibomian
Prior art date
Application number
TW094111310A
Other languages
English (en)
Chinese (zh)
Other versions
TW200526232A (en
Inventor
Stephen C Pflugfelder
Balakrishna L Lokeshwar
Marie Selzer
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami filed Critical Univ Miami
Publication of TW200526232A publication Critical patent/TW200526232A/zh
Application granted granted Critical
Publication of TWI255714B publication Critical patent/TWI255714B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW094111310A 1998-05-08 1999-05-25 Method for treating meibomian gland disease TWI255714B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8487398P 1998-05-08 1998-05-08

Publications (2)

Publication Number Publication Date
TW200526232A TW200526232A (en) 2005-08-16
TWI255714B true TWI255714B (en) 2006-06-01

Family

ID=22187748

Family Applications (2)

Application Number Title Priority Date Filing Date
TW094111310A TWI255714B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease
TW088107469A TWI255713B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW088107469A TWI255713B (en) 1998-05-08 1999-05-25 Method for treating meibomian gland disease

Country Status (12)

Country Link
US (6) US6455583B1 (https=)
EP (2) EP1676579B1 (https=)
JP (1) JP4860038B2 (https=)
AT (2) ATE418989T1 (https=)
AU (1) AU763164B2 (https=)
CA (1) CA2331257C (https=)
DE (2) DE69930252T2 (https=)
DK (2) DK1676579T3 (https=)
ES (2) ES2320579T3 (https=)
PT (2) PT1676579E (https=)
TW (2) TWI255714B (https=)
WO (1) WO1999058131A1 (https=)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US6432934B1 (en) 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
AU4684000A (en) * 1999-04-27 2000-11-10 Antibody Systems, Inc. Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders
AU2002256092C1 (en) * 2001-04-05 2009-10-15 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US7211267B2 (en) * 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
EP2329826A1 (en) * 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of multiple sclerosis
US20030073068A1 (en) * 2001-10-15 2003-04-17 Campbell Robert Edward Methods for application of tear-based biomarkers to ophthalmic product evaluation and clinical study management
EP1494681A4 (en) * 2002-04-16 2008-08-06 Collagenex Pharm Inc PROCESS FOR THE SIMULTANEOUS TREATMENT OF OCULAR ROSACEA AND ACNE ROSACEA
US8192749B2 (en) * 2003-04-16 2012-06-05 Galderma Laboratories Inc. Methods of simultaneously treating ocular rosacea and acne rosacea
US20050153943A1 (en) * 2002-05-06 2005-07-14 Ashley Robert A. Methods of simultaneously treating mucositis and fungal infection
KR20050092429A (ko) * 2003-01-22 2005-09-21 니찌방 가부시기가이샤 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환치료약의 눈의 국소 조직으로의 이행 방법
ES2534827T3 (es) * 2003-04-07 2015-04-29 Supernus Pharmaceuticals, Inc. Formulaciones de tetraciclinas en dosis única diaria
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
CN103040773A (zh) * 2003-07-25 2013-04-17 沃纳奇尔科特有限责任公司 多西环素金属络合物固体剂型
WO2007024972A2 (en) * 2005-08-22 2007-03-01 Quick-Med Technologies, Inc. Non-leaching absorbent wound dressing
CN100340241C (zh) * 2004-06-28 2007-10-03 中山大学中山眼科中心 一种滴眼液及其制备方法与用途
AU2006206359B2 (en) * 2005-01-21 2011-03-31 Allergan Pharmaceuticals International Limited A tetracycline metal complex in a solid dosage form
US7544373B2 (en) 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US20070060988A1 (en) * 2005-07-18 2007-03-15 Grenon Stephen M Melting meibomian gland obstructions
US7981095B2 (en) 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
US7981146B2 (en) * 2006-05-15 2011-07-19 Tearscience Inc. Inner eyelid treatment for treating meibomian gland dysfunction
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US8950405B2 (en) * 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US8083787B2 (en) 2005-07-18 2011-12-27 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction
US8255039B2 (en) 2006-09-29 2012-08-28 Tearscience, Inc. Meibomian gland illuminating and imaging
US20090043365A1 (en) * 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US7981145B2 (en) 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US20080114423A1 (en) * 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
US8007524B2 (en) * 2006-05-15 2011-08-30 Tearscience, Inc. Heat treatment and heat loss reduction for treating meibomian gland dysfunction
US9314369B2 (en) * 2006-05-15 2016-04-19 Tearscience, Inc. System for inner eyelid treatment of meibomian gland dysfunction
US8128673B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US7976573B2 (en) * 2006-05-15 2011-07-12 Tearscience, Inc. Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8128674B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US7981147B2 (en) * 2006-05-15 2011-07-19 Tearscience, Inc. Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8137390B2 (en) 2006-05-15 2012-03-20 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
WO2008027069A1 (en) * 2006-08-21 2008-03-06 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction employing fluid
CN107468415A (zh) 2006-08-21 2017-12-15 眼泪科学公司 用于治疗腺体功能障碍的方法和器械
US8249695B2 (en) 2006-09-29 2012-08-21 Tearscience, Inc. Meibomian gland imaging
EP2121109B1 (en) 2007-01-17 2018-09-05 Tearscience, Inc. Apparatus for heat treatment for treating meibomian gland dysfunction
WO2008097850A1 (en) * 2007-02-02 2008-08-14 Warner Chilcott Company, Inc. Tretracycline compositions for topical administration
US20080188446A1 (en) * 2007-02-02 2008-08-07 Warner Chilcott Company Inc. Tetracycline compositions for topical administration
BRPI0808410A2 (pt) * 2007-02-28 2015-06-23 Aciex Therapeutics Inc Métodos e composições para normalizar secreções da glândula meibomiana
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
EP2187900B1 (en) * 2007-08-16 2016-11-09 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
USD614303S1 (en) 2008-02-06 2010-04-20 Tearscience, Inc. Eye treatment apparatus
USD613408S1 (en) 2008-02-06 2010-04-06 Tearscience, Inc. Eye treatment head gear
USD617443S1 (en) 2008-02-06 2010-06-08 Tearscience, Inc. Eye treatment goggles
WO2009120881A1 (en) * 2008-03-26 2009-10-01 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin desease using tetracycline family antibiotics
JP2011527709A (ja) * 2008-07-10 2011-11-04 インスパイアー ファーマシューティカルズ，インコーポレイティド 眼瞼炎の治療方法
EP2393355A4 (en) * 2009-01-23 2012-07-25 Inspire Pharmaceuticals Inc METHOD FOR TREATING A DRY EYE WITH AZITHROMYCIN
CN102573497B (zh) 2009-04-01 2015-09-09 眼泪科学公司 眼睛泪液膜成像仪器
USD638128S1 (en) 2009-10-06 2011-05-17 Tearscience, Inc. Ocular device design
US8721572B1 (en) 2010-06-10 2014-05-13 Eyedetec Medical, Inc. Systems, devices, kits and methods for therapy of the eye
US20120190653A1 (en) * 2011-01-20 2012-07-26 Dow Pharmaceutical Sciences, Inc. Therapeutic eye drop comprising doxycycline and a stabilizer
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
US9636355B2 (en) 2011-09-22 2017-05-02 Theo Holdings, Llc Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion
UA109359C2 (xx) * 2011-11-10 2015-08-10 Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном
US9931031B2 (en) 2012-02-21 2018-04-03 Massachusetts Eye & Ear Infirmary Meibomian gland dysfunction
WO2014005138A1 (en) * 2012-06-29 2014-01-03 Kerschensteiner Daniel A Colorimetric gelatinase assay
WO2014031857A2 (en) 2012-08-22 2014-02-27 Tearscience, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
PT106679B (pt) * 2012-11-27 2015-03-25 Hovione Farmaciencia Sa Formulações tópicas de tetraciclinas, sua preparação e usos
US9763827B2 (en) 2013-04-30 2017-09-19 Tear Film Innovations, Inc. Systems and methods for the treatment of eye conditions
EP3424558B1 (en) 2013-04-30 2020-07-22 Alcon Inc. Systems for the treatment of eye conditions
JP6615748B2 (ja) 2013-05-03 2019-12-04 テイアサイエンス・インコーポレーテツド マイボーム腺分析のためにマイボーム腺を画像化するための眼瞼照射システムおよび方法
US10130507B2 (en) 2013-08-03 2018-11-20 Michael C. Whitehurst Dry eye treatment device
WO2016022066A1 (en) * 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
CA2968316A1 (en) 2014-11-19 2016-05-26 Nestle Skin Health Sa Modified release doxycycline composition
KR20170134514A (ko) 2015-03-23 2017-12-06 바이오팜엑스 인코포레이티드 피부과 사용을 위한 약학 테트라사이클린 조성물
EP3178462A1 (de) 2015-12-07 2017-06-14 WDT-Wolz-Dental-Technik GmbH Verfahren zur herstellung eines polychrom und/oder räumlich polychrom oder eines monochrom gefärbten keramischen körpers und vorrichtung hierfür
US10974063B2 (en) 2016-06-30 2021-04-13 Alcon Inc. Light therapy for eyelash growth
KR102433437B1 (ko) 2016-08-29 2022-08-17 니콜 경난 리노드 안대
FR3064482B1 (fr) * 2017-04-03 2020-11-13 Horus Pharma Composition topique de doxycycline
AU2018385766B2 (en) 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
WO2024008951A1 (en) * 2022-07-08 2024-01-11 Icm (Institut Du Cerveau Et De La Moelle Épinière) Tetracycline derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788479A (fr) * 1971-09-06 1973-01-02 Medimpex Gyogyszerkulkereskede Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques
CA1263606A (en) * 1985-05-29 1989-12-05 Jeffrey P. Gilbard Non-toxic opthalmic preparations
IE74244B1 (en) * 1985-10-01 1997-07-16 Bimeda Res Dev Ltd A process for preparing an antibiotic composition
US4866049A (en) * 1987-08-10 1989-09-12 Spectra Pharmaceutical Services, Inc. Ophthalmic compositionn and method of using same
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
FR2660193B1 (fr) * 1990-04-03 1994-11-04 Philippe Maincent Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules.
US5340572A (en) * 1993-02-08 1994-08-23 Insite Vision Incorporated Alkaline ophthalmic suspensions
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US6015803A (en) * 1998-05-04 2000-01-18 Wirostko; Emil Antibiotic treatment of age-related macular degeneration
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US6432934B1 (en) * 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease

Also Published As

Publication number Publication date
US20030114426A1 (en) 2003-06-19
EP1075265B1 (en) 2006-03-08
ATE418989T1 (de) 2009-01-15
DE69930252D1 (de) 2006-05-04
DK1075265T3 (da) 2006-06-26
EP1676579A2 (en) 2006-07-05
JP4860038B2 (ja) 2012-01-25
DE69930252T2 (de) 2006-12-14
ATE319456T1 (de) 2006-03-15
EP1676579A3 (en) 2006-07-12
US6455583B1 (en) 2002-09-24
DK1676579T3 (da) 2009-03-16
PT1676579E (pt) 2009-03-24
US20110039805A1 (en) 2011-02-17
EP1075265A1 (en) 2001-02-14
US20120088739A1 (en) 2012-04-12
TWI255713B (en) 2006-06-01
US20080214510A1 (en) 2008-09-04
ES2320579T3 (es) 2009-05-25
DE69940227D1 (de) 2009-02-12
WO1999058131A1 (en) 1999-11-18
CA2331257C (en) 2012-01-03
ES2260912T3 (es) 2006-11-01
EP1676579B1 (en) 2008-12-31
JP2002514602A (ja) 2002-05-21
CA2331257A1 (en) 1999-11-18
US20060154901A1 (en) 2006-07-13
HK1089696A1 (en) 2006-12-08
AU763164B2 (en) 2003-07-17
PT1075265E (pt) 2006-07-31
TW200526232A (en) 2005-08-16
AU3887999A (en) 1999-11-29
HK1034899A1 (en) 2001-11-09

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