TWI255713B - Method for treating meibomian gland disease - Google Patents
Method for treating meibomian gland diseaseInfo
- Publication number
- TWI255713B TWI255713B TW088107469A TW88107469A TWI255713B TW I255713 B TWI255713 B TW I255713B TW 088107469 A TW088107469 A TW 088107469A TW 88107469 A TW88107469 A TW 88107469A TW I255713 B TWI255713 B TW I255713B
- Authority
- TW
- Taiwan
- Prior art keywords
- meibomian gland
- gland disease
- tetracycline
- treating
- treating meibomian
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8487398P | 1998-05-08 | 1998-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TWI255713B true TWI255713B (en) | 2006-06-01 |
Family
ID=22187748
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW088107469A TWI255713B (en) | 1998-05-08 | 1999-05-25 | Method for treating meibomian gland disease |
TW094111310A TWI255714B (en) | 1998-05-08 | 1999-05-25 | Method for treating meibomian gland disease |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094111310A TWI255714B (en) | 1998-05-08 | 1999-05-25 | Method for treating meibomian gland disease |
Country Status (13)
Country | Link |
---|---|
US (6) | US6455583B1 (zh) |
EP (2) | EP1075265B1 (zh) |
JP (1) | JP4860038B2 (zh) |
AT (2) | ATE418989T1 (zh) |
AU (1) | AU763164B2 (zh) |
CA (1) | CA2331257C (zh) |
DE (2) | DE69930252T2 (zh) |
DK (2) | DK1075265T3 (zh) |
ES (2) | ES2260912T3 (zh) |
HK (2) | HK1034899A1 (zh) |
PT (2) | PT1676579E (zh) |
TW (2) | TWI255713B (zh) |
WO (1) | WO1999058131A1 (zh) |
Families Citing this family (82)
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---|---|---|---|---|
DK1075265T3 (da) * | 1998-05-08 | 2006-06-26 | Univ Miami | Anvendelse af tetracycliner til behandling af sygdom i de Meibomske kirtler |
US6432934B1 (en) | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
AU4684000A (en) * | 1999-04-27 | 2000-11-10 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
KR100982753B1 (ko) * | 2001-04-05 | 2010-09-16 | 콜라제넥스 파마슈티칼스, 인크 | 테트라사이클린 화합물 및 테트라사이클린 유도체의 전달조절 |
US7211267B2 (en) | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
EP2329826A1 (en) * | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
US20030073068A1 (en) * | 2001-10-15 | 2003-04-17 | Campbell Robert Edward | Methods for application of tear-based biomarkers to ophthalmic product evaluation and clinical study management |
US8192749B2 (en) * | 2003-04-16 | 2012-06-05 | Galderma Laboratories Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
US7008631B2 (en) | 2002-04-16 | 2006-03-07 | Collagenex Pharmaceuticals, Inc. | Methods of simultaneously treating ocular rosacea and acne rosacea |
WO2003092629A2 (en) * | 2002-05-06 | 2003-11-13 | Collagenex Pharmaceuticals, Inc. | Methods of simultaneously treating mucositis and fungal infection |
JP4629578B2 (ja) * | 2003-01-22 | 2011-02-09 | ニチバン株式会社 | 眼疾患治療用経皮吸収型製剤 |
US7749532B2 (en) | 2003-04-07 | 2010-07-06 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
CN1893956A (zh) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | 多西环素金属络合物固体剂型 |
WO2007024972A2 (en) * | 2005-08-22 | 2007-03-01 | Quick-Med Technologies, Inc. | Non-leaching absorbent wound dressing |
CN100340241C (zh) * | 2004-06-28 | 2007-10-03 | 中山大学中山眼科中心 | 一种滴眼液及其制备方法与用途 |
WO2006078925A2 (en) * | 2005-01-21 | 2006-07-27 | Warner Chilcott Company, Inc. | A tetracycline metal complex in a solid dosage form |
US20080241235A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US7541347B2 (en) | 2007-04-02 | 2009-06-02 | Medicis Pharmaceutical Coropration | Minocycline oral dosage forms for the treatment of acne |
US7544373B2 (en) | 2007-04-02 | 2009-06-09 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US8252776B2 (en) | 2007-04-02 | 2012-08-28 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US7919483B2 (en) * | 2005-06-24 | 2011-04-05 | Medicis Pharmaceutical Corporation | Method for the treatment of acne |
US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
US8083787B2 (en) | 2005-07-18 | 2011-12-27 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction |
US20070060988A1 (en) * | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
US7981095B2 (en) * | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
US7981146B2 (en) * | 2006-05-15 | 2011-07-19 | Tearscience Inc. | Inner eyelid treatment for treating meibomian gland dysfunction |
US8255039B2 (en) | 2006-09-29 | 2012-08-28 | Tearscience, Inc. | Meibomian gland illuminating and imaging |
US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
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US7981147B2 (en) * | 2006-05-15 | 2011-07-19 | Tearscience, Inc. | Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
US7976573B2 (en) * | 2006-05-15 | 2011-07-12 | Tearscience, Inc. | Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
US8007524B2 (en) | 2006-05-15 | 2011-08-30 | Tearscience, Inc. | Heat treatment and heat loss reduction for treating meibomian gland dysfunction |
US8128674B2 (en) * | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
EP2056753B1 (en) | 2006-08-21 | 2016-06-15 | Tearscience, Inc. | Apparatus for treating gland dysfunction |
WO2008027069A1 (en) * | 2006-08-21 | 2008-03-06 | Tearscience, Inc. | Method and apparatus for treating meibomian gland dysfunction employing fluid |
US8249695B2 (en) | 2006-09-29 | 2012-08-21 | Tearscience, Inc. | Meibomian gland imaging |
SG177990A1 (en) | 2007-01-17 | 2012-02-28 | Tearscience Inc | Methods, systems, and apparatuses for heat treatment for treating meibomian gland dysfunction |
WO2008097850A1 (en) * | 2007-02-02 | 2008-08-14 | Warner Chilcott Company, Inc. | Tretracycline compositions for topical administration |
US20080188446A1 (en) * | 2007-02-02 | 2008-08-07 | Warner Chilcott Company Inc. | Tetracycline compositions for topical administration |
BRPI0808410A2 (pt) * | 2007-02-28 | 2015-06-23 | Aciex Therapeutics Inc | Métodos e composições para normalizar secreções da glândula meibomiana |
US20080241197A1 (en) * | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline dosage forms for the treatment of acne |
WO2009025763A2 (en) * | 2007-08-16 | 2009-02-26 | Schepens Eye Research Institute | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues |
US20090131303A1 (en) * | 2007-11-16 | 2009-05-21 | Bor-Shyue Hong | Methods and compositions for treating dry eye |
USD617443S1 (en) | 2008-02-06 | 2010-06-08 | Tearscience, Inc. | Eye treatment goggles |
USD613408S1 (en) | 2008-02-06 | 2010-04-06 | Tearscience, Inc. | Eye treatment head gear |
JP2011515494A (ja) * | 2008-03-26 | 2011-05-19 | エリック ドネンフェルド, | テトラサイクリンファミリー抗生物質を用いる、眼瞼縁および涙液膜機能の改善ならびに眼瞼縁疾患の処置のための方法 |
WO2010006306A1 (en) * | 2008-07-10 | 2010-01-14 | Inspire Pharmaceuticals, Inc. | Method of treating blepharitis |
WO2010017310A1 (en) | 2008-08-06 | 2010-02-11 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
US20100190734A1 (en) * | 2009-01-23 | 2010-07-29 | Romulus Kimbro Brazzell | Method of treating dry eye disease with azithromycin |
EP2413699B1 (en) | 2009-04-01 | 2019-11-20 | Tearscience, Inc. | Ocular surface interferometry (osi) apparatus for imaging an ocular tear film |
USD638128S1 (en) | 2009-10-06 | 2011-05-17 | Tearscience, Inc. | Ocular device design |
US8721572B1 (en) | 2010-06-10 | 2014-05-13 | Eyedetec Medical, Inc. | Systems, devices, kits and methods for therapy of the eye |
US20120190653A1 (en) * | 2011-01-20 | 2012-07-26 | Dow Pharmaceutical Sciences, Inc. | Therapeutic eye drop comprising doxycycline and a stabilizer |
US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
US9636355B2 (en) | 2011-09-22 | 2017-05-02 | Theo Holdings, Llc | Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion |
UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
WO2013126599A1 (en) * | 2012-02-21 | 2013-08-29 | Massachusetts Eye & Ear Infirmary | Meibomian gland dysfunction |
WO2014005138A1 (en) * | 2012-06-29 | 2014-01-03 | Kerschensteiner Daniel A | Colorimetric gelatinase assay |
WO2014031857A2 (en) | 2012-08-22 | 2014-02-27 | Tearscience, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
PT106679B (pt) * | 2012-11-27 | 2015-03-25 | Hovione Farmaciencia Sa | Formulações tópicas de tetraciclinas, sua preparação e usos |
ES2821002T3 (es) | 2013-04-30 | 2021-04-23 | Alcon Inc | Sistemas para el tratamiento de enfermedades del ojo |
US9763827B2 (en) | 2013-04-30 | 2017-09-19 | Tear Film Innovations, Inc. | Systems and methods for the treatment of eye conditions |
CN108670190A (zh) | 2013-05-03 | 2018-10-19 | 眼泪科学公司 | 用于对睑板腺进行成像以供睑板腺分析的眼睑照明系统和方法 |
US10130507B2 (en) | 2013-08-03 | 2018-11-20 | Michael C. Whitehurst | Dry eye treatment device |
US20170232024A1 (en) * | 2014-08-04 | 2017-08-17 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
WO2016079590A1 (en) | 2014-11-19 | 2016-05-26 | Dr. Reddy's Laboratories Ltd. | Modified release doxycycline composition |
JP6793715B2 (ja) | 2015-03-23 | 2020-12-02 | バイオファーミクス・インコーポレイテッドBioPharmX, Inc. | テトラサイクリンの皮膚用医薬組成物 |
EP3178462A1 (de) | 2015-12-07 | 2017-06-14 | WDT-Wolz-Dental-Technik GmbH | Verfahren zur herstellung eines polychrom und/oder räumlich polychrom oder eines monochrom gefärbten keramischen körpers und vorrichtung hierfür |
US10974063B2 (en) | 2016-06-30 | 2021-04-13 | Alcon Inc. | Light therapy for eyelash growth |
KR102433437B1 (ko) | 2016-08-29 | 2022-08-17 | 니콜 경난 리노드 | 안대 |
FR3064482B1 (fr) * | 2017-04-03 | 2020-11-13 | Horus Pharma | Composition topique de doxycycline |
SI3723739T1 (sl) | 2017-12-15 | 2024-08-30 | Tarsus Pharmaceuticals, Inc. | Paraziticidni pripravki na osnovi izoksazolina in njihova uporaba za zdravljenje blefaritisa |
WO2024008951A1 (en) * | 2022-07-08 | 2024-01-11 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Tetracycline derivatives |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE788479A (fr) * | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
CA1263606A (en) * | 1985-05-29 | 1989-12-05 | Jeffrey P. Gilbard | Non-toxic opthalmic preparations |
IE74244B1 (en) * | 1985-10-01 | 1997-07-16 | Bimeda Res Dev Ltd | A process for preparing an antibiotic composition |
US4866049A (en) * | 1987-08-10 | 1989-09-12 | Spectra Pharmaceutical Services, Inc. | Ophthalmic compositionn and method of using same |
US5360611A (en) * | 1988-10-03 | 1994-11-01 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation |
FR2660193B1 (fr) * | 1990-04-03 | 1994-11-04 | Philippe Maincent | Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules. |
US5340572A (en) * | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US6015803A (en) * | 1998-05-04 | 2000-01-18 | Wirostko; Emil | Antibiotic treatment of age-related macular degeneration |
DK1075265T3 (da) * | 1998-05-08 | 2006-06-26 | Univ Miami | Anvendelse af tetracycliner til behandling af sygdom i de Meibomske kirtler |
US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
-
1999
- 1999-05-07 DK DK99921754T patent/DK1075265T3/da active
- 1999-05-07 ES ES99921754T patent/ES2260912T3/es not_active Expired - Lifetime
- 1999-05-07 ES ES06004523T patent/ES2320579T3/es not_active Expired - Lifetime
- 1999-05-07 DE DE69930252T patent/DE69930252T2/de not_active Expired - Lifetime
- 1999-05-07 DK DK06004523T patent/DK1676579T3/da active
- 1999-05-07 EP EP99921754A patent/EP1075265B1/en not_active Expired - Lifetime
- 1999-05-07 PT PT06004523T patent/PT1676579E/pt unknown
- 1999-05-07 EP EP06004523A patent/EP1676579B1/en not_active Expired - Lifetime
- 1999-05-07 PT PT99921754T patent/PT1075265E/pt unknown
- 1999-05-07 JP JP2000547982A patent/JP4860038B2/ja not_active Expired - Fee Related
- 1999-05-07 AU AU38879/99A patent/AU763164B2/en not_active Ceased
- 1999-05-07 AT AT06004523T patent/ATE418989T1/de active
- 1999-05-07 AT AT99921754T patent/ATE319456T1/de active
- 1999-05-07 CA CA2331257A patent/CA2331257C/en not_active Expired - Fee Related
- 1999-05-07 WO PCT/US1999/009965 patent/WO1999058131A1/en active IP Right Grant
- 1999-05-07 US US09/307,182 patent/US6455583B1/en not_active Expired - Fee Related
- 1999-05-07 DE DE69940227T patent/DE69940227D1/de not_active Expired - Lifetime
- 1999-05-25 TW TW088107469A patent/TWI255713B/zh not_active IP Right Cessation
- 1999-05-25 TW TW094111310A patent/TWI255714B/zh not_active IP Right Cessation
-
2001
- 2001-08-07 HK HK01105481A patent/HK1034899A1/xx not_active IP Right Cessation
-
2002
- 2002-08-22 US US10/225,341 patent/US20030114426A1/en not_active Abandoned
-
2005
- 2005-12-07 US US11/297,780 patent/US20060154901A1/en not_active Abandoned
-
2006
- 2006-10-20 HK HK06111578.1A patent/HK1089696A1/xx not_active IP Right Cessation
-
2007
- 2007-10-11 US US11/974,435 patent/US20080214510A1/en not_active Abandoned
-
2010
- 2010-07-21 US US12/841,058 patent/US20110039805A1/en not_active Abandoned
-
2011
- 2011-12-01 US US13/309,145 patent/US20120088739A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69940227D1 (de) | 2009-02-12 |
EP1075265B1 (en) | 2006-03-08 |
DE69930252D1 (de) | 2006-05-04 |
WO1999058131A1 (en) | 1999-11-18 |
US6455583B1 (en) | 2002-09-24 |
JP4860038B2 (ja) | 2012-01-25 |
DK1676579T3 (da) | 2009-03-16 |
HK1034899A1 (en) | 2001-11-09 |
DK1075265T3 (da) | 2006-06-26 |
ATE418989T1 (de) | 2009-01-15 |
AU3887999A (en) | 1999-11-29 |
US20060154901A1 (en) | 2006-07-13 |
HK1089696A1 (en) | 2006-12-08 |
US20110039805A1 (en) | 2011-02-17 |
TWI255714B (en) | 2006-06-01 |
PT1075265E (pt) | 2006-07-31 |
US20120088739A1 (en) | 2012-04-12 |
EP1676579A3 (en) | 2006-07-12 |
TW200526232A (en) | 2005-08-16 |
PT1676579E (pt) | 2009-03-24 |
EP1676579B1 (en) | 2008-12-31 |
EP1075265A1 (en) | 2001-02-14 |
EP1676579A2 (en) | 2006-07-05 |
CA2331257A1 (en) | 1999-11-18 |
ATE319456T1 (de) | 2006-03-15 |
ES2260912T3 (es) | 2006-11-01 |
US20080214510A1 (en) | 2008-09-04 |
JP2002514602A (ja) | 2002-05-21 |
AU763164B2 (en) | 2003-07-17 |
ES2320579T3 (es) | 2009-05-25 |
DE69930252T2 (de) | 2006-12-14 |
US20030114426A1 (en) | 2003-06-19 |
CA2331257C (en) | 2012-01-03 |
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