JP2002512615A - 微生物感染を予防または制御するための共生Bacillus芽胞の局所的使用 - Google Patents
微生物感染を予防または制御するための共生Bacillus芽胞の局所的使用Info
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.Bacillus種を、哺乳動物の皮膚または粘膜への局所適用のために適切である 薬学的に受容可能なキャリア中に含む、組成物。 2.前記Bacillus種が、芽胞の形態で前記組成物中に含まれている、請求項1に 記載の組成物。 3.前記Bacillus種が乾燥細胞塊の形態で前記組成物中に含まれている、請求項 1に記載の組成物。 4.前記Bacillus種が、Bacillus coagulans、Bacillus subtilis、Bacillus la terosporus、およびBacillus laevolacticusからなる群から選択される、請求項 1に記載の組成物。 5.前記組成物が、組成物1グラムあたり、103〜1012の生存可能な細菌または 芽胞を含む、請求項1に記載の組成物。 6.フルクト-オリゴサッカライド(FOS)の有効量をさらに含む、請求項1に記 載の組成物。 7.前記FOSが、組成物1グラムあたり、約10〜1000ミリグラムの量で存在する 、請求項6に記載の組成物。 8.前記FOSが、組成物1グラムあたり、約100〜500ミリグラムの量で存在する 、請求項6に記載の方法。 9.前記キャリアが、エマルジョン、クリーム、ローション、ゲル、オイル、軟 膏、懸濁液、エアロゾルスプレー、パウダー、エアロゾルパウダー、または半固 体処方物である、請求項1に記載の組成物。 10.Bacillus coagulans株の細胞外産物を、哺乳動物の皮膚または粘膜への局 所適用に適切な薬学的に受容可能なキャリア中に含む、組成物。 11.前記細胞外産物が、Baillus coagulans株の培養物の上清または濾液であ る、請求項10に記載の組成物。 12.前記キャリアが、エマルジョン、クリーム、ローション、ゲル、オイル、 軟膏、懸濁液、エアロゾルスプレー、パウダー、エアロゾルパウダー、または半 固体処方物である、請求項10に記載の組成物。 13.約1〜75重量%のエミュオイルをさらに含む、請求項10に記載の組成物 。 14.細菌、酵母、真菌、またはウイルスの感染を予防する方法であって、以下 : 哺乳動物の皮膚または粘膜に、Bacillus種を含む共生物質組成物を局所的に適 用する工程;および 該Bacillus種が、細菌、酵母、真菌、またはウイルスの増殖を阻害するのに十 分な時間、局所的に増殖することを可能にする工程、 を包含する、方法。 15.前記適用する工程の後に、前記共生物質組成物中に前記Bacillus種の芽胞 を提供する工程、および該芽胞が発芽することを可能にする工程をさらに包含す る、請求項14に記載の方法。 16.前記Bacillus種が、Bacillus coagulans、Bacillus subtilis、Bacillus laterosporus、およびBacillus laevolacticusからなる群から選択される、請求 項14に記載の方法。 17.前記組成物が、組成物1グラムあたり、103〜1012の生存可能な細菌また は芽胞を含む、請求項14に記載の方法。 18.前記投与する工程が、1日あたり、108〜1010の生存可能な細菌または芽 胞を適用する工程を包含する、請求項14に記載の方法。 19.前記投与する工程が、1日あたり、5×108〜109の生存可能な細菌または 芽胞を適用する工程を包含する、請求項14に記載の方法。 20.有効量のフルクト-オリゴサッカライド(FOS)をさらに包含する、請求項 14に記載の方法。 21.前記FOSが、組成物1グラムあたり、約10〜1000ミリグラムの量で存在す る、請求項20に記載の方法。 22.前記FOSが、組成物1グラムあたり、約100〜500ミリグラムの量で存在す る、請求項20に記載の方法。 23.前記Bacillus種が増殖することを可能にする工程が、Staphylococcus種、 Pseudomonas種、Escherichia coli、Proteus種、Klebsiella種、Candida種、お よびTrichophyton種からなる群から選択される1つ以上の微生物の増殖を阻害す る、請求項14に記載の方法。 24.前記適用する工程が、クリーム、ローション、ゲル、オイル、軟膏、懸濁 液、エアロゾルスプレー、パウダー、エアロゾルパウダー、または半固体処方物 の形態の共生物質組成物を適用する工程を包含する、請求項14に記載の方法。 25.細菌、酵母、真菌、ウイルス、またはこれらの組み合わせの増殖を阻害す る方法であって、以下: 皮膚または粘膜に、Bacilllus coagulans株の細胞外産物を含む組成物を局所 的に適用する工程;および 該組成物が、細菌、酵母、真菌、ウイルス、またはこれらの任意の組み合わせ の増殖を阻害するのに十分な時間存在することを可能にする工程、 を包含する、方法。 26.前記適用する工程が、クリーム、ローション、ゲル、オイル、軟膏、懸濁 液、エアロゾルスプレー、パウダー、エアロゾルパウダー、または半固体処方物 の形態の組成物を適用する工程を包含する、請求項25に記載の方法。 27.前記組成物が、約1〜75重量%のエミュオイルをさらに含む、請求項25 に記載の方法。 28.可撓性の物品および該可撓性の物品に適用された有効量のBacillus種を含 む製品であって、ここで、該可撓性の物品が、哺乳動物の皮膚または粘膜によっ て着用されるかまたはそれらに付着して、単離されたBacillus種の共生物質活性 が、該皮膚または該粘膜の付近でまたは該皮膚または該粘膜上で生じることを可 能にすることを意図されている、製品。 29.前記Bacillus種が、Bacillus coagulans、Bacillus subtilis、Bacillus laterosporus、およびBacillus laevolacticusからなる群から選択される、請求 項28に記載の製品。 30.前記有効量が、物品あたり、約103〜1012の生存可能な細菌または芽胞で ある、請求項28に記載の製品。 31.有効量のフルクト-オリゴサッカライド(FOS)をさらに含む、請求項28 に記載の製品。 32.前記FOSが、物品あたり、約10〜1000ミリグラムの量で存在する、請求項 31に記載の製品。 33.前記物品が、絆創膏、タンポン、女性の生理用ナプキン、または衣服の物 品からなる群から選択される、請求項28に記載の製品。 34.細菌、酵母、真菌、ウイルス、またはこれらの任意の組み合わせの増殖を 阻害する方法であって、以下: Bacillus種を含む組成物を、固体表面に適用する工程; 該Bacillus種が表面上に適用された該固体表面を、哺乳動物の皮膚または粘膜 と接触させる工程;および 該固体表面を、該単離されたBacillus種の共生物質活性の開始を可能にするの に十分な時間、該皮膚または粘膜に接触させ、該皮膚もしくは粘膜の付近のまた は該皮膚もしくは粘膜上での、細菌、酵母、真菌、ウイルス、またはこれらの組 み合わせの増殖を阻害する工程、 を包含する、方法。 35.前記固体表面が、オムツ、皮膚または粘膜を拭うための柔軟な物質、皮膚 パッチ、粘着テープ、吸収パッド、タンポン、または衣服の物品からなる群から 選択される可撓性の物品を包含する、請求項34に記載の方法。 36.前記適用する工程が、前記組成物を繊維性または非繊維性の固体マトリッ クスに染み込ませる工程を包含する、請求項34に記載の方法。 37.前記Bacillus種が、芽胞の形態で、前記組成物中に含まれる、請求項34 に記載の方法。 38.前記Bacillus種が、乾燥細胞塊の形態で、前記組成物中に含まれている、 請求項34に記載の方法。 39.前記Bacillus種が、Bacillus coagulans、Bacillus subtilis、Bacillus laterosporus、およびBacillus laevolacticusからなる群から選択される、請求 項34に記載の方法。 40.前記組成物が、組成物1グラムあたり、103〜1012の生存可能な細菌また は芽胞を含む、請求項34に記載の方法。 41.有効量のフルクト-オリゴサッカライド(FOS)をさらに含む、請求項34 に記載の方法。 42.前記FOSが、組成物1グラムあたり、約10〜1000ミリグラムの量で存在す る、請求項41に記載の方法。 43.前記FOSが、組成物1グラムあたり、約100〜500ミリグラムの量で存在す る、請求項41に記載の方法。 44.細菌、酵母、真菌、ウイルス、またはこれらの組み合わせの増殖を阻害す るための治療システムであって、ラベルおよび請求項1に記載のBacillusを含有 する組成物を含む容器を含み、ここで、該ラベルは、該増殖を阻害するための組 成物の使用のための使用説明書を含む、治療システム。
Applications Claiming Priority (3)
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US4464397P | 1997-04-18 | 1997-04-18 | |
US60/044,643 | 1997-04-18 | ||
PCT/US1998/007307 WO1998047374A1 (en) | 1997-04-18 | 1998-04-10 | Topical use of probiotic bacillus spores to prevent or control microbial infections |
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JP2009185292A Division JP2009269922A (ja) | 1997-04-18 | 2009-08-07 | 微生物感染を予防または制御するための共生Bacillus芽胞の局所的使用 |
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JP2002512615A true JP2002512615A (ja) | 2002-04-23 |
JP2002512615A5 JP2002512615A5 (ja) | 2005-11-24 |
JP4678896B2 JP4678896B2 (ja) | 2011-04-27 |
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JP2009185292A Withdrawn JP2009269922A (ja) | 1997-04-18 | 2009-08-07 | 微生物感染を予防または制御するための共生Bacillus芽胞の局所的使用 |
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US (2) | US20090186057A1 (ja) |
EP (2) | EP0975227B1 (ja) |
JP (2) | JP4678896B2 (ja) |
AT (2) | ATE308987T1 (ja) |
AU (1) | AU749001B2 (ja) |
CA (1) | CA2287451C (ja) |
DE (2) | DE69842080D1 (ja) |
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WO (1) | WO1998047374A1 (ja) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005299025A (ja) * | 2004-04-13 | 2005-10-27 | Nami Kazuji | 抗ウイルス性バイオシート繊維体 |
JP2007537270A (ja) * | 2004-05-11 | 2007-12-20 | ガネデン バイオテック インコーポレイテッド | 自己免疫障害の食事管理のための方法および組成物 |
JP2010509982A (ja) * | 2006-11-17 | 2010-04-02 | エスセーアー・ハイジーン・プロダクツ・アーベー | 微生物阻害組成物を含む衛生用品 |
JP2010512865A (ja) * | 2006-12-19 | 2010-04-30 | フェロサン エーエス | 乳酸菌を含む創傷または組織包帯 |
JP2010526539A (ja) * | 2007-05-11 | 2010-08-05 | マナテック、インク. | 選択された非病原性微生物による天然ポリサッカライドの加工、並びにその作製方法及び使用方法 |
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JP2011529484A (ja) * | 2008-07-29 | 2011-12-08 | ロレアル | 油性皮膚の処置の為の微生物の化粧的使用 |
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Also Published As
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ATE308987T1 (de) | 2005-11-15 |
AU749001B2 (en) | 2002-06-13 |
EP0975227A4 (en) | 2003-05-21 |
EP1629846A2 (en) | 2006-03-01 |
ES2255730T3 (es) | 2006-07-01 |
EP0975227A1 (en) | 2000-02-02 |
ATE493139T1 (de) | 2011-01-15 |
JP4678896B2 (ja) | 2011-04-27 |
AU7110298A (en) | 1998-11-13 |
US20090186057A1 (en) | 2009-07-23 |
EP1629846B1 (en) | 2010-12-29 |
DE69832267D1 (de) | 2005-12-15 |
DE69842080D1 (de) | 2011-02-10 |
EP0975227B1 (en) | 2005-11-09 |
CA2287451A1 (en) | 1998-10-29 |
CA2287451C (en) | 2014-06-10 |
EP1629846A3 (en) | 2008-02-27 |
DE69832267T2 (de) | 2006-08-10 |
WO1998047374A1 (en) | 1998-10-29 |
JP2009269922A (ja) | 2009-11-19 |
US20110274676A1 (en) | 2011-11-10 |
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