JP2002511449A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002511449A5 JP2002511449A5 JP2000543432A JP2000543432A JP2002511449A5 JP 2002511449 A5 JP2002511449 A5 JP 2002511449A5 JP 2000543432 A JP2000543432 A JP 2000543432A JP 2000543432 A JP2000543432 A JP 2000543432A JP 2002511449 A5 JP2002511449 A5 JP 2002511449A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- phenyl
- atom
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 nitro, amino Chemical group 0.000 description 47
- 125000000217 alkyl group Chemical group 0.000 description 40
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 40
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 30
- 229910052731 fluorine Inorganic materials 0.000 description 23
- 229910052801 chlorine Inorganic materials 0.000 description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 20
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 19
- 125000001153 fluoro group Chemical group F* 0.000 description 19
- 125000001309 chloro group Chemical group Cl* 0.000 description 17
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 description 16
- 125000003277 amino group Chemical group 0.000 description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 15
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 14
- 125000006563 (C1-3) alkylaminocarbonyl group Chemical group 0.000 description 13
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 description 13
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 13
- 125000004093 cyano group Chemical group *C#N 0.000 description 13
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 description 13
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 12
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 12
- 125000006842 cycloalkyleneimino group Chemical group 0.000 description 12
- 229910052740 iodine Inorganic materials 0.000 description 12
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 10
- 125000001424 substituent group Chemical group 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 9
- 125000002883 imidazolyl group Chemical group 0.000 description 9
- 125000004433 nitrogen atom Chemical group N* 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 6
- 125000004430 oxygen atom Chemical group O* 0.000 description 6
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 125000001841 imino group Chemical group [H]N=* 0.000 description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 4
- 125000005505 thiomorpholino group Chemical group 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 125000003282 alkyl amino group Chemical group 0.000 description 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 3
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- 150000001721 carbon Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 125000006239 protecting group Chemical group 0.000 description 3
- 125000004076 pyridyl group Chemical group 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 2
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 description 2
- 125000006164 6-membered heteroaryl group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 125000005805 dimethoxy phenyl group Chemical group 0.000 description 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 150000003951 lactams Chemical group 0.000 description 2
- 125000003506 n-propoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 2
- 125000002971 oxazolyl group Chemical group 0.000 description 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 2
- 125000003386 piperidinyl group Chemical group 0.000 description 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 125000004434 sulfur atom Chemical group 0.000 description 2
- 125000000335 thiazolyl group Chemical group 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000003944 tolyl group Chemical group 0.000 description 2
- XPHWQPIEXCZQNY-FLWNBWAVSA-N (3z)-n,n-diethyl-3-[(n-methyl-4-piperidin-1-ylanilino)-phenylmethylidene]-2-oxo-1h-indole-5-carboxamide Chemical compound C12=CC(C(=O)N(CC)CC)=CC=C2NC(=O)\C1=C(C=1C=CC=CC=1)/N(C)C(C=C1)=CC=C1N1CCCCC1 XPHWQPIEXCZQNY-FLWNBWAVSA-N 0.000 description 1
- ZUMBAMUYEPVFSC-DQSJHHFOSA-N (3z)-n,n-dimethyl-3-[(n-methyl-4-piperidin-1-ylanilino)-phenylmethylidene]-2-oxo-1h-indole-5-carboxamide Chemical compound C12=CC(C(=O)N(C)C)=CC=C2NC(=O)\C1=C(C=1C=CC=CC=1)/N(C)C(C=C1)=CC=C1N1CCCCC1 ZUMBAMUYEPVFSC-DQSJHHFOSA-N 0.000 description 1
- 125000006602 (C1-C3) alkylsulfonylamino group Chemical group 0.000 description 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 0 **(C=C1)C=CC(N(*)C2=*)=C1C2=C(*)N(*)* Chemical compound **(C=C1)C=CC(N(*)C2=*)=C1C2=C(*)N(*)* 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 150000003855 acyl compounds Chemical class 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 238000005932 reductive alkylation reaction Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19816624.9 | 1998-04-15 | ||
| DE19816624A DE19816624A1 (de) | 1998-04-15 | 1998-04-15 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/002436 WO1999052869A1 (de) | 1998-04-15 | 1999-04-10 | Substituierte indolinone mit inhibierender wirkung auf kinasen und cyclin/cdk-komplexe |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002511449A JP2002511449A (ja) | 2002-04-16 |
| JP2002511449A5 true JP2002511449A5 (enExample) | 2006-07-06 |
| JP4015365B2 JP4015365B2 (ja) | 2007-11-28 |
Family
ID=7864562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000543432A Expired - Lifetime JP4015365B2 (ja) | 1998-04-15 | 1999-04-10 | 新規な置換インドリノン、それらの調製及び医薬組成物としてのそれらの使用 |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1071665B1 (enExample) |
| JP (1) | JP4015365B2 (enExample) |
| KR (1) | KR100588250B1 (enExample) |
| CN (1) | CN100338036C (enExample) |
| AR (1) | AR015763A1 (enExample) |
| AT (1) | ATE251138T1 (enExample) |
| AU (1) | AU749829B2 (enExample) |
| BG (1) | BG64443B1 (enExample) |
| BR (1) | BR9909688A (enExample) |
| CA (1) | CA2323111C (enExample) |
| CO (1) | CO5011040A1 (enExample) |
| DE (2) | DE19816624A1 (enExample) |
| DK (1) | DK1071665T3 (enExample) |
| EA (1) | EA003532B1 (enExample) |
| EE (1) | EE04432B1 (enExample) |
| ES (1) | ES2207209T3 (enExample) |
| HU (1) | HUP0101568A3 (enExample) |
| ID (1) | ID26420A (enExample) |
| IL (1) | IL138036A0 (enExample) |
| MY (1) | MY122357A (enExample) |
| NO (1) | NO317298B1 (enExample) |
| NZ (1) | NZ507967A (enExample) |
| PL (1) | PL343314A1 (enExample) |
| PT (1) | PT1071665E (enExample) |
| SK (1) | SK283824B6 (enExample) |
| TR (1) | TR200002980T2 (enExample) |
| TW (1) | TW510897B (enExample) |
| UA (1) | UA63009C2 (enExample) |
| WO (1) | WO1999052869A1 (enExample) |
| YU (1) | YU59800A (enExample) |
| ZA (1) | ZA200004623B (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| GB9904995D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Substituted aza-oxindole derivatives |
| GB9904932D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy |
| GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| DE19924401A1 (de) * | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| WO2001016130A1 (de) * | 1999-08-27 | 2001-03-08 | Boehringer Ingelheim Pharma Kg | Substituierte indolinone als tyrosinkinase inhibitoren |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| US6573293B2 (en) | 2000-02-15 | 2003-06-03 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| WO2002048114A1 (en) * | 2000-11-27 | 2002-06-20 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| DE10117204A1 (de) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6599902B2 (en) | 2001-05-30 | 2003-07-29 | Sugen, Inc. | 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| DE60318188T2 (de) | 2002-03-26 | 2008-12-11 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| DE602004017884D1 (de) * | 2003-10-03 | 2009-01-02 | Boehringer Ingelheim Pharma | Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren |
| DE102004012070A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| ES2326907T3 (es) | 2004-12-27 | 2009-10-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso. |
| AU2006254758B2 (en) * | 2005-06-10 | 2012-04-05 | Merck Patent Gmbh | Oxindoles as kinase inhibitors |
| WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
| BRPI0720131A2 (pt) | 2006-12-06 | 2014-02-04 | Boehringer Ingelheim Int | Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos. |
| KR20110020902A (ko) | 2008-06-06 | 2011-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 유사체, 이의 제조방법, 약제학적 조성물 및 이의 용도 |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
| EP2780322B1 (en) * | 2011-11-14 | 2018-05-16 | Ligand Pharmaceuticals, Inc. | Methods and compositions associated with the granulocyte colony-stimulating factor receptor |
| WO2014150252A1 (en) * | 2013-03-15 | 2014-09-25 | Ligand Pharmaceuticals Incorporated | Methods of treatment associated with the granulocyte colony-stimulating factor receptor |
| CN107033064B (zh) * | 2017-04-28 | 2019-07-09 | 西安医学院 | 一种3-(吗啉取代芳亚胺基)吲哚类化合物及其制备方法和应用 |
| CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| DE19824922A1 (de) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
-
1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/de not_active Withdrawn
-
1999
- 1999-04-10 ID IDW20002062A patent/ID26420A/id unknown
- 1999-04-10 NZ NZ507967A patent/NZ507967A/xx unknown
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/xx unknown
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/hu unknown
- 1999-04-10 PT PT99920635T patent/PT1071665E/pt unknown
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/pt not_active Application Discontinuation
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/de not_active Ceased
- 1999-04-10 DK DK99920635T patent/DK1071665T3/da active
- 1999-04-10 ES ES99920635T patent/ES2207209T3/es not_active Expired - Lifetime
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/sk unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/zh not_active Expired - Fee Related
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 EA EA200001021A patent/EA003532B1/ru not_active IP Right Cessation
- 1999-04-10 AT AT99920635T patent/ATE251138T1/de active
- 1999-04-10 YU YU59800A patent/YU59800A/sh unknown
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/ja not_active Expired - Lifetime
- 1999-04-10 EP EP99920635A patent/EP1071665B1/de not_active Expired - Lifetime
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 PL PL99343314A patent/PL343314A1/xx not_active Application Discontinuation
- 1999-04-10 IL IL13803699A patent/IL138036A0/xx not_active IP Right Cessation
- 1999-04-10 DE DE59907199T patent/DE59907199D1/de not_active Expired - Lifetime
- 1999-04-10 EE EEP200000598A patent/EE04432B1/xx not_active IP Right Cessation
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/ko not_active Expired - Fee Related
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 TW TW088105963A patent/TW510897B/zh active
- 1999-04-14 AR ARP990101700A patent/AR015763A1/es active IP Right Grant
- 1999-04-14 CO CO99022218A patent/CO5011040A1/es unknown
- 1999-10-04 UA UA2000116456A patent/UA63009C2/uk unknown
-
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/xx unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/bg unknown
- 2000-10-13 NO NO20005151A patent/NO317298B1/no unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002511449A5 (enExample) | ||
| RU2348620C2 (ru) | Производные тиазола в качестве модуляторов каннабиноидного рецептора | |
| EP0564924B1 (en) | 2-Oxoethyl derivatives as immunosuppressants | |
| US20100087485A1 (en) | 4-aminopiperidine derivatives | |
| TW200640900A (en) | 1-(2h)-isoquinolone derivative | |
| HUP0402376A2 (hu) | Imidazol-4-karboxamid-származékok, előállításuk és az ezeket tartalmazó, elhízás kezelésére alkalmas gyógyszerkészítmények | |
| KR20010081112A (ko) | 벤즈아미드 유도체들 및 그들의 ａｐｏｂ-100 분비억제제로서의 용도 | |
| JP2006504761A5 (enExample) | ||
| WO2005095409A3 (en) | Tetrahydroquinoline derivatives and a process for preparing the same | |
| AU2008239018A1 (en) | 5-membered heterocyclic derivative and use thereof for medical purposes | |
| HUP0302966A2 (hu) | Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CA3208103A1 (en) | Anti-viral compounds | |
| JP2007528883A5 (enExample) | ||
| ATE302778T1 (de) | N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| AU2009262219B2 (en) | Piperidinyl derivative as a modulator of chemokine receptor activity | |
| JP2018517693A (ja) | 選択的ヒストンデアセチラーゼ阻害剤としてのヘテロ環状アルキル誘導体化合物及びこれを含有する薬剤学的組成物 | |
| EP0825983B1 (en) | Process for the preparation of 2,2'-bipyrrolyl-pyrromethene (prodigiosins) derivatives | |
| CA2354213A1 (en) | N-triazolylmethyl-piperazine compounds with neurokinin-receptor antagonist activity | |
| WO2006133588A1 (en) | ARYL UREA COMPOUNDS AS β-SECRETASE INHIBITORS | |
| JP3077047B2 (ja) | 新規ピペラジン誘導体 | |
| CA2511984A1 (en) | Indazolamides with analgesic activity | |
| KR101950057B1 (ko) | 파록세틴 유도체 | |
| NO20063111L (no) | Fremgangsmate for fremstilling av tiazolpyrimidiner | |
| JPH09508404A (ja) | フェニルピロール誘導体およびそのドーパミンｄ▲下３▼アンタゴニストとしての使用 | |
| NO20065789L (no) | Cinnamidforbindelse |