JP2002505261A - 知覚鈍麻歯科組成物 - Google Patents
知覚鈍麻歯科組成物Info
- Publication number
- JP2002505261A JP2002505261A JP2000534174A JP2000534174A JP2002505261A JP 2002505261 A JP2002505261 A JP 2002505261A JP 2000534174 A JP2000534174 A JP 2000534174A JP 2000534174 A JP2000534174 A JP 2000534174A JP 2002505261 A JP2002505261 A JP 2002505261A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- potassium
- chloride
- solute
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims abstract description 50
- 150000001875 compounds Chemical class 0.000 claims abstract description 44
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims abstract description 42
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims abstract description 30
- 210000004268 dentin Anatomy 0.000 claims abstract description 26
- 229910000160 potassium phosphate Inorganic materials 0.000 claims abstract description 25
- 235000011009 potassium phosphates Nutrition 0.000 claims abstract description 25
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 23
- 239000001110 calcium chloride Substances 0.000 claims abstract description 22
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 22
- 229910000027 potassium carbonate Inorganic materials 0.000 claims abstract description 21
- 229910001631 strontium chloride Inorganic materials 0.000 claims abstract description 20
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims abstract description 20
- 239000011698 potassium fluoride Substances 0.000 claims abstract description 15
- 235000003270 potassium fluoride Nutrition 0.000 claims abstract description 15
- 238000000586 desensitisation Methods 0.000 claims abstract description 10
- 235000011181 potassium carbonates Nutrition 0.000 claims abstract description 7
- 159000000001 potassium salts Chemical class 0.000 claims abstract description 4
- 229940034610 toothpaste Drugs 0.000 claims abstract description 4
- 239000000606 toothpaste Substances 0.000 claims abstract description 4
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 3
- 159000000008 strontium salts Chemical class 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 210000005239 tubule Anatomy 0.000 claims description 23
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 18
- 235000010234 sodium benzoate Nutrition 0.000 claims description 18
- 239000004299 sodium benzoate Substances 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 16
- 229910021641 deionized water Inorganic materials 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 12
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000008119 colloidal silica Substances 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 8
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 8
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 8
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000003205 fragrance Substances 0.000 claims description 7
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 230000002999 depolarising effect Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- 239000011591 potassium Substances 0.000 claims description 5
- 229910052700 potassium Inorganic materials 0.000 claims description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 claims description 4
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 3
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 claims description 3
- 229910001626 barium chloride Inorganic materials 0.000 claims description 3
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 claims description 3
- 229960003476 methylparaben sodium Drugs 0.000 claims description 3
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- 159000000009 barium salts Chemical class 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 2
- 150000003751 zinc Chemical class 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 2
- 239000001639 calcium acetate Substances 0.000 claims 2
- 235000011092 calcium acetate Nutrition 0.000 claims 2
- 229960005147 calcium acetate Drugs 0.000 claims 2
- RXSHXLOMRZJCLB-UHFFFAOYSA-L strontium;diacetate Chemical compound [Sr+2].CC([O-])=O.CC([O-])=O RXSHXLOMRZJCLB-UHFFFAOYSA-L 0.000 claims 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims 1
- 239000002386 air freshener Substances 0.000 claims 1
- 230000003385 bacteriostatic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004321 preservation Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 15
- 201000002170 dentin sensitivity Diseases 0.000 abstract description 5
- 238000009434 installation Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 20
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 12
- 239000001103 potassium chloride Substances 0.000 description 6
- 235000011164 potassium chloride Nutrition 0.000 description 6
- 208000004044 Hypesthesia Diseases 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 208000034783 hypoesthesia Diseases 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000004126 nerve fiber Anatomy 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000003178 glass ionomer cement Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- 102100024522 Bladder cancer-associated protein Human genes 0.000 description 1
- 101150110835 Blcap gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 101100493740 Oryza sativa subsp. japonica BC10 gene Proteins 0.000 description 1
- 101100219325 Phaseolus vulgaris BA13 gene Proteins 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 208000002599 Smear Layer Diseases 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- QXDMQSPYEZFLGF-UHFFFAOYSA-L calcium oxalate Chemical compound [Ca+2].[O-]C(=O)C([O-])=O QXDMQSPYEZFLGF-UHFFFAOYSA-L 0.000 description 1
- 235000021270 cold food Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 210000002455 dental arch Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- VEPSWGHMGZQCIN-UHFFFAOYSA-H ferric oxalate Chemical compound [Fe+3].[Fe+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O VEPSWGHMGZQCIN-UHFFFAOYSA-H 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000021268 hot food Nutrition 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000028161 membrane depolarization Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000008035 nerve activity Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Inorganic materials [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 1
- 235000010289 potassium nitrite Nutrition 0.000 description 1
- 239000004304 potassium nitrite Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 229940100890 silver compound Drugs 0.000 description 1
- 150000003379 silver compounds Chemical class 0.000 description 1
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver nitrate Substances [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- -1 solutions Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229910000018 strontium carbonate Inorganic materials 0.000 description 1
- 229910001637 strontium fluoride Inorganic materials 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003606 tin compounds Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98A000051 | 1998-03-06 | ||
| IT98FI000051A ITFI980051A1 (it) | 1998-03-06 | 1998-03-06 | Composizione ad uso odontoiatrico per la desensibilizzazione della dentina esposta |
| PCT/EP1998/002963 WO1999044570A1 (en) | 1998-03-06 | 1998-05-20 | Desensitizing dental composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002505261A true JP2002505261A (ja) | 2002-02-19 |
Family
ID=11352424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534174A Pending JP2002505261A (ja) | 1998-03-06 | 1998-05-20 | 知覚鈍麻歯科組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6689341B2 (cs) |
| EP (1) | EP1058535B1 (cs) |
| JP (1) | JP2002505261A (cs) |
| KR (1) | KR20010041671A (cs) |
| CN (1) | CN1286623A (cs) |
| AT (1) | ATE238030T1 (cs) |
| AU (1) | AU750735B2 (cs) |
| BG (1) | BG104750A (cs) |
| BR (1) | BR9815710A (cs) |
| CA (1) | CA2322645A1 (cs) |
| CZ (1) | CZ294068B6 (cs) |
| DE (1) | DE69813906T2 (cs) |
| ES (1) | ES2197497T3 (cs) |
| HU (1) | HUP0101016A2 (cs) |
| IT (1) | ITFI980051A1 (cs) |
| NO (1) | NO20004423L (cs) |
| PL (1) | PL189221B1 (cs) |
| PT (1) | PT1058535E (cs) |
| SK (1) | SK284912B6 (cs) |
| WO (1) | WO1999044570A1 (cs) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004824A1 (ja) * | 2003-07-15 | 2005-01-20 | Kao Corporation | 口腔用組成物 |
| JP2006056846A (ja) * | 2004-08-23 | 2006-03-02 | Sun Medical Co Ltd | 漂白時の知覚過敏を抑制する歯牙用漂白剤キット |
| JP2018511644A (ja) * | 2015-04-17 | 2018-04-26 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 口腔用組成物 |
| DE112009001130B4 (de) * | 2009-08-18 | 2019-08-14 | Osg Corporation | Rotierendes Einwegwerkzeug |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3432000A (en) * | 1999-04-15 | 2000-11-02 | Giani, Paola | Oral care system containing sunflower oil |
| US6306371B1 (en) * | 2000-02-18 | 2001-10-23 | Colgate-Palmolive Company | Color stable silver zeolite containing dentifrice compositions |
| US7182937B2 (en) | 2000-10-13 | 2007-02-27 | Block Drug Company, Inc. | Anhydrous dentrifice formulations for the delivery of incompatible ingredients |
| KR100797365B1 (ko) * | 2001-09-27 | 2008-01-22 | 주식회사 엘지생활건강 | 과민성 치아용 치약 조성물 |
| EP1308152A1 (en) * | 2001-10-30 | 2003-05-07 | Italmed S.N.C. Di Galli G. & Pacini G. | Single-component dental composition for dentin desensitisation |
| KR20020068491A (ko) * | 2002-08-10 | 2002-08-27 | 배병철 | 젤 은용액 치약 |
| WO2009098531A1 (en) * | 2008-02-07 | 2009-08-13 | Italmed S.R.L. | Dental composition for desensitization and disinfection of exposed dentin |
| ITFI20080034A1 (it) * | 2008-02-26 | 2009-08-27 | Italmed S R L | Composizione odontoiatrica per la desensibilizzazione disinfezione e protezione della dentina esposta. |
| US20090269288A1 (en) * | 2008-04-24 | 2009-10-29 | Zoya Lavrova | Black pearl toothpaste |
| AR076179A1 (es) | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | Composicion dentifrica no acuosa con vidrio bioaceptable y bioactivo y metodos de uso y fabricacion de la misma |
| TWI469795B (zh) | 2009-04-01 | 2015-01-21 | Colgate Palmolive Co | 防止過敏和促進再礦化之雙作用牙劑組成物 |
| CN101829329B (zh) * | 2010-05-11 | 2012-06-20 | 李少君 | 牙齿抗过敏组合物 |
| KR101457648B1 (ko) * | 2010-12-27 | 2014-10-31 | 더 홍콩 유니버시티 오브 사이언스 앤드 테크놀러지 | 방향물질 및 소독물질의 제어 방출용 무기겔 |
| KR101375632B1 (ko) * | 2011-11-07 | 2014-03-19 | 주식회사 넥스트미디어텍 | 과민감성 치아의 완화를 위한 치약 조성물 |
| WO2016167600A1 (ko) * | 2015-04-17 | 2016-10-20 | 주식회사 엘지생활건강 | 구강용 조성물 |
| KR102520101B1 (ko) * | 2016-02-24 | 2023-04-07 | 주식회사 엘지생활건강 | 시린이 방지용 구강 조성물 |
| CN107569395B (zh) * | 2017-09-04 | 2020-08-11 | 天津医科大学口腔医院 | 一种用于封闭牙本质小管使牙齿脱敏的材料 |
| WO2019143746A1 (en) * | 2018-01-17 | 2019-07-25 | The Procter & Gamble Company | Methods and compositions to increase the hardness and resistance of enamel |
| EP3996655A4 (en) * | 2019-07-10 | 2023-12-06 | Kytodent, LLC | MEDICAL DEVICES FOR TREATING DENTAL DISEASES AND METHODS FOR TREATING DENTAL DISEASES |
| CN111671869A (zh) * | 2020-06-29 | 2020-09-18 | 南京白敬宇制药有限责任公司 | 一种脱牙敏糊剂组份及制备方法 |
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| US5534244A (en) * | 1989-05-24 | 1996-07-09 | Tung; Ming S. | Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds |
| US5234971A (en) * | 1989-12-28 | 1993-08-10 | G-C Dental Industrial Corp. | Odontotherapeutical materials |
| CA2032556C (en) * | 1989-12-28 | 1995-10-24 | Yohji Imai | Odontotherapeutical materials |
| GB9018836D0 (en) * | 1990-08-29 | 1990-10-10 | Neirinckx Rudi | Desensitising dental composition |
| US5874066A (en) * | 1994-08-01 | 1999-02-23 | University Of Maryland, Baltimore | Method and kit for treating tooth hypersensitivity |
| US5522726A (en) * | 1994-10-27 | 1996-06-04 | Hodosh; Milton | Method for anesthetizing teeth |
| DE69531669T2 (de) * | 1994-12-07 | 2004-07-15 | Sun Medical Co., Ltd., Moriyama | Dentale zusammensetzung für hypersensitives dentin |
| JPH11500724A (ja) * | 1995-02-24 | 1999-01-19 | アメリカン デンタル アソシエイション ヘルス ファウンデーション | 石灰化組織の処置、鉱化及びフッ化物化用の炭酸塩化した溶液及びその使用方法 |
| JP3528181B2 (ja) * | 1995-08-08 | 2004-05-17 | エナメロン・インコーポレイテッド | 歯の病変部の再石灰用の改善された製品および方法 |
| US5603922A (en) * | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
| US5906809A (en) * | 1995-10-19 | 1999-05-25 | University Of Maryland, Baltimore | One-step method and preparation for reducing dentinal hypersensitivity |
| EP0939613B1 (en) * | 1996-09-18 | 2003-05-02 | Erling Johansen | Mouthwash comprising calcium and phosphate ions in supersaturated solution |
| US6159448A (en) * | 1996-09-27 | 2000-12-12 | Enamelon, Inc. | Products and methods for the remineralization and prevention of demineralization of teeth |
-
1998
- 1998-03-06 IT IT98FI000051A patent/ITFI980051A1/it unknown
- 1998-05-20 AT AT98940073T patent/ATE238030T1/de not_active IP Right Cessation
- 1998-05-20 US US09/623,578 patent/US6689341B2/en not_active Expired - Fee Related
- 1998-05-20 KR KR1020007009879A patent/KR20010041671A/ko not_active Application Discontinuation
- 1998-05-20 CN CN98813853A patent/CN1286623A/zh active Pending
- 1998-05-20 SK SK1325-2000A patent/SK284912B6/sk unknown
- 1998-05-20 AU AU88524/98A patent/AU750735B2/en not_active Ceased
- 1998-05-20 ES ES98940073T patent/ES2197497T3/es not_active Expired - Lifetime
- 1998-05-20 BR BR9815710-8A patent/BR9815710A/pt not_active IP Right Cessation
- 1998-05-20 JP JP2000534174A patent/JP2002505261A/ja active Pending
- 1998-05-20 WO PCT/EP1998/002963 patent/WO1999044570A1/en active IP Right Grant
- 1998-05-20 PT PT98940073T patent/PT1058535E/pt unknown
- 1998-05-20 CA CA002322645A patent/CA2322645A1/en not_active Abandoned
- 1998-05-20 EP EP98940073A patent/EP1058535B1/en not_active Expired - Lifetime
- 1998-05-20 PL PL98343120A patent/PL189221B1/pl not_active IP Right Cessation
- 1998-05-20 DE DE69813906T patent/DE69813906T2/de not_active Expired - Fee Related
- 1998-05-20 HU HU0101016A patent/HUP0101016A2/hu unknown
- 1998-05-20 CZ CZ20003245A patent/CZ294068B6/cs not_active IP Right Cessation
-
2000
- 2000-09-05 BG BG104750A patent/BG104750A/xx unknown
- 2000-09-05 NO NO20004423A patent/NO20004423L/no not_active Application Discontinuation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004824A1 (ja) * | 2003-07-15 | 2005-01-20 | Kao Corporation | 口腔用組成物 |
| US8557224B2 (en) | 2003-07-15 | 2013-10-15 | Kao Corporation | Oral cavity composition |
| JP2006056846A (ja) * | 2004-08-23 | 2006-03-02 | Sun Medical Co Ltd | 漂白時の知覚過敏を抑制する歯牙用漂白剤キット |
| DE112009001130B4 (de) * | 2009-08-18 | 2019-08-14 | Osg Corporation | Rotierendes Einwegwerkzeug |
| JP2018511644A (ja) * | 2015-04-17 | 2018-04-26 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 口腔用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010041671A (ko) | 2001-05-25 |
| BG104750A (en) | 2001-05-31 |
| PL189221B1 (pl) | 2005-07-29 |
| SK13252000A3 (sk) | 2001-02-12 |
| EP1058535B1 (en) | 2003-04-23 |
| CZ294068B6 (cs) | 2004-09-15 |
| WO1999044570A1 (en) | 1999-09-10 |
| ITFI980051A0 (it) | 1998-03-06 |
| HUP0101016A2 (hu) | 2001-08-28 |
| NO20004423D0 (no) | 2000-09-05 |
| CZ20003245A3 (cs) | 2001-01-17 |
| US20030194381A1 (en) | 2003-10-16 |
| DE69813906T2 (de) | 2004-02-19 |
| AU8852498A (en) | 1999-09-20 |
| ES2197497T3 (es) | 2004-01-01 |
| NO20004423L (no) | 2000-09-25 |
| US6689341B2 (en) | 2004-02-10 |
| PT1058535E (pt) | 2003-09-30 |
| ATE238030T1 (de) | 2003-05-15 |
| DE69813906D1 (de) | 2003-05-28 |
| ITFI980051A1 (it) | 1999-09-06 |
| SK284912B6 (sk) | 2006-02-02 |
| CN1286623A (zh) | 2001-03-07 |
| CA2322645A1 (en) | 1999-09-10 |
| EP1058535A1 (en) | 2000-12-13 |
| AU750735B2 (en) | 2002-07-25 |
| PL343120A1 (en) | 2001-07-30 |
| BR9815710A (pt) | 2000-11-14 |
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