JP2002505117A5 - - Google Patents
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- Publication number
- JP2002505117A5 JP2002505117A5 JP2000534677A JP2000534677A JP2002505117A5 JP 2002505117 A5 JP2002505117 A5 JP 2002505117A5 JP 2000534677 A JP2000534677 A JP 2000534677A JP 2000534677 A JP2000534677 A JP 2000534677A JP 2002505117 A5 JP2002505117 A5 JP 2002505117A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- primer
- zymogen
- molecule
- interest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 description 103
- 102000039446 nucleic acids Human genes 0.000 description 61
- 108020004707 nucleic acids Proteins 0.000 description 61
- 238000000034 method Methods 0.000 description 49
- 108020004414 DNA Proteins 0.000 description 48
- 239000013615 primer Substances 0.000 description 48
- 108010062466 Enzyme Precursors Proteins 0.000 description 37
- 102000010911 Enzyme Precursors Human genes 0.000 description 37
- 102000053602 DNA Human genes 0.000 description 36
- 230000003197 catalytic effect Effects 0.000 description 34
- 108091028043 Nucleic acid sequence Proteins 0.000 description 32
- 230000003321 amplification Effects 0.000 description 26
- 238000003199 nucleic acid amplification method Methods 0.000 description 26
- 230000000694 effects Effects 0.000 description 21
- 108091027757 Deoxyribozyme Proteins 0.000 description 17
- 230000000692 anti-sense effect Effects 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000005096 rolling process Methods 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108020001019 DNA Primers Proteins 0.000 description 2
- 239000003155 DNA primer Substances 0.000 description 2
- 241001430197 Mollicutes Species 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000005176 Hepatitis C Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000254101 Popillia japonica Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 208000034737 hemoglobinopathy Diseases 0.000 description 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 description 1
- 238000006263 metalation reaction Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 150000004032 porphyrins Chemical group 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7689998P | 1998-03-05 | 1998-03-05 | |
| US60/076,899 | 1998-03-05 | ||
| PCT/IB1999/000754 WO1999045146A1 (en) | 1998-03-05 | 1999-02-22 | Zymogenic nucleic acid detection methods, and related molecules and kits |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002505117A JP2002505117A (ja) | 2002-02-19 |
| JP2002505117A5 true JP2002505117A5 (https=) | 2006-04-20 |
| JP4318856B2 JP4318856B2 (ja) | 2009-08-26 |
Family
ID=22134859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534677A Expired - Fee Related JP4318856B2 (ja) | 1998-03-05 | 1999-02-22 | チモーゲン性核酸検出方法、および関連分子およびキット |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6140055A (https=) |
| EP (1) | EP1062367B1 (https=) |
| JP (1) | JP4318856B2 (https=) |
| KR (1) | KR100748863B1 (https=) |
| CN (1) | CN1167811C (https=) |
| AT (1) | ATE414169T1 (https=) |
| AU (1) | AU768627B2 (https=) |
| BR (1) | BR9908567A (https=) |
| CA (1) | CA2321948A1 (https=) |
| DE (1) | DE69939896D1 (https=) |
| IL (2) | IL164182A0 (https=) |
| WO (1) | WO1999045146A1 (https=) |
| ZA (1) | ZA991772B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
| WO1994003624A1 (en) * | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| WO1999045146A1 (en) | 1998-03-05 | 1999-09-10 | Johnson & Johnson Research Pty. Ltd. | Zymogenic nucleic acid detection methods, and related molecules and kits |
| DE19811618C1 (de) * | 1998-03-17 | 2000-08-31 | Andreas Jenne | Ribozym codierende DNA und ein Oligonucleotidsubstrat enthaltende Zusammensetzung und Verfahren zur Messung von Transkriptionsraten |
| AUPQ495700A0 (en) * | 2000-01-05 | 2000-02-03 | Johnson & Johnson Research Pty. Limited | Method for concurrent amplification and real time detection of polymorphic nucleic acid sequences |
| US7205129B1 (en) * | 2000-02-28 | 2007-04-17 | Qiagen Gmbh | Method for reducing artifacts in nucleic acid amplification |
| US20030104520A1 (en) * | 2000-06-15 | 2003-06-05 | Ellington Andrew D. | Regulatable, catalytically active nucleic acids |
| US7125660B2 (en) | 2000-09-13 | 2006-10-24 | Archemix Corp. | Nucleic acid sensor molecules and methods of using same |
| WO2003014375A2 (en) * | 2001-08-09 | 2003-02-20 | Archemix Corporation | Nucleic acid sensor molecules and methods of using same |
| US7297485B2 (en) * | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US6617137B2 (en) * | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| US7955795B2 (en) * | 2003-06-06 | 2011-06-07 | Qiagen Gmbh | Method of whole genome amplification with reduced artifact production |
| US8043834B2 (en) | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
| EP1611254B1 (en) | 2003-03-31 | 2014-09-10 | Roche Diagnostics GmbH | Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup |
| EP1689764B1 (en) * | 2003-11-19 | 2013-01-02 | AlleLogic Biosciences Corporation | Oligonucleotides labeled with a plurality of fluorophores |
| WO2005085474A2 (en) * | 2004-03-02 | 2005-09-15 | Clontech Laboratories Inc. | Fluorescent energy transfer labeled nucleic acid substrates and methods of use thereof |
| US7939251B2 (en) | 2004-05-06 | 2011-05-10 | Roche Molecular Systems, Inc. | SENP1 as a marker for cancer |
| US20060211018A1 (en) * | 2005-02-08 | 2006-09-21 | Applera Corporation | Nucleozymes and methods of use |
| US8309303B2 (en) | 2005-04-01 | 2012-11-13 | Qiagen Gmbh | Reverse transcription and amplification of RNA with simultaneous degradation of DNA |
| EP1880021A2 (en) * | 2005-05-02 | 2008-01-23 | Stratagene California | Oligonucleotide probe/primer compositions and methods for polynucleotide detection |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| JP5665272B2 (ja) * | 2005-10-07 | 2015-02-04 | スピーデクス ピーティーワイ リミテッド | 多成分核酸酵素およびそれらの使用方法 |
| WO2007056312A2 (en) * | 2005-11-07 | 2007-05-18 | Clontech Laboratories, Inc. | Universal reporter tag for nucleozyme assays |
| AU2006323930B2 (en) * | 2005-12-07 | 2012-06-21 | Janssen Sciences Ireland Uc | Methods, plasmid vectors and primers for assessing HIV viral fitness |
| WO2008001376A2 (en) * | 2006-06-28 | 2008-01-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Detection of analytes in a medium |
| DE102006035600B3 (de) * | 2006-07-27 | 2007-11-08 | Epigenomics Ag | Verfahren zum Nachweis eines Methylierungsmusters |
| EP1882746A3 (en) * | 2006-07-27 | 2008-03-19 | Epigenomics AG | Method for detecting a methylation pattern |
| ES2520023T3 (es) | 2006-10-06 | 2014-11-11 | Speedx Pty Ltd | Interruptores moleculares y métodos para su uso |
| US9938641B2 (en) * | 2006-12-18 | 2018-04-10 | Fluidigm Corporation | Selection of aptamers based on geometry |
| US8962238B2 (en) * | 2007-04-05 | 2015-02-24 | SpeedDx Pty Ltd | Nucleic acid enzymes and complexes and methods for their use |
| EP2071035A1 (en) | 2007-12-13 | 2009-06-17 | Epigenomics AG | Facilitator and method for amplification |
| WO2010147848A2 (en) | 2009-06-15 | 2010-12-23 | Rd Biosciences, Inc. | Kits and methods for selective amplification and detection of nucleic acid targets |
| CN101907573B (zh) * | 2010-08-17 | 2012-08-22 | 复旦大学 | 一种高灵敏度的集成cmos光学生物芯片 |
| WO2012034130A2 (en) | 2010-09-10 | 2012-03-15 | Qiagen | Methods and compositions for nucleic acid detection |
| ES2769028T3 (es) | 2011-04-15 | 2020-06-24 | Becton Dickinson Co | Termociclador microfluídico de barrido en tiempo real |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| AU2013202354A1 (en) * | 2012-06-18 | 2014-01-16 | Speedx Pty Ltd | Target detection and signal amplification |
| CN103013953B (zh) * | 2012-10-19 | 2014-09-17 | 中国科学院成都生物研究所 | 一种剪切dna的dna酶 |
| WO2015033650A1 (ja) * | 2013-09-05 | 2015-03-12 | Ｎｅｃソリューションイノベータ株式会社 | サンプルの製造方法およびターゲットの分析方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000159A (en) * | 1974-06-28 | 1976-12-28 | Phillips Petroleum Company | Preparation of n,n-disubstituted thioamides |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5176995A (en) * | 1985-03-28 | 1993-01-05 | Hoffmann-La Roche Inc. | Detection of viruses by amplification and hybridization |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| JP3276955B2 (ja) * | 1988-09-30 | 2002-04-22 | ジーン−トラック・システムス | Ｒｎａの鋳型の末端に結合したプローブ構造およびその使用方法 |
| US5112734A (en) * | 1989-05-26 | 1992-05-12 | Gene-Trak Systems | Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna |
| NZ314629A (en) * | 1991-01-17 | 2000-08-25 | Gen Hospital Corp | Use trans-splicing ribozymes to prepare medicaments for gene therapies |
| GB9115909D0 (en) * | 1991-07-23 | 1991-09-04 | Nickerson Int Seed | Recombinant dna |
| ATE217347T1 (de) * | 1992-12-04 | 2002-05-15 | Univ Yale | Diagnose mittels signalverstärkung durch ein ribozym |
| US5436143A (en) * | 1992-12-23 | 1995-07-25 | Hyman; Edward D. | Method for enzymatic synthesis of oligonucleotides |
| US5516664A (en) * | 1992-12-23 | 1996-05-14 | Hyman; Edward D. | Enzymatic synthesis of repeat regions of oligonucleotides |
| KR100218726B1 (ko) * | 1992-12-30 | 1999-09-01 | 김영환 | 고집적 반도체 소자의 접속장치 및 그 제조방법 |
| IL105894A (en) * | 1993-06-03 | 1997-02-18 | Asher Nathan | Method for the detection of nucleic acid sequence by using a detection ensemble and an amplification ensemble |
| US5582988A (en) * | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
| IL111857A (en) * | 1994-12-02 | 1999-09-22 | Intelligene Ltd | Detection of nucleic acid sequences |
| WO1998049346A1 (en) * | 1997-04-29 | 1998-11-05 | The Scripps Research Institute | Enzymatic dna molecules |
| US5807718A (en) * | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
| MX9706501A (es) * | 1995-02-27 | 1998-02-28 | Intelligene Ltd | Deteccion de biomoleculas. |
| AUPN245295A0 (en) * | 1995-04-13 | 1995-05-11 | Johnson & Johnson Research Pty. Limited | Assay for genetic abnormalities |
| DE69618957T2 (de) * | 1995-06-07 | 2002-08-14 | MERCK & CO., INC. | Dna-polymerase verlängungs assay |
| DE19805593A1 (de) * | 1998-02-12 | 1999-08-19 | Voith Sulzer Papiertech Patent | Eindicker |
| WO1999045146A1 (en) | 1998-03-05 | 1999-09-10 | Johnson & Johnson Research Pty. Ltd. | Zymogenic nucleic acid detection methods, and related molecules and kits |
-
1999
- 1999-02-22 WO PCT/IB1999/000754 patent/WO1999045146A1/en not_active Ceased
- 1999-02-22 IL IL16418299A patent/IL164182A0/xx unknown
- 1999-02-22 JP JP2000534677A patent/JP4318856B2/ja not_active Expired - Fee Related
- 1999-02-22 BR BR9908567-4A patent/BR9908567A/pt not_active Application Discontinuation
- 1999-02-22 IL IL13812699A patent/IL138126A0/xx not_active IP Right Cessation
- 1999-02-22 DE DE69939896T patent/DE69939896D1/de not_active Expired - Fee Related
- 1999-02-22 CN CNB998111147A patent/CN1167811C/zh not_active Expired - Fee Related
- 1999-02-22 EP EP99914694A patent/EP1062367B1/en not_active Expired - Lifetime
- 1999-02-22 KR KR1020007009783A patent/KR100748863B1/ko not_active Expired - Fee Related
- 1999-02-22 AT AT99914694T patent/ATE414169T1/de not_active IP Right Cessation
- 1999-02-22 US US09/253,955 patent/US6140055A/en not_active Expired - Lifetime
- 1999-02-22 CA CA002321948A patent/CA2321948A1/en not_active Abandoned
- 1999-02-22 AU AU33409/99A patent/AU768627B2/en not_active Ceased
- 1999-03-04 ZA ZA9901772A patent/ZA991772B/xx unknown
-
2000
- 2000-08-11 US US09/637,405 patent/US6201113B1/en not_active Expired - Lifetime
- 2000-12-21 US US09/746,985 patent/US6365724B2/en not_active Expired - Lifetime
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