JP2017516487A5 - - Google Patents
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- JP2017516487A5 JP2017516487A5 JP2016571229A JP2016571229A JP2017516487A5 JP 2017516487 A5 JP2017516487 A5 JP 2017516487A5 JP 2016571229 A JP2016571229 A JP 2016571229A JP 2016571229 A JP2016571229 A JP 2016571229A JP 2017516487 A5 JP2017516487 A5 JP 2017516487A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- population
- oligonucleotide
- genomic dna
- single stranded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 120
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021138555A JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009047P | 2014-06-06 | 2014-06-06 | |
| US62/009,047 | 2014-06-06 | ||
| US201562136093P | 2015-03-20 | 2015-03-20 | |
| US62/136,093 | 2015-03-20 | ||
| PCT/US2015/034724 WO2015188192A2 (en) | 2014-06-06 | 2015-06-08 | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138555A Division JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516487A JP2017516487A (ja) | 2017-06-22 |
| JP2017516487A5 true JP2017516487A5 (https=) | 2018-07-19 |
| JP7008407B2 JP7008407B2 (ja) | 2022-01-25 |
Family
ID=54767613
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571229A Active JP7008407B2 (ja) | 2014-06-06 | 2015-06-08 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2021138555A Pending JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A Pending JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138555A Pending JP2022001050A (ja) | 2014-06-06 | 2021-08-27 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
| JP2024038531A Pending JP2024060054A (ja) | 2014-06-06 | 2024-03-13 | ヌクレアーゼ、リガーゼ、ポリメラーゼ、及び配列決定反応の組み合わせを用いた、核酸配列、発現、コピー、またはｄｎａのメチル化変化の識別及び計数方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10407722B2 (https=) |
| EP (4) | EP3889271B1 (https=) |
| JP (3) | JP7008407B2 (https=) |
| CN (2) | CN113046413A (https=) |
| AU (2) | AU2015269103B2 (https=) |
| CA (2) | CA2950295C (https=) |
| DK (1) | DK3152331T3 (https=) |
| ES (3) | ES2864531T3 (https=) |
| IL (1) | IL249126B (https=) |
| PT (3) | PT3567122T (https=) |
| SG (2) | SG11201610134PA (https=) |
| WO (1) | WO2015188192A2 (https=) |
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| CN104946737B (zh) | 2013-12-11 | 2019-02-22 | 安可济控股有限公司 | 用于检测罕见序列变体的组合物和方法 |
| US11859246B2 (en) * | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| AU2015269103B2 (en) * | 2014-06-06 | 2021-12-23 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or DNA methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| WO2016170179A1 (en) | 2015-04-24 | 2016-10-27 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on solid support |
| US11085073B2 (en) * | 2015-04-24 | 2021-08-10 | Qiagen Gmbh | Method for immobilizing a nucleic acid molecule on a solid support |
| EP3380607B1 (en) | 2015-11-25 | 2021-10-27 | F. Hoffmann-La Roche AG | Purification of polymerase complexes |
| CN108699505A (zh) * | 2015-12-03 | 2018-10-23 | 安可济控股有限公司 | 用于形成连接产物的方法和组合物 |
| US20210214781A1 (en) * | 2016-02-14 | 2021-07-15 | Abhijit Ajit Patel | Measurement of nucleic acid |
| WO2017168331A1 (en) * | 2016-03-28 | 2017-10-05 | Boreal Genomics, Inc. | Linked duplex fragment sequencing |
| MX391039B (es) * | 2016-04-07 | 2025-03-21 | Univ Leland Stanford Junior | Diagnostico no invasivo por medio de la secuenciacion del adn libre de celulas 5-hidroxi-metilado. |
| US20190185913A1 (en) * | 2016-07-01 | 2019-06-20 | Natera, Inc. | Compositions and methods for detection of nucleic acid mutations |
| EP3532635B1 (en) * | 2016-10-31 | 2021-06-09 | F. Hoffmann-La Roche AG | Barcoded circular library construction for identification of chimeric products |
| WO2018114706A1 (en) * | 2016-12-20 | 2018-06-28 | F. Hoffmann-La Roche Ag | Single stranded circular dna libraries for circular consensus sequencing |
| CN109234388B (zh) * | 2017-07-04 | 2021-09-14 | 深圳华大生命科学研究院 | 用于dna高甲基化区域富集的试剂、富集方法及应用 |
| EP3682025A1 (en) * | 2017-09-14 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Novel method for generating circular single-stranded dna libraries |
| WO2019053215A1 (en) * | 2017-09-15 | 2019-03-21 | F. Hoffmann-La Roche Ag | HYBRIDIZATION-EXTENSION-LIGATURE STRATEGY TO GENERATE CIRCULAR SINGLE-STRAND DNA BANKS |
| US10350307B2 (en) * | 2017-09-18 | 2019-07-16 | General Electric Company | In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides |
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| US12104203B2 (en) | 2017-11-27 | 2024-10-01 | Bgi Shenzhen | Method for constructing library of cell-free DNAs in body fluids and application thereof |
| CA3276585A1 (en) | 2017-12-11 | 2026-03-02 | Umc Utrecht Holding B.V. | Methods for preparing nucleic acid molecules for sequencing |
| WO2019157339A1 (en) * | 2018-02-09 | 2019-08-15 | Children's Medical Center Corporation | Compositions and methods for identifying a single-nucleotide variant |
| JP7013960B2 (ja) * | 2018-03-13 | 2022-02-01 | 株式会社リコー | 核酸検出方法及び核酸検出装置、並びに、核酸検出キット |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
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| CN119753091A (zh) * | 2018-04-02 | 2025-04-04 | 格里尔公司 | 用于扩增与癌症相关联的cfDNA分子的化验板 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
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| US11639521B2 (en) * | 2019-06-03 | 2023-05-02 | The Chinese University Of Hong Kong | Method for determining the copy number of a tandem repeat sequence |
| CN112175939A (zh) * | 2019-07-03 | 2021-01-05 | 华大青兰生物科技(无锡)有限公司 | 一种基于同源序列的核酸拼接方法及其应用 |
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