JP2002502806A - 口臭治療用組成物 - Google Patents
口臭治療用組成物Info
- Publication number
- JP2002502806A JP2002502806A JP2000530187A JP2000530187A JP2002502806A JP 2002502806 A JP2002502806 A JP 2002502806A JP 2000530187 A JP2000530187 A JP 2000530187A JP 2000530187 A JP2000530187 A JP 2000530187A JP 2002502806 A JP2002502806 A JP 2002502806A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- composition
- composition according
- petroselinum
- bad breath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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Abstract
Description
成物、およびその投与に関する。
るのに使用される用語である。これは、多くの人々(口臭に苦しむ人々やその人
々の周りの、その状況が社会的に容認できないとしばしば気付く人々)を襲う問
題である。
チルメルカプタン)の生成と放出とによってもたらされ、不愉快な臭気の原因の
場所に応じて、口腔内(唇、下、歯、歯科用人工装具要素、歯周細胞、中咽頭)
または非口腔内[呼吸器官疾患、全身性疾患(肝機能不全、肝硬変、糖尿病性ケ トアシドーシス、ガンおよび酵素変則が生じる特定の代謝疾患)、胃腸器官疾患
、および特定の食物、飲料、タバコおよび薬物によって引き起こされるもの]に 分類できる。
、他方は天然産物の投与に基づいている。後者のうち、パセリ油またはひまわり
油と共にパセリの葉を使用することは、口臭を除去する周知の方法である。
できる薬剤の質を高める新規組成物を得るために、更なる調査が行なわれている
。驚くべきことには、オリーブ油とパセリ油の組み合わせが口臭に対処し有効に
作用することが見つかっている。更に、オリーブ油とパセリ油の混合物への他の
植物油(特に、ミント油、クロロフィルおよびメントール)の添加が口臭と有効
に作用するのみならず、非常においしい味と新鮮な感覚をもたらすことも見出さ
れている。この組成物は、口臭の治療をすることになっている医薬組成物を含む
、幾つかの投与形態を合成するのに適している。
〜7で含有する口臭の治療に好適な組成物(以降、本発明の組成物という)を提
供する。 オリーブは、モクセイ科に属するオリーブの木(オレア・ユーロペア・エル)
の果実である。水、油、炭化水素およびタンパク質の他に、オリーブは、多数の
鉱物、特にカルシウム、数種の有機酸およびビタミンA、B1、B2およびppを
含有している。オリーブの果肉から抽出されるオリーブ油は、本質的にオレイン
酸のグリセリド(70%)とより少ない割合の他の酸(例えば、リノール酸、パル
ミチン酸、リノレン酸およびアラキドン酸)のグリセリドから成り、通常、料理
に使用される。
ム・ミル、カルム・ペトロセリナム・ベンツ・アンド・フッカー)は、セリ科に
属する。その種子、葉および根が使用される。その香りと味は、複雑で様々な組
成のエキスによると思われ、アピオール、アピオシドおよびミリスチシンを含有
している。主成分は、揮発油、脂肪油、フラボノイド、ビタミンAおよびC、お
よび鉱物(特に、鉄、カルシウム、リンおよびマグネシウム)から成る。パセリ
は、その利尿効果、駆風効果、消化効果、鎮痙効果および栄養効果、並びに子宮
筋への刺激効果が知られている。パセリは、料理や、泌尿器感染、結石、脳浮腫
、胃腸障害および貧血の治療にも広く使用されている。パセリエキス油は、本発
明の課題である組成物の仕上げに用いられる。
有効であり得ることは、当該分野の報告では提案されていない。
いてよいが、これらに限定されない;アボガド油、バジル油、カスタードアップ
ルの木からの油、ルリヂサ油、カモミール油、大麻油、ベニバナ油、カユプテの
木からの油、シーダー油、糸杉油、ココヤシ油、菜種油、ゼラニウム油、ひまわ
り油、桃色マツヨイグサ油、ホホバ油、ラノリン油、ラベンダー油、レモン油、
あまに油、ペパーミント油、マツヨイグサ油、パーム油、ローズウッド油、パイ
ナップル油、サクラソウ油、ひまし油、ローズマリー油、セージ油、サンダルウ
ッド油、醤油、ティー・ツリー油、小麦麦芽油、ブドウ種子油およびベチベル油
。これらの植物油は、オリーブ油とパセリ油の混合物に様々な量で添加できる。
与えるのに寄与する他の製品を含有していてよい。特に、上述のオリーブ油とパ
セリ油の混合物へのミント油、メントールおよびクロロフィルの添加が、口臭い
有効に対処するのみならず、非常に望ましい味と新鮮味を与えることが観察され
た。これらの製品は、この混合物へ様々な量で添加できる。
、以下の組成を含有する。
種の植物を包含する。ハッカ類は、種の自発的な交わりから発生する多数の天然
混成物のために植物界で最も複雑なものの一つであり、一般には、(葉のない先
端に花をつける)穂状花序ミントと低級ミント(花が、肉茎のある葉の中で別の
輪生を形成する房の中にあるもの)に分類できる。ハッカ類は、エム・ロツンデ
ィフォリア・エル(M. rotundifolia L.)、エム・ヴィリディス・エル(M. viridi
s L.)、エム・クリパータ・スカード(M. crispata Schard)、エム・ロンギフォ リア・エル(M. longifolia L.)、エム・プレギウム・エル(M. pulegium L.)、エ
ム・アルヴェンシス・エル(M. arvensis L.)、エム・ピペリータ・エル(M. pipe
rita L.)、エム・アクアティカ・エル(M. aquatica L.)のような種を包含する。
通常、その葉を使用する。その主成分は、揮発油とタンニンである。消化に対す
るその駆風および刺激作用は、本発明により提供される組成物に付加価値である
。
。 クロロフィルは、植物の緑色の色素である。
息を提供し、おいしい味と新鮮味を口にもたらすのみならず、口臭の源での不愉
快な味を消す。それは、どのような理論にも結びつくものではないが、不愉快な
臭気の原因である揮発性の硫黄含有化合物が本発明の組成物中に含まれる植物油
に溶解し、その後、揮発性の硫黄含有化合物の前駆体の小腸での吸収を回避する
乳状脂粒粒子を被覆することによって、肺を介してのその排出を回避すると考え
られる。パセリ油は、消化組織を刺激すると考えられ、そのことが揮発性の硫黄
含有化合物の腸での吸収をより困難にする植物油の効果を高め、口臭を引き起こ
す胃腸障害の症状を向上する。
合物の中和作用を向上させて、揮発性化合物を可溶性にする植物油の効果を高め
、更には使用者に、製品の全防護期間に亙る、約8時間の長続きする新鮮味の感
覚を感じさせる、正の効果を発揮する。
できる。
よび賦形剤を組み込むことができる為、カプセル、ソフトゼラチンカプセル、菓
子、チューインガム、歯磨き剤、うがい薬および医薬組成物を含む、幾つかの形
態で存在することができる。更に、所望により、この組成物は、抗カリウス性剤
、抗菌剤および防腐剤を含有していてもよい。
いられる物質を包含する製薬上許容できる賦形剤と一緒に本発明の組成物を含有
する医薬組成物を提供する。本発明により提供される医薬組成物としては、好ま
しくは、口臭予防用組成物の経口投与に適した製剤(例えば、エリキシル剤、シ
ロップ、水薬などの液体口腔用形態、および例えば、被覆錠剤、カプセル、丸剤
、錠剤等の固体口腔用形態)が挙げられる。口臭予防用組成物のこれらの投与形
態は、通常の技術[トラタード・デ・ファルマシア・ガレニカ(Tratado de Farm
acia Galenica)、シー・ファウリ・イ・トリロ(C.Fauri i Trillo)、ルーザン5
エス・エイ・デ・エディシオンズ(Luzan 5 S.A.de Ediciones)、第1版(1993
年)、特に第34〜43章]を用いて容易に調製できる。本発明の好ましい態様にお
いて、この医薬組成物の投与形態は、ゼラチンカプセル、好ましくはソフトゼラ
チンカプセルの形態である(実施例2)。
、口臭予防用組成物の投与形態は、チューインガムである(実施例3)。
れる、口臭予防用組成物の投与形態は、練り歯磨きである(実施例4)。
される、口臭予防用の組成物の投与形態は、2層(油−水)のうがい薬である(
実施例5)。
明の範囲を限定するものではない。
販品である。
mg/カプセル)を混合することにより得られるソフトゼラチンカプセル中へ通
常の方法で内包することにより調製した[トラタード・デ・ファルマシア・ガレ
ニカ、シー・ファウリ・イ・トリロ、ルーザン5 エス・エイ・デ・エディシオ
ンズ、第1版(1993年)、第XLI章、第587〜592頁]。
態で調製される。
方法をたどった。ガムベースを、ブレード攪拌機を装備したジャケット付きミキ
サーに加え、約65℃に予備加熱する。ガムベースが軟化し始めたら、ソルビトー
ルを(粉末形態で)添加し始め、合計ソルビトールの約50〜60%を添加して、混
合する。次に、マルチトールシロップの約1/3を添加して混合する。ソルビト
ール(粉末)の約10%を添加して混合した後、マルチトールシロップの次の1/
3を添加し、混合し、ソルビトール(粉末)の10%、キシリトール、レシチンを
加えて全てを混合する。この後、マルチトールシロップの残りの1/3を加えて
混合し、ソルビトール(粉末)の残りを加えて混合して、ミントエキス油を加え
て混合する。
ーインガムラミネーターへ輸送する。
装填する。チューインガムを広く厚いシートとして押し出し、その両面に炭酸カ
ルシウムを振りかけて、ラミネート中に粘着するのを予防する。ラミネーターの
ローラーの各セットにより、錠剤に望ましい寸法が得られるまでチューインガム
の厚みを減らす。その後、チューインガムのシートを、切断するために2セット
のローラーに導入し、最初の切断でそれをストリップにし、2回目の切断で錠剤
を製造する。
ウェル中に置く。錠剤のコーティングは、70%ソルビトール溶液とソルビトール
(微粉末)とで開始する。その後、パセリエキス油とオリーブ油の量を秤量し、
各コーティング・ウェルに適したリン酸二カルシウムに吸着させて、それをソル
ビトール粉末と調剤する。その混合物を、湿潤チューインガム錠剤上に増加量で
添加する。その後、風味向上剤を、ソルビトール溶液中に分散したクロロフィル
と一緒にコーティング層上に加える。
ーにおいて、乾燥させる。乾燥錠剤をカルナウバワックスと蜜蝋との混合物で再
度研磨し、水分から保護するためにグレーズをかける。
市販品である。
−水)うがい薬を調製する。 各成分の対応量を混合して、このうがい薬を調製した。使用した製品は全て市
販品である。
め、このうがい薬は、2層(油−水)製剤である。このうがい薬は、脂溶性ミン
トエキス、抗カリウス性剤としてのキシリトール、天然甘味料および清涼飲料水
、並びにクロルヘキシジン(抗菌剤)を含有する。
Claims (14)
- 【請求項1】 オリーブ油(オレア・ユーロペア・エル(Olea europea L.) )とパセリ油(ペトロセリナム・サティヴァム・ホフム(Petroselinum sativum
Hoffm.)、ペトロセリナム・クリスプム・ミル(Petroselinum crispum Mill)、カ
ルム・ペトロセリナム・ベンツ・アンド・フッカー(Carum petroselinum Benth
& Hoocker))の混合物をオリーブ油:パセリ油の重量比1〜7で含有する口臭治
療に好適な組成物。 - 【請求項2】 植物油も含有する請求項1記載の組成物。
- 【請求項3】 植物油が、アボガド油、バジル油、カスタードアップルの木
からの油、ルリヂサ油、カモミール油、大麻油、ベニバナ油、カユプテの木から
の油、シーダー油、糸杉油、ココヤシ油、菜種油、ゼラニウム油、ひまわり油、
桃色マツヨイグサ油、ホホバ油、ラノリン油、ラベンダー油、レモン油、あまに
油、ペパーミント油、マツヨイグサ油、パーム油、ローズウッド油、パイナップ
ル油、サクラソウ油、ひまし油、ローズマリー油、セージ油、サンダルウッド油
、醤油、ティー・ツリー油、小麦麦芽油、ブドウ種子油、ベチベル油、およびそ
れらの混合物から成る群より選択される請求項2記載の組成物。 - 【請求項4】 ミント油、メントールおよびクロロフィルも含有する請求項
1〜3のいずれかに記載の組成物。 - 【請求項5】 以下の組成を含有する請求項4記載の組成物。
- 【請求項6】 以下の組成を含有する請求項5記載の組成物。
- 【請求項7】 請求項1〜6のいずれかに記載の組成物を製薬上許容できる
賦形剤と共に含有する医薬組成物。 - 【請求項8】 経口投与に適した調製形態の請求項7記載の医薬組成物。
- 【請求項9】 経口用液体形態の請求項8記載の医薬組成物。
- 【請求項10】 経口用固体形態の請求項8記載の医薬組成物。
- 【請求項11】 ソフトカプセルの形態の請求項10記載の医薬組成物。
- 【請求項12】 投与形態に適した添加物、ビヒクルおよび賦形剤と共に請
求項1〜6のいずれかに記載の組成物を含有する、該組成物の投与形態。 - 【請求項13】 抗菌剤、抗カリエス性剤および防腐剤から選択される試薬
も含有する、請求項12記載の投与形態。 - 【請求項14】 口の洗浄を行なうためのチューインガム、練り歯磨きおよ
びうがい薬から選択される、請求項12または13記載の投与形態。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9800228 | 1998-02-06 | ||
ES009800228A ES2134743B1 (es) | 1998-02-06 | 1998-02-06 | Composicion para el tratamiento de la halitosis. |
PCT/ES1998/000184 WO1999039686A1 (es) | 1998-02-06 | 1998-06-26 | Composicion para el tratamiento de la halitosis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002502806A true JP2002502806A (ja) | 2002-01-29 |
JP4511028B2 JP4511028B2 (ja) | 2010-07-28 |
Family
ID=8302655
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000530187A Expired - Lifetime JP4511028B2 (ja) | 1998-02-06 | 1998-06-26 | 口臭治療用組成物 |
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US (2) | US6350435B1 (ja) |
EP (1) | EP1053743B1 (ja) |
JP (1) | JP4511028B2 (ja) |
KR (1) | KR100500271B1 (ja) |
CN (1) | CN1155363C (ja) |
AT (1) | ATE210959T1 (ja) |
AU (1) | AU763274B2 (ja) |
BR (1) | BR9815085B1 (ja) |
CA (1) | CA2320162C (ja) |
CZ (1) | CZ298853B6 (ja) |
DE (1) | DE69803099T2 (ja) |
DK (1) | DK1053743T3 (ja) |
EE (1) | EE04140B1 (ja) |
ES (1) | ES2134743B1 (ja) |
HU (1) | HUP0100765A3 (ja) |
ID (1) | ID27499A (ja) |
LT (1) | LT4828B (ja) |
LV (1) | LV12584B (ja) |
NO (1) | NO20003929D0 (ja) |
NZ (1) | NZ506174A (ja) |
PL (1) | PL191784B1 (ja) |
PT (1) | PT1053743E (ja) |
RO (1) | RO118255B1 (ja) |
RU (1) | RU2201745C2 (ja) |
TR (1) | TR200002310T2 (ja) |
UA (1) | UA72453C2 (ja) |
WO (1) | WO1999039686A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20050169854A1 (en) * | 2004-02-03 | 2005-08-04 | Coro Carlos M. | Breath scent camouflage spray |
US20050191384A1 (en) * | 2004-02-06 | 2005-09-01 | Bretl Neil A. | Hunter's breath masking flavor for use in chewing gum and the like |
US7727565B2 (en) | 2004-08-25 | 2010-06-01 | Cadbury Adams Usa Llc | Liquid-filled chewing gum composition |
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DE102005019653A1 (de) * | 2005-04-26 | 2006-11-02 | Henkel Kgaa | Pflanzenextrakte gegen Halitosis, Gingivitis oder Parodontitis |
BE1016514A6 (nl) * | 2005-04-29 | 2006-12-05 | Huybrechts Lucas | Produkten voor gebruik tegen halitosis. |
US20060263306A1 (en) * | 2005-05-19 | 2006-11-23 | Pauline Pan | Compositions having improved substantivity |
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US7569478B2 (en) * | 2005-08-25 | 2009-08-04 | Tokyo Electron Limited | Method and apparatus for manufacturing semiconductor device, control program and computer storage medium |
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FR2908311B1 (fr) * | 2006-11-13 | 2010-02-26 | Pf Medicament | Composition d'hygiene buccale et son utilisation dans le traitement de l'halitose |
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US8273385B1 (en) | 2008-10-17 | 2012-09-25 | Thres Flo, LLC | Oral rinse composition and method |
US9884082B2 (en) | 2008-11-13 | 2018-02-06 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
US9597278B2 (en) | 2008-11-13 | 2017-03-21 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
EP2367526A1 (en) * | 2008-11-13 | 2011-09-28 | VDF Futureceuticals, Inc. | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
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FR2990349B1 (fr) | 2012-05-11 | 2014-08-08 | Pf Medicament | Film monocouche a desintegration rapide et son utilisation dans l'hygiene buccale |
CN102846791A (zh) * | 2012-09-03 | 2013-01-02 | 南通博大生化有限公司 | 一种祛口臭杀菌剂 |
KR101505924B1 (ko) * | 2013-02-19 | 2015-03-25 | 청학에프엔씨 주식회사 | 생약재를 함유하는 가글용 식물성 유지 조성물 |
DE102013212999A1 (de) * | 2013-07-03 | 2015-01-08 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel gegen Halitosis |
DE202014004954U1 (de) | 2014-06-13 | 2014-09-11 | Björn Puradiredja | Pflanzliches Getränk zur Vermeidung unangenehmer Mund- und Körpergerüche |
KR101692232B1 (ko) * | 2014-06-23 | 2017-01-03 | 주식회사 비오케이 | 천연 치약 제조 방법 |
KR102597685B1 (ko) * | 2015-09-25 | 2023-11-01 | 주식회사 엘지생활건강 | 파슬리 추출물을 포함하는 구강용 조성물 |
WO2017085927A1 (ja) * | 2015-11-18 | 2017-05-26 | 株式会社サンギ | 口腔用組成物 |
CN108601807A (zh) * | 2016-02-16 | 2018-09-28 | Atp研究有限公司 | 制剂和使用方法 |
US20180333349A1 (en) * | 2017-05-17 | 2018-11-22 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
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Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB601801A (en) * | 1945-12-03 | 1948-05-12 | Lakeland Foundation | Improvements relating to oral cleansing preparations and methods of making the same |
DE2611895A1 (de) * | 1976-03-20 | 1977-09-29 | Nicolas Fostieris | Verfahren zur herstellung eines speziellen praeparates gegen die mund- und koerpereigenen geruchsausduenstungen nach genuss stark riechender speisen oder genussmittel wie z.b. knoblauch, zwiebeln, tabak, alkohol usw. |
IL68027A (en) * | 1983-03-03 | 1986-09-30 | Univ Ramot | Dental preparation for preventing bacterial adherence to the tooth surface |
US4548809A (en) * | 1984-03-27 | 1985-10-22 | Fung Paul S T | Method for manufacturing a stomatic gargle |
US4572836A (en) * | 1984-11-28 | 1986-02-25 | Gourmeta, Inc. | Stabilized edible herb composition and method |
DE3844632A1 (de) * | 1988-07-07 | 1990-06-28 | Fred Smutny | Mittel auf pflanzlicher basis gegen knoblauchgeruch und allgemeinem mundgeruch |
US5248503A (en) * | 1992-01-03 | 1993-09-28 | Emanuel King Rosalba | Herbal dietary supplement |
DK0725639T3 (da) * | 1993-10-25 | 2000-12-11 | Merrell Pharma Inc | Stabil farmaceutisk sammensætning af terfenadin og ibuprofen |
IT1261861B (it) * | 1993-11-05 | 1996-06-03 | Emanuele Pili | Composizione di colluttorio curativo, estetico disinfettante con solo,ingredienti naturali, per gengive sane, denti bianchi ed alito fresco,procedimento di lavorazione e colluttorio risultante. |
JPH0959138A (ja) * | 1995-08-11 | 1997-03-04 | Shadan Shinbikai Raionzu Shika | 口臭防止剤 |
US5976604A (en) * | 1996-03-08 | 1999-11-02 | Mitsubishi Chemical Corporation | Oil-in-water emulsion composition having high oil content and method for producing the same |
US5900251A (en) * | 1996-06-10 | 1999-05-04 | Breath Asure, Inc. | Internal breath freshener and digestive aid |
US6005126A (en) * | 1997-08-08 | 1999-12-21 | Mitsubishiki Chemical Corporation | Solubilizing agent and hydrosol composition obtained by using the same |
ES2134743B1 (es) * | 1998-02-06 | 2000-05-01 | Biocosmetics Sl | Composicion para el tratamiento de la halitosis. |
-
1998
- 1998-02-06 ES ES009800228A patent/ES2134743B1/es not_active Expired - Fee Related
- 1998-06-26 UA UA2000084693A patent/UA72453C2/uk unknown
- 1998-06-26 AT AT98928343T patent/ATE210959T1/de not_active IP Right Cessation
- 1998-06-26 CA CA002320162A patent/CA2320162C/en not_active Expired - Fee Related
- 1998-06-26 ID IDW20001498A patent/ID27499A/id unknown
- 1998-06-26 AU AU80214/98A patent/AU763274B2/en not_active Ceased
- 1998-06-26 NZ NZ506174A patent/NZ506174A/xx unknown
- 1998-06-26 EE EEP200000452A patent/EE04140B1/xx not_active IP Right Cessation
- 1998-06-26 BR BRPI9815085-5A patent/BR9815085B1/pt not_active IP Right Cessation
- 1998-06-26 DK DK98928343T patent/DK1053743T3/da active
- 1998-06-26 TR TR2000/02310T patent/TR200002310T2/xx unknown
- 1998-06-26 RU RU2000123181/14A patent/RU2201745C2/ru not_active IP Right Cessation
- 1998-06-26 CN CNB988138808A patent/CN1155363C/zh not_active Expired - Fee Related
- 1998-06-26 EP EP98928343A patent/EP1053743B1/en not_active Expired - Lifetime
- 1998-06-26 KR KR10-2000-7008509A patent/KR100500271B1/ko not_active IP Right Cessation
- 1998-06-26 DE DE69803099T patent/DE69803099T2/de not_active Expired - Lifetime
- 1998-06-26 PL PL343367A patent/PL191784B1/pl not_active IP Right Cessation
- 1998-06-26 US US09/601,773 patent/US6350435B1/en not_active Expired - Lifetime
- 1998-06-26 CZ CZ20002881A patent/CZ298853B6/cs not_active IP Right Cessation
- 1998-06-26 WO PCT/ES1998/000184 patent/WO1999039686A1/es active IP Right Grant
- 1998-06-26 HU HU0100765A patent/HUP0100765A3/hu unknown
- 1998-06-26 PT PT98928343T patent/PT1053743E/pt unknown
- 1998-06-26 JP JP2000530187A patent/JP4511028B2/ja not_active Expired - Lifetime
- 1998-06-26 RO ROA200000776A patent/RO118255B1/ro unknown
-
2000
- 2000-08-03 NO NO20003929A patent/NO20003929D0/no not_active Application Discontinuation
- 2000-08-04 LT LT2000077A patent/LT4828B/lt not_active IP Right Cessation
- 2000-09-12 LV LVP-00-105A patent/LV12584B/lv unknown
-
2001
- 2001-11-28 US US09/996,541 patent/US6555093B2/en not_active Expired - Lifetime
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JP2004511506A (ja) * | 2000-10-16 | 2004-04-15 | バイオコスメティックス・ソシエダッド・リミターダ | 口腔内のバクテリアによるプラークおよび/またはバクテリアを除去または低減するための口内衛生製品の調製におけるオリーブオイルの用途 |
WO2006106990A1 (ja) * | 2005-03-31 | 2006-10-12 | Kobayashi Pharmaceutical Co., Ltd. | 口腔用組成物 |
WO2006106991A1 (ja) * | 2005-03-31 | 2006-10-12 | Kobayashi Pharmaceutical Co., Ltd. | 口腔用組成物 |
JP2006306844A (ja) * | 2005-03-31 | 2006-11-09 | Kobayashi Pharmaceut Co Ltd | 口腔用組成物 |
JP4644285B2 (ja) * | 2005-08-22 | 2011-03-02 | キャドバリー アダムス ユーエスエー エルエルシー | 生分解性チューインガム |
JP2009504195A (ja) * | 2005-08-22 | 2009-02-05 | キャドバリー アダムス ユーエスエー エルエルシー | 生分解性チューインガム |
JP2008024696A (ja) * | 2006-06-19 | 2008-02-07 | Morishita Jintan Kk | 口臭除去用多重ソフトカプセル |
JP2011526245A (ja) * | 2008-06-13 | 2011-10-06 | コルゲート・パーモリブ・カンパニー | 口腔用組成物およびその使用 |
WO2020137695A1 (ja) * | 2018-12-28 | 2020-07-02 | 小林製薬株式会社 | カプセル剤 |
JP2020105141A (ja) * | 2018-12-28 | 2020-07-09 | 小林製薬株式会社 | カプセル剤 |
JP2020105140A (ja) * | 2018-12-28 | 2020-07-09 | 小林製薬株式会社 | カプセル剤 |
JP7362248B2 (ja) | 2018-12-28 | 2023-10-17 | 小林製薬株式会社 | カプセル剤 |
JP7399617B2 (ja) | 2018-12-28 | 2023-12-18 | 小林製薬株式会社 | カプセル剤 |
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