JP2002501387A - アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 - Google Patents
アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地Info
- Publication number
- JP2002501387A JP2002501387A JP50042499A JP50042499A JP2002501387A JP 2002501387 A JP2002501387 A JP 2002501387A JP 50042499 A JP50042499 A JP 50042499A JP 50042499 A JP50042499 A JP 50042499A JP 2002501387 A JP2002501387 A JP 2002501387A
- Authority
- JP
- Japan
- Prior art keywords
- medium
- animal
- proteinaceous material
- derived
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/21—Haemophilus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.病原性細菌の免疫原性因子を調製するためのプロセスであって、Helicobact er pylori、Haemophilus influenzae、Corynebacterium diphtheriae、Neisseri a meningitidis、Bordetella pertussis、またはClostridium tetaniから選択さ れる病原性細菌を、少なくとも20乾燥重量%の動物由来でないタンパク質性物質 を含み、かつ動物由来タンパク質性物質を含まない培地中で培養する工程、およ び必要に応じて、該培地から該免疫原性因子を精製する工程を包含し、ここで、 該動物由来でないタンパク質性物質は、酵母抽出物および/または大豆由来タン パク質組成物である、プロセス。 2.ワクチン生成のためのプロセスであって、請求項1に記載のプロセスによっ て病原性細菌の免疫原性因子を調製する工程、および該因子を薬学的に受容可能 なキャリアと結合させる工程を包含し、ここで、該因子は必要に応じてトキソイ ド化される、プロセス。 3.免疫原性因子を生成するために、Helicobacter pylori、Haemophilus influ enzae、Corynebacterium diphtheriae、Neisseria meningitidis、Bordetella p ertussis、またはClostridium tetaniから選択される病原性細菌を培養するため の培地の作製プロセスであって、病原性細菌を培養するための該培地が、少なく とも20乾燥重量%の動物由来でないタンパク質性物質を含み、かつ動物由来のタ ンパク質性物質を含まないように、充分な動物由来でないタンパク質性物質を、 細菌を培養するための動物由来タンパク質性物質を含まない標準培地に添加する 工程を包含し、ここで、該動物由来でないタンパク質性物質は、酵母抽出物およ び/または大豆由来タンパク質組成物である、プロセス。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9710981.3A GB9710981D0 (en) | 1997-05-28 | 1997-05-28 | Culture medium |
GB9710981.3 | 1997-05-28 | ||
GB9806802.6 | 1998-03-30 | ||
GBGB9806802.6A GB9806802D0 (en) | 1998-03-30 | 1998-03-30 | Culture medium |
PCT/IB1998/000938 WO1998054296A1 (en) | 1997-05-28 | 1998-05-28 | Culture medium with yeast or soy bean extract as aminoacid source and no protein complexes of animal origin |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008101788A Division JP2008200047A (ja) | 1997-05-28 | 2008-04-09 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002501387A true JP2002501387A (ja) | 2002-01-15 |
JP4173560B2 JP4173560B2 (ja) | 2008-10-29 |
Family
ID=26311607
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50042499A Expired - Fee Related JP4173560B2 (ja) | 1997-05-28 | 1998-05-28 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
JP2008101788A Withdrawn JP2008200047A (ja) | 1997-05-28 | 2008-04-09 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
JP2011179095A Withdrawn JP2012005495A (ja) | 1997-05-28 | 2011-08-18 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008101788A Withdrawn JP2008200047A (ja) | 1997-05-28 | 2008-04-09 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
JP2011179095A Withdrawn JP2012005495A (ja) | 1997-05-28 | 2011-08-18 | アミノ酸源として酵母または大豆抽出物を含み、動物起源のタンパク質複合体を含まない培養培地 |
Country Status (10)
Country | Link |
---|---|
EP (4) | EP2199382A3 (ja) |
JP (3) | JP4173560B2 (ja) |
AT (2) | ATE372376T1 (ja) |
AU (1) | AU7545298A (ja) |
CY (2) | CY1107812T1 (ja) |
DE (2) | DE69842010D1 (ja) |
DK (1) | DK0983342T3 (ja) |
ES (1) | ES2293681T3 (ja) |
PT (2) | PT983342E (ja) |
WO (1) | WO1998054296A1 (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006502140A (ja) * | 2002-08-16 | 2006-01-19 | メリアル リミテッド | 非動物製品含有獣医製剤 |
JP2007506427A (ja) * | 2003-09-25 | 2007-03-22 | アラーガン、インコーポレイテッド | ボツリヌス毒素を取得するための動物性生成物を含まない培地および方法 |
JP2008531046A (ja) * | 2005-03-03 | 2008-08-14 | アラーガン、インコーポレイテッド | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
JP2014500269A (ja) * | 2011-11-11 | 2014-01-09 | ノバルティス アーゲー | ヒトワクチンとしての使用に適するジフテリアトキソイドの生成のための動物由来成分を含まない発酵培地 |
JP2014012005A (ja) * | 2005-10-11 | 2014-01-23 | Probiotical Spa | 非アレルギー性プロバイオティックバクテリア培養物の生成方法とその使用 |
JP2018533366A (ja) * | 2015-11-17 | 2018-11-15 | ファイザー・インク | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
US11124786B2 (en) | 2009-07-13 | 2021-09-21 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
JP2022520925A (ja) * | 2019-01-04 | 2022-04-04 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 弱毒化ボルデテラ・ブロンキセプチカ株、当該弱毒化株を含む経口ワクチン並びに前記の製造及び使用方法 |
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US6475725B1 (en) | 1997-06-20 | 2002-11-05 | Baxter Aktiengesellschaft | Recombinant cell clones having increased stability and methods of making and using the same |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
US6558926B1 (en) * | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
EP1074612A1 (en) * | 1999-08-04 | 2001-02-07 | Pasteur Merieux Serums Et Vaccins | Use of vegetal peptones for DNA vaccine production |
MXPA03006561A (es) | 2001-01-23 | 2004-10-15 | Aventis Pasteur | Vacuna del conjugado proteina-polisacarido meningococico, multivalente. |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
WO2004033623A2 (en) * | 2002-05-16 | 2004-04-22 | Aventis Pasteur, Inc. | Animal component free meningococcal polysaccharide fermentation and seedbank development |
EP1520008B1 (en) | 2002-07-09 | 2012-09-05 | Baxter International Inc. | Animal protein free media for cultivation of cells |
US7160699B2 (en) | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
US7452697B2 (en) | 2003-09-25 | 2008-11-18 | Allergan, Inc. | Chromatographic method and system for purifying a botulinum toxin |
US20070280967A1 (en) * | 2003-12-03 | 2007-12-06 | Tim Lee | Cryo-protective agents for microorganisms |
CN1894399A (zh) * | 2003-12-12 | 2007-01-10 | 圣诺菲·帕斯图尔有限公司 | 白喉毒素的制备 |
GB0408978D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Meningococcal fermentation for preparing conjugate vaccines |
WO2006042542A2 (en) * | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
NL1029059C2 (nl) * | 2005-05-17 | 2006-11-20 | Noord Nl Oliemolen Holding B V | Peptidenpreparaat voor het groeien en/of kweken van micro-organismen en/of cellen. |
PL2522717T3 (pl) | 2006-01-04 | 2014-08-29 | Baxalta Inc | Pożywki do hodowli komórkowych wolne od oligopeptydów |
DK1893033T3 (da) * | 2006-07-07 | 2009-01-05 | Alpro Nv | Fremgangsmåde til fremstilling af en mælkeproduktanalog |
EP3332791A1 (en) | 2007-03-05 | 2018-06-13 | OM Pharma | Bacterial extract for respiratory disorders and process for its preparation |
FR2918671B1 (fr) | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
EP2275527A1 (en) * | 2009-07-17 | 2011-01-19 | ActoGeniX NV | Animal component-free culture medium for bacterial fermentation |
DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
BR102012013110A2 (pt) | 2012-05-31 | 2014-05-27 | Cristalia Prod Quimicos Farm | Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica |
CN104263678A (zh) * | 2014-09-02 | 2015-01-07 | 成都欧林生物科技股份有限公司 | 一种白喉杆菌培养基及应用其制备白喉类毒素的方法 |
CN107849093B (zh) | 2015-05-06 | 2022-02-18 | 瓦赫宁恩大学 | 培养阿克曼氏菌的方法 |
UA127497C2 (uk) | 2017-04-22 | 2023-09-13 | Байолоджикал Е Лімітед | СПОСІБ ВЕЛИКОМАСШТАБНОГО ВИРОБНИЦТВА CRM<sub>197</sub> |
CN112646747B (zh) * | 2021-01-08 | 2024-03-15 | 苏州聚微生物科技有限公司 | 破伤风梭状芽孢杆菌培养基 |
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DE4220889A1 (de) * | 1992-06-25 | 1994-02-24 | Mueller Karl & Co Kg | Reaktivierungsmischung für Starterkulturen zur Rohwurstherstellung |
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- 1998-05-28 PT PT98923023T patent/PT983342E/pt unknown
- 1998-05-28 EP EP10002348A patent/EP2199382A3/en not_active Withdrawn
- 1998-05-28 AT AT98923023T patent/ATE372376T1/de active
- 1998-05-28 EP EP07075660A patent/EP1849860B1/en not_active Expired - Lifetime
- 1998-05-28 JP JP50042499A patent/JP4173560B2/ja not_active Expired - Fee Related
- 1998-05-28 DE DE69842010T patent/DE69842010D1/de not_active Expired - Lifetime
- 1998-05-28 AT AT07075660T patent/ATE488574T1/de active
- 1998-05-28 EP EP10176826.5A patent/EP2267113B1/en not_active Expired - Lifetime
- 1998-05-28 DE DE69838383T patent/DE69838383T2/de not_active Expired - Lifetime
- 1998-05-28 AU AU75452/98A patent/AU7545298A/en not_active Abandoned
- 1998-05-28 WO PCT/IB1998/000938 patent/WO1998054296A1/en active IP Right Grant
- 1998-05-28 EP EP98923023A patent/EP0983342B1/en not_active Expired - Lifetime
- 1998-05-28 DK DK98923023T patent/DK0983342T3/da active
- 1998-05-28 PT PT07075660T patent/PT1849860E/pt unknown
- 1998-05-28 ES ES98923023T patent/ES2293681T3/es not_active Expired - Lifetime
-
2007
- 2007-11-26 CY CY20071101507T patent/CY1107812T1/el unknown
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- 2008-04-09 JP JP2008101788A patent/JP2008200047A/ja not_active Withdrawn
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- 2011-02-09 CY CY20111100146T patent/CY1111178T1/el unknown
- 2011-08-18 JP JP2011179095A patent/JP2012005495A/ja not_active Withdrawn
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006502140A (ja) * | 2002-08-16 | 2006-01-19 | メリアル リミテッド | 非動物製品含有獣医製剤 |
JP2007506427A (ja) * | 2003-09-25 | 2007-03-22 | アラーガン、インコーポレイテッド | ボツリヌス毒素を取得するための動物性生成物を含まない培地および方法 |
US9725705B2 (en) | 2003-09-25 | 2017-08-08 | Allergan, Inc. | Animal product free system and process for purifying a botulinum toxin |
JP2015051019A (ja) * | 2003-09-25 | 2015-03-19 | アラーガン、インコーポレイテッドAllergan,Incorporated | ボツリヌス毒素を取得するための動物性生成物を含まない培地および方法 |
JP2012070759A (ja) * | 2003-09-25 | 2012-04-12 | Allergan Inc | ボツリヌス毒素を取得するための動物性生成物を含まない培地および方法 |
JP4913074B2 (ja) * | 2005-03-03 | 2012-04-11 | アラーガン、インコーポレイテッド | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
JP2012125251A (ja) * | 2005-03-03 | 2012-07-05 | Allergan Inc | クロストリジウム・バクテリアの培地およびクロストリジウム毒素を得るための方法 |
JP2008531047A (ja) * | 2005-03-03 | 2008-08-14 | アラーガン、インコーポレイテッド | クロストリジウム・バクテリアの培地およびクロストリジウム毒素を得るための方法 |
JP2008531046A (ja) * | 2005-03-03 | 2008-08-14 | アラーガン、インコーポレイテッド | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
JP2012041356A (ja) * | 2005-03-03 | 2012-03-01 | Allergan Inc | 動物由来産物不含方法およびボツリヌス毒素を精製するための方法 |
JP2014012005A (ja) * | 2005-10-11 | 2014-01-23 | Probiotical Spa | 非アレルギー性プロバイオティックバクテリア培養物の生成方法とその使用 |
US11518986B2 (en) | 2009-07-13 | 2022-12-06 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
US11124786B2 (en) | 2009-07-13 | 2021-09-21 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
US11203748B2 (en) | 2009-07-13 | 2021-12-21 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
US11530400B2 (en) | 2009-07-13 | 2022-12-20 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
US11525130B2 (en) | 2009-07-13 | 2022-12-13 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
US11326155B2 (en) | 2009-07-13 | 2022-05-10 | Allergan, Inc. | Process and system for obtaining botulinum neurotoxin |
JP2014500269A (ja) * | 2011-11-11 | 2014-01-09 | ノバルティス アーゲー | ヒトワクチンとしての使用に適するジフテリアトキソイドの生成のための動物由来成分を含まない発酵培地 |
JP2018533366A (ja) * | 2015-11-17 | 2018-11-15 | ファイザー・インク | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
JP2022017529A (ja) * | 2015-11-17 | 2022-01-25 | ファイザー・インク | 細菌細胞培養物中で多糖を生成するための培地および発酵方法 |
JP2022520925A (ja) * | 2019-01-04 | 2022-04-04 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 弱毒化ボルデテラ・ブロンキセプチカ株、当該弱毒化株を含む経口ワクチン並びに前記の製造及び使用方法 |
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AU7545298A (en) | 1998-12-30 |
ATE488574T1 (de) | 2010-12-15 |
WO1998054296A1 (en) | 1998-12-03 |
EP1849860B1 (en) | 2010-11-17 |
DE69838383T2 (de) | 2008-06-05 |
ES2293681T3 (es) | 2008-03-16 |
JP2008200047A (ja) | 2008-09-04 |
EP2267113B1 (en) | 2013-07-17 |
DE69838383D1 (de) | 2007-10-18 |
DE69842010D1 (de) | 2010-12-30 |
EP2267113A1 (en) | 2010-12-29 |
CY1111178T1 (el) | 2015-06-11 |
CY1107812T1 (el) | 2013-06-19 |
JP4173560B2 (ja) | 2008-10-29 |
EP2199382A2 (en) | 2010-06-23 |
PT983342E (pt) | 2007-12-13 |
EP1849860A3 (en) | 2008-04-02 |
EP2199382A3 (en) | 2010-09-22 |
PT1849860E (pt) | 2011-02-23 |
EP0983342B1 (en) | 2007-09-05 |
EP1849860A2 (en) | 2007-10-31 |
DK0983342T3 (da) | 2008-01-07 |
JP2012005495A (ja) | 2012-01-12 |
EP0983342A1 (en) | 2000-03-08 |
ATE372376T1 (de) | 2007-09-15 |
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