JP2002100318A - 質量分析方法および装置 - Google Patents
質量分析方法および装置Info
- Publication number
- JP2002100318A JP2002100318A JP2001175716A JP2001175716A JP2002100318A JP 2002100318 A JP2002100318 A JP 2002100318A JP 2001175716 A JP2001175716 A JP 2001175716A JP 2001175716 A JP2001175716 A JP 2001175716A JP 2002100318 A JP2002100318 A JP 2002100318A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- ions
- ion
- daughter
- mode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004949 mass spectrometry Methods 0.000 title claims description 79
- 150000002500 ions Chemical class 0.000 claims abstract description 578
- 238000013467 fragmentation Methods 0.000 claims abstract description 106
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 106
- 238000000034 method Methods 0.000 claims abstract description 103
- 230000007935 neutral effect Effects 0.000 claims abstract description 35
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 8
- 238000001819 mass spectrum Methods 0.000 claims description 41
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 238000001914 filtration Methods 0.000 claims description 16
- 230000003287 optical effect Effects 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 230000008034 disappearance Effects 0.000 claims description 9
- 238000005040 ion trap Methods 0.000 claims description 8
- 230000005684 electric field Effects 0.000 claims description 7
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 6
- 238000003795 desorption Methods 0.000 claims description 6
- 238000004811 liquid chromatography Methods 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 5
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 4
- 238000000451 chemical ionisation Methods 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
- 238000004817 gas chromatography Methods 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 239000010452 phosphate Substances 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims 2
- 238000001228 spectrum Methods 0.000 abstract description 96
- 238000004587 chromatography analysis Methods 0.000 abstract description 6
- 239000002243 precursor Substances 0.000 description 31
- 238000012360 testing method Methods 0.000 description 13
- 239000007789 gas Substances 0.000 description 12
- 102000011632 Caseins Human genes 0.000 description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 108010076119 Caseins Proteins 0.000 description 8
- 238000004885 tandem mass spectrometry Methods 0.000 description 8
- 238000001360 collision-induced dissociation Methods 0.000 description 7
- 230000029087 digestion Effects 0.000 description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 6
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 238000007796 conventional method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 4
- 229910052786 argon Inorganic materials 0.000 description 4
- 229960001230 asparagine Drugs 0.000 description 4
- 235000009582 asparagine Nutrition 0.000 description 4
- 150000001793 charged compounds Chemical class 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 235000021249 α-casein Nutrition 0.000 description 4
- 235000021247 β-casein Nutrition 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000003570 air Substances 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 101800003778 Fibrinopeptide B Proteins 0.000 description 1
- 102400001063 Fibrinopeptide B Human genes 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 101710150593 Protein beta Proteins 0.000 description 1
- 101100370021 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TOF2 gene Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- 239000002359 drug metabolite Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- MYRIFIVQGRMHRF-OECXYHNASA-N fibrinopeptide b Chemical compound N([C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)CNC(=O)[C@@H]1CCC(=O)N1 MYRIFIVQGRMHRF-OECXYHNASA-N 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- 238000002542 parent ion scan Methods 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 description 1
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 238000002541 precursor ion scan Methods 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014062A GB0014062D0 (en) | 2000-06-09 | 2000-06-09 | Methods and apparatus for tandem mass spectrometry |
| GB0014062.4 | 2000-06-09 | ||
| GB0101048A GB0101048D0 (en) | 2001-01-15 | 2001-01-15 | Methods and apparatus for tandem mass spectrometry |
| GB0101048.7 | 2001-01-15 | ||
| GB0105227.3 | 2001-03-02 | ||
| GB0105227A GB2364168B (en) | 2000-06-09 | 2001-03-02 | Methods and apparatus for mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002100318A true JP2002100318A (ja) | 2002-04-05 |
Family
ID=27255755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001175716A Pending JP2002100318A (ja) | 2000-06-09 | 2001-06-11 | 質量分析方法および装置 |
| JP2001175747A Expired - Lifetime JP4588925B2 (ja) | 2000-06-09 | 2001-06-11 | 質量分析方法および装置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001175747A Expired - Lifetime JP4588925B2 (ja) | 2000-06-09 | 2001-06-11 | 質量分析方法および装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6717130B2 (enExample) |
| EP (4) | EP1622188B1 (enExample) |
| JP (2) | JP2002100318A (enExample) |
| AT (2) | ATE329369T1 (enExample) |
| CA (2) | CA2340150C (enExample) |
| DE (2) | DE60120337T2 (enExample) |
| GB (1) | GB2363249B (enExample) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005241637A (ja) * | 2004-02-06 | 2005-09-08 | Micromass Uk Ltd | マススペクトロメータ |
| JP2006521005A (ja) * | 2003-03-20 | 2006-09-14 | サイエンス アンド テクノロジー コーポレイション アット ユニバーシティ オブ ニューメキシコ | Ｍｓ及び同時無走査ｍｓ／ｍｓ用の飛行距離スペクトロメーター |
| WO2008130055A1 (ja) | 2007-04-18 | 2008-10-30 | Nippon Steel Corporation | ハイドロフォーム加工方法 |
| WO2008130056A1 (ja) | 2007-04-18 | 2008-10-30 | Nippon Steel Corporation | ハイドロフォーム加工品 |
| JP2009513954A (ja) * | 2005-10-28 | 2009-04-02 | エムディーエス アナリティカル テクノロジーズ， ア ビジネス ユニット オブ エムディーエス インコーポレイテッド | 特定のニュートラルディファレンスと関連する反応対の特定な同定のための方法、システムおよびコンピュータソフトウェア製品 |
| JP2009516842A (ja) * | 2005-11-23 | 2009-04-23 | マイクロマス ユーケー リミテッド | 質量分析計 |
| JP2009516903A (ja) * | 2005-11-23 | 2009-04-23 | マイクロマス ユーケー リミテッド | 質量分析計 |
| JP2009516843A (ja) * | 2005-11-23 | 2009-04-23 | マイクロマス ユーケー リミテッド | 質量分析計 |
| JP2009522558A (ja) * | 2006-01-05 | 2009-06-11 | エムディーエス アナリティカル テクノロジーズ， ア ビジネス ユニット オブ エムディーエス インコーポレイテッド， ドゥーイング ビジネス スルー イッツ サイエックス ディビジョン | 質量欠損によりトリガされる情報依存収集 |
| JP2009526206A (ja) * | 2006-02-07 | 2009-07-16 | アプライド バイオシステムズ インコーポレイテッド | 質量分析のための化学ノイズの低減 |
| JP2009536338A (ja) * | 2006-05-10 | 2009-10-08 | マイクロマス ユーケー リミテッド | 質量分析計 |
| JP2010526987A (ja) * | 2006-12-26 | 2010-08-05 | ブリガム・ヤング・ユニバーシティ | 血清プロテオミクスシステムと関連する方法 |
| WO2013150351A1 (en) * | 2012-04-02 | 2013-10-10 | Dh Technologies Development Pte. Ltd. | Systems and methods for sequential windowed acquisition across a mass range using an ion trap |
| JP2014502725A (ja) * | 2010-12-29 | 2014-02-03 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 依存的質量分析走査をトリガするための方法 |
| US8704164B2 (en) | 2002-07-24 | 2014-04-22 | Micromass Uk Limited | Mass analysis using alternating fragmentation modes |
| JP2014527276A (ja) * | 2011-09-16 | 2014-10-09 | マイクロマス ユーケー リミテッド | プロダクトイオンの帰属を支援するためのプリカーサーイオンビームのエンコード |
| US8909481B2 (en) | 2000-12-26 | 2014-12-09 | The Institute Of Systems Biology | Method of mass spectrometry for identifying polypeptides |
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| GB2364168B (en) * | 2000-06-09 | 2002-06-26 | Micromass Ltd | Methods and apparatus for mass spectrometry |
| US7038197B2 (en) * | 2001-04-03 | 2006-05-02 | Micromass Limited | Mass spectrometer and method of mass spectrometry |
| WO2003073464A1 (de) * | 2002-02-28 | 2003-09-04 | Metanomics Gmbh & Co. Kgaa | Massenspektrometrisches verfahren zur analyse von substanzgemischen |
| JP3743717B2 (ja) * | 2002-06-25 | 2006-02-08 | 株式会社日立製作所 | 質量分析データの解析方法および質量分析データの解析装置および質量分析データの解析プログラムならびにソリューション提供システム |
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| JP4690641B2 (ja) * | 2003-07-28 | 2011-06-01 | 株式会社日立ハイテクノロジーズ | 質量分析計 |
| GB0322356D0 (en) * | 2003-09-24 | 2003-10-22 | Micromass Ltd | Mass spectrometer |
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Also Published As
| Publication number | Publication date |
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| DE60126055T2 (de) | 2007-08-23 |
| GB2363249B (en) | 2002-08-28 |
| EP1220290A2 (en) | 2002-07-03 |
| GB2363249A (en) | 2001-12-12 |
| DE60120337T2 (de) | 2007-05-24 |
| ATE329369T1 (de) | 2006-06-15 |
| JP4588925B2 (ja) | 2010-12-01 |
| EP1225618B1 (en) | 2007-01-17 |
| EP1225618A3 (en) | 2004-03-31 |
| JP2002110081A (ja) | 2002-04-12 |
| US6717130B2 (en) | 2004-04-06 |
| EP1638133B1 (en) | 2009-10-07 |
| DE60120337D1 (de) | 2006-07-20 |
| EP1225618A2 (en) | 2002-07-24 |
| CA2340150A1 (en) | 2001-12-09 |
| EP1225618B3 (en) | 2015-02-18 |
| EP1622188A2 (en) | 2006-02-01 |
| CA2340150C (en) | 2005-11-22 |
| CA2350041A1 (en) | 2001-12-09 |
| CA2350041C (en) | 2008-01-08 |
| US20020063206A1 (en) | 2002-05-30 |
| GB0114166D0 (en) | 2001-08-01 |
| DE60126055D1 (de) | 2007-03-08 |
| EP1220290A3 (en) | 2004-03-31 |
| EP1638133B3 (en) | 2012-06-13 |
| ATE352097T1 (de) | 2007-02-15 |
| EP1638133A2 (en) | 2006-03-22 |
| DE60126055T3 (de) | 2015-05-13 |
| EP1622188B1 (en) | 2012-06-13 |
| EP1622188A3 (en) | 2007-12-19 |
| EP1220290B1 (en) | 2006-06-07 |
| EP1638133A3 (en) | 2007-12-05 |
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