EP1622188A3 - Methods and apparatus for mass spectrometry - Google Patents

Methods and apparatus for mass spectrometry Download PDF

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Publication number
EP1622188A3
EP1622188A3 EP05022407A EP05022407A EP1622188A3 EP 1622188 A3 EP1622188 A3 EP 1622188A3 EP 05022407 A EP05022407 A EP 05022407A EP 05022407 A EP05022407 A EP 05022407A EP 1622188 A3 EP1622188 A3 EP 1622188A3
Authority
EP
European Patent Office
Prior art keywords
ions
collision cell
ion
mass
mass filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05022407A
Other languages
German (de)
French (fr)
Other versions
EP1622188A2 (en
EP1622188B1 (en
Inventor
Robert Harold Bateman
John Brian Hoyes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27255755&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1622188(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0014062A external-priority patent/GB0014062D0/en
Priority claimed from GB0101048A external-priority patent/GB0101048D0/en
Priority claimed from GB0105227A external-priority patent/GB2364168B/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of EP1622188A2 publication Critical patent/EP1622188A2/en
Publication of EP1622188A3 publication Critical patent/EP1622188A3/en
Application granted granted Critical
Publication of EP1622188B1 publication Critical patent/EP1622188B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

An improved method of parent ion scanning is disclosed. In one embodiment a quadrupole mass filter 3 upstream of a collision cell 4 is arranged to operate in a highpass mode. Parent ions transmitted by the mass filter 3 are fragmented in the collision cell 4 and detected by an orthogonal time of flight analyser 5 which obtains a daughter ion mass spectrum. Ions having a mass to charge ratio below the cutoff of the mass filter 3 are identified as daughter ions, and candidate parent ions may then be discovered and their identity confirmed by obtaining corresponding daughter ion spectra. In a second embodiment, the collision cell 4 alternates between high and low fragmentation and candidate parent ions can additionally be identified on the basis of the loss of a predetermined ion or neutral particle.
EP05022407A 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry Expired - Lifetime EP1622188B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0014062A GB0014062D0 (en) 2000-06-09 2000-06-09 Methods and apparatus for tandem mass spectrometry
GB0101048A GB0101048D0 (en) 2001-01-15 2001-01-15 Methods and apparatus for tandem mass spectrometry
GB0105227A GB2364168B (en) 2000-06-09 2001-03-02 Methods and apparatus for mass spectrometry
EP01302377A EP1220290B1 (en) 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP01302377A Division EP1220290B1 (en) 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry
EP01302377.5 Division 2001-03-14

Publications (3)

Publication Number Publication Date
EP1622188A2 EP1622188A2 (en) 2006-02-01
EP1622188A3 true EP1622188A3 (en) 2007-12-19
EP1622188B1 EP1622188B1 (en) 2012-06-13

Family

ID=27255755

Family Applications (4)

Application Number Title Priority Date Filing Date
EP05022407A Expired - Lifetime EP1622188B1 (en) 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry
EP01302377A Expired - Lifetime EP1220290B1 (en) 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry
EP05025116A Expired - Lifetime EP1638133B3 (en) 2000-06-09 2001-06-11 Methods and apparatus for mass spectrometry
EP01305040.6A Expired - Lifetime EP1225618B3 (en) 2000-06-09 2001-06-11 Mass spectrometer and methods of mass spectrometry

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP01302377A Expired - Lifetime EP1220290B1 (en) 2000-06-09 2001-03-14 Methods and apparatus for mass spectrometry
EP05025116A Expired - Lifetime EP1638133B3 (en) 2000-06-09 2001-06-11 Methods and apparatus for mass spectrometry
EP01305040.6A Expired - Lifetime EP1225618B3 (en) 2000-06-09 2001-06-11 Mass spectrometer and methods of mass spectrometry

Country Status (7)

Country Link
US (1) US6717130B2 (en)
EP (4) EP1622188B1 (en)
JP (2) JP2002100318A (en)
AT (2) ATE329369T1 (en)
CA (2) CA2340150C (en)
DE (2) DE60120337T2 (en)
GB (1) GB2363249B (en)

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Also Published As

Publication number Publication date
EP1622188A2 (en) 2006-02-01
ATE352097T1 (en) 2007-02-15
EP1638133A2 (en) 2006-03-22
DE60126055D1 (en) 2007-03-08
EP1638133B1 (en) 2009-10-07
EP1220290A2 (en) 2002-07-03
CA2340150A1 (en) 2001-12-09
EP1638133B3 (en) 2012-06-13
JP2002100318A (en) 2002-04-05
US20020063206A1 (en) 2002-05-30
GB0114166D0 (en) 2001-08-01
ATE329369T1 (en) 2006-06-15
DE60120337D1 (en) 2006-07-20
JP2002110081A (en) 2002-04-12
CA2350041C (en) 2008-01-08
DE60120337T2 (en) 2007-05-24
DE60126055T2 (en) 2007-08-23
JP4588925B2 (en) 2010-12-01
EP1622188B1 (en) 2012-06-13
EP1638133A3 (en) 2007-12-05
CA2350041A1 (en) 2001-12-09
EP1225618A3 (en) 2004-03-31
EP1225618A2 (en) 2002-07-24
EP1220290A3 (en) 2004-03-31
GB2363249A (en) 2001-12-12
EP1225618B3 (en) 2015-02-18
GB2363249B (en) 2002-08-28
EP1220290B1 (en) 2006-06-07
DE60126055T3 (en) 2015-05-13
US6717130B2 (en) 2004-04-06
EP1225618B1 (en) 2007-01-17
CA2340150C (en) 2005-11-22

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