CA2340150C - Methods and apparatus for mass spectrometry - Google Patents
Methods and apparatus for mass spectrometry Download PDFInfo
- Publication number
- CA2340150C CA2340150C CA002340150A CA2340150A CA2340150C CA 2340150 C CA2340150 C CA 2340150C CA 002340150 A CA002340150 A CA 002340150A CA 2340150 A CA2340150 A CA 2340150A CA 2340150 C CA2340150 C CA 2340150C
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- Prior art keywords
- ions
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 136
- 238000004949 mass spectrometry Methods 0.000 title claims description 96
- 150000002500 ions Chemical class 0.000 claims abstract description 678
- 238000013467 fragmentation Methods 0.000 claims abstract description 140
- 238000006062 fragmentation reaction Methods 0.000 claims abstract description 140
- 238000001819 mass spectrum Methods 0.000 claims abstract description 47
- 230000007935 neutral effect Effects 0.000 claims abstract description 41
- 239000002245 particle Substances 0.000 claims abstract description 14
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 12
- 230000003287 optical effect Effects 0.000 claims description 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 24
- 239000003480 eluent Substances 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 20
- 230000005540 biological transmission Effects 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 238000005040 ion trap Methods 0.000 claims description 10
- 238000004458 analytical method Methods 0.000 claims description 9
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 8
- 238000003795 desorption Methods 0.000 claims description 7
- 238000004811 liquid chromatography Methods 0.000 claims description 7
- 125000000524 functional group Chemical group 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 5
- 238000000451 chemical ionisation Methods 0.000 claims description 5
- 230000005684 electric field Effects 0.000 claims description 5
- 238000004817 gas chromatography Methods 0.000 claims description 5
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims 3
- 238000001228 spectrum Methods 0.000 abstract description 95
- 239000002243 precursor Substances 0.000 description 31
- 238000004885 tandem mass spectrometry Methods 0.000 description 25
- 239000000047 product Substances 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 14
- 239000012634 fragment Substances 0.000 description 12
- 239000007789 gas Substances 0.000 description 12
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 238000007796 conventional method Methods 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 6
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 102000011632 Caseins Human genes 0.000 description 4
- 108010076119 Caseins Proteins 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 229910052786 argon Inorganic materials 0.000 description 4
- 150000001793 charged compounds Chemical class 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 229960001230 asparagine Drugs 0.000 description 3
- 235000009582 asparagine Nutrition 0.000 description 3
- 239000005018 casein Substances 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000003570 air Substances 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- -1 for example Chemical class 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000021249 α-casein Nutrition 0.000 description 2
- 235000021247 β-casein Nutrition 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 238000002539 daughter ion scan Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- 239000012502 diagnostic product Substances 0.000 description 1
- 239000002359 drug metabolite Substances 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 description 1
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014062A GB0014062D0 (en) | 2000-06-09 | 2000-06-09 | Methods and apparatus for tandem mass spectrometry |
| GB0014062.4 | 2000-06-09 | ||
| GB0101048A GB0101048D0 (en) | 2001-01-15 | 2001-01-15 | Methods and apparatus for tandem mass spectrometry |
| GB0101048.7 | 2001-01-15 | ||
| GB0105227.3 | 2001-03-02 | ||
| GB0105227A GB2364168B (en) | 2000-06-09 | 2001-03-02 | Methods and apparatus for mass spectrometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2340150A1 CA2340150A1 (en) | 2001-12-09 |
| CA2340150C true CA2340150C (en) | 2005-11-22 |
Family
ID=27255755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002340150A Expired - Fee Related CA2340150C (en) | 2000-06-09 | 2001-03-09 | Methods and apparatus for mass spectrometry |
| CA002350041A Expired - Lifetime CA2350041C (en) | 2000-06-09 | 2001-06-08 | Methods and apparatus for mass spectrometry |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002350041A Expired - Lifetime CA2350041C (en) | 2000-06-09 | 2001-06-08 | Methods and apparatus for mass spectrometry |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6717130B2 (enExample) |
| EP (4) | EP1622188B1 (enExample) |
| JP (2) | JP2002100318A (enExample) |
| AT (2) | ATE329369T1 (enExample) |
| CA (2) | CA2340150C (enExample) |
| DE (2) | DE60120337T2 (enExample) |
| GB (1) | GB2363249B (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2364168B (en) * | 2000-06-09 | 2002-06-26 | Micromass Ltd | Methods and apparatus for mass spectrometry |
| US20020115056A1 (en) * | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US7038197B2 (en) * | 2001-04-03 | 2006-05-02 | Micromass Limited | Mass spectrometer and method of mass spectrometry |
| WO2003073464A1 (de) * | 2002-02-28 | 2003-09-04 | Metanomics Gmbh & Co. Kgaa | Massenspektrometrisches verfahren zur analyse von substanzgemischen |
| JP3743717B2 (ja) * | 2002-06-25 | 2006-02-08 | 株式会社日立製作所 | 質量分析データの解析方法および質量分析データの解析装置および質量分析データの解析プログラムならびにソリューション提供システム |
| GB0305796D0 (en) * | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| US7041968B2 (en) * | 2003-03-20 | 2006-05-09 | Science & Technology Corporation @ Unm | Distance of flight spectrometer for MS and simultaneous scanless MS/MS |
| US7202473B2 (en) | 2003-04-10 | 2007-04-10 | Micromass Uk Limited | Mass spectrometer |
| US7462821B2 (en) * | 2003-04-25 | 2008-12-09 | Griffin Analytical Technologies, L.L.C. | Instrumentation, articles of manufacture, and analysis methods |
| JP4690641B2 (ja) * | 2003-07-28 | 2011-06-01 | 株式会社日立ハイテクノロジーズ | 質量分析計 |
| GB0322356D0 (en) * | 2003-09-24 | 2003-10-22 | Micromass Ltd | Mass spectrometer |
| US7022980B2 (en) * | 2004-02-02 | 2006-04-04 | Agilent Technologies, Inc. | Spectral axis transform |
| US20060186028A1 (en) * | 2004-02-06 | 2006-08-24 | Micromass Uk Limited | Mass spectrometer |
| DE202005001630U1 (de) * | 2004-02-06 | 2005-06-23 | Micromass Uk Ltd. | Massenspektrometer |
| WO2005079263A2 (en) * | 2004-02-13 | 2005-09-01 | Waters Investments Limited | Apparatus and method for identifying peaks in liquid chromatography/mass spectrometry data and for forming spectra and chromatograms |
| US7994474B2 (en) * | 2004-02-23 | 2011-08-09 | Andreas Hieke | Laser desorption ionization ion source with charge injection |
| US8003934B2 (en) * | 2004-02-23 | 2011-08-23 | Andreas Hieke | Methods and apparatus for ion sources, ion control and ion measurement for macromolecules |
| EP1756852B1 (en) | 2004-05-20 | 2014-04-30 | Waters Technologies Corporation | Method and apparatus for identifying proteins in mixtures |
| DE112005001143B4 (de) * | 2004-05-20 | 2014-10-30 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | System und Verfahren zum Gruppieren von Vorläufer- und Fragmentionen unter Verwendung von Chromatogrammen ausgewählter Ionen |
| DE112005001385T5 (de) * | 2004-06-15 | 2007-05-10 | Griffin analytical Technologies Inc., West Lafayette | Analyseinstrumente, -baugruppen und -verfahren |
| GB0416288D0 (en) * | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| DE102004045534B4 (de) | 2004-09-20 | 2010-07-22 | Bruker Daltonik Gmbh | Tochterionenspektren mit Flugzeitmassenspektrometern |
| US7197402B2 (en) * | 2004-10-14 | 2007-03-27 | Highchem, Ltd. | Determination of molecular structures using tandem mass spectrometry |
| GB0508239D0 (en) * | 2005-04-23 | 2005-06-01 | Smiths Group Plc | Detection apparatus |
| GB2439261B (en) | 2005-04-25 | 2011-02-23 | Griffin Analytical Technologies Llc | Analytical apparatuses and methods |
| WO2006133192A2 (en) | 2005-06-03 | 2006-12-14 | Waters Investments Limited | Generation and use of a catalog of polypeptide-related information for chemical analyses |
| DE102005025497B4 (de) * | 2005-06-03 | 2007-09-27 | Bruker Daltonik Gmbh | Leichte Bruckstückionen mit Ionenfallen messen |
| WO2006133191A2 (en) | 2005-06-03 | 2006-12-14 | Waters Investments Limited | Methods and apparatus for performing retention-time matching |
| US7417223B2 (en) | 2005-10-28 | 2008-08-26 | Mds Inc. | Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences |
| GB2432712B (en) * | 2005-11-23 | 2007-12-27 | Micromass Ltd | Mass spectrometer |
| GB0523806D0 (en) * | 2005-11-23 | 2006-01-04 | Micromass Ltd | Mass spectrometer |
| GB0523811D0 (en) * | 2005-11-23 | 2006-01-04 | Micromass Ltd | Mass stectrometer |
| GB0524972D0 (en) | 2005-12-07 | 2006-01-18 | Micromass Ltd | Mass spectrometer |
| CA2629203C (en) * | 2006-01-05 | 2014-11-04 | Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division | Mass defect triggered information dependent acquisition |
| EP1982349B1 (en) * | 2006-02-07 | 2018-07-25 | DH Technologies Development Pte. Ltd. | Chemical noise reduction for mass spectrometry |
| JP4782579B2 (ja) * | 2006-02-15 | 2011-09-28 | 株式会社日立ハイテクノロジーズ | タンデム型質量分析システム及び方法 |
| DE112007000931B4 (de) | 2006-04-13 | 2014-05-22 | Thermo Fisher Scientific (Bremen) Gmbh | Ionenenergiestreuungsreduzierung für ein Massenspektrometer |
| GB0607542D0 (en) * | 2006-04-13 | 2006-05-24 | Thermo Finnigan Llc | Mass spectrometer |
| GB0609253D0 (en) | 2006-05-10 | 2006-06-21 | Micromass Ltd | Mass spectrometer |
| US7479629B2 (en) * | 2006-08-24 | 2009-01-20 | Agilent Technologies, Inc. | Multichannel rapid sampling of chromatographic peaks by tandem mass spectrometer |
| US7992424B1 (en) | 2006-09-14 | 2011-08-09 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation and sample analysis methods |
| US8134121B2 (en) * | 2006-10-31 | 2012-03-13 | Shimadzu Corporation | Chromatographic mass spectrometer |
| US7511267B2 (en) * | 2006-11-10 | 2009-03-31 | Thermo Finnigan Llc | Data-dependent accurate mass neutral loss analysis |
| KR20090115930A (ko) * | 2006-12-26 | 2009-11-10 | 브라이엄 영 유니버시티 | 혈청 단백질체학 시스템 및 관련 방법 |
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| CN108140537B (zh) | 2015-08-06 | 2020-01-17 | 株式会社岛津制作所 | 质谱分析装置 |
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| CN110494955B (zh) * | 2017-04-10 | 2022-04-26 | 株式会社岛津制作所 | 离子分析装置及离子裂解方法 |
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| JP6465190B2 (ja) * | 2017-10-31 | 2019-02-06 | 株式会社島津製作所 | 質量分析方法及び質量分析装置 |
| CN109830426B (zh) | 2017-11-23 | 2021-04-02 | 株式会社岛津制作所 | 质谱数据采集方法 |
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2001
- 2001-03-09 CA CA002340150A patent/CA2340150C/en not_active Expired - Fee Related
- 2001-03-14 EP EP05022407A patent/EP1622188B1/en not_active Expired - Lifetime
- 2001-03-14 EP EP01302377A patent/EP1220290B1/en not_active Expired - Lifetime
- 2001-03-14 DE DE60120337T patent/DE60120337T2/de not_active Expired - Lifetime
- 2001-03-14 AT AT01302377T patent/ATE329369T1/de not_active IP Right Cessation
- 2001-06-08 CA CA002350041A patent/CA2350041C/en not_active Expired - Lifetime
- 2001-06-08 US US09/876,122 patent/US6717130B2/en not_active Expired - Lifetime
- 2001-06-11 EP EP05025116A patent/EP1638133B3/en not_active Expired - Lifetime
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- 2001-06-11 GB GB0114166A patent/GB2363249B/en not_active Expired - Lifetime
- 2001-06-11 AT AT01305040T patent/ATE352097T1/de not_active IP Right Cessation
- 2001-06-11 JP JP2001175747A patent/JP4588925B2/ja not_active Expired - Lifetime
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| DE60126055T2 (de) | 2007-08-23 |
| GB2363249B (en) | 2002-08-28 |
| EP1220290A2 (en) | 2002-07-03 |
| GB2363249A (en) | 2001-12-12 |
| DE60120337T2 (de) | 2007-05-24 |
| ATE329369T1 (de) | 2006-06-15 |
| JP4588925B2 (ja) | 2010-12-01 |
| EP1225618B1 (en) | 2007-01-17 |
| EP1225618A3 (en) | 2004-03-31 |
| JP2002110081A (ja) | 2002-04-12 |
| US6717130B2 (en) | 2004-04-06 |
| EP1638133B1 (en) | 2009-10-07 |
| DE60120337D1 (de) | 2006-07-20 |
| EP1225618A2 (en) | 2002-07-24 |
| CA2340150A1 (en) | 2001-12-09 |
| EP1225618B3 (en) | 2015-02-18 |
| EP1622188A2 (en) | 2006-02-01 |
| CA2350041A1 (en) | 2001-12-09 |
| CA2350041C (en) | 2008-01-08 |
| US20020063206A1 (en) | 2002-05-30 |
| JP2002100318A (ja) | 2002-04-05 |
| GB0114166D0 (en) | 2001-08-01 |
| DE60126055D1 (de) | 2007-03-08 |
| EP1220290A3 (en) | 2004-03-31 |
| EP1638133B3 (en) | 2012-06-13 |
| ATE352097T1 (de) | 2007-02-15 |
| EP1638133A2 (en) | 2006-03-22 |
| DE60126055T3 (de) | 2015-05-13 |
| EP1622188B1 (en) | 2012-06-13 |
| EP1622188A3 (en) | 2007-12-19 |
| EP1220290B1 (en) | 2006-06-07 |
| EP1638133A3 (en) | 2007-12-05 |
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