JP2001527068A5 - - Google Patents

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Publication number
JP2001527068A5
JP2001527068A5 JP2000526490A JP2000526490A JP2001527068A5 JP 2001527068 A5 JP2001527068 A5 JP 2001527068A5 JP 2000526490 A JP2000526490 A JP 2000526490A JP 2000526490 A JP2000526490 A JP 2000526490A JP 2001527068 A5 JP2001527068 A5 JP 2001527068A5
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JP
Japan
Prior art keywords
alkyl
group
butyl
phenyl
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000526490A
Other languages
English (en)
Japanese (ja)
Other versions
JP4754068B2 (ja
JP2001527068A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/027350 external-priority patent/WO1999033806A1/en
Publication of JP2001527068A publication Critical patent/JP2001527068A/ja
Publication of JP2001527068A5 publication Critical patent/JP2001527068A5/ja
Application granted granted Critical
Publication of JP4754068B2 publication Critical patent/JP4754068B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2000526490A 1997-12-24 1998-12-23 δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類 Expired - Lifetime JP4754068B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6879497P 1997-12-24 1997-12-24
US60/068,794 1997-12-24
PCT/US1998/027350 WO1999033806A1 (en) 1997-12-24 1998-12-23 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor

Publications (3)

Publication Number Publication Date
JP2001527068A JP2001527068A (ja) 2001-12-25
JP2001527068A5 true JP2001527068A5 (https=) 2006-01-12
JP4754068B2 JP4754068B2 (ja) 2011-08-24

Family

ID=22084747

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000526490A Expired - Lifetime JP4754068B2 (ja) 1997-12-24 1998-12-23 δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類

Country Status (11)

Country Link
EP (1) EP1049676B1 (https=)
JP (1) JP4754068B2 (https=)
AT (1) ATE306472T1 (https=)
AU (1) AU2009799A (https=)
CA (1) CA2316341A1 (https=)
DE (1) DE69831876T2 (https=)
DK (1) DK1049676T3 (https=)
ES (1) ES2251121T3 (https=)
TW (1) TW476755B (https=)
WO (1) WO1999033806A1 (https=)
ZA (1) ZA9811842B (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
EP1512683B1 (en) * 1998-03-10 2011-08-31 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
JP2003500392A (ja) * 1999-05-25 2003-01-07 セプラコール, インク. 複素環式鎮痛性化合物およびその使用方法
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6645980B1 (en) 2000-05-25 2003-11-11 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
JP2003518119A (ja) * 1999-12-22 2003-06-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 4−[アリール(8−アザビシクロ[3.2.1]オクタン−3−イル)]アミノ安息香酸誘導体
SE0001208D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0001207D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
US6887876B2 (en) 2000-12-14 2005-05-03 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
IL155995A0 (en) 2000-12-15 2003-12-23 Astrazeneca Ab New process for the preparation of diaryl-4-amino-piperidinyl compounds
US6699890B2 (en) * 2000-12-22 2004-03-02 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
MXPA03007261A (es) * 2001-02-14 2006-03-09 Abbott Lab Moduladores del receptor de glucocorticoides.
SE0101773D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
DK1395567T3 (da) 2001-05-18 2009-04-06 Astrazeneca Ab 4-(phenylpiperazinylmethyl)-benzamidderivater og deres anvendelse til behandling af smerte, angst eller mavetarmslidelser
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101766D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101765D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101768D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0103313D0 (sv) 2001-10-03 2001-10-03 Astrazeneca Ab Novel compounds
EP1539697A1 (en) 2002-07-19 2005-06-15 Memory Pharmaceutical Corporation Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
RU2354648C2 (ru) 2002-07-19 2009-05-10 Мемори Фармасьютиклз Корпорейшн Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4
ATE387443T1 (de) 2002-10-15 2008-03-15 Janssen Pharmaceutica Nv Substituierte aminochinuclidin verbindungen und deren verwendung als delta-opioid rezeptor liganden
WO2004035541A1 (en) * 2002-10-15 2004-04-29 Janssen Pharmaceutica, N.V. Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
AU2003295656B2 (en) 2002-11-19 2010-11-11 Memory Pharmaceuticals Corporation Pyridine N-oxide compounds as phosphodiesterase 4 inhibitors
EP1613597B1 (en) 2003-03-07 2007-11-07 Eli Lilly and Company 6-substituted nicotinamide derivatives as opioid receptor antagonists
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
CA2549009A1 (en) * 2003-12-12 2005-07-07 Eli Lilly And Company Opioid receptor antagonists
EP1735268B1 (en) 2004-03-15 2012-02-15 Eli Lilly And Company Opioid receptor antagonists
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
EP1910353A1 (en) 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
SE0402485D0 (sv) 2004-10-13 2004-10-13 Astrazeneca Ab Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt
ATE432279T1 (de) 2004-12-22 2009-06-15 Janssen Pharmaceutica Nv Tricyclische delta-opioid-modulatoren
JP2008525483A (ja) 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
KR20070104380A (ko) 2005-01-06 2007-10-25 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절제
ATE490251T1 (de) 2005-06-16 2010-12-15 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren
JP2007099761A (ja) * 2005-09-08 2007-04-19 Mitsui Chemicals Inc アミド誘導体ならびにその殺虫剤としての使用方法
MY148880A (en) 2006-10-20 2013-06-14 Astrazeneca Ab N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression
JP5781527B2 (ja) * 2009-10-30 2015-09-24 ヤンセン ファーマシューティカ エヌ.ベー. 4−置換−2−フェノキシ−フェニルアミンデルオピオイド受容体調節因子
CN113979997A (zh) * 2021-11-12 2022-01-28 中国科学院昆明植物研究所 N,n-(4-哌啶基、芳基)-3-氨基苯酚类衍生物及其药物组合物和其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
IT1275433B (it) * 1995-05-19 1997-08-07 Smithkline Beecham Farma Derivati di diarildiammine
IT1277597B1 (it) * 1995-09-15 1997-11-11 Smithkline Beecham Spa Derivati di diarilalchenilammina
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds

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