JP2001525359A5 - - Google Patents

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Publication number
JP2001525359A5
JP2001525359A5 JP2000523983A JP2000523983A JP2001525359A5 JP 2001525359 A5 JP2001525359 A5 JP 2001525359A5 JP 2000523983 A JP2000523983 A JP 2000523983A JP 2000523983 A JP2000523983 A JP 2000523983A JP 2001525359 A5 JP2001525359 A5 JP 2001525359A5
Authority
JP
Japan
Prior art keywords
composition
human
xerostomia
hydrogen
amifostine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000523983A
Other languages
English (en)
Other versions
JP2001525359A (ja
Filing date
Publication date
Priority claimed from US08/987,550 external-priority patent/US5994409A/en
Application filed filed Critical
Publication of JP2001525359A publication Critical patent/JP2001525359A/ja
Publication of JP2001525359A5 publication Critical patent/JP2001525359A5/ja
Pending legal-status Critical Current

Links

Description

【特許請求の範囲】
【請求項１】
口内乾燥症を治療するための組成物であって、式：
Ｒ1ＮＨ（ＣＨ2）nＮＨ（ＣＨ2）mＳＲ2
（式中、
Ｒ1は、水素、Ｃ5〜Ｃ7アリール、Ｃ2〜Ｃ7アシルまたはＣ1〜Ｃ7アルキルであり；
Ｒ2は、水素、ＰＯ3Ｈ2またはＲ3（ここでＲ3は、Ｒ1ＮＨ（ＣＨ2）nＮＨ（ＣＨ2）mＳ−である）であり；
ｎは、１〜10の整数であり、
ｍは、１〜10の整数である）
で表される化合物または製剤学的に許容可能なその付加塩もしくは水和物を有効成分として含む組成物。
【請求項２】
口内乾燥症を治療するための組成物であって、式：
Ｒ−ＮＨ−（ＣnＨ2n）−ＮＨ−（ＣmＨ2m）−Ｓ−ＰＯ3Ｈ2
（式中、
Ｒは、水素、または１〜７個の炭素原子を有するアルキル基であり、
ｍおよびｎは、互いに独立して、１〜10の値である）
で表される化合物または製剤学的に許容可能なその付加塩もしくは水和物を有効成分として含む組成物。
【請求項３】
化合物がアミホスチンである、請求項１に記載の組成物。
【請求項４】
化合物がアミホスチンである、請求項２に記載の組成物。
【請求項５】
口内乾燥症が、ヒトへの治療薬の投与またはヒトの放射線への曝露に伴うものである、請求項１〜４のいずれか１項に記載の組成物。
【請求項６】
口内乾燥症が、ヒトへの治療薬の投与またはヒトの放射線への曝露に伴うものであり、ヒトにおける口内乾燥症の発生後に投与される、請求項１〜４のいずれか１項に記載の組成物。
【予納台帳番号】 015244
【納付金額】 3200
JP2000523983A 1997-12-09 1998-12-09 アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法 Pending JP2001525359A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/987,550 1997-12-09
US08/987,550 US5994409A (en) 1997-12-09 1997-12-09 Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
PCT/US1998/026096 WO1999029312A1 (en) 1997-12-09 1998-12-09 Methods for treatment of neuro- and nephro-disorders and therapeutic toxicities using aminothiol compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006064774A Division JP2006188532A (ja) 1997-12-09 2006-03-09 アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法

Publications (2)

Publication Number Publication Date
JP2001525359A JP2001525359A (ja) 2001-12-11
JP2001525359A5 true JP2001525359A5 (ja) 2006-05-11

Family

ID=25533362

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000523983A Pending JP2001525359A (ja) 1997-12-09 1998-12-09 アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法
JP2006064774A Pending JP2006188532A (ja) 1997-12-09 2006-03-09 アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006064774A Pending JP2006188532A (ja) 1997-12-09 2006-03-09 アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法

Country Status (13)

Country Link
US (7) US5994409A (ja)
EP (2) EP1039887B1 (ja)
JP (2) JP2001525359A (ja)
CN (1) CN1161113C (ja)
AT (1) ATE326956T1 (ja)
AU (1) AU739068B2 (ja)
BR (1) BR9813524A (ja)
CA (1) CA2313089C (ja)
DE (1) DE69834658T2 (ja)
DK (1) DK1039887T3 (ja)
ES (1) ES2260857T3 (ja)
PT (1) PT1039887E (ja)
WO (1) WO1999029312A1 (ja)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0954283B1 (en) * 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US6573253B2 (en) 1997-02-12 2003-06-03 Medimmune Oncology Inc. Methods for the administration of amifostine and related compounds
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6239119B1 (en) * 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
US7314637B1 (en) 1999-06-29 2008-01-01 Neopharm, Inc. Method of administering liposomal encapsulated taxane
US6384259B1 (en) * 1998-11-16 2002-05-07 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and dosage form
WO2001070220A1 (en) * 2000-03-22 2001-09-27 Neopharm, Inc. A method of administering liposomal encapsulated taxane
KR20030014208A (ko) * 2000-04-26 2003-02-15 오레곤 헬스 사이언시즈 유니버시티 티올계 화학보호제 화합물의 투여
EP1289556B1 (en) * 2000-06-14 2007-06-06 The United States of America, represented by The Secretary, Dept. of Health and Human Services, the Natl. Institutes of Health Isoflavones against radiation-induced mortality
EP1365803A2 (en) * 2000-08-30 2003-12-03 Oregon Health and Science University Chemoprotectant for gastric toxicity
WO2002041837A2 (en) * 2000-11-22 2002-05-30 Rxkinetix, Inc. Treatment of mucositis
US7053072B2 (en) 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
JP2005510471A (ja) * 2001-09-24 2005-04-21 トスク インコーポレーティッド 減少した毒性のシスプラチン製剤及びそれを使用する方法
CN100391941C (zh) * 2001-12-07 2008-06-04 海门慧聚药业有限公司 一种胺基硫醇及其硫代衍生物
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US7345018B2 (en) 2002-04-25 2008-03-18 Reception Aps Method of treating side effects induced by therapeutic agents
US7981928B2 (en) * 2002-09-05 2011-07-19 Nanodynamics, Inc. Chemotherapy method using x-rays
WO2004039336A2 (en) * 2002-10-31 2004-05-13 Oregon Health & Science University Use of thiol-based compositions in treating chemotherapeutic agent-induced thrombocytopenia
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
MXPA05008284A (es) * 2003-02-03 2006-03-21 Neopharm Inc Taxano y otros farmacos antineoplasicos encapsulados, liposomicos, estables, susceptibles de esterilizacion por filtracion.
WO2004080429A2 (en) * 2003-03-13 2004-09-23 Oregon Health & Science University Use of thiol-based compositions in ameliorating mucosal injury
US8580321B2 (en) * 2003-12-02 2013-11-12 The Cleveland Clinic Foundation Method for reducing the effects of chemotherapy using flagellin related polypeptides
US20050187608A1 (en) * 2004-02-24 2005-08-25 O'hara Michael D. Radioprotective compound coating for medical devices
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
CA2584138A1 (en) * 2004-10-18 2006-04-27 Raphael C. Lee Methods and compositions for treatment of free radical injury
US20070082858A1 (en) * 2004-12-21 2007-04-12 Oregon Health & Science University Methods and compositions for the prevention of toxic side effects of aminoglycoside medications
EP2460534A1 (en) 2004-12-22 2012-06-06 Cleveland Clinic Foundation Flagellin related polypeptides and uses thereof
US7658913B2 (en) 2005-11-28 2010-02-09 Verrow Pharmaceuticals, Inc. Compositions useful for reducing nephrotoxicity and methods of use thereof
JP2009517402A (ja) * 2005-11-28 2009-04-30 ディー． ロウェ，バーノン 腎毒性の低減に有用な組成物及びその使用方法
US9585849B2 (en) 2006-04-17 2017-03-07 The Burlington Hc Research Group, Inc. Broad spectrum antiviral and methods of use
EP2010166B1 (en) * 2006-04-17 2013-11-06 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Organic disulfide antiretroviral agents
US8138227B2 (en) * 2006-07-06 2012-03-20 Trustees Of Dartmouth College Method for inhibiting or reversing non-enzymatic glycation
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
WO2008060441A2 (en) * 2006-11-09 2008-05-22 Scidose Llc Stable amifostine liquid concentrate
WO2008119032A1 (en) * 2007-03-27 2008-10-02 Perscitus Biosciences, Llc Compositions and methods for protecting cells from toxic exposures
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8372389B2 (en) * 2007-11-28 2013-02-12 Hadasit Medical Research Services And Development Ltd. Methods for the treatment of radiation or chemotherapy-induced tissue damage
WO2009113984A1 (en) * 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Chemoprotective methods and compositions
WO2010014957A1 (en) 2008-08-01 2010-02-04 Cleveland Biolabs, Inc. Methods for treating reperfusion injuries
CN101347412B (zh) * 2008-09-02 2011-07-27 大连美罗药业股份有限公司 三水合氨磷汀结晶冻干制剂及其制备方法
CA2824438A1 (en) 2011-01-10 2012-07-19 Cleveland Biolabs, Inc. Use of toll-like receptor agonist for treating cancer
WO2012103520A1 (en) * 2011-01-28 2012-08-02 Board Of Regents Of The University Of Nebraska Methods and compositions for modulating cyclophilin d
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
WO2014204854A1 (en) * 2013-06-18 2014-12-24 Aminomdix Inc. Compositions and methods for the preparation of kidney protective agents comprising amifostine and amino acids
CN107087411B (zh) 2014-07-30 2021-06-29 基因组保护股份有限公司 鞭毛蛋白组合物及用途
US10183056B2 (en) 2014-10-16 2019-01-22 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
CN107753490B (zh) * 2017-11-19 2018-07-27 宋在明 一种治疗肿瘤放疗所致口腔黏膜炎的透皮给药制剂
US20220259164A1 (en) * 2019-06-13 2022-08-18 Shanghai Kechow Pharma, Inc. Use of aminothiol compounds as cerebral nerve or heart protective agent
CN114712350B (zh) * 2021-12-28 2024-04-12 中国医学科学院放射医学研究所 Dttz在制备预防、治疗化疗损伤药物中的应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892824A (en) * 1968-12-16 1975-07-01 Southern Res Inst S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
US4424216A (en) * 1979-07-31 1984-01-03 The Rockefeller University Method for the reduction of mucin viscosity
US4742050B1 (en) 1982-08-17 1994-06-28 Alpha Therapeutic Corp Sensitization of hypoxic tumor cells and control of growth thereof
US4656034A (en) 1985-05-20 1987-04-07 Survival Technology, Inc. Absorption enhancing agents
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
MY102796A (en) 1987-04-15 1992-10-31 Freezone Pty Ltd A tyre bead breaker
US5091180A (en) 1987-11-20 1992-02-25 Administrators Of The Tulane Educational Fund Protection against rhabdomyolysis-induced nephrotoxicity
AU629533B2 (en) * 1987-12-22 1992-10-08 U.S. Bioscience, Inc. Improving toxicity profiles in chemotherapy
US5112954A (en) 1988-02-26 1992-05-12 Neorx Corporation Method of enhancing the effect of cytotoxic agents
JPH04505760A (ja) * 1989-05-24 1992-10-08 ユー・エス・バイオサイエンス Ａｚｔの副作用および毒性からの保護方法
US5167947A (en) 1989-10-26 1992-12-01 Southwest Research Institute Enhancement of absorption of radioprotective drugs
US5217964A (en) 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
US5554655A (en) * 1991-09-30 1996-09-10 Jess G. Thoene Method of treating HIV infection
US5567686A (en) * 1992-03-13 1996-10-22 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5869338A (en) * 1992-03-13 1999-02-09 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis
US5578643A (en) 1992-05-20 1996-11-26 Loyola University Of Chicago Protective prostaglandins for use in conjunction with chemotherapeutic agents
US5618823A (en) 1992-06-24 1997-04-08 Boehringer Mannheim Italia S.P.A. Glutathione as chemoprotective agent
US5424471A (en) * 1992-07-31 1995-06-13 U.S. Bioscience, Inc. Crystalline amifostine compositions and methods of the preparation and use of same
SG47101A1 (en) * 1992-07-31 1998-03-20 Us Bioscience Crystalline amifostine compositions and methods for the preparation and use of same
DE4234257A1 (de) * 1992-10-10 1994-04-14 Roehm Gmbh Verfahren zur Herstellung von Thiol(meth)acrylaten
KR100311851B1 (ko) 1993-02-23 2002-04-24 슈테펜엘.네스비트 방사선보호제로서의폴리아민유도체
US5824664A (en) * 1993-03-26 1998-10-20 U.S. Bioscience, Inc. Suppression of HIV expression by organic thiophosphate
CA2124021A1 (en) 1993-05-21 1994-11-22 John Samonides Sr. Adhesive for labels and the like
AU679236B2 (en) 1993-05-26 1997-06-26 Merrell Dow Pharmaceuticals Inc. N-alkylthio polyamine derivatives as radioprotective agents
CA2099070A1 (en) 1993-06-23 1994-12-24 Nelson Mak Process and apparatus for deinking wastepaper with molten fatty acid
US5467947A (en) * 1994-04-08 1995-11-21 Metra Electronics Corporation Mounting kit for mounting one of several types of audio equipment in an automotive dashboard
US5846958A (en) * 1995-02-17 1998-12-08 U.S. Bioscience, Inc. Methods of using aminothiols to promote hematopoietic progenitor cell growth
GB9504995D0 (en) * 1995-03-11 1995-04-26 Zeneca Ltd Compositions
US6106866A (en) 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US5974409A (en) * 1995-08-23 1999-10-26 Microsoft Corporation System and method for locating information in an on-line network
WO1997011667A2 (en) * 1995-09-25 1997-04-03 Samir Chachoua Therapeutic applications using horse serum
US6096339A (en) * 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US6110891A (en) 1996-06-21 2000-08-29 Alizyme Therapeutics Ltd. Lectin compositions and uses thereof
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
US6573253B2 (en) * 1997-02-12 2003-06-03 Medimmune Oncology Inc. Methods for the administration of amifostine and related compounds
US6051563A (en) * 1997-02-12 2000-04-18 U.S. Bioscience, Inc. Methods for the administration of amifostine and related compounds
US5919934A (en) 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
FR2761606B1 (fr) 1997-04-08 1999-05-14 Cird Galderma Utilisation de derives aminothiolesters dans le domaine pharmaceutique
US6284259B1 (en) * 1997-11-12 2001-09-04 The Procter & Gamble Company Antimicrobial wipes which provide improved residual benefit versus Gram positive bacteria
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
WO1999030705A1 (en) 1997-12-16 1999-06-24 William Darwin Garner Reduction of uv induced skin cancer by topical amines
JPH11240252A (ja) 1997-12-22 1999-09-07 Tdk Corp 光記録媒体
US6239119B1 (en) * 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
US6384259B1 (en) * 1998-11-16 2002-05-07 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and dosage form
US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same
US6054622A (en) 1998-12-18 2000-04-25 Alliedsignal Inc Aromatic hydroxythiol synthesis using diazonium salts
US6075053A (en) 1999-02-09 2000-06-13 Bionumerik Pharmaceuticals, Inc. Method of reducing or reversing neuropathy
US6489312B1 (en) * 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates

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