JP2001524364A - 立体特異性薬剤の電気搬送式投与 - Google Patents
立体特異性薬剤の電気搬送式投与Info
- Publication number
- JP2001524364A JP2001524364A JP2000522969A JP2000522969A JP2001524364A JP 2001524364 A JP2001524364 A JP 2001524364A JP 2000522969 A JP2000522969 A JP 2000522969A JP 2000522969 A JP2000522969 A JP 2000522969A JP 2001524364 A JP2001524364 A JP 2001524364A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- isomer
- ketorolac
- electrotransport
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 137
- 229940079593 drug Drugs 0.000 title claims abstract description 130
- 230000000707 stereoselective effect Effects 0.000 title description 10
- 239000000203 mixture Substances 0.000 claims abstract description 49
- 238000012377 drug delivery Methods 0.000 claims abstract description 23
- 229960004752 ketorolac Drugs 0.000 claims description 84
- -1 asenocoumarol Chemical compound 0.000 claims description 53
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 35
- 238000011282 treatment Methods 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 17
- 238000001647 drug administration Methods 0.000 claims description 14
- 150000002148 esters Chemical class 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
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- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 229960002052 salbutamol Drugs 0.000 claims description 9
- 230000004941 influx Effects 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 6
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- 239000003795 chemical substances by application Substances 0.000 claims description 6
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- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims description 6
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- 239000002260 anti-inflammatory agent Substances 0.000 claims description 5
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 claims description 5
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- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 5
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 4
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 claims description 4
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- DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 claims description 3
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- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims description 3
- KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 claims description 3
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 3
- LRXFKKPEBXIPMW-UHFFFAOYSA-N 2-(9h-fluoren-2-yl)propanoic acid Chemical compound C1=CC=C2C3=CC=C(C(C(O)=O)C)C=C3CC2=C1 LRXFKKPEBXIPMW-UHFFFAOYSA-N 0.000 claims description 3
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 3
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- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 claims description 3
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- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 claims description 3
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 claims description 3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
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| US08/982,245 US6136327A (en) | 1997-12-01 | 1997-12-01 | Stereospecific delivery of a drug using electrotransport |
| US08/982,245 | 1997-12-01 | ||
| PCT/US1998/025387 WO1999027990A2 (en) | 1997-12-01 | 1998-11-30 | Stereospecific delivery of a drug using electrotransport |
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| JP2007133841A Division JP2007216053A (ja) | 1997-12-01 | 2007-05-21 | 電気搬送式薬剤投与装置 |
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| JP2001524364A true JP2001524364A (ja) | 2001-12-04 |
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| JP2007133841A Pending JP2007216053A (ja) | 1997-12-01 | 2007-05-21 | 電気搬送式薬剤投与装置 |
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| EP (1) | EP1035891B1 (enExample) |
| JP (2) | JP2001524364A (enExample) |
| AU (1) | AU1800699A (enExample) |
| DE (1) | DE69814147T2 (enExample) |
| ES (1) | ES2198781T3 (enExample) |
| WO (1) | WO1999027990A2 (enExample) |
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| TWI277418B (en) * | 2001-06-18 | 2007-04-01 | Noven Pharma | Enhanced drug delivery in transdermal systems |
| US20040197397A1 (en) * | 2002-08-30 | 2004-10-07 | Watson Pharmaceuticals, Inc. | Drug delivery system for treatment of urinary incontinence |
| AU2003285012A1 (en) * | 2002-10-24 | 2004-05-13 | Sepracor, Inc. | Compositions comprising zopiclone derivatives and methods of making and using the same |
| WO2005011662A1 (ja) * | 2003-07-31 | 2005-02-10 | Hisamitsu Pharmaceutical Co., Inc. | 貼付剤 |
| US20120035203A1 (en) * | 2009-04-27 | 2012-02-09 | Cambria Pharmaceuticals, Inc. | Butaclamol for the treatment of amyotrophic lateral sclerosis |
| CN110072437B (zh) * | 2016-12-13 | 2022-04-08 | 阿莫生命科学有限公司 | 贴片型传感器模块 |
| US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
| CN108888593B (zh) * | 2018-06-27 | 2021-09-21 | 济南康和医药科技有限公司 | 一种阿替洛尔注射液及其制备方法 |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| JP2025096725A (ja) * | 2022-05-30 | 2025-06-30 | キッコーマン株式会社 | 経皮通電パッチ |
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|---|---|---|---|---|
| US4800162A (en) | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
| US5114946A (en) * | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
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| US4927854A (en) * | 1987-12-24 | 1990-05-22 | Analgesic Associates | Sustained/enhanced analgesia |
| US5147296A (en) * | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
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| US5091182A (en) * | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
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| DE69328042T2 (de) * | 1992-12-31 | 2000-11-16 | Alza Corp., Palo Alto | Elektrotransporteinrichtung |
| US5591767A (en) * | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
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-
1997
- 1997-12-01 US US08/982,245 patent/US6136327A/en not_active Expired - Lifetime
-
1998
- 1998-11-30 DE DE69814147T patent/DE69814147T2/de not_active Expired - Lifetime
- 1998-11-30 WO PCT/US1998/025387 patent/WO1999027990A2/en not_active Ceased
- 1998-11-30 EP EP98962857A patent/EP1035891B1/en not_active Expired - Lifetime
- 1998-11-30 ES ES98962857T patent/ES2198781T3/es not_active Expired - Lifetime
- 1998-11-30 JP JP2000522969A patent/JP2001524364A/ja not_active Withdrawn
- 1998-11-30 AU AU18006/99A patent/AU1800699A/en not_active Abandoned
-
2007
- 2007-05-21 JP JP2007133841A patent/JP2007216053A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999027990A2 (en) | 1999-06-10 |
| US6136327A (en) | 2000-10-24 |
| DE69814147T2 (de) | 2004-03-18 |
| EP1035891A1 (en) | 2000-09-20 |
| JP2007216053A (ja) | 2007-08-30 |
| DE69814147D1 (de) | 2003-06-05 |
| EP1035891B1 (en) | 2003-05-02 |
| AU1800699A (en) | 1999-06-16 |
| ES2198781T3 (es) | 2004-02-01 |
| WO1999027990A3 (en) | 1999-09-10 |
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