ATE118208T1 - Chirale azabicycloheptanone und verfahren zu ihrer herstellung. - Google Patents

Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Info

Publication number
ATE118208T1
ATE118208T1 AT90311253T AT90311253T ATE118208T1 AT E118208 T1 ATE118208 T1 AT E118208T1 AT 90311253 T AT90311253 T AT 90311253T AT 90311253 T AT90311253 T AT 90311253T AT E118208 T1 ATE118208 T1 AT E118208T1
Authority
AT
Austria
Prior art keywords
chiral
azabicycloheptanones
production
lactamase
amino
Prior art date
Application number
AT90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ATE118208T1 publication Critical patent/ATE118208T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90311253T 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung. ATE118208T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ATE118208T1 true ATE118208T1 (de) 1995-02-15

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311253T ATE118208T1 (de) 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (2) US5498625A (de)
EP (1) EP0424064B1 (de)
JP (1) JP2648013B2 (de)
AT (1) ATE118208T1 (de)
DE (1) DE69016739T2 (de)
DK (1) DK0424064T3 (de)
ES (1) ES2067693T3 (de)
GR (1) GR3015887T3 (de)

Families Citing this family (44)

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Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10506384A (ja) * 1994-08-19 1998-06-23 カイロサイエンス・リミテッド 二環式ラクタム鏡像体の分離法
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
US6780634B1 (en) 1998-07-09 2004-08-24 Lonza Ag Method for producing (1R,4S)-2-azabicyclo[2.2.1]-hept-5-en-3-on derivatives
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
AU5479700A (en) * 1999-06-28 2001-01-31 Biocryst Pharmaceuticals, Inc. Process for preparing (-)-(1s,4r) n-protected 4-amino-2-cyclopentene-1-carboxylate esters
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
EP1334969A4 (de) * 2000-10-18 2005-08-24 Kuraray Co VERFAHREN ZUR HERSTELLUNG VON 4-N-SUBSTITUIERTEN AMINO-2-AZA-1-OXABICYCLOç3.3.0!OCT-2-EN-6-CARBONSÄUREESTERN UND VERFAHREN ZUR HERSTELLUNG IHRER ZWISCHENPRODUKTE
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
DE60307077T2 (de) * 2002-03-13 2007-03-01 O-Pen Aps Berührungs-pad und verfahren zum betreiben des berührungs-pads
EP1348765B1 (de) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
JP2006523869A (ja) * 2003-03-12 2006-10-19 オー−プン・アンパルトセルスカブ 放射線を放射する要素の位置を測定するシステム及び方法
WO2005026938A2 (en) 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation scattering/reflecting element
WO2005026930A2 (en) * 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation emitting element
AR061570A1 (es) 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto de glicina sustituido en el n heteroaromatico composicion farmaceutica que lo comprende, su uso para preparar un medicamento, procedimientos para preparar dicha composicion farmaceutica y para preparar el compuesto
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
WO2015108480A1 (en) 2014-01-16 2015-07-23 Flatfrog Laboratories Ab Improvements in tir-based optical touch systems of projection-type
US10146376B2 (en) 2014-01-16 2018-12-04 Flatfrog Laboratories Ab Light coupling in TIR-based optical touch systems
US10161886B2 (en) 2014-06-27 2018-12-25 Flatfrog Laboratories Ab Detection of surface contamination
EP3250993B1 (de) 2015-01-28 2019-09-04 FlatFrog Laboratories AB Dynamische berührungsquarantänerahmen
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
WO2016130074A1 (en) 2015-02-09 2016-08-18 Flatfrog Laboratories Ab Optical touch system comprising means for projecting and detecting light beams above and inside a transmissive panel
CN107250855A (zh) 2015-03-02 2017-10-13 平蛙实验室股份公司 用于光耦合的光学部件
KR102400705B1 (ko) 2015-12-09 2022-05-23 플라트프로그 라보라토리즈 에이비 개선된 스타일러스 식별
EP3545392A4 (de) 2016-11-24 2020-07-29 FlatFrog Laboratories AB Automatische optimierung von berührungssignalen
KR102629629B1 (ko) 2016-12-07 2024-01-29 플라트프로그 라보라토리즈 에이비 개선된 터치 장치
EP3458946B1 (de) 2017-02-06 2020-10-21 FlatFrog Laboratories AB Optische kopplung bei berührungsempfindlichen systemen
WO2018174788A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Object characterisation for touch displays
EP4036697A1 (de) 2017-03-28 2022-08-03 FlatFrog Laboratories AB Optische berührungserfassungsvorrichtung
CN117311543A (zh) 2017-09-01 2023-12-29 平蛙实验室股份公司 触摸感测设备
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
US11943563B2 (en) 2019-01-25 2024-03-26 FlatFrog Laboratories, AB Videoconferencing terminal and method of operating the same
CN115039063A (zh) 2020-02-10 2022-09-09 平蛙实验室股份公司 改进的触摸感测设备

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025599B1 (de) * 1979-09-13 1984-12-19 The Wellcome Foundation Limited Benzopyran-Verbindungen, die als chemiotherapeutische Mittel verwendbar sind
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
US5688933A (en) 1997-11-18
DE69016739T2 (de) 1995-06-14
JPH03218380A (ja) 1991-09-25
EP0424064A1 (de) 1991-04-24
JP2648013B2 (ja) 1997-08-27
ES2067693T3 (es) 1995-04-01
DK0424064T3 (da) 1995-06-26
DE69016739D1 (de) 1995-03-23
GR3015887T3 (en) 1995-07-31
US5498625A (en) 1996-03-12
EP0424064B1 (de) 1995-02-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee