DE69016739T2 - Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung. - Google Patents

Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung.

Info

Publication number
DE69016739T2
DE69016739T2 DE69016739T DE69016739T DE69016739T2 DE 69016739 T2 DE69016739 T2 DE 69016739T2 DE 69016739 T DE69016739 T DE 69016739T DE 69016739 T DE69016739 T DE 69016739T DE 69016739 T2 DE69016739 T2 DE 69016739T2
Authority
DE
Germany
Prior art keywords
chiral
azabicycloheptanones
preparation
lactamase
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69016739T
Other languages
English (en)
Other versions
DE69016739D1 (de
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Publication of DE69016739D1 publication Critical patent/DE69016739D1/de
Application granted granted Critical
Publication of DE69016739T2 publication Critical patent/DE69016739T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
DE69016739T 1989-10-16 1990-10-15 Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung. Expired - Lifetime DE69016739T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (2)

Publication Number Publication Date
DE69016739D1 DE69016739D1 (de) 1995-03-23
DE69016739T2 true DE69016739T2 (de) 1995-06-14

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69016739T Expired - Lifetime DE69016739T2 (de) 1989-10-16 1990-10-15 Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung.

Country Status (8)

Country Link
US (2) US5498625A (de)
EP (1) EP0424064B1 (de)
JP (1) JP2648013B2 (de)
AT (1) ATE118208T1 (de)
DE (1) DE69016739T2 (de)
DK (1) DK0424064T3 (de)
ES (1) ES2067693T3 (de)
GR (1) GR3015887T3 (de)

Families Citing this family (44)

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Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10506384A (ja) * 1994-08-19 1998-06-23 カイロサイエンス・リミテッド 二環式ラクタム鏡像体の分離法
GB9618340D0 (en) 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
DK1095160T3 (da) * 1998-07-09 2004-05-17 Lonza Ag Fremgangsmåde til fremstilling af (1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivater
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
EP1206443A2 (de) 1999-06-28 2002-05-22 Biocryst Pharmaceuticals, Inc. Verfahren zur herstellung n-geschützter (-)-(1s,4r)-4-amino-2-cyclopenten-1-carbonsäureester
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US7038059B2 (en) 2000-10-18 2006-05-02 Kuraray Co., Ltd. Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0] oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
US20050162398A1 (en) * 2002-03-13 2005-07-28 Eliasson Jonas O.P. Touch pad, a stylus for use with the touch pad, and a method of operating the touch pad
DE60211646T2 (de) * 2002-03-28 2007-05-24 Council Of Scientific And Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
US7435940B2 (en) * 2003-03-12 2008-10-14 Flatfrog Laboratories Ab System and a method of determining the position of a radiation emitting element
US7442914B2 (en) * 2003-09-12 2008-10-28 Flatfrog Laboratories Ab System and method of determining a position of a radiation emitting element
WO2005026938A2 (en) 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation scattering/reflecting element
TWI394747B (zh) 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
WO2015108479A1 (en) 2014-01-16 2015-07-23 Flatfrog Laboratories Ab Light coupling in tir-based optical touch systems
US10126882B2 (en) 2014-01-16 2018-11-13 Flatfrog Laboratories Ab TIR-based optical touch systems of projection-type
US10161886B2 (en) 2014-06-27 2018-12-25 Flatfrog Laboratories Ab Detection of surface contamination
US11182023B2 (en) 2015-01-28 2021-11-23 Flatfrog Laboratories Ab Dynamic touch quarantine frames
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
CN107209609A (zh) 2015-02-09 2017-09-26 平蛙实验室股份公司 包括在传输面板上方和内部投射和检测光束的装置的光学触摸系统
WO2016140612A1 (en) 2015-03-02 2016-09-09 Flatfrog Laboratories Ab Optical component for light coupling
CN108369470B (zh) 2015-12-09 2022-02-08 平蛙实验室股份公司 改进的触控笔识别
WO2018096430A1 (en) 2016-11-24 2018-05-31 Flatfrog Laboratories Ab Automatic optimisation of touch signal
PT3667475T (pt) 2016-12-07 2022-10-17 Flatfrog Lab Ab Dispositivo tátil curvo
US10963104B2 (en) 2017-02-06 2021-03-30 Flatfrog Laboratories Ab Optical coupling in touch-sensing systems
US10481737B2 (en) 2017-03-22 2019-11-19 Flatfrog Laboratories Ab Pen differentiation for touch display
CN110663015A (zh) 2017-03-28 2020-01-07 平蛙实验室股份公司 触摸感应装置和用于组装的方法
CN117311543A (zh) 2017-09-01 2023-12-29 平蛙实验室股份公司 触摸感测设备
WO2019172826A1 (en) 2018-03-05 2019-09-12 Flatfrog Laboratories Ab Improved touch-sensing apparatus
US11943563B2 (en) 2019-01-25 2024-03-26 FlatFrog Laboratories, AB Videoconferencing terminal and method of operating the same
CN115039063A (zh) 2020-02-10 2022-09-09 平蛙实验室股份公司 改进的触摸感测设备

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5651470A (en) * 1979-09-13 1981-05-09 Wellcome Found Flavan derivative
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
ES2067693T3 (es) 1995-04-01
EP0424064B1 (de) 1995-02-08
JP2648013B2 (ja) 1997-08-27
US5498625A (en) 1996-03-12
DK0424064T3 (da) 1995-06-26
DE69016739D1 (de) 1995-03-23
GR3015887T3 (en) 1995-07-31
JPH03218380A (ja) 1991-09-25
US5688933A (en) 1997-11-18
EP0424064A1 (de) 1991-04-24
ATE118208T1 (de) 1995-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIROTECH TECHNOLOGY LTD., CAMBRIDGE, GB