JP2001521039A5 - - Google Patents
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- Publication number
- JP2001521039A5 JP2001521039A5 JP2000517980A JP2000517980A JP2001521039A5 JP 2001521039 A5 JP2001521039 A5 JP 2001521039A5 JP 2000517980 A JP2000517980 A JP 2000517980A JP 2000517980 A JP2000517980 A JP 2000517980A JP 2001521039 A5 JP2001521039 A5 JP 2001521039A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- quinolinyl
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 42
- -1 3-quinolyl Chemical group 0.000 description 34
- 125000001072 heteroaryl group Chemical group 0.000 description 18
- 229910052739 hydrogen Inorganic materials 0.000 description 14
- 239000001257 hydrogen Substances 0.000 description 14
- 125000003118 aryl group Chemical group 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 125000003107 substituted aryl group Chemical group 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000002140 halogenating effect Effects 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- RLKHFSNWQCZBDC-UHFFFAOYSA-N n-(benzenesulfonyl)-n-fluorobenzenesulfonamide Chemical group C=1C=CC=CC=1S(=O)(=O)N(F)S(=O)(=O)C1=CC=CC=C1 RLKHFSNWQCZBDC-UHFFFAOYSA-N 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 2
- LQZMLBORDGWNPD-UHFFFAOYSA-N N-iodosuccinimide Chemical compound IN1C(=O)CCC1=O LQZMLBORDGWNPD-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000104 sodium hydride Inorganic materials 0.000 description 2
- 239000012312 sodium hydride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- JFZMMCYRTJBQQI-UHFFFAOYSA-M 1-fluoropyridin-1-ium;trifluoromethanesulfonate Chemical compound F[N+]1=CC=CC=C1.[O-]S(=O)(=O)C(F)(F)F JFZMMCYRTJBQQI-UHFFFAOYSA-M 0.000 description 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- ZSTJMYZXBGCMIG-UHFFFAOYSA-M 3,5-dichloro-1-fluoropyridin-1-ium;trifluoromethanesulfonate Chemical compound [O-]S(=O)(=O)C(F)(F)F.F[N+]1=CC(Cl)=CC(Cl)=C1 ZSTJMYZXBGCMIG-UHFFFAOYSA-M 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 0 C[C@@](C[C@@]1N(C)C)O[C@@](*)[C@@]1O* Chemical compound C[C@@](C[C@@]1N(C)C)O[C@@](*)[C@@]1O* 0.000 description 1
- 229910019093 NaOCl Inorganic materials 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 125000000392 cycloalkenyl group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- VHHHONWQHHHLTI-UHFFFAOYSA-N hexachloroethane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)Cl VHHHONWQHHHLTI-UHFFFAOYSA-N 0.000 description 1
- PGGWSBRXMHAXEG-UHFFFAOYSA-N n-fluoro-n,4-dimethylbenzenesulfonamide Chemical compound CN(F)S(=O)(=O)C1=CC=C(C)C=C1 PGGWSBRXMHAXEG-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95988197A | 1997-10-29 | 1997-10-29 | |
| US08/959,881 | 1997-10-29 | ||
| US15423998A | 1998-09-16 | 1998-09-16 | |
| US09/154,239 | 1998-09-16 | ||
| PCT/US1998/022989 WO1999021871A1 (en) | 1997-10-29 | 1998-10-29 | 2-halo-6-o-substituted ketolide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001521039A JP2001521039A (ja) | 2001-11-06 |
| JP2001521039A5 true JP2001521039A5 (https=) | 2006-01-05 |
Family
ID=26851273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000517980A Pending JP2001521039A (ja) | 1997-10-29 | 1998-10-29 | ２−ハロ−６−ｏ−置換ケトライド誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1027362B1 (https=) |
| JP (1) | JP2001521039A (https=) |
| KR (1) | KR100536420B1 (https=) |
| CN (1) | CN1240707C (https=) |
| AR (1) | AR015994A1 (https=) |
| AT (1) | ATE298760T1 (https=) |
| AU (1) | AU751448B2 (https=) |
| BG (1) | BG64707B1 (https=) |
| BR (1) | BR9813319A (https=) |
| CA (1) | CA2307788C (https=) |
| CO (1) | CO4990960A1 (https=) |
| CZ (1) | CZ300063B6 (https=) |
| DE (1) | DE69830739T2 (https=) |
| DK (1) | DK1027362T3 (https=) |
| ES (1) | ES2244094T3 (https=) |
| HU (1) | HUP0004282A3 (https=) |
| IL (1) | IL135519A0 (https=) |
| NO (1) | NO20002190L (https=) |
| NZ (1) | NZ503822A (https=) |
| PL (1) | PL191453B1 (https=) |
| PT (1) | PT1027362E (https=) |
| SK (1) | SK286397B6 (https=) |
| TR (1) | TR200001142T2 (https=) |
| WO (1) | WO1999021871A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39743E1 (en) * | 1998-10-15 | 2007-07-24 | Aventis Pharma S.A. | 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use |
| FR2784682B1 (fr) | 1998-10-15 | 2002-12-06 | Hoechst Marion Roussel Inc | Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| ID30547A (id) * | 1999-04-16 | 2001-12-20 | Kosan Biosciences Inc | Zat anti-infeksi makrolida |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6569836B2 (en) | 1999-12-02 | 2003-05-27 | Abbott Laboratories | 6-O-alkyl-2-nor-2-substituted ketolide derivatives |
| JP2003527347A (ja) * | 1999-12-02 | 2003-09-16 | アボット・ラボラトリーズ | ６−ｏ−アルキル−２−ノル−２−置換ケトリド誘導体 |
| JP2001261694A (ja) | 2000-03-06 | 2001-09-26 | Pfizer Prod Inc | ケトライド抗生物質 |
| US6605707B1 (en) | 2000-03-23 | 2003-08-12 | Abbott Laboratories | Process for the preparation of 6-O-propargyl erythromycin derivatives |
| DE60104240T2 (de) | 2000-06-30 | 2005-08-04 | Pfizer Products Inc., Groton | Makrolid-Antibiotika |
| US6472372B1 (en) | 2000-12-06 | 2002-10-29 | Ortho-Mcneil Pharmaceuticals, Inc. | 6-O-Carbamoyl ketolide antibacterials |
| WO2003024986A1 (en) | 2001-09-17 | 2003-03-27 | Ortho-Mcneil Pharmaceutical, Inc. | 6-o-carbamate-11,12-lacto-ketolide antimicrobials |
| NZ533282A (en) | 2001-12-05 | 2006-09-29 | Ortho Mcneil Pharm Inc | 6-O-Acyl ketolide derivatives of erythromycine useful as antibacterials |
| JP2005522453A (ja) * | 2002-02-13 | 2005-07-28 | アボット・ラボラトリーズ | マクロライド抗菌化合物 |
| WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
| JP2005528409A (ja) * | 2002-04-25 | 2005-09-22 | アボット・ラボラトリーズ | オキソリド抗菌薬 |
| WO2004078771A1 (ja) * | 2003-03-07 | 2004-09-16 | Taisho Pharmaceutical Co., Ltd. | ２－フルオロ－６－ｏ－置換ケトライド誘導体 |
| JP2007254285A (ja) * | 2004-03-16 | 2007-10-04 | Taisho Pharmaceut Co Ltd | ２−フルオロ−６−ｏ−置換ケトライド誘導体 |
| BRPI1011959A2 (pt) * | 2009-05-27 | 2016-04-26 | Wockhardt Research Center | compostos de cetolídeo tendo atividade antimicrobiana. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8506380D0 (en) * | 1985-03-12 | 1985-04-11 | Beecham Group Plc | Chemical compounds |
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| ATE135707T1 (de) * | 1992-04-22 | 1996-04-15 | Taisho Pharmaceutical Co Ltd | 5-0-desosaminylerythronolid a derivate |
| FR2742757B1 (fr) * | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
-
1998
- 1998-10-27 CO CO98062730A patent/CO4990960A1/es unknown
- 1998-10-28 AR ARP980105407A patent/AR015994A1/es unknown
- 1998-10-29 PL PL340290A patent/PL191453B1/pl not_active IP Right Cessation
- 1998-10-29 DK DK98956338T patent/DK1027362T3/da active
- 1998-10-29 EP EP98956338A patent/EP1027362B1/en not_active Expired - Lifetime
- 1998-10-29 CA CA002307788A patent/CA2307788C/en not_active Expired - Fee Related
- 1998-10-29 KR KR10-2000-7004613A patent/KR100536420B1/ko not_active Expired - Fee Related
- 1998-10-29 DE DE69830739T patent/DE69830739T2/de not_active Expired - Lifetime
- 1998-10-29 AT AT98956338T patent/ATE298760T1/de not_active IP Right Cessation
- 1998-10-29 HU HU0004282A patent/HUP0004282A3/hu unknown
- 1998-10-29 CN CNB988127326A patent/CN1240707C/zh not_active Expired - Fee Related
- 1998-10-29 PT PT98956338T patent/PT1027362E/pt unknown
- 1998-10-29 SK SK633-2000A patent/SK286397B6/sk not_active IP Right Cessation
- 1998-10-29 NZ NZ503822A patent/NZ503822A/xx unknown
- 1998-10-29 AU AU12881/99A patent/AU751448B2/en not_active Ceased
- 1998-10-29 WO PCT/US1998/022989 patent/WO1999021871A1/en not_active Ceased
- 1998-10-29 JP JP2000517980A patent/JP2001521039A/ja active Pending
- 1998-10-29 ES ES98956338T patent/ES2244094T3/es not_active Expired - Lifetime
- 1998-10-29 BR BR9813319-5A patent/BR9813319A/pt not_active Application Discontinuation
- 1998-10-29 TR TR2000/01142T patent/TR200001142T2/xx unknown
- 1998-10-29 IL IL13551998A patent/IL135519A0/xx not_active IP Right Cessation
- 1998-10-29 CZ CZ20001525A patent/CZ300063B6/cs not_active IP Right Cessation
-
2000
- 2000-04-27 NO NO20002190A patent/NO20002190L/no not_active Application Discontinuation
- 2000-05-15 BG BG104434A patent/BG64707B1/bg unknown
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