JP2010520174A5 - - Google Patents
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- Publication number
- JP2010520174A5 JP2010520174A5 JP2009551216A JP2009551216A JP2010520174A5 JP 2010520174 A5 JP2010520174 A5 JP 2010520174A5 JP 2009551216 A JP2009551216 A JP 2009551216A JP 2009551216 A JP2009551216 A JP 2009551216A JP 2010520174 A5 JP2010520174 A5 JP 2010520174A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pyrrolidinone
- pyridinyl
- cyclobutyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 26
- 239000003381 stabilizer Substances 0.000 claims 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 12
- 239000000725 suspension Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- YFRBKEVUUCQYOW-UHFFFAOYSA-N 1-[6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]pyridin-3-yl]pyrrolidin-2-one Chemical compound O=C1CCCN1C(C=N1)=CC=C1OC1=CC=C(CCN(CC2)C3CCC3)C2=C1 YFRBKEVUUCQYOW-UHFFFAOYSA-N 0.000 claims 6
- -1 3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl Chemical group 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 235000015165 citric acid Nutrition 0.000 claims 4
- 239000012458 free base Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- RUPLXYFCPNFEAZ-UHFFFAOYSA-N 3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepine Chemical compound C1CCC1N1CCC2=CC=CC=C2CC1 RUPLXYFCPNFEAZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000007373 indentation Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 235000002639 sodium chloride Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89226707P | 2007-03-01 | 2007-03-01 | |
| US60/892,267 | 2007-03-01 | ||
| PCT/EP2008/052430 WO2008104590A2 (en) | 2007-03-01 | 2008-02-28 | Novel dosage form |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191832A Division JP2015038098A (ja) | 2007-03-01 | 2014-09-19 | 新規剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520174A JP2010520174A (ja) | 2010-06-10 |
| JP2010520174A5 true JP2010520174A5 (https=) | 2011-04-21 |
| JP5743177B2 JP5743177B2 (ja) | 2015-07-01 |
Family
ID=39248198
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551216A Expired - Fee Related JP5743177B2 (ja) | 2007-03-01 | 2008-02-28 | 新規剤形 |
| JP2014191832A Withdrawn JP2015038098A (ja) | 2007-03-01 | 2014-09-19 | 新規剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014191832A Withdrawn JP2015038098A (ja) | 2007-03-01 | 2014-09-19 | 新規剤形 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US20110014283A1 (https=) |
| EP (1) | EP2131818B1 (https=) |
| JP (2) | JP5743177B2 (https=) |
| KR (1) | KR101504371B1 (https=) |
| CN (1) | CN101674806B (https=) |
| AR (1) | AR065529A1 (https=) |
| AU (1) | AU2008220795B2 (https=) |
| BR (1) | BRPI0807882A2 (https=) |
| CA (1) | CA2679529A1 (https=) |
| CL (1) | CL2008000596A1 (https=) |
| CO (1) | CO6220900A2 (https=) |
| CR (1) | CR11013A (https=) |
| DK (1) | DK2131818T3 (https=) |
| DO (1) | DOP2009000207A (https=) |
| EA (1) | EA019865B1 (https=) |
| ES (1) | ES2463468T3 (https=) |
| HR (1) | HRP20140390T1 (https=) |
| IL (1) | IL200619A (https=) |
| MA (1) | MA31198B1 (https=) |
| MX (1) | MX2009009362A (https=) |
| NZ (1) | NZ579374A (https=) |
| PE (1) | PE20090114A1 (https=) |
| PL (1) | PL2131818T3 (https=) |
| PT (1) | PT2131818E (https=) |
| SI (1) | SI2131818T1 (https=) |
| TW (1) | TWI424856B (https=) |
| UA (1) | UA102515C2 (https=) |
| WO (1) | WO2008104590A2 (https=) |
| ZA (1) | ZA200905866B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103382174A (zh) | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| EP2328587A1 (en) * | 2008-08-29 | 2011-06-08 | Glaxo Group Limited | Dosage form comprising 1-isopropyl-4-{ [4-(tetrahydro-2h-pyran- 4-yloxy)phenyl]carbonyl}hexahydro-1h-1,4-diazepine or a salt thereof |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2011051423A1 (en) | 2009-11-02 | 2011-05-05 | Glaxo Group Limited | Treatment or prophylaxis of dementia, neurodegenerative disorders, schizophrenia, adhd, somnolence or epilepsy |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| WO2016100184A1 (en) | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| MX2017016231A (es) | 2015-06-10 | 2018-11-29 | Axovant Sciences Gmbh | Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina. |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7719894A (en) * | 1993-09-03 | 1995-03-22 | Smithkline Beecham Corporation | Stabilized tablet formulation |
| PL197077B1 (pl) * | 1998-12-01 | 2008-02-29 | Reddys Lab Inc Dr | Kompozycja farmaceutyczna zawierająca 5-[[4-[3-metylo-4-okso-3,4-dihydro-2-chinazolinylo]metoksy]fenylometylo]-tiazolidyno-2,4-dion lub jego sól dopuszczalną do stosowania w farmacji i sposób jej wytwarzania |
| US20040037869A1 (en) * | 2002-08-16 | 2004-02-26 | Douglas Cleverly | Non-animal product containing veterinary formulations |
| EP2133340B1 (en) * | 2002-12-20 | 2013-01-16 | Glaxo Group Limited | Novel benzazepine derivatives |
| CN1805938B (zh) * | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
| EP1640021A4 (en) * | 2003-06-30 | 2008-01-23 | Takeda Pharmaceutical | MEANS FOR THE PREVENTION / TREATMENT OF HARVESE DISORDERS |
| WO2005042491A1 (en) * | 2003-10-22 | 2005-05-12 | Arena Pharmaceuticals, Inc. | Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases |
| US20060002986A1 (en) * | 2004-06-09 | 2006-01-05 | Smithkline Beecham Corporation | Pharmaceutical product |
| WO2005123723A1 (en) * | 2004-06-18 | 2005-12-29 | Glaxo Group Limited | 3-cycloalkylbenzazepines as histamine h3 antagonists |
| JP2006022039A (ja) * | 2004-07-08 | 2006-01-26 | Towa Yakuhin Kk | 高い安定性を有するシンバスタチン固形製剤 |
| GB0418267D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-02-27 CL CL200800596A patent/CL2008000596A1/es unknown
- 2008-02-28 ES ES08717221.9T patent/ES2463468T3/es active Active
- 2008-02-28 CN CN2008800144640A patent/CN101674806B/zh not_active Expired - Fee Related
- 2008-02-28 KR KR1020097020444A patent/KR101504371B1/ko not_active Expired - Fee Related
- 2008-02-28 EA EA200970817A patent/EA019865B1/ru not_active IP Right Cessation
- 2008-02-28 SI SI200831205T patent/SI2131818T1/sl unknown
- 2008-02-28 NZ NZ579374A patent/NZ579374A/en not_active IP Right Cessation
- 2008-02-28 PL PL08717221T patent/PL2131818T3/pl unknown
- 2008-02-28 MX MX2009009362A patent/MX2009009362A/es active IP Right Grant
- 2008-02-28 PE PE2008000398A patent/PE20090114A1/es not_active Application Discontinuation
- 2008-02-28 AR ARP080100842A patent/AR065529A1/es unknown
- 2008-02-28 HR HRP20140390AT patent/HRP20140390T1/hr unknown
- 2008-02-28 EP EP08717221.9A patent/EP2131818B1/en not_active Not-in-force
- 2008-02-28 DK DK08717221.9T patent/DK2131818T3/da active
- 2008-02-28 WO PCT/EP2008/052430 patent/WO2008104590A2/en not_active Ceased
- 2008-02-28 JP JP2009551216A patent/JP5743177B2/ja not_active Expired - Fee Related
- 2008-02-28 CA CA002679529A patent/CA2679529A1/en not_active Abandoned
- 2008-02-28 PT PT87172219T patent/PT2131818E/pt unknown
- 2008-02-28 BR BRPI0807882-3A2A patent/BRPI0807882A2/pt not_active IP Right Cessation
- 2008-02-28 UA UAA200909976A patent/UA102515C2/ru unknown
- 2008-02-28 AU AU2008220795A patent/AU2008220795B2/en not_active Ceased
- 2008-02-28 US US12/528,492 patent/US20110014283A1/en not_active Abandoned
- 2008-02-29 TW TW097106936A patent/TWI424856B/zh not_active IP Right Cessation
-
2009
- 2009-08-24 ZA ZA200905866A patent/ZA200905866B/xx unknown
- 2009-08-27 IL IL200619A patent/IL200619A/en not_active IP Right Cessation
- 2009-08-28 DO DO2009000207A patent/DOP2009000207A/es unknown
- 2009-08-31 MA MA32184A patent/MA31198B1/fr unknown
- 2009-09-02 CR CR11013A patent/CR11013A/es unknown
- 2009-09-10 CO CO09097361A patent/CO6220900A2/es not_active Application Discontinuation
-
2014
- 2014-09-19 JP JP2014191832A patent/JP2015038098A/ja not_active Withdrawn
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