JP2001518930A - 抗cd−22抗体を使用したb細胞悪性疾患の免疫療法 - Google Patents
抗cd−22抗体を使用したb細胞悪性疾患の免疫療法Info
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- JP2001518930A JP2001518930A JP54576198A JP54576198A JP2001518930A JP 2001518930 A JP2001518930 A JP 2001518930A JP 54576198 A JP54576198 A JP 54576198A JP 54576198 A JP54576198 A JP 54576198A JP 2001518930 A JP2001518930 A JP 2001518930A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Immunology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 薬学的に許容できる担体と少なくとも1種の裸の抗CD22抗体を含む 治療用組成物を、B細胞悪性疾患を有する被験者に投与するステップを含んでな るB細胞悪性疾患の治療方法。 2. 前記抗CD22抗体を、20〜100mg蛋白質/投与の投与量で非経 口的に投与することを特徴とする請求項1に記載の治療方法。 3. 前記被験者が、抗CD22抗体を、20〜100mg蛋白質/投与の投 与量で繰り返して非経口投与として摂取することを特徴とする請求項1に記載の 治療方法。 4. 前記抗CD22抗体が、類人霊長類抗体、ネズミモノクローナル抗体、 キメラ抗体とヒト化抗体からなる群から選択されることを特徴とする請求項1に 記載の治療方法。 5. 前記抗CD22抗体がLL2抗体であることを特徴とする請求項4に記 載の治療方法。 6. 前記治療用組成物が、異なるCD22エピトープと結合する少なくとも 2種のモノクローナル抗体を含み、前記CD22エピトープが、エピトープA、 エピトープB、エピトープC、エピトープDとエピトープEからなる群から選択 されることを特徴とする請求項1に記載の治療方法。 7. 前記B細胞悪性疾患が無痛形B細胞リンパ腫、攻撃形B細胞リンパ腫、 慢性リンパ性白血病と急性リンパ性白血病からなる群から選択されることを特徴 とする請求項1に記載の治療方法。 8. 前記B細胞リンパ腫が、ノンホジキンリンパ腫であること特徴とする請 求項7に記載の方法。 9. 治療用蛋白質を投与するまたは化学療法剤による治療を行うステップを さらに含み、前記治療用蛋白質が、抗体、免疫複合体、抗体−免疫調節因子融合 蛋白質と抗体−毒素融合蛋白質からなる群から選択されることを特徴とする請求 項1に記載の治療方法。 10. 前記抗CD22抗体の投与前に、前記治療用蛋白質が投与されるまた は前記化学療法剤による治療が行われることを特徴とする請求項9に記載の治療 方法。 11. 前記抗CD22抗体の投与と同時に、前記治療用蛋白質が投与される または前記化学療法剤による治療が行われることを特徴とする請求項9に記載の 治療方法。 12. 前記抗CD22抗体の投与後に、前記治療用蛋白質が投与されるまた は前記化学療法剤による治療が行われることを特徴とする請求項9に記載の治療 方法。 13. 前記化学療法剤による治療が、シクロホスファミド、エトポシド、ビ ンクリスチン、プロカルバジン、プレドニゾン、カルムスチン、ドキソルビシン 、メトトレキサート、ブレオマイシン、デキサメタゾン、フェニルブチレート、 ブロスタチン−1とロイコボリンからなる群から選択される少なくとも一つの薬 剤の投与を含んでなることを特徴する請求項9に記載の治療方法。 14. 前記治療用蛋白質が、裸の抗CD19抗体か裸の抗CD20のいずれ かであることを特徴とする請求項9に記載の治療方法。 15. 前記治療用蛋白質が、放射標識された免疫複合体である、請求項9に 記載の治療方法。 16. 前記放射標識された免疫複合体が、198Au、32P、125I、131I、9 0 Y、186Re、188Re、67Cu、211Atからなる群から選択される放射性核種 を含んでなることを特徴とする請求項15に記載の治療方法。 17. 前記放射標識された免疫複合体が、CD19、CD20とCD22か らなる群から選択される抗原と結合する抗体または抗体フラグメントを含んでな ることを特徴とする請求項16に記載の治療方法。 18. 前記放射標識された免疫複合体が、放射標識された抗CD22免疫複 合体であることを特徴とする請求項17に記載の治療方法。 19. 前記放射標識された免疫複合体がサイトカイン部分をさらに含み、前 記サイトカイン部分がインターロイキン−1(IL−1)、IL−2、IL−3 、TL−6、IL−10、IL−12、インターフェロン−α、インターフェロ ン−βとインターフェロン−γからなる群から選択されることを特徴とする請求 項18に記載の治療方法。 20. 前記治療用蛋白質が、リシン、アブリン、リボヌクレアーゼ、DNA アーゼI、ブドウ球菌(Staphylococcal)エンテロトキシン−A、ヤマゴボウ抗 ウイルス蛋白質、ケロニン、ジフテリア毒素、シュードモナス(Psedomonas)外 毒素とシュードモナス内毒素からなる群から選択される毒素を含んでなる免疫複 合体または抗体−毒素融合蛋白質であることを特徴とする請求項9に記載の治療 方法。 21. 前記免疫複合体または前記抗体−毒素融合蛋白質が、CD19、CD 20とCD22からなる群から選択される抗原と結合する抗体または抗体フラグ メントを含んでなることを特徴とする請求項20に記載の治療方法。 22. 前記治療用蛋白質が免疫複合体または融合蛋白質であり、前記免疫複 合体または融合蛋白質が、インターロイキン−1(IL−1)、IL−2、IL −3、IL−6、IL−10、IL−12、インターフェロン−α、インターフ ェロン−βとインターフェロン−γ、顆粒球−コロニー刺激因子、顆粒球マクロ ファージ−コロニー刺激因子とリンフォトキシンからなる群から選択される免疫 調節因子を含んでなることを特徴とする請求項9に記載の治療方法。 23. 前記免疫調節因子または前記抗体−免疫調節因子融合蛋白質が、CD 19、CD20とCD22からなる群から選択される抗原と結合することを特徴 とする請求項22に記載の治療方法。 24. B細胞悪性疾患を治療する方法に使用するための医薬品の調製におい て少なくとも1種の裸の抗CD22抗体の使用であって、前記方法においてB細 胞悪性疾患を患っている被験者に、治療的に有効な量の裸のCD22抗体を投与 する使用。 25. 前記抗CD22抗体がLL2抗体であることを特徴とする請求項24 に記載の使用。 26. 前記治療用組成物が、異なるCD22エピトープと結合する少なくと も2種のモノクローナル抗体を含み、前記CD22エピトープが、エピトープA 、エピトープB、エピトープC、エピトープDとエピトープEからなる群から選 択されることを特徴とする請求項24に記載の使用。 27. 前記B細胞悪性疾患が無痛形B細胞リンパ腫、攻撃形B細胞リンパ腫 、慢性リンパ性白血病と急性リンパ性白血病からなる群から選択されることを特 徴とする請求項24に記載の使用。 28. 治療用蛋白質を投与するまたは化学療法剤による治療を行うステップ をさらに含み、前記治療用蛋白質が、抗体、免疫複合体、抗体−免疫調節因子融 合蛋白質と抗体−毒素融合蛋白質からなる群から選択されることを特徴とする請 求項24に記載の使用。 29. 前記治療用蛋白質が、裸の抗CD19抗体か裸の抗CD20のいずれ かであることを特徴とする請求項24に記載の使用。 30. 前記治療用蛋白質が免疫複合体または融合蛋白質であり、前記免疫複 合体または融合蛋白質が、インターロイキン−1(IL−1)、IL−2、IL −3、IL−6、IL−10、IL−12、インターフェロン−α、インターフ ェロン−βとインターフェロン−γ、顆粒球−コロニー刺激因子、顆粒球マクロ ファージ−コロニー刺激因子とリンフォトキシンからなる群から選択される免 疫調節因子を含んでなることを特徴とする請求項28に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US4150697P | 1997-03-24 | 1997-03-24 | |
US60/041,506 | 1997-03-24 | ||
PCT/US1998/005075 WO1998042378A1 (en) | 1997-03-24 | 1998-03-17 | Immunotherapy of b-cell malignancies using anti-cd22 antibodies |
Related Child Applications (1)
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JP2009237426A Division JP2010031032A (ja) | 1997-03-24 | 2009-10-14 | 抗cd−22抗体を使用したb細胞悪性疾患の免疫療法 |
Publications (2)
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JP2001518930A true JP2001518930A (ja) | 2001-10-16 |
JP4584363B2 JP4584363B2 (ja) | 2010-11-17 |
Family
ID=21916876
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP54576198A Expired - Fee Related JP4584363B2 (ja) | 1997-03-24 | 1998-03-17 | 抗cd−22抗体を使用したb細胞悪性疾患の免疫療法 |
JP2009237426A Pending JP2010031032A (ja) | 1997-03-24 | 2009-10-14 | 抗cd−22抗体を使用したb細胞悪性疾患の免疫療法 |
Family Applications After (1)
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JP2009237426A Pending JP2010031032A (ja) | 1997-03-24 | 2009-10-14 | 抗cd−22抗体を使用したb細胞悪性疾患の免疫療法 |
Country Status (12)
Country | Link |
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US (1) | US6183744B1 (ja) |
EP (4) | EP2332576A1 (ja) |
JP (2) | JP4584363B2 (ja) |
AT (1) | ATE297759T1 (ja) |
AU (1) | AU728325B2 (ja) |
CA (1) | CA2284829C (ja) |
DE (1) | DE69830570T3 (ja) |
DK (1) | DK0969866T4 (ja) |
ES (1) | ES2241129T5 (ja) |
IN (1) | IN189313B (ja) |
WO (1) | WO1998042378A1 (ja) |
ZA (1) | ZA982438B (ja) |
Cited By (15)
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WO2004087763A1 (ja) * | 2003-03-31 | 2004-10-14 | Chugai Seiyaku Kabushiki Kaisha | Cd22に対する改変抗体およびその利用 |
JP2005524700A (ja) * | 2002-05-02 | 2005-08-18 | ワイス・ホールディングズ・コーポレイション | カリチェアミシン誘導体−キャリアコンジュゲート |
US7691588B2 (en) | 2003-03-13 | 2010-04-06 | Chugai Seiyaku Kabushiki Kaisha | Ligand having agonistic activity to mutated receptor |
US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
JP2010189413A (ja) * | 2002-12-31 | 2010-09-02 | Immunomedics Inc | 非コンジュゲートおよびコンジュゲート抗体、抗体の組合せおよび融合タンパク質を用いるb細胞悪性腫瘍および自己免疫疾患の免疫療法 |
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Also Published As
Publication number | Publication date |
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IN189313B (ja) | 2003-02-08 |
ATE297759T1 (de) | 2005-07-15 |
DE69830570D1 (de) | 2005-07-21 |
DK0969866T3 (da) | 2005-10-03 |
EP0969866A1 (en) | 2000-01-12 |
DK0969866T4 (da) | 2009-03-30 |
EP0969866B2 (en) | 2009-02-18 |
CA2284829C (en) | 2012-10-23 |
AU6761098A (en) | 1998-10-20 |
EP1431311B1 (en) | 2016-07-20 |
EP2332576A1 (en) | 2011-06-15 |
ZA982438B (en) | 1998-11-04 |
EP1459768A2 (en) | 2004-09-22 |
AU728325B2 (en) | 2001-01-04 |
EP0969866B1 (en) | 2005-06-15 |
WO1998042378A1 (en) | 1998-10-01 |
EP1431311A1 (en) | 2004-06-23 |
ES2241129T3 (es) | 2005-10-16 |
US6183744B1 (en) | 2001-02-06 |
ES2241129T5 (es) | 2009-06-04 |
EP1459768A3 (en) | 2008-10-15 |
JP2010031032A (ja) | 2010-02-12 |
DE69830570T3 (de) | 2009-09-03 |
DE69830570T2 (de) | 2005-11-03 |
CA2284829A1 (en) | 1998-10-01 |
JP4584363B2 (ja) | 2010-11-17 |
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